Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

Name: Work Video:
Duration: 3 min 30 s
Sara Duarte-Pereira; Isabel Pereira‐Castro; Sarah S. Silva; Mariana Gonçalves Correia; Célia Neto; Luís Teixeira da Costa; António Amorim; Raquel M. Silva
{'id': 'https://openalex.org/W2235472906', 'doi': 'https://doi.org/10.18632/oncotarget.6538', 'title': 'Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors', 'display_name': 'Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors', 'publication_year': 2015, 'publication_date': '2015-12-09', 'ids': {'openalex': 'https://openalex.org/W2235472906', 'doi': 'https://doi.org/10.18632/oncotarget.6538', 'mag': '2235472906', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26675378', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4811510'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6538', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6538&path%5B%5D=18123', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6538&path%5B%5D=18123', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071235209', 'display_name': 'Sara Duarte-Pereira', 'orcid': 'https://orcid.org/0000-0001-5244-068X'}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Sara Duarte-Pereira', 'raw_affiliation_strings': ['IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025712968', 'display_name': 'Isabel Pereira‐Castro', 'orcid': 'https://orcid.org/0000-0003-4149-4310'}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}, {'id': 'https://openalex.org/I4210158732', 'display_name': 'i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto', 'ror': 'https://ror.org/04wjk1035', 'country_code': 'PT', 'type': 'facility', 'lineage': ['https://openalex.org/I182534213', 'https://openalex.org/I4210158732']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Isabel Pereira-Castro', 'raw_affiliation_strings': ['Gene Regulation Group, i3S/IBMC - Instituto de Investigação e Inovação em Saúde/Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal', 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}, {'raw_affiliation_string': 'Gene Regulation Group, i3S/IBMC - Instituto de Investigação e Inovação em Saúde/Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I4210158732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035565540', 'display_name': 'Sarah S. Silva', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Sarah S. Silva', 'raw_affiliation_strings': ['IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065251352', 'display_name': 'Mariana Gonçalves Correia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Mariana Gonçalves Correia', 'raw_affiliation_strings': ['IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064990470', 'display_name': 'Célia Neto', 'orcid': 'https://orcid.org/0000-0003-3256-5228'}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Célia Neto', 'raw_affiliation_strings': ['IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004093123', 'display_name': 'Luís Teixeira da Costa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}, {'id': 'https://openalex.org/I21803372', 'display_name': 'University of Évora', 'ror': 'https://ror.org/02gyps716', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I21803372']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Luís Teixeira da Costa', 'raw_affiliation_strings': ['ICAAM - Instituto de Ciências Agrárias e Ambientais Mediterrânicas, University of Évora, Évora, Portugal', 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}, {'raw_affiliation_string': 'ICAAM - Instituto de Ciências Agrárias e Ambientais Mediterrânicas, University of Évora, Évora, Portugal', 'institution_ids': ['https://openalex.org/I21803372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073725489', 'display_name': 'António Amorim', 'orcid': 'https://orcid.org/0000-0002-7518-6247'}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}, {'id': 'https://openalex.org/I4210158732', 'display_name': 'i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto', 'ror': 'https://ror.org/04wjk1035', 'country_code': 'PT', 'type': 'facility', 'lineage': ['https://openalex.org/I182534213', 'https://openalex.org/I4210158732']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'António Amorim', 'raw_affiliation_strings': ['Faculty of Sciences, University of Porto, Porto, Portugal', 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}, {'raw_affiliation_string': 'Faculty of Sciences, University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}, {'raw_affiliation_string': 'Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I4210158732']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057086325', 'display_name': 'Raquel M. Silva', 'orcid': 'https://orcid.org/0000-0001-5926-8042'}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}, {'id': 'https://openalex.org/I60858718', 'display_name': 'University of Aveiro', 'ror': 'https://ror.org/00nt41z93', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I60858718']}], 'countries': ['PT'], 'is_corresponding': True, 'raw_author_name': 'Raquel M. Silva', 'raw_affiliation_strings': ['IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'IPATIMUP -Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'Institute for Biomedicine - iBiMED & IEETA, University of Aveiro, Aveiro, Portugal'], 'affiliations': [{'raw_affiliation_string': 'IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}, {'raw_affiliation_string': 'Institute for Biomedicine - iBiMED & IEETA, University of Aveiro, Aveiro, Portugal', 'institution_ids': ['https://openalex.org/I60858718']}, {'raw_affiliation_string': 'IPATIMUP -Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5057086325'], 'corresponding_institution_ids': ['https://openalex.org/I182534213', 'https://openalex.org/I60858718'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.456, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.899585, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '7', 'issue': '2', 'first_page': '1973', 'last_page': '1983'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nicotinamide-phosphoribosyltransferase', 'display_name': 'Nicotinamide phosphoribosyltransferase', 'score': 0.9864254}, {'id': 'https://openalex.org/keywords/phosphoribosyltransferase', 'display_name': 'Phosphoribosyltransferase', 'score': 0.6086377}, {'id': 'https://openalex.org/keywords/adenine-phosphoribosyltransferase', 'display_name': 'Adenine phosphoribosyltransferase', 'score': 0.4804856}], 'concepts': [{'id': 'https://openalex.org/C2780391879', 'wikidata': 'https://www.wikidata.org/wiki/Q18035058', 'display_name': 'Nicotinamide phosphoribosyltransferase', 'level': 4, 'score': 0.9864254}, {'id': 'https://openalex.org/C75520062', 'wikidata': 'https://www.wikidata.org/wiki/Q15321392', 'display_name': 'NAD+ kinase', 'level': 3, 'score': 0.9525767}, {'id': 'https://openalex.org/C2776901170', 'wikidata': 'https://www.wikidata.org/wiki/Q12499775', 'display_name': 'Nicotinamide adenine dinucleotide', 'level': 4, 'score': 0.77701247}, {'id': 'https://openalex.org/C2777991568', 'wikidata': 'https://www.wikidata.org/wiki/Q7187556', 'display_name': 'Phosphoribosyltransferase', 'level': 5, 'score': 0.6086377}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.58646226}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.50199056}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.48731717}, {'id': 'https://openalex.org/C40507961', 'wikidata': 'https://www.wikidata.org/wiki/Q355965', 'display_name': 'Adenine phosphoribosyltransferase', 'level': 4, 'score': 0.4804856}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.46205205}, {'id': 'https://openalex.org/C197957613', 'wikidata': 'https://www.wikidata.org/wiki/Q407280', 'display_name': 'Cofactor', 'level': 3, 'score': 0.44462013}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.41608864}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.39709836}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39094442}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32347238}, {'id': 'https://openalex.org/C78179603', 'wikidata': 'https://www.wikidata.org/wiki/Q14864606', 'display_name': 'Hypoxanthine-guanine phosphoribosyltransferase', 'level': 4, 'score': 0.3156845}, {'id': 'https://openalex.org/C2776476023', 'wikidata': 'https://www.wikidata.org/wiki/Q188261', 'display_name': 'Purine', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D054409', 'descriptor_name': 'Nicotinamide Phosphoribosyltransferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010430', 'descriptor_name': 'Pentosyltransferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017398', 'descriptor_name': 'Alternative Splicing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6538', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6538&path%5B%5D=18123', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4811510', 'pdf_url': 'https://europepmc.org/articles/pmc4811510?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811510', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26675378', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6538', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6538&path%5B%5D=18123', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.73, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1788843509', 'https://openalex.org/W1790543114', 'https://openalex.org/W1806378671', 'https://openalex.org/W182244197', 'https://openalex.org/W1953904757', 'https://openalex.org/W1964044719', 'https://openalex.org/W1971212654', 'https://openalex.org/W1980799482', 'https://openalex.org/W1981106431', 'https://openalex.org/W1988971922', 'https://openalex.org/W1990869264', 'https://openalex.org/W1994586573', 'https://openalex.org/W2002811789', 'https://openalex.org/W2004772109', 'https://openalex.org/W2011125600', 'https://openalex.org/W2012034410', 'https://openalex.org/W2012538520', 'https://openalex.org/W2016527093', 'https://openalex.org/W2019240387', 'https://openalex.org/W2019394625', 'https://openalex.org/W2023747218', 'https://openalex.org/W2026462693', 'https://openalex.org/W2031050244', 'https://openalex.org/W2033133339', 'https://openalex.org/W2034660710', 'https://openalex.org/W2037609296', 'https://openalex.org/W2038617558', 'https://openalex.org/W2042081254', 'https://openalex.org/W2046109186', 'https://openalex.org/W2053682896', 'https://openalex.org/W2066142272', 'https://openalex.org/W2068816187', 'https://openalex.org/W2072944938', 'https://openalex.org/W2080595001', 'https://openalex.org/W2081417394', 'https://openalex.org/W2083287520', 'https://openalex.org/W2086274343', 'https://openalex.org/W2088716619', 'https://openalex.org/W2092679826', 'https://openalex.org/W2093048027', 'https://openalex.org/W2096525273', 'https://openalex.org/W2098401378', 'https://openalex.org/W2099580944', 'https://openalex.org/W2105545925', 'https://openalex.org/W2114382609', 'https://openalex.org/W2118151336', 'https://openalex.org/W2119700304', 'https://openalex.org/W2123051989', 'https://openalex.org/W2132926880', 'https://openalex.org/W2133273912', 'https://openalex.org/W2139320630', 'https://openalex.org/W2141820415', 'https://openalex.org/W2144424664', 'https://openalex.org/W2144724079', 'https://openalex.org/W2145203699', 'https://openalex.org/W2151625863', 'https://openalex.org/W2159249646', 'https://openalex.org/W2167402014', 'https://openalex.org/W2169685494', 'https://openalex.org/W2195577082', 'https://openalex.org/W2280782183', 'https://openalex.org/W255996521', 'https://openalex.org/W36365898', 'https://openalex.org/W4230266413', 'https://openalex.org/W4239678514', 'https://openalex.org/W58740590'], 'related_works': ['https://openalex.org/W81385415', 'https://openalex.org/W2991968425', 'https://openalex.org/W2460211985', 'https://openalex.org/W224133139', 'https://openalex.org/W2171213200', 'https://openalex.org/W2106971666', 'https://openalex.org/W2094579172', 'https://openalex.org/W2047567471', 'https://openalex.org/W2037668525', 'https://openalex.org/W1994016728'], 'abstract_inverted_index': {'//': [0, 132], 'Sara': [1], 'Duarte-Pereira': [2], '1': [3, 12, 17, 21, 37], ',': [4, 8, 13, 18, 22, 28], 'Isabel': [5], 