Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2235541028', 'doi': 'https://doi.org/10.1016/j.xphs.2015.11.023', 'title': 'Integrated Application of Quality-by-Design Principles to Drug Product Development: A Case Study of Brivanib Alaninate Film–Coated Tablets', 'display_name': 'Integrated Application of Quality-by-Design Principles to Drug Product Development: A Case Study of Brivanib Alaninate Film–Coated Tablets', 'publication_year': 2016, 'publication_date': '2016-01-01', 'ids': {'openalex': 'https://openalex.org/W2235541028', 'doi': 'https://doi.org/10.1016/j.xphs.2015.11.023', 'mag': '2235541028', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26852852'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.xphs.2015.11.023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S130661733', 'display_name': 'Journal of Pharmaceutical Sciences', 'issn_l': '0022-3549', 'issn': ['0022-3549', '1520-6017'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012000730', 'display_name': 'Sherif Badawy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Sherif I.F. Badawy', 'raw_affiliation_strings': ['Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084402007', 'display_name': 'Ajit S. Narang', 'orcid': 'https://orcid.org/0000-0002-9417-1307'}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ajit S. Narang', 'raw_affiliation_strings': ['Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051330799', 'display_name': 'Keirnan R. LaMarche', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Keirnan R. LaMarche', 'raw_affiliation_strings': ['Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011640326', 'display_name': 'Ganeshkumar A. Subramanian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ganeshkumar A. Subramanian', 'raw_affiliation_strings': ['Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076083486', 'display_name': 'Sailesh A. Varia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sailesh A. Varia', 'raw_affiliation_strings': ['Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035438320', 'display_name': 'Jay Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Judy Lin', 'raw_affiliation_strings': ['Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078265042', 'display_name': 'Tim Stevens', 'orcid': 'https://orcid.org/0009-0007-4683-6910'}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tim Stevens', 'raw_affiliation_strings': ['Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002764819', 'display_name': 'Pankaj A. Shah', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pankaj A. Shah', 'raw_affiliation_strings': ['Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903'], 'affiliations': [{'raw_affiliation_string': 'Analytical and Bioanalytical Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903', 'institution_ids': ['https://openalex.org/I4210091812']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5012000730'], 'corresponding_institution_ids': ['https://openalex.org/I4210091812'], 'apc_list': {'value': 3620, 'currency': 'USD', 'value_usd': 3620, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.228, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.835302, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '105', 'issue': '1', 'first_page': '168', 'last_page': '181'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10256', 'display_name': 'Drug Delivery Systems', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10256', 'display_name': 'Drug Delivery Systems', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Methods in Drug Discovery', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11460', 'display_name': 'Green Analytical Chemistry in Pharmaceutical Analysis', 'score': 0.9635, 'subfield': {'id': 'https://openalex.org/subfields/1602', 'display_name': 'Analytical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/quality-by-design', 'display_name': 'Quality by Design', 'score': 0.58596027}, {'id': 'https://openalex.org/keywords/drug-solubility', 'display_name': 'Drug Solubility', 'score': 0.455431}], 'concepts': [{'id': 'https://openalex.org/C204320433', 'wikidata': 'https://www.wikidata.org/wiki/Q7268772', 'display_name': 'Quality by Design', 'level': 3, 'score': 0.58596027}, {'id': 'https://openalex.org/C2779530757', 'wikidata': 'https://www.wikidata.org/wiki/Q1207505', 'display_name': 'Quality (philosophy)', 'level': 2, 'score': 0.57062674}, {'id': 'https://openalex.org/C90673727', 'wikidata': 'https://www.wikidata.org/wiki/Q901718', 'display_name': 'Product (mathematics)', 'level': 2, 'score': 0.5362235}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.5238331}, {'id': 'https://openalex.org/C19351080', 'wikidata': 'https://www.wikidata.org/wiki/Q1395034', 'display_name': 'New product development', 'level': 2, 'score': 0.44762442}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.4064478}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.39551124}, {'id': 'https://openalex.org/C21880701', 'wikidata': 'https://www.wikidata.org/wiki/Q2144042', 'display_name': 'Process engineering', 'level': 1, 'score': 0.3434899}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34122998}, {'id': 'https://openalex.org/C144133560', 'wikidata': 'https://www.wikidata.org/wiki/Q4830453', 'display_name': 'Business', 'level': 0, 'score': 0.26390257}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25573826}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.21941146}, {'id': 'https://openalex.org/C162853370', 'wikidata': 'https://www.wikidata.org/wiki/Q39809', 'display_name': 'Marketing', 'level': 1, 'score': 0.118239164}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.099288374}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2524010', 