Title: PP11.12 – 2286: A case of narcolepsy in a 3-year-old girl
Abstract: Objective Narcolepsy is characterized by excessive daytime somnolence associated with sleep paralysis, hallucinations during falling asleep or awakening, and cataplexy. Early onset of narcolepsy is very rare and has significant clinical implication such as development and growth. We experienced a case of narcolepsy in a 3-year-old girl presenting with excessive sleepiness and cataplexy. Methods The patient underwent brain MRI and 24 hr-video electroencephalogram (EEG) monitoring. Polysomnography (PSG) with multiple sleep latency test (MSLT) and human leukocyte antigen (HLA) DQ typing were performed. Results Long-term video-EEG monitoring revealed no abnormal slow or epileptiform discharge during tongue thrusting, dropping head with laughter, or flopping down while standing up, which were consistent with cataplexy associated with narcolepsy. Mean sleep latency was 2.5 min and 4 episodes of sleep-onset REM periods in 5 naps were observed in PSG with MSLT. She was positive in HLA-DQB1*0602. Based on these findings, she was diagnosed as narcolepsy with cataplexy. Conclusion The history, combined with PSG and MSLT are helpful in the diagnosis of narcolepsy. We report a case of early-onset narcolepsy presenting with excessive sleepiness and narcolepsy. Narcolepsy is characterized by excessive daytime somnolence associated with sleep paralysis, hallucinations during falling asleep or awakening, and cataplexy. Early onset of narcolepsy is very rare and has significant clinical implication such as development and growth. We experienced a case of narcolepsy in a 3-year-old girl presenting with excessive sleepiness and cataplexy. The patient underwent brain MRI and 24 hr-video electroencephalogram (EEG) monitoring. Polysomnography (PSG) with multiple sleep latency test (MSLT) and human leukocyte antigen (HLA) DQ typing were performed. Long-term video-EEG monitoring revealed no abnormal slow or epileptiform discharge during tongue thrusting, dropping head with laughter, or flopping down while standing up, which were consistent with cataplexy associated with narcolepsy. Mean sleep latency was 2.5 min and 4 episodes of sleep-onset REM periods in 5 naps were observed in PSG with MSLT. She was positive in HLA-DQB1*0602. Based on these findings, she was diagnosed as narcolepsy with cataplexy. The history, combined with PSG and MSLT are helpful in the diagnosis of narcolepsy. We report a case of early-onset narcolepsy presenting with excessive sleepiness and narcolepsy.
Publication Year: 2015
Publication Date: 2015-05-01
Language: en
Type: article
Indexed In: ['crossref']
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