Title: Ineffective quinidine therapy in early onset epileptic encephalopathy with <scp><i>KCNT</i></scp><i>1</i> mutation
Abstract: Annals of NeurologyVolume 79, