Publication Information

{'id': 'https://openalex.org/W2253788727', 'doi': None, 'title': 'Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.', 'display_name': 'Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.', 'publication_year': 1994, 'publication_date': '1994-06-01', 'ids': {'openalex': 'https://openalex.org/W2253788727', 'mag': '2253788727', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8022420'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8022420', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054084974', 'display_name': 'Leah C. Knickle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125749732', 'display_name': 'Western University', 'ror': 'https://ror.org/02grkyz14', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I125749732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'L C Knickle', 'raw_affiliation_strings': ['Department of Pharmacology, and Toxicology, University of Western Ontario, London, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, and Toxicology, University of Western Ontario, London, Canada.', 'institution_ids': ['https://openalex.org/I125749732']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112799049', 'display_name': 'John R. Bend', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J R Bend', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.786, 'has_fulltext': False, 'cited_by_count': 49, 'citation_normalized_percentile': {'value': 0.758953, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '45', 'issue': '6', 'first_page': '1273', 'last_page': '80'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.982, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microsoma', 'display_name': 'Microsoma', 'score': 0.54079956}, {'id': 'https://openalex.org/keywords/hydroxyeicosatetraenoic-acid', 'display_name': 'Hydroxyeicosatetraenoic acid', 'score': 0.49234664}], 'concepts': [{'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.8818481}, {'id': 'https://openalex.org/C13002179', 'wikidata': 'https://www.wikidata.org/wiki/Q6901821', 'display_name': 'Monooxygenase', 'level': 4, 'score': 0.81078696}, {'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.79243726}, {'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.74216974}, {'id': 'https://openalex.org/C119795356', 'wikidata': 'https://www.wikidata.org/wiki/Q407801', 'display_name': 'Isozyme', 'level': 3, 'score': 0.69490063}, {'id': 'https://openalex.org/C2778815084', 'wikidata': 'https://www.wikidata.org/wiki/Q79803', 'display_name': 'Guinea pig', 'level': 2, 'score': 0.66299057}, {'id': 'https://openalex.org/C2776524530', 'wikidata': 'https://www.wikidata.org/wiki/Q4119721', 'display_name': 'Microsoma', 'level': 4, 'score': 0.54079956}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5208057}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5089836}, {'id': 'https://openalex.org/C2779630222', 'wikidata': 'https://www.wikidata.org/wiki/Q65658502', 'display_name': 'Hydroxyeicosatetraenoic acid', 'level': 4, 'score': 0.49234664}, {'id': 'https://openalex.org/C2780768313', 'wikidata': 'https://www.wikidata.org/wiki/Q408068', 'display_name': 'Cytochrome', 'level': 3, 'score': 0.46615943}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.45970923}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.39140958}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33291352}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.33138764}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.09023288}], 'mesh': [{'descriptor_ui': 'D015126', 'descriptor_name': '8,11,14-Eicosatrienoic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D015126', 'descriptor_name': '8,11,14-Eicosatrienoic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015126', 'descriptor_name': '8,11,14-Eicosatrienoic Acid', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001571', 'descriptor_name': 'Benzoflavones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001571', 'descriptor_name': 'Benzoflavones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006168', 'descriptor_name': 'Guinea Pigs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008797', 'descriptor_name': 'Metyrapone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008797', 'descriptor_name': 