Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2238959222', 'doi': 'https://doi.org/10.1002/eji.201445388', 'title': 'Deciphering CD137 (4‐1BB) signaling in T‐cell costimulation for translation into successful cancer immunotherapy', 'display_name': 'Deciphering CD137 (4‐1BB) signaling in T‐cell costimulation for translation into successful cancer immunotherapy', 'publication_year': 2016, 'publication_date': '2016-02-09', 'ids': {'openalex': 'https://openalex.org/W2238959222', 'doi': 'https://doi.org/10.1002/eji.201445388', 'mag': '2238959222', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26773716'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/eji.201445388', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201445388', 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201445388', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026821355', 'display_name': 'Alfonso R. Sánchez-Paulete', 'orcid': 'https://orcid.org/0000-0001-7475-1913'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}, {'id': 'https://openalex.org/I4210112085', 'display_name': 'Navarre Institute of Health Research', 'ror': 'https://ror.org/023d5h353', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I4210112085']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Alfonso R. Sanchez‐Paulete', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain'], 'affiliations': [{'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'institution_ids': ['https://openalex.org/I4210112085']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077791294', 'display_name': 'Sara Labiano', 'orcid': 'https://orcid.org/0000-0002-2173-9416'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}, {'id': 'https://openalex.org/I4210112085', 'display_name': 'Navarre Institute of Health Research', 'ror': 'https://ror.org/023d5h353', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I4210112085']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Sara Labiano', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain'], 'affiliations': [{'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'institution_ids': ['https://openalex.org/I4210112085']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065123693', 'display_name': 'María E. Rodríguez-Ruiz', 'orcid': 'https://orcid.org/0000-0002-9765-2499'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}, {'id': 'https://openalex.org/I4210112085', 'display_name': 'Navarre Institute of Health Research', 'ror': 'https://ror.org/023d5h353', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I4210112085']}, {'id': 'https://openalex.org/I4210135003', 'display_name': 'Clinica Universidad de Navarra', 'ror': 'https://ror.org/03phm3r45', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210135003']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Maria E. Rodriguez‐Ruiz', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'University Clinic University of Navarra Pamplona Spain'], 'affiliations': [{'raw_affiliation_string': 'University Clinic University of Navarra Pamplona Spain', 'institution_ids': ['https://openalex.org/I88155538', 'https://openalex.org/I4210135003']}, {'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'institution_ids': ['https://openalex.org/I4210112085']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022244845', 'display_name': 'Arantza Azpilikueta', 'orcid': 'https://orcid.org/0000-0001-8511-6050'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}, {'id': 'https://openalex.org/I4210112085', 'display_name': 'Navarre Institute of Health Research', 'ror': 'https://ror.org/023d5h353', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I4210112085']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Arantza Azpilikueta', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain'], 'affiliations': [{'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'institution_ids': ['https://openalex.org/I4210112085']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072852574', 'display_name': 'Iñaki Etxeberría', 'orcid': 'https://orcid.org/0000-0003-2713-0836'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}, {'id': 'https://openalex.org/I4210112085', 'display_name': 'Navarre Institute of Health Research', 'ror': 