Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2238886653', 'doi': 'https://doi.org/10.1016/j.cca.2016.01.003', 'title': 'Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations', 'display_name': 'Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations', 'publication_year': 2016, 'publication_date': '2016-01-11', 'ids': {'openalex': 'https://openalex.org/W2238886653', 'doi': 'https://doi.org/10.1016/j.cca.2016.01.003', 'mag': '2238886653', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26790753'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.cca.2016.01.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S207549998', 'display_name': 'Clinica Chimica Acta', 'issn_l': '0009-8981', 'issn': ['0009-8981', '1873-3492'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031985588', 'display_name': 'Milena Romanello', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126152', 'display_name': 'Ospedale Santa Maria della Misericordia di Udine', 'ror': 'https://ror.org/02zpc2253', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126152']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Milena Romanello', 'raw_affiliation_strings': ['Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy', 'institution_ids': ['https://openalex.org/I4210126152']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055610157', 'display_name': 'Stefania Zampieri', 'orcid': 'https://orcid.org/0000-0003-3921-8405'}, 'institutions': [{'id': 'https://openalex.org/I4210126152', 'display_name': 'Ospedale Santa Maria della Misericordia di Udine', 'ror': 'https://ror.org/02zpc2253', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126152']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefania Zampieri', 'raw_affiliation_strings': ['Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy', 'institution_ids': ['https://openalex.org/I4210126152']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110362939', 'display_name': 'Nadia Bortolotti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126152', 'display_name': 'Ospedale Santa Maria della Misericordia di Udine', 'ror': 'https://ror.org/02zpc2253', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126152']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Nadia Bortolotti', 'raw_affiliation_strings': ['Clinical Pathology Institute, University Hospital Santa Maria della Misericordia, Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pathology Institute, University Hospital Santa Maria della Misericordia, Udine, Italy', 'institution_ids': ['https://openalex.org/I4210126152']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019794874', 'display_name': 'Laura Deroma', 'orcid': 'https://orcid.org/0000-0003-1483-7533'}, 'institutions': [{'id': 'https://openalex.org/I4210126152', 'display_name': 'Ospedale Santa Maria della Misericordia di Udine', 'ror': 'https://ror.org/02zpc2253', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126152']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Laura Deroma', 'raw_affiliation_strings': ['Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy', 'institution_ids': ['https://openalex.org/I4210126152']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035291469', 'display_name': 'Annalisa Sechi', 'orcid': 'https://orcid.org/0000-0003-1708-7563'}, 'institutions': [{'id': 'https://openalex.org/I4210126152', 'display_name': 'Ospedale Santa Maria della Misericordia di Udine', 'ror': 'https://ror.org/02zpc2253', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126152']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Annalisa Sechi', 'raw_affiliation_strings': ['Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy', 'institution_ids': ['https://openalex.org/I4210126152']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003242281', 'display_name': 'Agata Fiumara', 'orcid': 'https://orcid.org/0000-0003-3216-2154'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Agata Fiumara', 'raw_affiliation_strings': ['Department of Pediatrics, Regional Referral Center for Inherited Metabolic Disease, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Regional Referral Center for Inherited Metabolic Disease, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083680735', 'display_name': 'Rossella Parini', 'orcid': 'https://orcid.org/0000-0003-4505-1306'}, 'institutions': [{'id': 'https://openalex.org/I4210110840', 'display_name': 'Azienda Ospedaliera San Gerardo', 'ror': 'https://ror.org/01xf83457', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110840']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Rossella Parini', 'raw_affiliation_strings': ['Rare Metabolic Diseases Unit, Pediatric Clinic, San Gerardo Hospital, Monza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Rare Metabolic Diseases Unit, Pediatric Clinic, San Gerardo Hospital, Monza, Italy', 'institution_ids': ['https://openalex.org/I4210110840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090580473', 'display_name': 'Barbara Borroni', 'orcid': 'https://orcid.org/0000-0001-9340-9814'}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Barbara Borroni', 'raw_affiliation_strings': ['Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037394247', 'display_name': 'Francesco Brancati', 'orcid': 'https://orcid.org/0000-0003-3624-2354'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Brancati', 'raw_affiliation_strings': ['Medical Genetics Unit, Tor Vergata University, Roma, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Genetics Unit, Tor Vergata University, Roma, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059411860', 'display_name': 'Amalia C. Bruni', 'orcid': 'https://orcid.org/0000-0003-3471-3343'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Amalia Bruni', 'raw_affiliation_strings': ['Regional Neurogenetic Centre, ASPCZ, Lamezia Terme, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Neurogenetic Centre, ASPCZ, Lamezia Terme, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055284599', 'display_name': 'Cinzia Valeria Russo', 'orcid': 'https://orcid.org/0000-0003-0345-8319'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cinzia V. Russo', 'raw_affiliation_strings': ['Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041383749', 'display_name': 'Andrea Bordugo', 'orcid': 'https://orcid.org/0000-0003-1927-8187'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Bordugo', 'raw_affiliation_strings': ['Regional Centre for Newborn Screening, Diagnosis and Treatment of Inherited Metabolic Disorders and Inherited Metabolic Diseases Unit, Department of Pediatrics, Verona, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Centre for Newborn Screening, Diagnosis and Treatment of Inherited Metabolic Disorders and Inherited Metabolic Diseases Unit, Department of Pediatrics, Verona, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046731360', 'display_name': 'Bruno Bembi', 'orcid': 