Title: Modulation of Nicotinic AChR Channels by Prostaglandin E<sub>2</sub>in Chick Sympathetic Ganglion Neurons
Abstract: Tan, Wen, Chuang Du, Steven A. Siegelbaum, and Lorna W. Role. Modulation of nicotinic AChR channels by prostaglandin E 2 in chick sympathetic ganglion neurons. J. Neurophysiol. 79: 870–879, 1998. The effects of prostaglandin E 2 (PGE 2 ), an important metabolite of arachidonic acid, were studied on the activity of nicotinic AChR channels in cultured chick sympathetic ganglion neurons. In whole cell recordings, PGE 2 (25 nM) inhibited significantly the ACh-evoked macroscopic current. In cell-attached patch recordings, PGE 2 significantly inhibited single AChR channel currents as a result of a decrease in the frequency of channel opening, with no change in open time and conductance. PGE 2 did not alter the extent or rate of agonist-induced desensitization of the AChR channels. These effects are specific since the related compound PGD 2 had no effect on AChR channel function. Because there is an abundant endogenous production of PGE 2 within sympathetic ganglia in response to certain stimuli, the inhibition of AChR channel function by PGE 2 could serve an important role to modulate synaptic transmission in the sympathetic nervous system.
Publication Year: 1998
Publication Date: 1998-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 23
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