'https://ror.org/023d5h353', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I4210112085']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Iñaki Etxeberria', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain'], 'affiliations': [{'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'institution_ids': ['https://openalex.org/I4210112085']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062239854', 'display_name': 'Elixabet Bolaños', 'orcid': 'https://orcid.org/0000-0003-3780-9244'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}, {'id': 'https://openalex.org/I4210112085', 'display_name': 'Navarre Institute of Health Research', 'ror': 'https://ror.org/023d5h353', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I4210112085']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Elixabet Bolaños', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain'], 'affiliations': [{'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'institution_ids': ['https://openalex.org/I4210112085']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103549778', 'display_name': 'V. S. Lang', 'orcid': 'https://orcid.org/0000-0001-9954-7898'}, 'institutions': [], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Valérie Lang', 'raw_affiliation_strings': ['Ubiquitylation and Cancer Molecular Biology Laboratory Foundation for Stem Cell Research, Fundación Inbiomed San Sebastián Spain'], 'affiliations': [{'raw_affiliation_string': 'Ubiquitylation and Cancer Molecular Biology Laboratory Foundation for Stem Cell Research, Fundación Inbiomed San Sebastián Spain', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041436608', 'display_name': 'Maria Rodriguez‐Oroz', 'orcid': 'https://orcid.org/0000-0001-5962-772X'}, 'institutions': [{'id': 'https://openalex.org/I4210099749', 'display_name': 'Institut de Pharmacologie et de Biologie Structurale', 'ror': 'https://ror.org/016zvc994', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I134560555', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210099749']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210126285', 'display_name': 'Institut des Technologies Avancées en sciences du Vivant', 'ror': 'https://ror.org/028pmgd25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I134560555', 'https://openalex.org/I4210126285', 'https://openalex.org/I4210133643', 'https://openalex.org/I4210139971']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Manuel Rodriguez', 'raw_affiliation_strings': ['Advanced Technology Institute in Life Sciences (ITAV), CNRS-USR3505, Toulouse, France', 'Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS-UMR5089, Toulouse, France', 'Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS‐UMR5089 Toulouse France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS‐UMR5089 Toulouse France', 'institution_ids': ['https://openalex.org/I4210099749', 'https://openalex.org/I1294671590']}, {'raw_affiliation_string': 'Advanced Technology Institute in Life Sciences (ITAV), CNRS-USR3505, Toulouse, France', 'institution_ids': ['https://openalex.org/I4210126285', 'https://openalex.org/I1294671590']}, {'raw_affiliation_string': 'Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS-UMR5089, Toulouse, France', 'institution_ids': ['https://openalex.org/I4210099749', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057236167', 'display_name': 'M. Ángela Aznar', 'orcid': 'https://orcid.org/0000-0002-7970-1672'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'M. Angela Aznar', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019908292', 'display_name': 'Maria Jure‐Kunkel', 'orcid': 'https://orcid.org/0000-0002-3751-1934'}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maria Jure‐Kunkel', 'raw_affiliation_strings': ['Bristol-Myers Squibb Company, Princeton, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Bristol-Myers Squibb Company, Princeton, NJ, USA', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029243551', 'display_name': 'Ignacio Melero', 'orcid': 'https://orcid.org/0000-0002-1360-348X'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}, {'id': 'https://openalex.org/I4210112085', 'display_name': 'Navarre Institute of Health Research', 'ror': 'https://ror.org/023d5h353', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I4210112085']}, {'id': 'https://openalex.org/I4210135003', 