Publication Information

{'id': 'https://openalex.org/W2243920008', 'doi': 'https://doi.org/10.1074/mcp.m115.053819', 'title': 'Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression', 'display_name': 'Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression', 'publication_year': 2015, 'publication_date': '2015-08-14', 'ids': {'openalex': 'https://openalex.org/W2243920008', 'doi': 'https://doi.org/10.1074/mcp.m115.053819', 'mag': '2243920008', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26272979', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4813700'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m115.053819', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1074/mcp.m115.053819', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101704537', 'display_name': 'Yupeng Zheng', 'orcid': 'https://orcid.org/0000-0002-3351-5161'}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yupeng Zheng', 'raw_affiliation_strings': ['Departments of Chemistry and Molecular Biosciences, and the Proteomics Center of Excellence, Northwestern University, 2145 N. 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'https://openalex.org/W4242256187'], 'related_works': ['https://openalex.org/W4390904861', 'https://openalex.org/W3082608639', 'https://openalex.org/W2159831588', 'https://openalex.org/W2078508114', 'https://openalex.org/W2070959297', 'https://openalex.org/W2065064903', 'https://openalex.org/W2060002736', 'https://openalex.org/W2058176071', 'https://openalex.org/W2043346845', 'https://openalex.org/W2038611688'], 'abstract_inverted_index': {'Histones,': [0, 271], 'and': [1, 10, 49, 109, 124, 182, 219, 252, 272, 281, 320, 380, 395, 453, 490, 523, 592, 750, 854, 1049, 1186, 1223, 1274, 1276, 1283, 1454, 1591, 1667, 1673, 1752, 1754, 1838, 1884, 1926, 2124, 2203, 2242, 2424, 2485, 2499, 2524, 2595, 2633, 2668, 2700, 2761, 2768, 2773, 2853, 2872, 2877, 2946, 3088, 3100, 3151, 3178, 3248, 3258, 3279, 3292, 3524, 3564, 3588, 3642, 3672, 3736, 3757, 3781, 3823, 3833, 3862, 3883, 3895, 4009, 4013, 4034, 4054, 4147, 4172, 4253, 4277, 4291], 'their': [2, 253, 273, 524, 1264, 2873, 2947, 3259, 3643], 'modifications,': [3, 274, 1195, 1260], 'are': [4, 275, 1204, 1300, 1913, 2194, 2695], 'critical': [5, 276, 563, 2497, 3529], 'components': [6, 277], 'of': [7, 44, 67, 75, 89, 106, 114, 158, 161, 171, 176, 190, 199, 208, 278, 315, 338, 346, 360, 377, 385, 429, 432, 442, 447, 461, 470, 479, 544, 550, 589, 595, 622, 658, 859, 887, 895, 1209, 1248, 1269, 1297, 1307, 1677, 1731, 1742, 1749, 1775, 1786, 1811, 1832, 1917, 1923, 1931, 1948, 1964, 1968, 1974, 1984, 1989, 2151, 2184, 2198, 2244, 2264, 2280, 2303, 2318, 2365, 2369, 2377, 2396, 2403, 2410, 2520, 2564, 2580, 2599, 2655, 2702, 2812, 2844, 2932, 2943, 2977, 3012, 3039, 3107, 3123, 3149, 3226, 3255, 3355, 3388, 3432, 3489, 3507, 3540, 3567, 3744, 3964, 3986, 4135, 4142, 4164, 4176, 4202, 4212, 4226, 4256, 4258], 'cellular': [8, 250, 279, 521, 2163, 2629, 3753], 'programming': [9, 280, 591], 'epigenetic': [11, 282, 656, 2881], 'inheritance.': [12, 283], 'Recently,': [13, 284, 2181], 'cancer': [14, 285, 672, 1312, 1975], 'genome': [15, 286], 'sequencing': [16, 287], 'has': [17, 288, 546, 2186, 2398], 'uncovered': [18, 289], 'driver': [19, 290, 1309, 1669], 'mutations': [20, 30, 291, 301, 753, 848, 1045, 1135, 1310, 1420, 1456, 1587, 1670, 2067], 'in': [21, 83, 127, 150, 166, 180, 187, 201, 292, 354, 398, 421, 437, 451, 458, 472, 552, 565, 660, 852, 902, 1046, 1053, 1136, 1267, 1286, 1421, 1424, 1444, 1457, 1588, 1595, 1818, 1868, 1971, 1991, 1993, 2068, 2118, 2131, 2248, 2283, 2401, 2482, 2493, 2504, 2665, 2771, 2980, 3126, 3185, 3285, 3328, 3414, 3429, 3512, 3521, 3762, 3778, 3881, 3893, 3967, 4022, 4124, 4217], 'chromatin': [22, 293, 1050, 1131, 1218, 1293, 1592, 1717, 1776, 2063, 2129, 2191, 2245], 'modifying': [23, 294, 1316], 'enzymes': [24, 295, 1317], 'spurring': [25, 296], 'high': [26, 197, 297, 468, 2602, 3532, 3558, 3902, 4282], 'interest': [27, 298], 'how': [28, 299, 2653, 2691], 'such': [29, 225, 300, 496], 'change': [31, 302], 'histone': [32, 54, 69, 107, 132, 222, 303, 325, 340, 378, 403, 493, 899, 1047, 1315, 1458, 1589, 1732, 1782, 1790, 1834, 1901, 1949, 1969, 2152, 2171, 2281, 2307, 2322, 2370, 2703, 2813, 2846, 2922, 2955, 3014, 3041, 3108, 3124, 3155, 3182, 3227, 3256, 3287, 3357, 3389, 3433, 3922, 4007, 4018, 4185, 4213], 'modification': [33, 304, 1743, 3122, 3289, 3631], 'patterns.': [34, 305], 'Here,': [35, 306, 2835], 'we': [36, 102, 307, 373, 2429, 2926, 3730], 'applied': [37, 308], 'Top-Down': [38, 258, 309, 529, 1927, 2842, 2929, 3150, 3382, 3423, 3741], 'mass': [39, 259, 310, 530, 1965, 2902, 2952, 2988, 3250, 3545, 3596, 3677, 4067, 4118, 4218, 4225], 'spectrometry': [40, 260, 311, 531, 2903, 3176, 3251, 4068], 'for': [41, 86, 142, 312, 357, 413, 746, 1217, 3103, 3154, 3253, 3384, 3422, 3492, 3518, 3531, 3553, 3629, 3716, 4151, 4219, 4241, 4261, 4327], 'the': [42, 68, 73, 81, 156, 188, 202, 206, 215, 313, 339, 344, 352, 427, 459, 473, 477, 486, 553, 587, 593, 1165, 1207, 1279, 1292, 1304, 1869, 1972, 1981, 2148, 2157, 2170, 2182, 2269, 2284, 2291, 2304, 2316, 2366, 2375, 2378, 2408, 2446, 2450, 2494, 2538, 2561, 2583, 2589, 2596, 2662, 2763, 2920, 2981, 3147, 3385, 3415, 3420, 3430, 3490, 3508, 3538, 3565, 3745, 4064, 4131, 4162, 4165, 4224, 4236, 4251, 4262], 'characterization': [43, 105, 314, 376, 2976, 3011, 3038, 3225, 3254, 3354, 3431, 3535], 'combinatorial': [45, 316, 1833, 2149, 2692, 2924, 3121, 3356], 'modifications': [46, 115, 317, 386, 1299, 1733, 1783, 1813, 1835, 1902, 1970, 2153, 2185, 2282, 2917], '(i.e.': [47, 318, 1271, 2923], 'methylation': [48, 126, 149, 164, 319, 397, 420, 435, 1197, 1270, 1747, 2130, 2320, 2670, 2693, 3924], 'acetylation)': [50, 321], 'on': [51, 322, 898, 1164, 1278, 1291, 1789, 1836, 2268, 2290, 2374, 2697, 2858, 2919, 3712, 4072, 4250, 4323], 'full': [52, 323, 3663], 'length': [53, 324], 'H3': [55, 133, 326, 404, 900, 1709, 2814, 2847, 2870, 3109, 3125, 3923], 'from': [56, 61, 327, 332, 558, 573, 671, 1150, 2196, 2277, 2528, 3140, 3419, 3855], 