Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2254250606', 'doi': 'https://doi.org/10.1080/1028415x.2015.1135559', 'title': 'Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells', 'display_name': 'Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells', 'publication_year': 2016, 'publication_date': '2016-02-08', 'ids': {'openalex': 'https://openalex.org/W2254250606', 'doi': 'https://doi.org/10.1080/1028415x.2015.1135559', 'mag': '2254250606', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26856988'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/1028415x.2015.1135559', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132280141', 'display_name': 'Nutritional Neuroscience', 'issn_l': '1028-415X', 'issn': ['1028-415X', '1476-8305'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108210998', 'display_name': 'Jagatheesan Nataraj', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197081775', 'display_name': 'Annamalai University', 'ror': 'https://ror.org/01x24z140', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I197081775']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Jagatheesan Nataraj', 'raw_affiliation_strings': ['Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamilnadu 608 002, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamilnadu 608 002, India', 'institution_ids': ['https://openalex.org/I197081775']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052925147', 'display_name': 'Thamilarasan Manivasagam', 'orcid': 'https://orcid.org/0000-0002-3948-8328'}, 'institutions': [{'id': 'https://openalex.org/I197081775', 'display_name': 'Annamalai University', 'ror': 'https://ror.org/01x24z140', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I197081775']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Thamilarasan Manivasagam', 'raw_affiliation_strings': ['Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamilnadu 608 002, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamilnadu 608 002, India', 'institution_ids': ['https://openalex.org/I197081775']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033759468', 'display_name': 'Arokiasamy Justin Thenmozhi', 'orcid': 'https://orcid.org/0000-0001-8822-4751'}, 'institutions': [{'id': 'https://openalex.org/I197081775', 'display_name': 'Annamalai University', 'ror': 'https://ror.org/01x24z140', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I197081775']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Arokiasamy Justin Thenmozhi', 'raw_affiliation_strings': ['Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamilnadu 608 002, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamilnadu 608 002, India', 'institution_ids': ['https://openalex.org/I197081775']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071713965', 'display_name': 'Musthafa Mohamed Essa', 'orcid': 'https://orcid.org/0000-0001-7505-9785'}, 'institutions': [{'id': 'https://openalex.org/I47818738', 'display_name': 'Sultan Qaboos University', 'ror': 'https://ror.org/04wq8zb47', 'country_code': 'OM', 'type': 'education', 'lineage': ['https://openalex.org/I47818738']}], 'countries': ['OM'], 'is_corresponding': False, 'raw_author_name': 'Musthafa Mohamed Essa', 'raw_affiliation_strings': ['Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman', 'Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman'], 'affiliations': [{'raw_affiliation_string': 'Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman', 'institution_ids': ['https://openalex.org/I47818738']}, {'raw_affiliation_string': 'Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman', 'institution_ids': ['https://openalex.org/I47818738']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5052925147'], 'corresponding_institution_ids': ['https://openalex.org/I197081775'], 'apc_list': None, 'apc_paid': None, 'fwci': 12.423, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.999875, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '20', 'issue': '6', 'first_page': '351', 'last_page': '359'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12891', 'display_name': 'Medicinal Plants and Neuroprotection', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12891', 'display_name': 'Medicinal Plants and Neuroprotection', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rotenone', 'display_name': 'Rotenone', 'score': 0.8956404}], 'concepts': [{'id': 'https://openalex.org/C2778389096', 'wikidata': 'https://www.wikidata.org/wiki/Q412388', 'display_name': 'Rotenone', 'level': 3, 'score': 0.8956404}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.88188964}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.8153613}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6684636}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6296616}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.5110977}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.46533978}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4593229}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.4283609}, {'id': 'https://openalex.org/C2779491571', 'wikidata': 'https://www.wikidata.org/wiki/Q312229', 'display_name': 'Lipoic acid', 'level': 3, 'score': 0.41132677}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.39840394}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3407476}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30003768}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29994136}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1754986}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.13517088}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D015507', 'descriptor_name': 'Drugs, Investigational', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D053978', 'descriptor_name': 'Pentacyclic Triterpenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000978', 'descriptor_name': 