'Metyrapone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010634', 'descriptor_name': 'Phenobarbital', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010634', 'descriptor_name': 'Phenobarbital', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011335', 'descriptor_name': 'Proadifen', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011335', 'descriptor_name': 'Proadifen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019324', 'descriptor_name': 'beta-Naphthoflavone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8022420', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life below water', 'score': 0.4, 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2419414102', 'https://openalex.org/W2253788727', 'https://openalex.org/W2149151880', 'https://openalex.org/W2074076166', 'https://openalex.org/W2052667022', 'https://openalex.org/W2051936541', 'https://openalex.org/W2045270715', 'https://openalex.org/W1996238121', 'https://openalex.org/W1963514896', 'https://openalex.org/W1539452355'], 'abstract_inverted_index': {'Guinea': [0], 'pig': [1, 58, 211, 228], 'lung': [2, 229], 'microsomes': [3, 36, 43], 'converted': [4], 'arachidonic': [5], 'acid': [6], '(AA)': [7], 'to': [8, 159, 175, 224], 'two': [9], 'classes': [10, 134], 'of': [11, 27, 29, 53, 77, 89, 132, 135, 171, 184, 187, 200, 203, 213, 222, 234], 'cytochrome': [12], 'P450': [13, 54, 92, 145, 161, 177, 214, 235], '(P450)-dependent': [14], 'metabolites,': [15], '16-': [16], 'through': [17], '20-hydroxyeicosatetraenoic': [18], 'acids': [19, 23], '[(16-20)-OH-AA]': [20], 'and': [21, 69, 84, 100, 230], 'epoxyeicosatrienoic': [22], '(EETs).': [24], 'The': [25], 'rate': [26], 'formation': [28, 107, 131, 151, 166, 170, 183, 199], '(16-20)-OH-AA': [30, 117, 156, 252], 'was': [31, 97], 'approximately': [32], '3-fold': [33], 'higher': [34], 'in': [35, 56, 62, 94, 193, 226], 'from': [37, 44], 'beta-naphthoflavone-induced': [38], 'versus': [39], 'untreated': [40, 45], 'animals.': [41], 'In': [42], 'or': [46, 74, 110, 241], 'induced': [47], 'animals': [48], 'EETs,': [49], 'the': [50, 78, 87, 130, 169, 182, 198, 209, 220], 'major': [51], 'class': [52, 186, 202], 'metabolites': [55, 136], 'guinea': [57, 210, 227], 'lung,': [59], 'were': [60], 'formed': [61], 'a': [63, 122, 144, 232, 238], 'regioselective': [64], 'manner,': [65], 'with': [66, 113, 125, 152], '8,9-,': [67], '11,12-,': [68], '14,15-regioisomers': [70], 'accounting': [71], 'for': [72, 219, 251], '>': [73, 109, 138], '=': [75, 111], '90%': [76], 'total': [79], 'EETs.': [80], 'With': [81], 'isozyme-selective': [82], 'inhibitors': [83], 'inhibitory': [85], 'antibodies': [86, 174], 'role': [88], 'individual': [90], 'pulmonary': [91], 'isozymes': [93], 'AA': [95, 223], 'metabolism': [96], 'examined.': [98], 'Metyrapone': [99], 'SKF-525A': [101], '(P450': [102, 190], '2B': [103], 'selective)': [104], 'inhibited': [105, 129], 'EET': [106, 150, 165], 'by': [108, 137, 247], '85%': [112], 'little': [114, 153], 'effect': [115, 154], 'on': [116, 155], 'formation.': [118, 157, 253], '1-Aminobenzotriazole': [119], '(1': [120, 142], 'mM),': [121], 'mechanism-based': [123, 147], 'inhibitor': [124], 'low': [126], 'isozyme': [127], 'selectivity,': [128], 'both': [133], '95%,': [139], 'whereas': [140, 173], 'N-alpha-methylbenzyl-1-aminobenzotriazole': [141], 'microM),': [143], '2B-selective': [146], 'inhibitor,': [148], 'abolished': [149, 164], 'Antibodies': [158], 'rabbit': [160, 176], '2B4': [162, 215], 'also': [163], 'without': [167], 'inhibiting': [168], '(16-20)-OH-AA,': [172], '4B1': [178], 'did': [179, 195], 'not': [180, 196], 'inhibit': [181, 197], 'either': [185, 201], 'metabolites.': [188, 204], 'alpha-Naphthoflavone': [189], '1A1': [191], 'selective': [192], 'lung)': [194], 'These': [205], 'data': [206], 'demonstrate': [207], 'that': [208, 231], 'orthologue': [212], 'is': [216, 245, 249], 'solely': [217], 'responsible': [218, 250], 'bioactivation': [221], 'EETs': [225], 'form': [233], 'other': [236], 'than': [237], '2B,': [239], '4B,': [240], '1A': [242], 'isozyme,': [243], 'which': [244], 'inducible': [246], 'beta-naphthoflavone,': [248]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2253788727', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-08T16:24:14.795395', 'created_date': '2016-06-24'}