'human': [57, 328, 570, 903, 2250, 2954, 2978, 3013, 3040, 3127, 3187, 3921], 'cell': [58, 329, 575, 596, 1675, 2211, 2251, 2521, 2534, 2559, 2587], 'lines': [59, 330, 2212], 'derived': [60, 331], 'multiple': [62, 143, 333, 414, 2199, 2404, 2433, 2506, 2531, 2622, 3568, 3709, 4320], 'myeloma': [63, 334, 2405, 2532, 2623, 2764], 'patients': [64, 335], 'with': [65, 139, 173, 214, 224, 336, 410, 444, 485, 495, 2336, 3082, 3537, 3557, 3766, 3792, 3837, 3858, 3866, 3878, 3885, 4049, 4154, 4288], 'overexpression': [66, 157, 337, 428, 2654], 'methyltransferase': [70, 341, 2756], 'MMSET': [71, 159, 200, 342, 430, 471, 1992, 2294, 2397, 2447, 2565, 2600, 2625], 'as': [72, 343, 556, 1219, 1261, 1263, 1712, 2156, 2297, 2407, 3907, 4296], 'result': [74, 345, 2409], 'a': [76, 174, 185, 347, 445, 456, 1220, 1713, 1907, 1985, 2475, 2488, 2529, 2656, 3043, 3396, 3495, 3516, 3541, 3550, 3942, 3962, 3983, 4038, 4050, 4059, 4102, 4139, 4173, 4193, 4210, 4272], 't(4;14)': [77, 348, 2413, 2505], 'chromosomal': [78, 349, 2411], 'translocation.': [79, 350], 'Using': [80, 351], 'latest': [82, 353], 'Orbitrap-based': [84, 355, 3543], 'technology': [85, 356], 'clean': [87, 358], 'isolation': [88, 359, 3523, 3556, 4252, 4275], 'isobaric': [90, 361, 4243], 'proteoforms': [91, 210, 223, 241, 362, 481, 494, 512, 3390], 'containing': [92, 211, 363, 482, 3829], 'up': [93, 98, 266, 364, 369, 537], 'to': [94, 99, 245, 267, 365, 370, 516, 538, 569, 577, 673, 1153, 1206, 1715, 1761, 2126, 2160, 2189, 2205, 2273, 2487, 2502, 2574, 2576, 2628, 2661, 2818, 2839, 2880, 3145, 3380, 3425, 3732, 3739, 3897, 4179, 4208, 4223, 4235, 4281, 4293], '10': [95, 366, 3819], 'methylations': [96, 367], 'and/or': [97, 368], 'two': [100, 371, 1735, 1914, 2845, 3528], 'acetylations,': [101, 372], 'provide': [103, 374, 1906], 'extensive': [104, 375], 'H3.1': [108, 233, 379, 504, 4008], 'H3.3': [110, 151, 381, 422, 1048, 1459, 1590, 4010], 'proteoforms.': [111, 382], 'Differential': [112, 383], 'analysis': [113, 194, 384, 465, 1922, 1947, 1967, 2243, 2689, 2931, 2942, 3156, 3387, 3591], 'by': [116, 155, 237, 387, 426, 508, 1303, 1903, 1919, 1980, 2569, 2950, 2985, 3016, 3084, 3592, 3667, 3846, 3864, 4000, 4015], 'electron-based': [117, 388], 'dissociation': [118, 389, 2554, 2906, 2909, 3570, 3575, 3595, 3612, 3628, 3675], 'recapitulated': [119, 390], 'antagonistic': [120, 391], 'crosstalk': [121, 264, 392, 535], 'between': [122, 393], 'K27': [123, 394], 'K36': [125, 148, 396, 419], 'H3.1,': [128, 399], 'validating': [129, 400], 'that': [130, 196, 257, 401, 467, 528, 2147, 3513], 'full-length': [131, 402, 1932], '(15': [134, 405, 3795], 'kDa)': [135, 406, 3111], 'can': [136, 261, 407, 532, 1759, 1814, 1860, 1905, 2154], 'be': [137, 408, 2206], 'analyzed': [138, 236, 409, 507], 'site-specific': [140, 411], 'assignments': [141, 412], 'modifications.': [144, 192, 415, 463], 'It': [145, 416], 'also': [146, 417, 3143], 'revealed': [147, 418, 2652], 'was': [152, 423, 1977, 2566, 2592, 2838, 3412, 3515, 3875, 4268], 'affected': [153, 424], 'less': [154, 425], 'because': [160, 431], 'its': [162, 433, 562, 1862, 2121], 'higher': [163, 434], 'levels': [165, 198, 436, 469], 'control': [167, 438], 'cells.': [168, 439], 'The': [169, 440, 542, 620, 1295, 1962, 2142, 2363, 2621, 3245, 3485, 3873, 4229], 'co-occurrence': [170, 441, 2276], 'acetylation': [172, 443, 1199, 1865], 'minimum': [175, 446], 'three': [177, 268, 448, 539, 1745], 'methyl': [178, 449], 'groups': [179, 450], 'H3K9': [181, 452], 'H3K27': [183, 454, 2667, 2774], 'suggested': [184, 455], 'hierarchy': [186, 457], 'addition': [189, 460], 'certain': [191, 462], 'Comparative': [193, 464], 'showed': [195, 466], 'myeloma-like': [203, 474], 'cells': [204, 475, 3759, 3774], 'drove': [205, 476], 'formation': [207, 478, 749], 'hypermethyled': [209, 480], 'H3K36me2': [212, 483], 'co-existent': [213, 484], 'repressive': [216, 487], 'marks': [217, 488, 1788], 'H3K9me2/3': [218, 489], 'H3K27me2/3.': [220, 491], 'Unique': [221, 492], '“trivalent': [226, 497], 'hypermethylation”': [227, 498], '(K9me2/3-K27me2/3-K36me2)': [228, 499], 'were': [229, 235, 500, 506, 2526, 3760, 3775, 3790, 3844, 3853, 3890, 3939, 4011, 4020, 4035, 4070, 4190, 4206, 4248], 'not': [230, 501, 2288, 2855], 'discovered': [231, 502, 561], 'when': [232, 503, 1864], 'peptides': [234, 505], 'Bottom-Up.': [238, 509], 'Such': [239, 510], 'disease-correlated': [240, 511], 'could': [242, 513], 'link': [243, 514], 'tightly': [244, 515], 'aberrant': [246, 517], 'transcription': [247, 518, 3083], 'programs': [248, 519], 'driving': [249, 520], 'proliferation,': [251, 522], 'precise': [254, 525], 'description': [255, 526], 'demonstrates': [256, 527], 'now': [262, 533], 'decode': [263, 534], 'involving': [265, 536], 'modified': [269, 540, 2944, 3748], 'sites.': [270, 541], 'field': [543, 1973], 'epigenetics': [545, 1210, 1976], 'seen': [547], 'an': [548, 2278, 3713, 3990, 4073, 4198, 4324], 'explosion': [549], 'research': [551], 'past': [554], 'decade': [555], 'scientists': [557], 'different': [559, 1265, 2210], 'fields': [560], 'roles': [564, 1216, 1285], 'many': [566, 1308, 1812, 3141], 'aspects': [567, 3530], 'related': [568, 1205, 1756], 'health,': [571], 'ranging': [572], 'stem': [574, 3189], 'pluripotency': [576], 'aging': [578], '(1.Ladewig': [579], 'J.': [580, 780, 828, 919, 986, 1010, 1039, 1071, 1095, 1097, 1113, 1117, 1157, 1327, 1343, 1349, 1357, 1365, 1461, 1528, 1552, 1581, 1695, 2003, 2027, 2029, 2045, 2049, 2089, 2214, 2604, 2796, 3160, 3438, 3464, 3466, 3584, 3657, 4093], 'Koch': [581], 'P.': [582, 804, 962, 988, 1000, 1029, 1031, 1504, 1530, 1542, 1571, 1573, 1618, 2216, 2343, 2347, 2788, 3691, 4302], 'Brustle': [583], 'O.': [584, 736, 740, 1025, 1567, 1646, 2360, 2752, 2808, 3619], 'Leveling': [585], 'Waddington:': [586], 'emergence': [588], 'direct': [590], 'loss': [594], 'fate': [597], 'hierarchies.Nat.': [598], 'Rev.': [599, 1167, 1226, 1951, 2324, 2883], 'Mol.': [600, 1227, 1888, 2325, 2508], 'Cell': [601, 1228, 1889, 2326, 2884, 3090], 'Biol.': [602, 1229, 1842, 1890, 2327, 2380, 2886, 3091, 3230], '2013;': [603, 