Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2245508158', 'doi': 'https://doi.org/10.1038/srep19408', 'title': 'Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway', 'display_name': 'Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway', 'publication_year': 2016, 'publication_date': '2016-01-14', 'ids': {'openalex': 'https://openalex.org/W2245508158', 'doi': 'https://doi.org/10.1038/srep19408', 'mag': '2245508158', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26762881', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4725955'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep19408', 'pdf_url': 'https://www.nature.com/articles/srep19408.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/srep19408.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101844703', 'display_name': 'Jin Li', 'orcid': 'https://orcid.org/0009-0001-4479-9868'}, 'institutions': [{'id': 'https://openalex.org/I4210086973', 'display_name': 'Affiliated Eye Hospital of Wenzhou Medical College', 'ror': 'https://ror.org/000sxmx78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086973']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'funder', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin Li', 'raw_affiliation_strings': ['Zhejiang Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Zhejiang Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China', 'institution_ids': ['https://openalex.org/I4210086973', 'https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101470571', 'display_name': 'Ruzhi Deng', 'orcid': 'https://orcid.org/0000-0002-4587-7223'}, 'institutions': [{'id': 'https://openalex.org/I4210086973', 'display_name': 'Affiliated Eye Hospital of Wenzhou Medical College', 'ror': 'https://ror.org/000sxmx78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086973']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'funder', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'None Ruzhi Deng', 'raw_affiliation_strings': ['Zhejiang Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Zhejiang Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China', 'institution_ids': ['https://openalex.org/I4210086973', 'https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100756704', 'display_name': 'Xia Hua', 'orcid': 'https://orcid.org/0000-0001-5481-2838'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210130637', 'display_name': 'Ocular Surface Center', 'ror': 'https://ror.org/03tghjn41', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I4210130637']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xia Hua', 'raw_affiliation_strings': ['Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA', 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I4210130637']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100461208', 'display_name': 'Lili Zhang', 'orcid': 'https://orcid.org/0000-0002-9341-5832'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210130637', 'display_name': 'Ocular Surface Center', 'ror': 'https://ror.org/03tghjn41', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I4210130637']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lili Zhang', 'raw_affiliation_strings': ['Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA', 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I4210130637']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100371042', 'display_name': 'Fan Lü', 'orcid': 'https://orcid.org/0000-0002-8794-6944'}, 'institutions': [{'id': 'https://openalex.org/I4210086973', 'display_name': 'Affiliated Eye Hospital of Wenzhou Medical College', 'ror': 'https://ror.org/000sxmx78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086973']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'funder', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fan Lu', 'raw_affiliation_strings': ['Zhejiang Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Zhejiang Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China', 'institution_ids': ['https://openalex.org/I4210086973', 'https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108825485', 'display_name': 'Terry G. Coursey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130637', 'display_name': 'Ocular Surface Center', 'ror': 'https://ror.org/03tghjn41', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I4210130637']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Terry G. Coursey', 'raw_affiliation_strings': ['Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA', 'institution_ids': ['https://openalex.org/I4210130637', 'https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086607086', 'display_name': 'Stephen C. Pflugfelder', 'orcid': 'https://orcid.org/0000-0002-9341-3482'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210130637', 'display_name': 'Ocular Surface Center', 'ror': 'https://ror.org/03tghjn41', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I4210130637']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen C. Pflugfelder', 'raw_affiliation_strings': ['Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA', 