'wikidata': 'https://www.wikidata.org/wiki/Q8087', 'display_name': 'Geometry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D013678', 'descriptor_name': 'Technology, Pharmaceutical', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D013678', 'descriptor_name': 'Technology, Pharmaceutical', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': True}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000268', 'descriptor_name': 'Adhesiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002626', 'descriptor_name': 'Chemistry, Pharmaceutical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004339', 'descriptor_name': 'Drug Compounding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065546', 'descriptor_name': 'Drug Liberation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004349', 'descriptor_name': 'Drug Packaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004355', 'descriptor_name': 'Drug Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010316', 'descriptor_name': 'Particle Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011786', 'descriptor_name': 'Quality Control', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012995', 'descriptor_name': 'Solubility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019265', 'descriptor_name': 'Spectroscopy, Near-Infrared', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013608', 'descriptor_name': 'Tablets, Enteric-Coated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013678', 'descriptor_name': 'Technology, Pharmaceutical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.xphs.2015.11.023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S130661733', 'display_name': 'Journal of Pharmaceutical Sciences', 'issn_l': '0022-3549', 'issn': ['0022-3549', '1520-6017'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26852852', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1959555815', 'https://openalex.org/W1967900999', 'https://openalex.org/W1975859978', 'https://openalex.org/W1984917553', 'https://openalex.org/W1991618236', 'https://openalex.org/W1994016286', 'https://openalex.org/W1994055424', 'https://openalex.org/W1999435663', 'https://openalex.org/W1999481657', 'https://openalex.org/W2031608958', 'https://openalex.org/W2036691179', 'https://openalex.org/W2041515373', 'https://openalex.org/W2045588346', 'https://openalex.org/W2052976085', 'https://openalex.org/W2063026837', 'https://openalex.org/W2072031819', 'https://openalex.org/W2084718767', 'https://openalex.org/W2088482441', 'https://openalex.org/W2118471405', 'https://openalex.org/W2314740280', 'https://openalex.org/W2339207792', 'https://openalex.org/W2464052544', 'https://openalex.org/W2508179643', 'https://openalex.org/W2526755799', 'https://openalex.org/W2582839354', 'https://openalex.org/W4234424430'], 'related_works': ['https://openalex.org/W4381388734', 'https://openalex.org/W4297963644', 'https://openalex.org/W4283829432', 'https://openalex.org/W3211706159', 'https://openalex.org/W2983486423', 'https://openalex.org/W2183016685', 'https://openalex.org/W2132650451', 'https://openalex.org/W2073750282', 'https://openalex.org/W2048058024', 'https://openalex.org/W1783868685'], 'abstract_inverted_index': {'Modern': [0], 'drug': [1, 41], 'product': [2, 42, 63, 77, 97], 'development': [3, 43, 64, 93], 'is': [4, 47], 'expected': [5], 'to': [6, 40, 62, 105, 111, 126, 151, 173], 'follow': [7], 'quality-by-design': [8], '(QbD)': [9], 'paradigm.': [10], 'At': [11], 'the': [12, 22, 26, 35, 57, 67, 73, 90, 106, 128, 131, 141, 152, 159, 182], 'same': [13], 'time,': [14], 'although': [15], 'there': [16], 'are': [17], 'several': [18], 'issue-specific': [19], 'examples': [20], 'in': [21, 72], 'literature': [23], 'that': [24], 'demonstrate': [25], 'application': [27, 36, 59], 'of': [28, 34, 37, 60, 69, 76, 96, 103, 122, 130, 143, 165, 181], 'QbD': [29, 38, 61, 70], 'principles,': [30], 'a': [31, 87, 137], 'holistic': [32], 'demonstration': [33], 'principles': [39], 'and': [44, 65, 78, 108, 113, 120, 140, 155, 169, 178], 'control': [45, 161, 174], 'strategy,': [46], 'lacking.': [48], 'This': [49], 'article': [50], 'provides': [51], 'an': [52], 'integrated': [53], 'case': [54], 'study': [55], 'on': [56, 147], 'systematic': [58], 'demonstrates': [66], 'implementation': [68], 'concepts': [71], 'different': [74], 'aspects': [75], 'process': [79, 145, 156, 166], 'design': [80, 121], 'for': [81, 92, 136], 'brivanib': [82], 'alaninate': [83], 'film-coated': [84], 'tablets.': [85], 'Using': [86], 'risk-based': [88], 'approach,': [89], 'strategy': [91, 162], 'entailed': [94], 'identification': [95], 'critical': [98], 'quality': [99, 129, 180], 'attributes': [100, 177], '(CQAs),': [101], 'assessment': [102], 'risks': [104], 'CQAs,': [107], 'performing': [109], 'experiments': [110, 123], 'understand': [112, 127], 'mitigate': [114], 'identified': [115], 'risks.': [116], 'Quality': [117], 'risk': [118], 'assessments': [119], 'were': [124], 'performed': [125], 'input': [132], 'raw': [133], 'materials': [134], 'required': [135], 'robust': [138], 'formulation': [139], 'impact': [142], 'manufacturing': [144], 'parameters': [146], 'CQAs.': [148], 'In': [149], 'addition': [150], 'material': [153, 176], 'property': [154], 'parameter': [157], 'controls,': [158], 'proposed': [160], 'includes': [163], 'use': [164], 'analytical': [167, 171], 'technology': [168], 'conventional': [170], 'tests': [172], 'in-process': [175], 'ensure': [179], 'final': [183], 'product.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2235541028', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-09-19T13:09:26.880514', 'created_date': '2016-06-24'}