624, 758, 1142, 1169, 1190, 1230, 1428, 1446, 1680, 1891, 2074, 3403, 4107], '14:': [604, 1170, 1231, 3263, 3499, 3930], '225-236Crossref': [605], 'Scopus': [606, 633, 667, 767, 867, 914, 1060, 1146, 1173, 1233, 1255, 1432, 1450, 1602, 1684, 1723, 1804, 1852, 1895, 1958, 2078, 2138, 2177, 2257, 2332, 2391, 2440, 2514, 2639, 2713, 2781, 2831, 2891, 2962, 2996, 3026, 3053, 3096, 3134, 3199, 3266, 3299, 3336, 3370, 3407, 3502, 3606, 3638, 3684, 3725, 3933, 4111], '(174)': [607], 'Google': [608, 635, 669, 769, 869, 916, 1062, 1148, 1175, 1235, 1257, 1434, 1452, 1604, 1686, 1725, 1806, 1854, 1897, 1960, 2080, 2140, 2179, 2259, 2334, 2393, 2442, 2516, 2641, 2715, 2783, 2833, 2893, 2964, 2998, 3028, 3055, 3098, 3136, 3201, 3235, 3268, 3301, 3338, 3372, 3409, 3504, 3608, 3640, 3686, 3727, 3935, 4113], 'Scholar,': [609, 636, 770, 870, 917, 1063, 1176, 1236, 1435, 1605, 1687, 2081, 2716, 2784, 2965, 2999, 3029, 3056, 3202, 3236, 3269, 3302, 3339, 3687], '2.López-Otín': [610], 'C.': [611, 948, 982, 1027, 1037, 1121, 1490, 1524, 1569, 1579, 2053, 3308, 3697, 4082, 4308], 'Blasco': [612], 'M.A.': [613, 846, 3324], 'Partridge': [614], 'L.': [615, 693, 732, 968, 1093, 1325, 1510, 1701, 2025, 2228, 3222, 3480, 4076], 'Serrano': [616], 'M.': [617, 681, 687, 786, 802, 808, 818, 842, 938, 944, 956, 964, 970, 984, 992, 1004, 1081, 1321, 1375, 1407, 1480, 1486, 1498, 1506, 1512, 1526, 1534, 1546, 1691, 2013, 2095, 2232, 2234, 2238, 2738, 2742, 2794, 3472, 3625, 3699, 4310], 'Kroemer': [618], 'G.': [619, 1012, 1115, 1184, 1379, 1554, 1624, 1650, 2047, 2868], 'hallmarks': [621], 'aging.Cell.': [623], '153:': [625], '1194-1217Abstract': [626], 'Full': [627, 629, 761, 763, 1798, 1800, 1846, 1848, 2385, 2387, 2825, 2827, 3364, 3366], 'Text': [628, 630, 762, 764, 1799, 1801, 1847, 1849, 2386, 2388, 2826, 2828, 3365, 3367], 'PDF': [631, 765, 1802, 1850, 2389, 2829, 3368], 'PubMed': [632, 666, 766, 866, 913, 1059, 1145, 1172, 1254, 1431, 1449, 1601, 1683, 1722, 1803, 1851, 1894, 1957, 2077, 2137, 2176, 2256, 2331, 2390, 2439, 2513, 2638, 2712, 2780, 2830, 2890, 2961, 2995, 3025, 3052, 3095, 3133, 3198, 3234, 3265, 3298, 3335, 3369, 3406, 3501, 3605, 3637, 3683, 3724, 3932, 4110, 4335], '(7742)': [634], '3.Greer': [637], 'E.L.': [638, 1766], 'Maures': [639], 'T.J.': [640, 2457, 3316], 'Ucar': [641], 'D.': [642, 792, 816, 931, 1008, 1033, 1397, 1473, 1550, 1575, 1642, 1648, 2362, 2864, 3158, 3655], 'Hauswirth': [643], 'A.G.': [644], 'Mancini': [645], 'E.': [646, 697, 927, 1091, 1413, 1469, 2023, 2678, 2720], 'Lim': [647], 'J.P.': [648, 2099, 2610, 2612, 2750, 3470], 'Benayoun': [649], 'B.A.': [650, 1944, 2804, 3113, 3277, 3351], 'Shi': [651, 1213, 2801], 'Y.': [652, 683, 701, 714, 820, 1067, 1214, 1999, 2087, 2341, 2672, 2730, 2736, 2740, 2798, 3058, 3454, 3911], 'Brunet': [653], 'A.': [654, 812, 822, 921, 946, 950, 966, 976, 990, 1006, 1015, 1244, 1331, 1367, 1463, 1488, 1492, 1508, 1518, 1532, 1548, 1557, 1638, 1707, 2101, 2105, 2349, 2466, 3238, 3240, 3621, 3703, 4314], 'Transgenerational': [655], 'inheritance': [657], 'longevity': [659], 'Caenorhabditis': [661], 'elegans.Nature.': [662], '2011;': [663, 1843, 2253, 2822], '479:': [664], '365-371Crossref': [665], '(451)': [668], 'Scholar),': [670, 1149, 2443, 3609], 'microbial': [674], 'infection': [675], '(4.Béguelin': [676], 'W.': [677, 974, 980, 1395, 1516, 1522, 2618, 2806], 'Popovic': [678, 2113, 2675], 'R.': [679, 724, 782, 810, 814, 830, 832, 1073, 1101, 1107, 1242, 1359, 1383, 1652, 1654, 1697, 2005, 2033, 2039, 2114, 2230, 2676, 2718, 3208, 3695, 4306], 'Teater': [680], 'Jiang': [682, 1326, 2739], 'Bunting': [684], 'K.L.': [685], 'Rosen': [686], 'Shen': [688], 'H.': [689, 699, 800, 824, 1021, 1323, 1351, 1403, 1563, 1626, 2608, 3653], 'Yang': [690], 'S.N.': [691], 'Wang': [692, 1066, 1086, 1394, 1998, 2018, 2227, 2613, 2749], 'Ezponda': [694, 2090, 2725], 'T.': [695, 954, 960, 1023, 1240, 1363, 1496, 1502, 1565, 2091, 2166, 2236, 2417, 2726], 'Martinez-Garcia': [696, 2677, 2719], 'Zhang': [698, 1026, 1070, 1568, 2002, 2225, 2723], 'Zheng': [700, 2086, 2729, 3453], 'Verma': [702], 'S.K.': [703, 878, 1699], 'McCabe': [704], 'M.T.': [705, 2968], 'Ott': [706], 'H.M.': [707, 1069, 1689, 2001], 'Van': [708, 1616], 'Aller': [709], 'G.S.': [710], 'Kruger': [711], 'R.G.': [712], 'Liu': [713, 922, 1112, 1464, 2044, 3692, 4303], 'McHugh': [715], 'C.F.': [716, 2345], 'Scott': [717, 873], 'D.W.': [718], 'Chung': [719, 1408], 'Y.R.': [720], 'Kelleher': [721, 2109, 2685, 2747, 2939, 2973, 3006, 3032, 3073, 3118, 3393, 3481, 3916], 'N.': [722, 952, 1043, 1111, 1439, 1494, 1585, 1611, 1615, 2043, 2220, 3001, 3206, 3444], 'Shaknovich': [723], 'Creasy': [725], 'C.L.': [726, 3318], 'Gascoyne': [727, 843], 'R.D.': [728, 772, 844, 1333, 3220, 3458], 'Wong': [729], 'K.K.': [730, 1337], 'Cerchietti': [731], 'Levine': [733, 2102], 'R.L.': [734, 2103, 3066], 'Abdel-Wahab': [735], 'Licht': [737, 2111, 2683, 2753], 'J.D.': [738, 1065, 1329, 1772, 1997, 2112, 2680, 2684, 2754, 3913], 'Elemento': [739, 2751], 'Melnick': [741, 2100], 'A.M.': [742, 933, 1475, 1664, 1942, 2606, 3070, 3689, 4086, 4300], 'EZH2': [743, 752, 850, 891, 2759], 'is': [744, 1866, 2301, 2500, 2851, 2854, 3080, 3376], 'required': [745], 'germinal': [747], 'center': [748], 'somatic': [751, 1455], 'promote': [754], 'lymphoid': [755, 1994, 2132], 'transformation.Cancer': [756], 'Cell.': [757, 1793, 2821, 3359], '23:': [759, 1252], '677-692Abstract': [760], '(580)': [768], '5.Morin': [771], 'Johnson': [773], 'N.A.': [774], 'Severson': [775], 'T.M.': [776], 'Mungall': [777], 'A.J.': [778, 2786, 3659, 3707, 4318], 'An': [779, 1245], 'Goya': [781], 'Paul': [783], 'J.E.': [784, 1079, 2011, 3578, 4084], 'Boyle': [785], 'Woolcock': [787], 'B.W.': [788], 'Kuchenbauer': [789], 'F.': [790, 1085, 1129, 2017, 2061, 3693, 4304], 'Yap': [791], 'Humphries': [793], 'R.K.': [794, 3442], 'Griffith': [795], 'O.L.': [796], 'Shah': [797, 2727], 'S.': [798, 838, 840, 942, 1319, 1345, 1391, 1484, 1607, 1613, 1628, 1630, 1632, 2866, 3060, 3068, 3218, 3244, 3271, 3273, 3440, 3623, 3661], 'Zhu': [799], 'Kimbara': [801], 