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I4210130637']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101882729', 'display_name': 'De‐Quan Li', 'orcid': 'https://orcid.org/0000-0001-9449-4686'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210130637', 'display_name': 'Ocular Surface Center', 'ror': 'https://ror.org/03tghjn41', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I4210130637']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'De-Quan Li', 'raw_affiliation_strings': ['Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA', 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I4210130637']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 10.631, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 108, 'citation_normalized_percentile': {'value': 0.937983, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11828', 'display_name': 'Corneal Surgery and Treatments', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11828', 'display_name': 'Corneal Surgery and Treatments', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10997', 'display_name': 'Ocular Surface and Contact Lens', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10250', 'display_name': 'Glaucoma and retinal disorders', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pterostilbene', 'display_name': 'Pterostilbene', 'score': 0.82508445}, {'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.46219733}, {'id': 'https://openalex.org/keywords/malondialdehyde', 'display_name': 'Malondialdehyde', 'score': 0.442441}], 'concepts': [{'id': 'https://openalex.org/C2781196776', 'wikidata': 'https://www.wikidata.org/wiki/Q2908011', 'display_name': 'Pterostilbene', 'level': 3, 'score': 0.82508445}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.8023988}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.6615352}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.6410309}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.58859795}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5419025}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.46219733}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.45341027}, {'id': 'https://openalex.org/C2778401633', 'wikidata': 'https://www.wikidata.org/wiki/Q418661', 'display_name': 'Malondialdehyde', 'level': 3, 'score': 0.442441}, {'id': 'https://openalex.org/C2779257441', 'wikidata': 'https://www.wikidata.org/wiki/Q2040445', 'display_name': 'Corneal epithelium', 'level': 3, 'score': 0.4338149}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40202388}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3226571}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29450458}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.25850624}, {'id': 'https://openalex.org/C2776882836', 'wikidata': 'https://www.wikidata.org/wiki/Q168291', 'display_name': 'Cornea', 'level': 2, 'score': 0.16692618}, {'id': 'https://openalex.org/C2776816829', 'wikidata': 'https://www.wikidata.org/wiki/Q407329', 'display_name': 'Resveratrol', 'level': 2, 'score': 0.07840511}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D029798', 'descriptor_name': 'Blueberry Plants', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019573', 'descriptor_name': 'Epithelium, Corneal', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D007634', 'descriptor_name': 'Keratitis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029798', 'descriptor_name': 'Blueberry Plants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019573', 'descriptor_name': 'Epithelium, Corneal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007634', 'descriptor_name': 'Keratitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007634', 'descriptor_name': 'Keratitis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007634', 'descriptor_name': 'Keratitis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009994', 'descriptor_name': 'Osmolar Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013267', 'descriptor_name': 'Stilbenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013267', 'descriptor_name': 'Stilbenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep19408', 'pdf_url': 'https://www.nature.com/articles/srep19408.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4725955', 'pdf_url': 'https://europepmc.org/articles/pmc4725955?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725955', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26762881', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep19408', 'pdf_url': 'https://www.nature.com/articles/srep19408.