'https://orcid.org/0000-0003-0486-1329'}, 'institutions': [{'id': 'https://openalex.org/I4210126152', 'display_name': 'Ospedale Santa Maria della Misericordia di Udine', 'ror': 'https://ror.org/02zpc2253', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126152']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Bruno Bembi', 'raw_affiliation_strings': ['Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy', 'institution_ids': ['https://openalex.org/I4210126152']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052930244', 'display_name': 'Andrea Dardis', 'orcid': 'https://orcid.org/0000-0001-7024-8181'}, 'institutions': [{'id': 'https://openalex.org/I4210126152', 'display_name': 'Ospedale Santa Maria della Misericordia di Udine', 'ror': 'https://ror.org/02zpc2253', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126152']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Andrea Dardis', 'raw_affiliation_strings': ['Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy'], 'affiliations': [{'raw_affiliation_string': 'Regional Coordinator Centre for Rare Diseases, University Hospital Santa Maria della Misericordia, Udine, Italy', 'institution_ids': ['https://openalex.org/I4210126152']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5052930244'], 'corresponding_institution_ids': ['https://openalex.org/I4210126152'], 'apc_list': {'value': 3200, 'currency': 'USD', 'value_usd': 3200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.997, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.876348, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '455', 'issue': None, 'first_page': '39', 'last_page': '45'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10835', 'display_name': 'Carbohydrate Chemistry and Synthesis', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9745, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/npc1', 'display_name': 'NPC1', 'score': 0.7851}, {'id': 'https://openalex.org/keywords/hepatosplenomegaly', 'display_name': 'Hepatosplenomegaly', 'score': 0.68181366}, {'id': 'https://openalex.org/keywords/niemann–pick-disease', 'display_name': 'Niemann–Pick disease', 'score': 0.6794512}, {'id': 'https://openalex.org/keywords/compound-heterozygosity', 'display_name': 'Compound heterozygosity', 'score': 0.51410514}, {'id': 'https://openalex.org/keywords/oxysterol', 'display_name': 'Oxysterol', 'score': 0.41582566}], 'concepts': [{'id': 'https://openalex.org/C2778552423', 'wikidata': 'https://www.wikidata.org/wiki/Q14914279', 'display_name': 'NPC1', 'level': 4, 'score': 0.7851}, {'id': 'https://openalex.org/C2779440204', 'wikidata': 'https://www.wikidata.org/wiki/Q1260186', 'display_name': 'Hepatosplenomegaly', 'level': 3, 'score': 0.68181366}, {'id': 'https://openalex.org/C2779489717', 'wikidata': 'https://www.wikidata.org/wiki/Q1419931', 'display_name': 'Niemann–Pick disease', 'level': 3, 'score': 0.6794512}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.6663115}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.53291845}, {'id': 'https://openalex.org/C12125453', 'wikidata': 'https://www.wikidata.org/wiki/Q5156837', 'display_name': 'Compound heterozygosity', 'level': 4, 'score': 0.51410514}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5112605}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.50166965}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.49607047}, {'id': 'https://openalex.org/C2780635549', 'wikidata': 'https://www.wikidata.org/wiki/Q2067267', 'display_name': 'Niemann–Pick disease, type C', 'level': 3, 'score': 0.42137185}, {'id': 'https://openalex.org/C2778111914', 'wikidata': 'https://www.wikidata.org/wiki/Q7116159', 'display_name': 'Oxysterol', 'level': 3, 'score': 0.41582566}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.40265498}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.38731256}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3560744}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3205253}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.3190232}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23715264}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12883928}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002776', 'descriptor_name': 'Cholestanes', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D007653', 'descriptor_name': 'Ketocholesterols', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009542', 'descriptor_name': 'Niemann-Pick Diseases', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002138', 'descriptor_name': 'Calibration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002776', 'descriptor_name': 'Cholestanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007558', 'descriptor_name': 'Italy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007653', 'descriptor_name': 'Ketocholesterols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077296', 'descriptor_name': 'Niemann-Pick C1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009542', 'descriptor_name': 'Niemann-Pick Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009542', 'descriptor_name': 'Niemann-Pick Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015203', 'descriptor_name': 'Reproducibility of Results', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.cca.2016.01.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S207549998', 'display_name': 'Clinica Chimica Acta', 'issn_l': '0009-8981', 'issn': ['0009-8981', '1873-3492'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26790753', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.8}], 'grants': [{'funder': 'https://openalex.org/F4320338282', 'funder_display_name': 'Actelion Pharmaceuticals', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W104571512', 'https://openalex.org/W1794989353', 'https://openalex.org/W1967917811', 'https://openalex.org/W1973698024', 'https://openalex.org/W1975595058', 'https://openalex.org/W1991876246', 'https://openalex.org/W2024286256', 'https://openalex.org/W2045625322', 'https://openalex.org/W2068262899', 'https://openalex.org/W2068338012', 'https://openalex.org/W2080524944', 'https://openalex.org/W2081981367', 'https://openalex.org/W2083778497', 'https://openalex.org/W2092592677', 'https://openalex.org/W2125424702', 'https://openalex.org/W2129679875', 'https://openalex.org/W2137644470', 'https://openalex.org/W2404743493', 'https://openalex.org/W3209992856'], 'related_works': ['https://openalex.org/W4225398035', 'https://openalex.org/W4210607818', 'https://openalex.org/W3150467293', 'https://openalex.org/W2789598102', 'https://openalex.org/W2762574701', 'https://openalex.org/W2320537617', 'https://openalex.org/W2238886653', 'https://openalex.org/W2163662904', 'https://openalex.org/W2071782152', 'https://openalex.org/W2024286256'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2238886653', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-09T20:20:50.894269', 'created_date': '2016-06-24'}