'Shashkin': [803], 'Charlot': [805], 'J.F.': [806, 1180], 'Tcherpakov': [807], 'Corbett': [809], 'Tam': [811], 'Varhol': [813], 'Smailus': [815], 'Moksa': [817], 'Zhao': [819, 1402, 3207], 'Delaney': [821], 'Qian': [823], 'Birol': [825], 'I.': [826, 1377, 2455, 3446], 'Schein': [827], 'Moore': [829, 3209], 'Holt': [831], 'Horsman': [833], 'D.E.': [834], 'Connors': [835], 'J.M.': [836], 'Jones': [837, 924, 1466], 'Aparicio': [839], 'Hirst': [841], 'Marra': [845], 'Somatic': [847], 'altering': [849], '(Tyr641)': [851], 'follicular': [853], 'diffuse': [855], 'large': [856, 1935], 'B-cell': [857, 904], 'lymphomas': [858], 'germinal-center': [860], 'origin.Nat.': [861], 'Genet.': [862, 1141, 1679, 2073, 2509, 2776], '2010;': [863, 910, 3092], '42:': [864], '181-185Crossref': [865], '(1311)': [868], '6.Sneeringer': [871], 'C.J.': [872, 3462], 'M.P.': [874, 1703], 'Kuntz': [875], 'K.W.': [876], 'Knutson': [877], 'Pollock': [879], 'R.M.': [880, 2358], 'Richon': [881], 'V.M.': [882], 'Copeland': [883], 'R.A.': [884, 2744], 'Coordinated': [885], 'activities': [886], 'wild-type': [888], 'plus': [889], 'mutant': [890], 'drive': [892], 'tumor-associated': [893], 'hypertrimethylation': [894], 'lysine': [896, 2371, 2816], '27': [897, 2699], '(H3K27)': [901], 'lymphomas.Proc.': [905], 'Natl.': [906, 2705, 3191, 3598], 'Acad.': [907, 2706, 3192, 3599], 'Sci.': [908, 2707, 3193, 3600], 'U.S.A.': [909, 2708, 3194, 3601], '107:': [911], '20980-20985Crossref': [912], '(525)': [915, 1685], '7.Schwartzentruber': [918], 'Korshunov': [920, 1462], 'X.-Y.': [923, 1465], 'D.T.W.': [925, 1467], 'Pfaff': [926, 1468], 'Jacob': [928, 1470], 'K.': [929, 936, 994, 1017, 1105, 1471, 1478, 1536, 1559, 1824, 2037, 2790, 3164, 3322], 'Sturm': [930, 1472], 'Fontebasso': [932, 1474], 'Quang': [934, 1476], 'D.-A.': [935, 1477], 'Tonjes': [937, 1479], 'Hovestadt': [939, 1481], 'V.': [940, 1103, 1482, 1634, 2035, 3701, 4312], 'Albrecht': [941, 1483], 'Kool': [943, 1485], 'Nantel': [945, 1487], 'Konermann': [947, 1489], 'Lindroth': [949, 1491], 'Jäger': [951, 1493], 'Rausch': [953, 1495], 'Ryzhova': [955, 1497], 'Korbel': [957, 1499], 'J.O.': [958, 1500], 'Hielscher': [959, 1501], 'Hauser': [961, 1503], 'Garami': [963, 1505], 'Klekner': [965, 1507], 'Bognar': [967, 1509], 'Ebinger': [969, 1511], 'Schuhmann': [971, 1513], 'M.U.': [972, 1514], 'Scheurlen': [973, 1515], 'Pekrun': [975, 1517], 'Fruhwald': [977, 1519], 'M.C.': [978, 1520], 'Roggendorf': [979, 1521], 'Kramm': [981, 1523], 'Durken': [983, 1525], 'Atkinson': [985, 1527], 'Lepage': [987, 1529], 'Montpetit': [989, 1531], 'Zakrzewska': [991, 1533], 'Zakrzewski': [993, 1535], 'Liberski': [995, 1537], 'P.P.': [996, 1538], 'Dong': [997, 1539], 'Z.': [998, 1087, 1099, 1540, 2019, 2031, 2093, 3204], 'Siegel': [999, 1541], 'Kulozik': [1001, 1543], 'A.E.': [1002, 1182, 1381, 1544], 'Zapatka': [1003, 1545], 'Guha': [1005, 1547], 'Malkin': [1007, 1549], 'Felsberg': [1009, 1551], 'Reifenberger': [1011, 1553], 'von': [1013, 1555], 'Deimling': [1014, 1556], 'Ichimura': [1016, 1558], 'Collins': [1018, 1560], 'V.P.': [1019, 1561], 'Witt': [1020, 1024, 1562, 1566], 'Milde': [1022, 1564], 'Castelo-Branco': [1028, 1570], 'Lichter': [1030, 1572], 'Faury': [1032, 1574], 'Tabori': [1034, 1576], 'U.': [1035, 1577], 'Plass': [1036, 1578], 'Majewski': [1038, 1580], 'Pfister': [1040, 1582], 'S.M.': [1041, 1369, 1583, 1822, 2674, 3212, 3919], 'Jabado': [1042, 1584], 'Driver': [1044, 1586], 'remodelling': [1051, 1593], 'genes': [1052, 1423, 1594], 'paediatric': [1054, 1596], 'glioblastoma.Nature.': [1055, 1597], '2012;': [1056, 1598, 1795, 2328, 2709, 3231, 3680], '482:': [1057, 1599], '226-231Crossref': [1058, 1600], '(1707)': [1061, 1603], '8.Jaffe': [1064], 'Chan': [1068, 2000], 'Huether': [1072, 2004], 'Kryukov': [1074, 2006], 'G.V.': [1075, 2007], 'Bhang': [1076, 2008], 'H.E.': [1077, 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'leukemia.Nat.': [1140, 2072], '45:': [1143, 1681, 2075], '1386-1391Crossref': [1144, 2076], '(185)': [1147, 2079], 'memory': [1151], 'processing': [1152], 'drug': [1154], 'addiction': [1155], '(9.Gräff': [1156], 'Tsai': [1158], 'L.H.': [1159], 'Histone': [1160, 1194, 1708, 1876, 2755, 2869, 3077, 3325], 'acetylation:': [1161], 'molecular': [1162], 'mnemonics': [1163], 'chromatin.Nat.': [1166], 'Neurosci.': [1168], '97-111Crossref': [1171], '(426)': [1174], '10.Schmidt': [1177], 'H.D.': [1178], 'McGinty': [1179], 'West': [1181], 'Sadri-Vakili': [1183], 'Epigenetics': [1185], 'psychostimulant': [1187], 'addiction.Perspectives': [1188], 'Med.': [1189], '3:': [1191], 'a012047Google': [1192], 'Scholar).': [1193, 1258, 1726, 1855, 1898, 1961, 2141, 2180, 2260, 2394, 2517, 2642, 2834, 2894, 3137, 3373, 3410, 3505, 3728, 3936], 'including': [1196, 3572], '(me),': [1198], '(ac),': [1200], 'monoubiquitylation': [1201], '(ub1),': [1202], 'etc.,': [1203], 'study': [1208, 1716, 3514], '(11.Badeaux': [1211], 'A.I.': [1212], 'Emerging': [1215], 'signal': [1221], 'integration': [1222], 'storage': [1224], 'platform.Nat.': [1225], '211-224Crossref': [1232], '(214)': [1234], '12.Berger': [1237], 'S.L.': [1238, 1622], 'Kouzarides': [1239], 'Shiekhattar': [1241], 'Shilatifard': [1243, 1706], 'operational': [1246], 'definition': [1247], 'epigenetics.Genes': [1249], 'Develop.': [1250, 2885], '2009;': [1251, 2382, 3361], '781-783Crossref': [1253], '(1239)': [1256], 'These': [1259, 3527], 'well': [1262], 'states': [1266, 1748], 'case': [1268], 'mono-,': [1272, 1750], 'di-,': [1273, 1751], 'trimethylation)': [1275], 'positions': [1277], 'histone,': [1280, 3750], 'play': [1281], 'important': [1282], 'distinct': [1284, 1746], 'almost': [1287], 'every': [1288, 4152], 'activity': [1289, 2123], 'operative': [1290], 'template.': [1294], 'significance': [1296], 'these': [1298, 4259], 'further': [1301, 1978], 'underscored': [1302], 'unexpected': [1305, 1816], 'identification': [1306, 1983], 'underlying': [1311], 'biology': [1313], 'within': [1314], '(13.Zaidi': [1318], 'Choi': [1320], 'Wakimoto': [1322], 'Overton': [1328], 'Romano-Adesman': [1330], 'Bjornson': [1332], 'Breitbart': [1334], 