'Antiparkinson Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000978', 'descriptor_name': 'Antiparkinson Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015507', 'descriptor_name': 'Drugs, Investigational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053978', 'descriptor_name': 'Pentacyclic Triterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012402', 'descriptor_name': 'Rotenone', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D012402', 'descriptor_name': 'Rotenone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014475', 'descriptor_name': 'Uncoupling Agents', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D014475', 'descriptor_name': 'Uncoupling Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/1028415x.2015.1135559', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132280141', 'display_name': 'Nutritional Neuroscience', 'issn_l': '1028-415X', 'issn': ['1028-415X', '1476-8305'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26856988', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1504584187', 'https://openalex.org/W1530199299', 'https://openalex.org/W1539469412', 'https://openalex.org/W1690033192', 'https://openalex.org/W1968355999', 'https://openalex.org/W1968705390', 'https://openalex.org/W1968882667', 'https://openalex.org/W1969280474', 'https://openalex.org/W1969457041', 'https://openalex.org/W1970878854', 'https://openalex.org/W1976505302', 'https://openalex.org/W1977913875', 'https://openalex.org/W1980912158', 'https://openalex.org/W1991062363', 'https://openalex.org/W1994583626', 'https://openalex.org/W1999553106', 'https://openalex.org/W2000687549', 'https://openalex.org/W2002246326', 'https://openalex.org/W2013005819', 'https://openalex.org/W2017064363', 'https://openalex.org/W2031740174', 'https://openalex.org/W2035966342', 'https://openalex.org/W2050897300', 'https://openalex.org/W2059971906', 'https://openalex.org/W2062132320', 'https://openalex.org/W2062605045', 'https://openalex.org/W2073351779', 'https://openalex.org/W2075474183', 'https://openalex.org/W2079678859', 'https://openalex.org/W2089225800', 'https://openalex.org/W2089663038', 'https://openalex.org/W2091930637', 'https://openalex.org/W2096151015', 'https://openalex.org/W2102409753', 'https://openalex.org/W2114918609', 'https://openalex.org/W2126902508', 'https://openalex.org/W2152070721', 'https://openalex.org/W2168478576', 'https://openalex.org/W2170926992', 'https://openalex.org/W2171030272', 'https://openalex.org/W2341565810', 'https://openalex.org/W2377416684', 'https://openalex.org/W2415602239', 'https://openalex.org/W2472781452', 'https://openalex.org/W4247088117'], 'related_works': ['https://openalex.org/W4390172269', 'https://openalex.org/W4231299286', 'https://openalex.org/W3173576495', 'https://openalex.org/W3115759622', 'https://openalex.org/W2894579039', 'https://openalex.org/W2784324436', 'https://openalex.org/W2388621967', 'https://openalex.org/W2339364768', 'https://openalex.org/W2049053571', 'https://openalex.org/W2035493315'], 'abstract_inverted_index': {"Parkinson's": [0], 'disease': [1, 55], '(PD)': [2], 'is': [3, 29, 42, 61], 'a': [4, 62, 95, 119], 'chronic': [5], 'neurodegenerative': [6], 'disease,': [7], 'manifested': [8], 'due': [9, 157], 'to': [10, 19, 47, 115, 158, 177], 'the': [11, 51, 90, 110, 129, 185], 'loss': [12], 'of': [13, 27, 53, 92, 99, 107, 112, 122, 144, 173], 'dopaminergic': [14], 'neurons,': [15], 'which': [16], 'ultimately': [17], 'leads': [18], 'impaired': [20], 'movement': [21], 'in': [22, 84, 94, 104, 131, 170], 'elderly': [23], 'populations.': [24], 'The': [25], 'pathogenesis': [26], 'PD': [28, 174], 'associated': [30], 'with': [31, 150], 'numerous': [32], 'factors': [33], 'including': [34], 'oxidative': [35], 'stress,': [36], 'mitochondrial': [37, 100, 124, 132], 'dysfunction': [38, 125], 'and': [39, 74, 135, 138, 146, 162], 'apoptosis.': [40], 'There': [41], 'no': [43], 'effective': [44], 'therapy': [45], 'available': [46], 'cure': [48], 'or': [49], 'halt': [50], 'progression': [52], 'this': [54, 85], 'still': [56], 'now.': [57], 'Asiatic': [58], 'acid': [59], '(AA)': [60], 'triterpene': [63], 'extracted': [64], 'from': [65], 'Centella': [66], 'asiatica': [67], 'has': [68], 'been': [69], 'reported': [70], 'as': [71], 'an': [72], 'antioxidant': [73], 'anti-inflammatory': [75], 'agent,': [76], 'that': [77], 'offers': [78], 'neuroprotection': [79], 'against': [80], 'glutamate': [81], 'toxicity.': [82], 'Therefore,': [83], 'study,': [86], 'we': [87], 'have': [88], 'investigated': [89], 'effect': [91, 181], 'AA': [93, 151, 179], 'rotenone': [96], '(an': [97], 'inhibitor': [98], 'complex': [101], 'I)': [102], 'induced': [103], 'vitro': [105], 'model': [106], 'PD.': [108], 'Following': [109], 'exposure': [111], 'SH-SY5Y': [113], 'cells': [114], 'rotenone,': [116], 'there': [117], 'was': [118], 'marked': [120], 'overproduction': [121], 'ROS,': [123], '(as': [126], 'indexed': [127], 'by': [128], 'decrease': [130], 'membrane': [133], 'potential)': [134], 'apoptosis': [136], '(Hoechst': [137], 'dual': [139], 'staining,': [140], 'comet': [141], 'assay;': [142], 'expressions': [143], 'pro-apoptotic': [145], 'anti-apoptotic': [147, 163], 'indices).': [148], 'Pre-treatment': [149], 'reversed': [152], 'these': [153], 'changes': [154], 'might': [155], 'be': [156], 'its': [159], 'antioxidant,': [160], 'mitoprotective': [161], 'properties.': [164], 'However': [165], 'further': [166], 'extensive': [167], 'studies': [168], 'on': [169], 'vivo': [171], 'models': [172], 'are': [175], 'warranted': [176], 'prove': [178], 'neuroprotective': [180], 'before': [182], 'entering': [183], 'into': [184], 'clinical': [186], 'trial.': [187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2254250606', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}], 'updated_date': '2024-12-30T19:51:57.216393', 'created_date': '2016-06-24'}