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1542814291', 'https://openalex.org/W1571886384', 'https://openalex.org/W1572685041', 'https://openalex.org/W1855379264', 'https://openalex.org/W1970531479', 'https://openalex.org/W1979063194', 'https://openalex.org/W1979708061', 'https://openalex.org/W1992495439', 'https://openalex.org/W1993893812', 'https://openalex.org/W2002935341', 'https://openalex.org/W2005273232', 'https://openalex.org/W2009565960', 'https://openalex.org/W2015494251', 'https://openalex.org/W2018893722', 'https://openalex.org/W2021968547', 'https://openalex.org/W2023411987', 'https://openalex.org/W2029515932', 'https://openalex.org/W2037972678', 'https://openalex.org/W2045232907', 'https://openalex.org/W2046167249', 'https://openalex.org/W2050227446', 'https://openalex.org/W2050280746', 'https://openalex.org/W2051139838', 'https://openalex.org/W2052808939', 'https://openalex.org/W2054013327', 'https://openalex.org/W2057522312', 'https://openalex.org/W2062565730', 'https://openalex.org/W2064476565', 'https://openalex.org/W2065052738', 'https://openalex.org/W2071555402', 'https://openalex.org/W2088904701', 'https://openalex.org/W2092033904', 'https://openalex.org/W2093332028', 'https://openalex.org/W2109671318', 'https://openalex.org/W2112797831', 'https://openalex.org/W2115154692', 'https://openalex.org/W2115201309', 'https://openalex.org/W2123133124', 'https://openalex.org/W2124600315', 'https://openalex.org/W2124610153', 'https://openalex.org/W2126852430', 'https://openalex.org/W2137726115', 'https://openalex.org/W2140765499', 'https://openalex.org/W2144477621', 'https://openalex.org/W2146296415', 'https://openalex.org/W2153188352', 'https://openalex.org/W2153189178', 'https://openalex.org/W2167962247', 'https://openalex.org/W2184413367', 'https://openalex.org/W2230323274', 'https://openalex.org/W2321748683', 'https://openalex.org/W256458242', 'https://openalex.org/W2596391620', 'https://openalex.org/W950774417'], 'related_works': ['https://openalex.org/W4390413356', 'https://openalex.org/W3041632999', 'https://openalex.org/W3032685127', 'https://openalex.org/W2945407096', 'https://openalex.org/W2423865176', 'https://openalex.org/W2387681069', 'https://openalex.org/W2368062132', 'https://openalex.org/W2361415489', 'https://openalex.org/W2154735061', 'https://openalex.org/W1963764635'], 'abstract_inverted_index': {'Abstract': [0], 'Blueberries': [1], 'have': [2], 'been': [3], 'recognized': [4], 'to': [5, 52, 110, 117, 149], 'possess': [6], 'protective': [7, 195], 'properties': [8], 'from': [9, 188], 'inflammation': [10, 38, 190], 'and': [11, 18, 64, 76, 105, 142, 154, 163, 174, 191], 'various': [12], 'diseases,': [13], 'but': [14], 'not': [15], 'for': [16], 'eye': [17], 'ocular': [19, 36], 'disorders.': [20], 'This': [21], 'study': [22], 'explores': [23], 'potential': [24], 'benefits': [25], 'of': [26, 32, 45, 91, 97, 133, 167, 197], 'pterostilbene': [27], '(PS),': [28], 'a': [29, 124], 'natural': [30], 'component': [31], 'blueberries,': [33], 'in': [34, 41, 107, 123], 'preventing': [35], 'surface': [37], 'using': [39, 86], 'an': [40], 'vitro': [42], 'culture': [43], 'model': [44], 'human': [46, 186], 'corneal': [47], 'epithelial': [48], 'cells': [49], '(HCECs)': [50], 'exposed': [51, 109], 'hyperosmotic': [53, 111, 178], 'medium': [54], 'at': [55], '450': [56], 'mOsM.': [57], 'Gene': [58], 'expression': [59, 96, 162], 'was': [60, 69, 84, 147], 'detected': [61], 'by': [62, 71, 157], 'RT-qPCR': [63], 'protein': [65], 'production': [66, 83], 'or': [67], 'activity': [68, 166], 'determined': [70], 'ELISA,': [72], 'zymography,': [73], 'Western': [74], 'blotting': [75], 'immunofluorescent': [77], 'staining.': [78], 'Reactive': [79], 'oxygen': [80], 'species': [81], '(ROS)': [82], 'measured': [85], 'DCFDA': [87], 'kit.': [88], 'The': [89], 'addition': [90], 'PS': [92, 115, 128, 146, 184, 198], 'significantly': [93, 129], 'reduced': [94], 'the': [95, 131, 165], 'pro-inflammatory': [98], 'mediators,': [99], 'TNF-α,': [100], 'IL-1': [101], 'β,': [102], 'IL-6,': [103], 'MMP-2': [104], 'MMP-9': [106], 'HCECs': [108], 'medium.': [112], 'Pre-treatment': [113], 'with': [114], '(5': [116], '20': [118], 'μM)': [119], 'suppressed': [120], 'ROS': [121], 'overproduction': [122], 'dose-dependent': [125], 'manner.': [126], 'Additionally,': [127], 'decreased': [130], 'levels': [132], 'oxidative': [134, 192], 'damage': [135], 'biomarkers,': [136], 'malondialdehyde': [137], '(MDA),': [138], '4-hydroxynonenal': [139], '(4-HNE),': [140], 'aconitase-2': [141], '8-hydroxydeoxyguanosine': [143], '(8-OHdG).': [144], 'Importantly,': [145], 'found': [148], 'rebalance': [150], 'homeostasis': [151], 'between': [152], 'oxygenases': [153], 'anti-oxidative': [155], 'enzymes': [156], 'decreasing': [158], 'cyclooxygenase': [159], '2': [160], '(COX2)': [161], 'restoring': [164], 'antioxidant': [168], 'enzymes,': [169], 'superoxide': [170], 'dismutase': [171], '1': [172], '(SOD1)': [173], 'peroxiredoxin-4': [175], '(PRDX4)': [176], 'during': [177], 'stress.': [179], 'Our': [180], 'findings': [181], 'demonstrate': [182], 'that': [183], 'protects': [185], 'cornea': [187], 'hyperosmolarity-induced': [189], 'stress,': [193], 'suggesting': [194], 'effects': [196], 'on': [199], 'dry': [200], 'eye.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2245508158', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 6}], 'updated_date': '2025-01-25T10:17:34.477297', 'created_date': '2016-06-24'}