'R.E.': [1335], 'Brown': [1336], 'Carriero': [1338], 'N.J.': [1339], 'Cheung': [1340, 2346, 2787], 'Y.H.': [1341], 'Deanfield': [1342], 'DePalma': [1344], 'Fakhro': [1346], 'K.A.': [1347], 'Glessner': [1348], 'Hakonarson': [1350], 'Italia': [1352], 'M.J.': [1353, 3003, 3242, 3582], 'Kaltman': [1354], 'Kaski': [1356], 'Kim': [1358], 'Kline': [1360], 'J.K.': [1361], 'Lee': [1362], 'Leipzig': [1364], 'Lopez': [1366], 'Mane': [1368], 'Mitchell': [1370], 'L.E.': [1371], 'Newburger': [1372], 'J.W.': [1373, 1640], 'Parfenov': [1374], "Pe'er": [1376], 'Porter': [1378], 'Roberts': [1380], 'Sachidanandam': [1382], 'Sanders': [1384], 'S.J.': [1385], 'Seiden': [1386], 'H.S.': [1387], 'State': [1388], 'M.W.': [1389], 'Subramanian': [1390], 'Tikhonova': [1392], 'I.R.': [1393], 'Warburton': 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2887, 3262, 3332, 3498, 3929], '345:': [1720], '1065-1070Crossref': [1721], '(130)': [1724], 'Widely': [1727], 'used': [1728, 2188, 2544, 4207], 'antibody-based': [1729, 2265], 'measurements': [1730, 4069], 'face': [1734], 'analytical': [1736, 3945], 'challenges:': [1737], '(1)': [1738], 'similar': [1739], 'chemical': [1740], 'structure': [1741], '(e.g.': [1744], 'tri-methylation)': [1753], 'closely': [1755], 'flanking': [1757], 'sequence': [1758, 2272, 3590, 3665], 'lead': [1760], 'cross-reactivity': [1762], '(17.Peach': [1763], 'S.E.': [1764], 'Rudomin': [1765], 'Udeshi': [1767], 'N.D.': [1768], 'Jaffe': [1771], 'Quantitative': [1773, 2941], 'assessment': [1774], 'immunoprecipitation': [1777], 'grade': [1778], 'antibodies': [1779], 'directed': [1780], 'against': [1781], 'patterns': [1785, 2694], 'co-occurring': [1787, 2918], 'protein': [1791, 1840, 3400, 3589], 'molecules.Mol.': [1792], 'Proteomics.': [1794, 3360], '11:': [1796], '128-137Abstract': [1797], '(61)': [1805], 'Scholar);': [1807], '(2)': [1808], 'close': [1809, 2575], 'proximity': [1810], 'have': [1815, 2927, 3282], 'effects': [1817], 'antibody': [1819, 1837, 1859], 'recognition': [1820, 1863], '(18.Fuchs': [1821], 'Krajewski': [1823], 'Baker': [1825], 'R.W.': [1826], 'Miller': [1827], 'V.L.': [1828], 'Strahl': [1829], 'Influence': [1831], 'effector': [1839], 'recognition.Curr.': [1841], '21:': [1844], '53-58Abstract': [1845], '(134)': [1853], 'For': [1856, 4183], 'example,': [1857], 'H4K20me2': [1858], 'lose': [1861], 'present': [1867], 'neighboring': [1870], 'H4K16': [1871], '(19.Hsiao': [1872], 'K.Y.': [1873], 'Mizzen': [1874, 2937, 2971, 3004, 3034, 3075, 3116], 'C.A.': [1875, 2938, 2972, 3005, 3035, 3076, 3117, 3349], 'H4': [1877, 3183, 3434], 'deacetylation': [1878], 'facilitates': [1879], '53BP1': [1880], 'DNA': [1881, 2271], 'damage': [1882], 'signaling': [1883], 'double-strand': [1885], 'break': [1886], 'repair.J.': [1887], '5:': [1892, 2993, 3023, 3050], '157-165Crossref': [1893], '(124)': [1896], 'Therefore,': [1899, 3729], 'analyzing': [1900], 'MS': [1904, 2646, 2930, 3102, 3153], 'highly': [1908, 2207, 3747], 'valuable': [1909], 'orthogonal': [1910], 'measurement.': [1911], 'There': [1912], 'general': [1915], 'modes': [1916], 'interrogation': [1918, 3743], 'MS:': [1920], 'Bottom-Up': [1921, 2645], 'tryptic': [1924], 'peptides,': [1925, 1937], 'or': [1928, 1934, 2299], 'Middle-Down': [1929, 3101, 3152], 'measurement': [1930, 2843], 'histones': [1933, 2934, 2979, 3852, 3889, 3938], 'tail': [1936], 'respectively': [1938], '(20.Yuan': [1939], 'Z.F.': [1940], 'Arnaudo': [1941], 'Garcia': [1943, 2803, 3276, 3350], 'Mass': [1945, 3036, 3175], 'spectrometric': [1946, 1966, 3037], 'proteoforms.Annu.': [1950], 'Anal.': [1952], 'Chem.': [1953, 2381, 2957, 3294, 3679, 3720, 4106, 4331], '7:': [1955, 2511], '113-128Crossref': [1956], '(46)': [1959], 'value': [1963, 4201], 'demonstrated': [1979, 3413], 'recent': [1982], 'recurrent': [1986], 'point': [1987], 'mutation': [1988, 2116], 'E1099K': [1990, 2117], 'malignancies': [1995], '(8.Jaffe': [1996], '21.Oyer': [2082], 'J.A.': [2083, 3172], 'Huang': [2084, 3307], 'Shim': [2088], 'Carpenter': [2092, 2313], 'Allegretta': [2094], 'Okot-Kotber': [2096], 'C.I.': [2097], 'Patel': [2098], 'Ferrando': [2104], 'Mackerell': [2106], 'Jr.,': [2107, 4090], 'A.D.': [2108], 'N.L.': [2110, 2686, 2748, 2940, 2974, 3007, 3033, 3074, 3119, 3341, 3394, 3482, 3484, 3917], 'Point': [2115], 'MMSET/NSD2': [2119, 2757], 'enhances': [2120], 'methyltranferase': [2122], 'leads': [2125, 2573], 'altered': [2127], 'global': [2128, 2663, 2767], 'malignancies.Leukemia.': [2133], '28:': [2135], '198-201Crossref': [2136], '(94)': [2139, 3027], '“histone': [2143], 'code”': [2144], 'hypothesis': [2145], 'posits': [2146], 'nature': [2150, 2376], 'serve': [2155], 'binding': [2158, 2760], 'platform': [2159], 'elicit': [2161], 'specific': [2162], 'processes': [2164], '(22.Jenuwein': [2165], 'Allis': [2167], 'C.D.': [2168], 'Translating': [2169], 'code.Science.': [2172], '2001;': [2173], '293:': [2174], '1074-1080Crossref': [2175], '(7632)': [2178], 'combination': [2183, 3644], 'been': [2187, 2399], 'states,': [2192], 'which': [2193, 2444, 2572], 'generated': [2195], 'meta-analysis': [2197], 'ChIP-Seq': [2200], 'data': [2201], 'sets': [2202], 'found': [2204], 'dynamic': [2208], 'among': [2209], '(23.Ernst': [2213], 'Kheradpour': [2215], 'Mikkelsen': [2217], 'T.S.': [2218], 'Shoresh': [2219], 'Ward': [2221], 'L.D.': [2222], 'Epstein': [2223], 'C.B.': [2224], 'Issner': [2229], 'Coyne': [2231], 'Ku': [2233], 'Durham': [2235], 'Kellis': [2237], 'Mapping': [2241], 'state': [2246], 'dynamics': [2247], 'nine': [2249], 'types.Nature.': [2252], '473:': [2254], '43-49Crossref': [2255], '(2063)': [2258], 'However,': [2261, 3374], 'this': [2262], 'type': [2263], 'technique': [2266], 'relies': [2267], 'associated': [2270, 2624, 3081], 'infer': [2274], 'PTM': [2275], 'average': [2279], 'same': [2285, 2292, 2921], 'locus': [2286], 'but': [2287], 'necessarily': [2289], 'molecule.': [2293], '(also': [2295], 'known': [2296, 2306], 'WHSC1)': [2300], 'one': [2302, 4227], 'eight': [2305], 'methyltransferases': [2308, 2372], 'targeting': [2309, 2658], 'H3K36': [2310, 2659, 2669, 