'Pereira-Castro': [6], '1,6': [7], 'Sarah': [9], 'S.': [10], 'Silva': [11, 35], 'Mariana': [14], 'Gon&ccedil;alves': [15], 'Correia': [16], 'C&eacute;lia': [19], 'Neto': [20], 'Lu&iacute;s': [23], 'Teixeira': [24], 'da': [25], 'Costa': [26], '1,2': [27], 'Ant&oacute;nio': [29], 'Amorim': [30], '1,3,4': [31], 'and': [32, 44, 170, 179, 198, 221, 247, 253, 268, 308, 313], 'Raquel': [33, 128], 'M.': [34, 129], '1,5': [36], 'IPATIMUP': [38], '-': [39, 55, 94, 108], 'Institute': [40, 91], 'of': [41, 46, 49, 64, 70, 73, 99, 207, 212, 216, 228, 245, 272, 280, 292, 304, 310], 'Molecular': [42, 118], 'Pathology': [43], 'Immunology': [45], 'the': [47, 188, 205, 213, 226, 270, 281, 290, 302, 305], 'University': [48, 63, 72, 98], 'Porto,': [50, 51, 74, 75, 87, 88, 123, 124], 'Portugal': [52, 67, 76, 89, 102, 125], '2': [53], 'ICAAM': [54], 'Instituto': [56, 78, 109], 'de': [57, 79, 110, 116], 'Ci&ecirc;ncias': [58], 'Agr&aacute;rias': [59], 'e': [60, 81, 112, 119], 'Ambientais': [61], 'Mediterr&acirc;nicas,': [62], '&Eacute;vora,': [65, 66], '3': [68], 'Faculty': [69], 'Sciences,': [71], '4': [77], 'Investiga&ccedil;&atilde;o': [80, 111], 'Inova&ccedil;&atilde;o': [82, 113], 'em': [83, 114], 'Sa&uacute;de,': [84], 'Universidade': [85, 121], 'do': [86, 122], '5': [90], 'for': [92, 173, 225], 'Biomedicine': [93], 'iBiMED': [95], '&amp;': [96], 'IEETA,': [97], 'Aveiro,': [100, 101], '6': [103], 'Gene': [104], 'Regulation': [105], 'Group,': [106], 'i3S/IBMC': [107], 'Sa&uacute;de/Instituto': [115], 'Biologia': [117], 'Celular,': [120], 'Correspondence': [126], 'to:': [127], 'Silva,': [130], 'email:': [131], 'Keywords': [133], ':': [134, 145, 150, 155], 'human': [135, 251], 'NAD': [136, 186, 190], 'salvage,': [137], 'NAPRT,': [138], 'NAMPT,': [139], 'alternative': [140], 'transcripts,': [141], 'anti-cancer': [142, 209], 'therapies': [143, 235], 'Received': [144], 'June': [146], '23,': [147], '2015': [148, 153, 158], 'Accepted': [149], 'November': [151], '21,': [152], 'Published': [154], 'December': [156], '09,': [157], 'Abstract': [159], 'Nicotinamide': [160], 'adenine': [161], 'dinucleotide': [162], '(NAD)': [163], 'is': [164, 223, 299], 'a': [165, 171, 242], 'cofactor': [166], 'in': [167, 193, 204, 219, 234, 294], 'redox': [168], 'reactions': [169], 'substrate': [172], 'NAD-consuming': [174], 'enzymes,': [175], 'such': [176], 'as': [177, 232], 'PARPs': [178], 'sirtuins.': [180], 'As': [181], 'cancer': [182], 'cells': [183], 'have': [184], 'increased': [185], 'requirements,': [187], 'main': [189], 'salvage': [191], 'enzymes': [192], 'humans,': [194], 'nicotinamide': [195], 'phosphoribosyltransferase': [196, 200], '(NAMPT)': [197], 'nicotinate': [199], '(NAPRT),': [201], 'are': [202, 262], 'involved': [203], 'development': [206], 'novel': [208, 273], 'therapies.': [210], 'Knowledge': [211], 'expression': [214, 249, 284, 306], 'patterns': [215], 'both': [217, 260, 311], 'genes': [218, 261], 'tissues': [220, 252], 'tumors': [222], 'critical': [224], 'use': [227], 'nicotinic': [229], 'acid': [230], '(NA)': [231], 'cytoprotective': [233], 'using': [236], 'NAMPT': [237, 248, 297, 312], 'inhibitors.': [238], 'Herein,': [239], 'we': [240, 277], 'provide': [241], 'comprehensive': [243], 'study': [244], 'NAPRT': [246, 274, 282, 314], 'across': [250], 'tumor': [254], 'cell': [255], 'lines.': [256], 'We': [257], 'show': [258], 'that': [259, 289], 'widely': [263], 'expressed': [264], 'under': [265], 'normal': [266], 'conditions': [267], 'describe': [269], 'occurrence': [271], 'transcripts.': [275], 'Also,': [276], 'explore': [278], 'some': [279], 'gene': [283], 'mechanisms.': [285], 'Our': [286], 'findings': [287], 'underline': [288], 'efficiency': [291], 'NA': [293], 'treatments': [295], 'with': [296], 'inhibitors': [298], 'dependent': [300], 'on': [301], 'knowledge': [303], 'profiles': [307], 'regulation': [309], '.': [315]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2235472906', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-09T00:25:06.739368', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