'display_name': 'Clinica Universidad de Navarra', 'ror': 'https://ror.org/03phm3r45', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210135003']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Ignacio Melero', 'raw_affiliation_strings': ['Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'University Clinic University of Navarra Pamplona Spain'], 'affiliations': [{'raw_affiliation_string': 'University Clinic University of Navarra Pamplona Spain', 'institution_ids': ['https://openalex.org/I88155538', 'https://openalex.org/I4210135003']}, {'raw_affiliation_string': 'Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Instituto de Investigación Sanitaria de Navarra (IdISNA) Pamplona Spain', 'institution_ids': ['https://openalex.org/I4210112085']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5029243551'], 'corresponding_institution_ids': ['https://openalex.org/I88155538', 'https://openalex.org/I4210112085', 'https://openalex.org/I4210135003'], 'apc_list': {'value': 4120, 'currency': 'USD', 'value_usd': 4120, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.991, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 112, 'citation_normalized_percentile': {'value': 0.999402, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '46', 'issue': '3', 'first_page': '513', 'last_page': '522'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11491', 'display_name': 'Chimeric Antigen Receptor T Cell Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11491', 'display_name': 'Chimeric Antigen Receptor T Cell Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Natural Killer Cells in Immunity', 'score': 0.9838, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd137', 'display_name': 'CD137', 'score': 0.8127064}, {'id': 'https://openalex.org/keywords/cancer-immunotherapy', 'display_name': 'Cancer immunotherapy', 'score': 0.67585504}, {'id': 'https://openalex.org/keywords/nk-cell-activation', 'display_name': 'NK Cell Activation', 'score': 0.518532}, {'id': 'https://openalex.org/keywords/nk-cell-recognition', 'display_name': 'NK Cell Recognition', 'score': 0.508971}], 'concepts': [{'id': 'https://openalex.org/C2780249625', 'wikidata': 'https://www.wikidata.org/wiki/Q14913226', 'display_name': 'CD137', 'level': 4, 'score': 0.8127064}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.811586}, {'id': 'https://openalex.org/C2780674031', 'wikidata': 'https://www.wikidata.org/wiki/Q2012719', 'display_name': 'Cancer immunotherapy', 'level': 4, 'score': 0.67585504}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.5934022}, {'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.5682953}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.45256713}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4486775}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44617796}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4177836}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.37598926}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.36018133}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3154229}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.2525896}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15980044}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.10192707}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.078789085}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D016219', 'descriptor_name': 'Immunotherapy, Adoptive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D013602', 'descriptor_name': 'T-Lymphocytes, Cytotoxic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D053261', 'descriptor_name': 'Tumor Necrosis Factor Receptor Superfamily, Member 9', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053261', 'descriptor_name': 'Tumor Necrosis Factor Receptor Superfamily, Member 9', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000920', 'descriptor_name': 'Antibody-Dependent Cell Cytotoxicity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017322', 'descriptor_name': 'Clinical Trials, Phase II as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016219', 'descriptor_name': 'Immunotherapy, Adoptive', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013602', 'descriptor_name': 'T-Lymphocytes, Cytotoxic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053261', 