2772], '(24.Wagner': [2311], 'E.J.': [2312], 'P.B.': [2314], 'Understanding': [2315], 'language': [2317], 'Lys36': [2319], 'at': [2321, 2815, 3783, 3848, 3982, 4003, 4029, 4063, 4130, 4159, 4170], 'H3.Nat.': [2323], '13:': [2329, 3232, 3333], '115-126Crossref': [2330], '(632)': [2333], 'specificity': [2337], 'toward': [2338], 'dimethylation': [2339, 2811], '(25.Li': [2340], 'Trojer': [2342], 'Xu': [2344, 2357], 'Kuo': [2348], 'Drury': [2350], 'W.J.': [2352], 'Qiao': [2353], 'Q.': [2354, 2614, 2724], 'Neubert': [2355], 'T.A.': [2356], 'Gozani': [2359, 2807], 'Reinberg': [2361], 'target': [2364, 4200], 'NSD': [2367], 'family': [2368, 2984], 'depends': [2373], 'substrate.J.': [2379], '284:': [2383], '34283-34295Abstract': [2384], '(211)': [2392], 'Overexpression': [2395], 'documented': [2400], '∼20%': [2402], 'cases': [2406], 'translocation': [2412], '(26.Keats': [2414], 'J.J.': [2415, 2936, 2970, 3009, 3062, 3115, 3174, 3460, 3580, 4088], 'Reiman': [2416], 'Belch': [2418], 'A.R.': [2419], 'Pilarski': [2420], 'L.M.': [2421, 3392], 'Ten': [2422], 'years': [2423], 'counting:': [2425], 'so': [2426], 'what': [2427], 'do': [2428], 'know': [2430], 'about': [2431], 't(4;14)(p16;q32)': [2432], 'myeloma.Leuk.': [2434], 'Lymphoma.': [2435], '2006;': [2436, 2958, 2992, 3022, 3049], '47:': [2437], '2289-2300Crossref': [2438], '(75)': [2441], 'places': [2445], 'gene': [2448, 2491, 2591, 2626, 2983], 'under': [2449], 'strong': [2451], 'immunoglobulin': [2452], 'enhancers': [2453], '(27.Stec': [2454], 'Wright': [2456], 'van': [2458, 2464, 3650], 'Ommen': [2459], 'G.J.': [2460], 'de': [2461], 'Boer': [2462], 'Haeringen': [2465], 'Moorman': [2467], 'A.F.': [2468, 3649, 3705, 4316], 'Altherr': [2469], 'den': [2471, 3651], 'Dunnen': [2472], 'J.T.': [2473], 'WHSC1,': [2474], '90': [2476, 3968], 'kb': [2477], 'SET': [2478], 'domain-containing': [2479], 'gene,': [2480], 'expressed': [2481], 'early': [2483], 'development': [2484, 2876, 3539], 'homologous': [2486, 2570], 'Drosophila': [2489], 'dysmorphy': [2490], 'maps': [2492], 'Wolf-Hirschhorn': [2495], 'syndrome': [2496], 'region': [2498], 'fused': [2501], 'IgH': [2503], 'myeloma.Human': [2507], '1998;': [2510], '1071-1082Crossref': [2512], '(251)': [2515], 'A': [2518], 'pair': [2519], 'lines,': [2522], 'TKO': [2523, 3756], 'NTKO,': [2525], 'engineered': [2527], 't(4;14)+': [2530], 'patient-derived': [2533], 'line,': [2535, 2560, 2588], 'KMS11.': [2536], 'In': [2537, 2582], 'targeted': [2539, 2895], 'knockout': [2540, 2585, 2896], '(TKO)': [2541], '1The': [2542], 'abbreviations': [2543], 'are:TKOtargeted': [2545], 'knockoutHILIChydrophilic': [2546], 'interaction': [2547, 2898], 'chromatographyLCliquid': [2548], 'chromatographyMSmass': [2549], 'spectrometryETDelectron': [2550], 'transfer': [2551, 2553, 2905, 2908, 3574, 3594, 4100, 4155], 'dissociationEThcDelectron': [2552], '–': [2555, 2910], 'higher-energy': [2556, 2911, 3610, 3673], 'collision': [2557, 2912, 3674], 'dissociation.': [2558, 2913], 'translocated': [2562], 'copy': [2563], 'knocked': [2567, 2593], 'out': [2568, 2594], 'recombination,': [2571], 'normal': [2577], 'expression': [2578, 2597], 'level': [2579, 2598], 'MMSET.': [2581], 'nontargeted': [2584], '(NTKO)': [2586], 'non-translocated': [2590], 'remains': [2601], '(28.Lauring': [2603], 'Abukhdeir': [2605], 'Konishi': [2607], 'Garay': [2609], 'Gustin': [2611], 'Arceci': [2615], 'R.J.': [2616, 3210], 'Matsui': [2617], 'Park': [2619, 2799], 'B.H.': [2620, 2800], 'contributes': [2627], 'adhesion,': [2630], 'clonogenic': [2631], 'growth,': [2632], 'tumorigenicity.Blood.': [2634], '2008;': [2635, 3195], '111:': [2636], '856-864Crossref': [2637], '(129)': [2640], 'Our': [2643], 'quantitative': [2644], 'assay': [2647], 'using': [2648, 3899, 3941, 3961, 3989, 4037, 4138, 4197, 4271], 'selective': [2649], 'reaction': [2650], 'monitoring': [2651], 'HMT': [2657], 'led': [2660], 'changes': [2664, 2770], 'both': [2666], '(29.Zheng': [2671], 'Sweet': [2673, 3918], 'Tipton': [2679, 3912], 'Thomas': [2681, 3447, 3914], 'P.M.': [2682, 3448, 3915], 'Total': [2687], 'kinetic': [2688], 'established': [2696], 'lysines': [2698], '36': [2701, 2817], 'H3.Proc.': [2704], '109:': [2710], '13549-13554Crossref': [2711], '(93)': [2714], '30.Popovic': [2717], 'Giannopoulou': [2721], 'E.G.': [2722], 'M.Y.': [2728], 'Will': [2731], 'C.M.': [2732, 3314], 'Small': [2733], 'E.C.': [2734], 'Hua': [2735], 'Bulic': [2737], 'Carrara': [2741], 'Calogero': [2743], 'Kath': [2745], 'W.L.': [2746], 'alters': [2758], 'reprograms': [2762], 'epigenome': [2765], 'through': [2766], 'focal': [2769], 'methylation.PLoS': [2775], '10:': [2778, 3404], 'e1004566Crossref': [2779], '(148)': [2782], '31.Kuo': [2785], 'Chen': [2789], 'Zee': [2791], 'B.M.': [2792], 'Kioi': [2793], 'Lauring': [2795], 'Xi': [2797], 'Li': [2805], 'links': [2810], 'oncogenic': [2819], 'programming.Mol.': [2820], '44:': [2823], '609-620Abstract': [2824], '(298)': [2832], 'our': [2836], 'goal': [2837], 'make': [2840], 'differential': [2841], 'variants,': [2848], 'whose': [2849, 3547], 'synthesis': [2850], '(H3.1)': [2852], '(H3.3)': [2856], 'dependent': [2857], 'replication': [2859], 'during': [2860, 2875], 'S': [2861], 'phase': [2862, 3901], '(32.Filipescu': [2863], 'Muller': [2865], 'Almouzni': [2867], 'variants': [2871, 3257], 'chaperones': [2874], 'disease:': [2878], 'contributing': [2879], 'control.Ann.': [2882], '30:': [2888], '615-646Crossref': [2889], '(77)': [2892, 3503], 'hydrophilic': [2897], 'chromatography': [2899, 2901, 3905], 'liquid': [2900, 3779, 3904], 'electron': [2904, 2907, 3017, 3573, 3593, 4099], 'To': [2914], 'directly': [2915], 'catalogue': [2916], 'modifications),': [2925], 'reported': [2928], 'all': [2933], '(33.Pesavento': [2935], 'proteins': [2945], 'positional': [2948], 'isomers': [2949], 'tandem': [2951, 3676], 'spectrometry:': [2953], 'H4.Anal.': [2956], '78:': [2959], '4271-4280Crossref': [2960], '(201)': [2963], '34.Boyne': [2966], '2nd,': [2967], 'Pesavento': [2969, 3008, 3061, 3114], 'Precise': [2975], 'H2A': [2982], 'top': [2986], 'down': [2987], 'spectrometry.J.': [2989], 'Proteome': [2990, 3020, 3047], 'Res.': [2991, 3021, 3048, 3331], '248-253Crossref': [2994], '(142)': [2997, 3200], '35.Siuti': [3000], 'Roth': [3002], 'Gene-specific': [3010], 'H2B': [3015], 'capture': [3018], 'dissociation.J.': [3019], '233-239Crossref': [3024], '36.Thomas': [3030], 'H3:': [3042], "bird's": [3044], 'eye': [3045], 'view.J.': [3046], '240-247Crossref': [3051], '(169)': [3054], '37.Zheng': [3057], 'John': [3059], 'Schultz-Norton': [3063], 'Schiltz': [3065], 'Baek': [3067], 'Nardulli': [3069], 'Hager': [3071], 'G.L.': [3072], 'H1': [3078, 3326], 'phosphorylation': [3079, 3327], 'RNA': [3085], 'polymerases': [3086], 'I': [3087], 'II.J.': [3089], '189:': [3093], '407-415Crossref': [3094], '(81)': [3097], '1–50': [3104], 'N-terminal': [3105], 'piece': [3106], '(5.3': [3110], '(38.Garcia': [3112], 'Pervasive': [3120], 'cells.Nat.': [3128], 'Methods.': [3129, 3402, 3633], '2007;': [3130, 3634], '4:': [3131, 3635], '487-489Crossref': [3132], '(195)': [3135], 'Great': [3138], 'efforts': [3139], 'laboratories': [3142], 'continue': [3144], 'improve': [3146], 'utility': [3148], '(39.Phanstiel': [3157], 'Brumbaugh': [3159], 'Berggren': [3161], 'W.T.': [3162], 'Conard': [3163], 'Feng': [3165], 'Levenstein': [3167], 'M.E.': [3168, 3306], 'McAlister': [3169], 'G.C.': [3170, 4091], 'Thomson': [3171], 'Coon': [3173, 3579], 'identifies': [3177], 'quantifies': [3179], '74': [3180], 'unique': [3181], 'isoforms': [3184], 'differentiating': [3186], 'embryonic': [3188], 'cells.Proc.': [3190], '105:': [3196], '4093-4098Crossref': [3197], '40.Tian': [3203], 'Tolic': [3205, 3443], 'Hengel': [3211], 'E.W.': [3214], 'Stenoien': [3215], 'D.L.': [3216, 4080], 'Wu': [3217, 3439], 'Smith': [3219], 'Pasa-Tolic': [3221, 3479], 'Enhanced': [3223], 'top-down': [3224, 3493, 3717, 4328], 'post-translational': [3228, 3260, 3288], 'modifications.Genome': [3229], 'R86Crossref': [3233], '41.Moradian': [3237], 'Kalli': [3239], 'Sweredoski': [3241], 'Hess': [3243], 'top-down,': [3246], 'middle-down,': [3247], 'bottom-up': [3249], 'approaches': [3252], 'modifications.Proteomics.': [3261], '489-497Crossref': [3264], '(113)': [3267], '42.Sidoli': [3270], 'Lin': [3272], 'Karch': [3274], 'K.R.': [3275, 3456], 'Bottom-up': [3278], 'middle-down': [3280], 'proteomics': [3281], 'comparable': [3283], 'accuracies': [3284], 'defining': [3286], 'relative': [3290], 'abundance': [3291], 'stoichiometry.Anal.': [3293], '2015;': [3295, 3721, 4332], '87:': [3296, 3722, 4333], '3129-3133Crossref': [3297], '(44)': [3300], '43.Harshman': [3303], 'S.W.': [3304], 'Hoover': [3305], 'Branson': [3309], 'O.E.': [3310], 'Chaney': [3311], 'S.B.': [3312], 'Cheney': [3313], 'Rosol': [3315], 'Shapiro': [3317], 'Wysocki': [3319], 'V.H.': [3320], 'Huebner': [3321], 'Freitas': [3323], 'breast': [3329], 'cancer.J.Proteome': [3330], '2453-2467Crossref': [3334], '(31)': [3337], '44.Young': [3340], 'DiMaggio': [3342], 'Plazas-Mayorca': [3344], 'M.D.': [3345], 'Baliban': [3346], 'R.C.': [3347], 'Floudas': [3348], 'High': [3352], 'throughput': [3353], 'codes.Mol.': [3358], '8:': [3362], '2266-2284Abstract': [3363], '(245)': [3371], 'it': [3375], 'still': [3377], 'very': [3378], 'challenging': [3379], 'apply': [3381], 'approach': [3383], 'routine': [3386], '(45.Smith': [3391], 'Proteoform:': [3395], 'single': [3397], 'term': [3398], 'describing': [3399], 'complexity.Nat.': [3401], '186-187Crossref': [3405], '(884)': [3408], 'This': [3411], 'first': [3416, 3486, 3877, 4280], 'pilot': [3417, 3487], 'project': [3418, 3488], 'Consortium': [3421], 'Proteomics': [3424], 'assess': [3426], 'intra-laboratory': [3427], 'variation': [3428], '(46.Dang': [3435], 'Scotcher': [3437], 'Chu': [3441], 'Ntai': [3445], 'Fellers': [3449], 'R.T.': [3450], 'Early': [3451], 'B.P.': [3452], 'Durbin': [3455], 'Leduc': [3457], 'Wolff': [3459], 'Thompson': [3461], 'Pan': [3463], 'Han': [3465], 'Shaw': [3467], 'J.B.': [3468], 'Salisbury': [3469], 'Easterling': [3471], 'Borchers': [3473], 'C.H.': [3474], 'Brodbelt': [3475], 'J.S.': [3476], 'Agar': [3477], 'J.N.': [3478], 'Young': [3483], 'consortium': [3491], 'proteomics:': [3494], 'status': [3496], 'report.Proteomics.': [3497], '1130-1140Crossref': [3500], 'One': [3506], 'key': [3509], 'limitations': [3510], 'identified': [3511], 'need': [3517], 'continued': [3519], 'improvement': [3520], 'high-resolution': [3522], 'high-efficiency': [3525], 'fragmentation.': [3526], 'quality': [3533], 'proteoform': [3534, 4214, 4244, 4266], 'align': [3536], 'new': [3542, 4103], 'tribrid': [3544], 'spectrometer,': [3546], 'architecture': [3548], 'includes': [3549], 'segmented': [3551], 'quadrupole': [3552, 4269], 'narrow': [3554], 'precursor': [3555], 'transmission': [3559], 'efficiency,': [3560], 'improved': [3561], 'vacuum': [3562], 'conditions,': [3563], 'optimization': [3566], 'ion': [3569, 4040, 4132, 4167], 'techniques': [3571], '(ETD)': [3576], '(47.Syka': [3577], 'Schroeder': [3581], 'Shabanowitz': [3583, 4092], 'Hunt': [3585, 4094], 'D.F.': [3586, 4095], 'Peptide': [3587], 'spectrometry.Proc.': [3597], '2004;': [3602], '101:': [3603], '9528-9533Crossref': [3604], '(1999)': [3607], 'collisional': [3611], '(HCD)': [3613], '(48.Olsen': [3614], 'J.V.': [3615], 'Macek': [3616], 'Lange': [3618], 'Makarov': [3620, 3702, 4313], 'Horning': [3622], 'Mann': [3624], 'Higher-energy': [3626], 'C-trap': [3627], 'peptide': [3630, 3664], 'analysis.Nat.': [3632], '709-712Crossref': [3636], '(719)': [3639], '(EThcD)': [3645], '(49.Frese': [3646], 'C.K.': [3647], 'Altelaar': [3648, 3704, 4315], 'Toorn': [3652], 'Nolting': [3654], 'Griep-Raming': [3656], 'Heck': [3658, 3706, 4317], 'Mohammed': [3660], 'Toward': [3662], 'coverage': [3666], 'dual': [3668], 'fragmentation': [3669, 3710, 4255, 4321], 'combining': [3670], 'electron-transfer': [3671], 'spectrometry.Anal.': [3678], '84:': [3681], '9668-9673Crossref': [3682], '(216)': [3685], '50.Brunner': [3688], 'Lossl': [3690, 4301], 'Huguet': [3694, 4305], 'Mullen': [3696, 4081, 4307], 'Yamashita': [3698, 4309], 'Zabrouskov': [3700, 4311], 'Benchmarking': [3708, 4319], 'methods': [3711, 4322], 'orbitrap': [3714, 