'descriptor_name': 'Tumor Necrosis Factor Receptor Superfamily, Member 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/eji.201445388', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201445388', 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26773716', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/eji.201445388', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201445388', 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 126, 'referenced_works': ['https://openalex.org/W1580205301', 'https://openalex.org/W1619537825', 'https://openalex.org/W1647507681', 'https://openalex.org/W1656949393', 'https://openalex.org/W1730447863', 'https://openalex.org/W1759105571', 'https://openalex.org/W1863453661', 'https://openalex.org/W1920235745', 'https://openalex.org/W1942897646', 'https://openalex.org/W1964162947', 'https://openalex.org/W1964937487', 'https://openalex.org/W1968160256', 'https://openalex.org/W1968831733', 'https://openalex.org/W1970230889', 'https://openalex.org/W1970472871', 'https://openalex.org/W1971274849', 'https://openalex.org/W1973425911', 'https://openalex.org/W1978354618', 'https://openalex.org/W1978454000', 'https://openalex.org/W1980137951', 'https://openalex.org/W1982696984', 'https://openalex.org/W1982861708', 'https://openalex.org/W1983358548', 'https://openalex.org/W1984293345', 'https://openalex.org/W1984330599', 'https://openalex.org/W1984964761', 'https://openalex.org/W1985278235', 'https://openalex.org/W1987029228', 'https://openalex.org/W1987504267', 'https://openalex.org/W1987891097', 'https://openalex.org/W1990602451', 'https://openalex.org/W1991385476', 'https://openalex.org/W1992546156', 'https://openalex.org/W1996073353', 'https://openalex.org/W1997634040', 'https://openalex.org/W1998006783', 'https://openalex.org/W1999944748', 'https://openalex.org/W2003494920', 'https://openalex.org/W2005055996', 'https://openalex.org/W2005971162', 'https://openalex.org/W2011435623', 'https://openalex.org/W2012108097', 'https://openalex.org/W2013165543', 'https://openalex.org/W2014392340', 'https://openalex.org/W2016775776', 'https://openalex.org/W2021235698', 'https://openalex.org/W2021293156', 'https://openalex.org/W2021710291', 'https://openalex.org/W2022162468', 'https://openalex.org/W2025884466', 'https://openalex.org/W2028582857', 'https://openalex.org/W2032566019', 'https://openalex.org/W2033899272', 'https://openalex.org/W2036599699', 'https://openalex.org/W2046510135', 'https://openalex.org/W2051870875', 'https://openalex.org/W2053313205', 'https://openalex.org/W2056086466', 'https://openalex.org/W2057127443', 'https://openalex.org/W2061300591', 'https://openalex.org/W2069584224', 'https://openalex.org/W2073280768', 'https://openalex.org/W2074801788', 'https://openalex.org/W2075840867', 'https://openalex.org/W2082849642', 'https://openalex.org/W2090024025', 'https://openalex.org/W2094804545', 'https://openalex.org/W2096751726', 'https://openalex.org/W2097765486', 'https://openalex.org/W2099241614', 'https://openalex.org/W2100455637', 'https://openalex.org/W2101538692', 'https://openalex.org/W2102141355', 'https://openalex.org/W2104057798', 'https://openalex.org/W2104088439', 'https://openalex.org/W2105400883', 'https://openalex.org/W2105548504', 'https://openalex.org/W2106268456', 'https://openalex.org/W2106461837', 'https://openalex.org/W2107009614', 'https://openalex.org/W2107806760', 'https://openalex.org/W2109490990', 'https://openalex.org/W2110218114', 'https://openalex.org/W2113052538', 'https://openalex.org/W2113170011', 'https://openalex.org/W2116929481', 'https://openalex.org/W2118796952', 'https://openalex.org/W2119220519', 'https://openalex.org/W2123641407', 'https://openalex.org/W2124002866', 'https://openalex.org/W2124146181', 'https://openalex.org/W2127975279', 'https://openalex.org/W2131931464', 'https://openalex.org/W2132486642', 'https://openalex.org/W2136186979', 'https://openalex.org/W2136364651', 'https://openalex.org/W2137401479', 'https://openalex.org/W2137693354', 'https://openalex.org/W2139249889', 'https://openalex.org/W2144704426', 'https://openalex.org/W2147051992', 'https://openalex.org/W2148808612', 'https://openalex.org/W2149827944', 'https://openalex.org/W2149835039', 'https://openalex.org/W2149854843', 'https://openalex.org/W2153519961', 'https://openalex.org/W2154932340', 'https://openalex.org/W2155754472', 'https://openalex.org/W2161184189', 'https://openalex.org/W2162839278', 'https://openalex.org/W2165248161', 'https://openalex.org/W2166024764', 'https://openalex.org/W2167550136', 'https://openalex.org/W2168302786', 'https://openalex.org/W2170758122', 'https://openalex.org/W2171260017', 'https://openalex.org/W2172183947', 'https://openalex.org/W2180091996', 'https://openalex.org/W2186797157', 'https://openalex.org/W2199851823', 'https://openalex.org/W2206643120', 'https://openalex.org/W2324715299', 'https://openalex.org/W2508885742', 'https://openalex.org/W4210637293', 'https://openalex.org/W4241646216', 'https://openalex.org/W4253435468'], 'related_works': ['https://openalex.org/W4313343001', 'https://openalex.org/W4223914026', 'https://openalex.org/W3185708072', 'https://openalex.org/W3111580887', 'https://openalex.org/W3049036915', 'https://openalex.org/W2999675030', 'https://openalex.org/W2939955202', 'https://openalex.org/W2893846263', 'https://openalex.org/W2400599632', 'https://openalex.org/W1898654834'], 'abstract_inverted_index': {'CD137': [0, 28, 59, 73, 108, 143, 171, 207, 219], '(4‐1BB,': [1], 'TNF‐receptor': [2], 'superfamily': [3], '9)': [4], 'is': [5, 29, 172], 'a': [6, 18, 63, 173], 'surface': [7], 'glycoprotein': [8], 'of': [9, 20, 72, 83, 128, 154, 170, 176, 206, 218], 'the': [10, 115, 120, 124, 129, 166, 193, 204, 216], 'TNFR': [11], 'family': [12], 'which': [13, 87], 'can': [14, 74, 110, 139], 'be': [15, 75, 111, 133, 140], 'induced': [16], 'on': [17], 'variety': [19], 'leukocyte': [21], 'subsets.': [22], 'On': [23], 'T': [24, 116, 155, 186], 'and': [25, 56, 91, 100, 148, 157, 190, 203], 'NK': [26], 'cells,': [27], 'expressed': [30], 'following': [31], 'activation': [32], 'and,': [33], 'if': [34], 'ligated': [35], 'by': [36, 80], 'its': [37], 'natural': [38], 'ligand': [39], '(CD137L),': [40], 'conveys': [41], 'polyubiquitination‐mediated': [42], 'signals': [43], 'via': [44], 'TNF': [45], 'receptor': [46], 'associated': [47], 'factor': [48], '2': [49], 'that': [50, 181], 'inhibit': [51], 'apoptosis,': [52], 'while': [53], 'enhancing': [54], 'proliferation': [55], 'effector': [57], 'functions.': [58], 'thus': [60], 'behaves': [61], 'as': [62], 'bona': [64], 'fide': [65], 'inducible': [66], 'costimulatory': [67], 'molecule.': [68], 'These': [69], 'functional': [70], 'properties': [71], 'exploited': [76], 'in': [77, 135, 162, 192, 209, 220], 'cancer': [78], 'immunotherapy': [79], 'systemic': [81], 'administration': [82], 'agonist': [84, 144, 201], 'monoclonal': [85], 'antibodies,': [86], 'increase': [88], 'anticancer': [89], 'CTLs': [90], 'enhance': [92], 'NK‐cell‐mediated': [93], 'antibody‐dependent': [94], 'cell‐mediated': [95], 'cytotoxicity.': [96], 'Reportedly,': [97], 'anti‐CD137': [98], 'mAb': [99], 'adoptive': [101, 136], 'T‐cell': [102, 137], 'therapy': [103, 138], 'strongly': [104], 'synergize,': [105], 'since': [106], '(i)': [107], 'expression': [109], 'used': [112, 134, 183], 'to': [113, 132, 184], 'select': [114], 'cells': [117, 156, 187], 'endowed': [118], 'with': [119, 142, 200], 'best': [121], 'activities': [122], 'against': [123, 188], 'tumor,': [125], '(ii)': [126], 'costimulation': [127], 'lymphocyte': [130], 'cultures': [131], 'done': [141], 'antibodies': [145, 158, 202], 'or': [146], 'CD137L,': [147], '(iii)': [149], 'synergistic': [150], 'effects': [151], 'upon': [152], 'coadministration': [153], 'are': [159, 182], 'readily': [160], 'observed': [161], 'mouse': [163], 'models.': [164], 'Furthermore,': [165], 'signaling': [167], 'cytoplasmic': [168], 'tail': [169], 'key': [174], 'component': [175], 'anti‐CD19': [177], 'chimeric': [178, 212], 'antigen': [179, 213], 'receptors': [180, 214], 'redirect': [185], 'leukemia': [189], 'lymphoma': [191], 'clinic.': [194], 'Ongoing': [195], 'phase': [196], 'II': [197], 'clinical': [198], 'trials': [199], 'presence': [205], 'sequence': [208], 'these': [210], 'successful': [211], 'highlight': [215], 'importance': [217], 'oncoimmunology.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2238959222', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 4}], 'updated_date': '2024-09-12T06:11:45.528368', 'created_date': '2016-06-24'}