4325], 'fusion': [3715, 4326], 'phospho-proteoform': [3718, 4329], 'characterization.Anal.': [3719, 4330], '4152-4158Crossref': [3723, 4334], '(85)': [3726], 'aimed': [3731], 'develop': [3733], 'proper': [3734], 'workflow': [3735], 'informatic': [3737], 'tools': [3738], 'enable': [3740], 'comparative': [3742], 'most': [3746, 4237], 'core': [3749], 'H3,': [3751], 'upon': [3752], 'perturbation.': [3754], 'KMS11': [3755], 'NTKO': [3758], 'cultured': [3761], 'RPMI': [3763], 'media': [3764], 'supplemented': [3765], '10%': [3767], 'FBS': [3768], '(Sigma,': [3769], 'St.': [3770], 'Louis,': [3771], 'MI).': [3772], 'Harvested': [3773], 'flash': [3776], 'frozen': [3777], 'nitrogen': [3780], 'stored': [3782], '−80': [3784], '°C': [3785], 'before': [3786], 'sample': [3787], 'preparation.': [3788], 'Nuclei': [3789], 'isolated': [3791, 3856, 4270], 'NIB': [3793, 3838], 'buffer': [3794, 3839], 'mm': [3796, 3799, 3802, 3805, 3808, 3811, 3814, 3820, 3825], 'Tris,': [3797], '60': [3798], 'KCl,': [3800], '15': [3801, 3950, 4177], 'NaCl,': [3803], '5': [3804, 3955], 'MgCl2,': [3806], '1': [3807, 3824, 4136], 'CaCl2,': [3809], '250': [3810], 'Sucrose,': [3812], '0.5': [3813], '4-(2-aminoethyl)benzenesulfonyl': [3815], 'fluoride': [3816], 'hydrochloride': [3817], '(AEBSF),': [3818], 'sodium': [3821], 'butyrate,': [3822], 'DTT,': [3826], 'pH': [3827], '7.5)': [3828], '0.3%': [3830], 'Nonidet': [3831], 'P-40': [3832], 'subsequently': [3834], 'washed': [3835, 3876], 'twice': [3836, 3884], 'without': [3840], 'detergent.': [3841], 'Isolated': [3842], 'nuclei': [3843, 3857], 'recovered': [3845, 3863], 'centrifugation': [3847], '600': [3849], 'rcf.': [3850], 'Crude': [3851, 3888], 'extracted': [3854], '0.4': [3859], 'N': [3860], 'H2SO4': [3861], 'precipitation': [3865], '20%': [3867, 4171], '(w/v,': [3868], 'final)': [3869], 'trichloroacetic': [3870], 'acid': [3871, 4026], '(TCA).': [3872], 'precipitate': [3874], '0.1%': [3879, 3974], 'HCl': [3880], 'acetone': [3882], 'pure': [3886], 'acetone.': [3887], 'then': [3891, 4292], 'resuspended': [3892, 4021], 'water': [3894], 'subjected': [3896, 4278], 'fractionation': [3898], 'reverse': [3900], 'pressure': [3903, 4129], '(RP-HPLC)': [3906], 'described': [3908, 4298], 'previously': [3909, 4297], '(51.Zheng': [3910], 'Site-specific': [3920], 'stability:': [3925], 'fast': [3926], 'K4me3': [3927], 'turnover.Proteomics.': [3928], '2190-2199Crossref': [3931], '(17)': [3934], 'Briefly,': [3937], 'separated': [3940], 'Jupiter': [3943], 'C18': [3944], 'column': [3946], '(Phenomenex,': [3947], 'Torrance,': [3948], 'CA),': [3949], 'cm': [3951], '×': [3952], '4.6': [3953], 'mm,': [3954], 'μm': [3956, 4031], 'diam.,': [3957], '300': [3958], 'Å': [3959], 'pores,': [3960], 'gradient': [3963], '30–57%': [3965], 'B': [3966], 'min': [3969], '(Buffer': [3970], 'A:': [3971], '5%': [3972], 'ACN,': [3973, 3979], 'TFA;': [3975], 'Buffer': [3976], 'B:': [3977], '90%': [3978], '0.094%': [3980], 'TFA)': [3981], 'flow': [3984], 'rate': [3985], '0.8': [3987], 'ml/min': [3988], 'Agilent': [3991], '1100': [3992], 'HPLC': [3993], 'system': [3994], '(Agilent,': [3995], 'Santa': [3996], 'Clara,': [3997], 'CA)': [3998, 4047], 'monitored': [3999], 'UV': [4001], 'absorbance': [4002], '214': [4004], 'nm.': [4005], 'Fractionated': [4006], 'collected': [4012], 'dried': [4014], 'speed-vacuum.': [4016], 'Dried': [4017], 'pellets': [4019], '49.95:49.95:0.1': [4023], '(v:v:v)': [4024], 'water/acetonitrile/formic': [4025], '(LC-MS': [4027], 'grade)': [4028], '∼1': [4030], 'final': [4032], 'concentration,': [4033], 'sprayed': [4036], 'NanoFlex': [4039], 'source': [4041, 4166, 4174], '(Thermo': [4042, 4120], 'Fisher': [4043, 4121], 'Scientific,': [4044], 'San': [4045], 'Jose,': [4046], 'equipped': [4048], 'nanoelectrospray': [4051], 'static': [4052], 'probe': [4053], 'coated': [4055], 'glass': [4056], 'emitters,': [4057], 'applying': [4058], '1.7–1.9': [4060], 'kV': [4061], 'potential': [4062], 'emitter.': [4065], 'All': [4066], 'performed': [4071, 4287, 4295], 'fETD-enabled': [4074], '(52.Earley': [4075], 'Anderson': [4077], 'L.C.': [4078], 'Bai': [4079], 'Syka': [4083], 'English': [4085], 'Dunyach': [4087], 'Stafford': [4089], 'Compton': [4096], 'P.D.': [4097], 'Front-end': [4098], 'dissociation:': [4101], 'ionization': [4104], 'source.Anal.': [4105], '85:': [4108], '8385-8390Crossref': [4109], '(50)': [4112], 'Orbitrap': [4115], 'Fusion': [4116], 'Lumos': [4117], 'spectrometer': [4119], 'Scientific)': [4122], 'operating': [4123, 4169], 'Intact': [4125], 'Protein': [4126], 'Mode': [4127], '(N2': [4128], 'routing': [4133], 'multipole': [4134], 'mTorr),': [4137], 'resolving': [4140], 'power': [4141], '60,000': [4143], '(at': [4144], 'm/z': [4145, 4195, 4232], '200)': [4146], 'averaging': [4148], 'five': [4149], 'microscans': [4150], 'scan,': [4153], 'capillary': [4156], 'temperature': [4157], 'set': [4158], '275': [4160], '°C,': [4161], 'RF': [4163], 'funnel': [4168], 'offset': [4175], 'V': [4178], 'favor': [4180], 'adduct': [4181], 'removal.': [4182], 'each': [4184, 4242, 4257], 'fraction,': [4186], 'broadband': [4187], 'MS1': [4188, 4204], 'spectra': [4189, 4205], 'recorded': [4191], 'over': [4192], '500–2000': [4194], 'window': [4196], 'AGC': [4199], '2e5.': [4203], 'list': [4211, 4230], 'peaks': [4215], 'differing': [4216], '∼14': [4220], 'Da,': [4221], 'corresponding': [4222, 4234], 'methylation.': [4228], 'included': [4231], 'values': [4233], 'abundant': [4238], 'isotopic': [4239], 'distribution': [4240], 'cluster.': [4245], 'MS2': [4246], 'experiments': [4247], 'based': [4249], 'subsequent': [4254], 'clusters': [4260], '18+': [4263], 'precursor.': [4264], 'Each': [4265], 'cluster': [4267], '0.6': [4273], 'Th': [4274], 'window,': [4276], 'sequentially': [4279], 'capacity': [4283], 'ETD': [4284], '(ETD': [4285], 'HD)': [4286], 'increasing': [4289], 'duration,': [4290], 'EThcD,': [4294], '(50.Brunner': [4299], 'Scop': [4336]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2243920008', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-15T08:49:49.543641', 'created_date': '2016-06-24'}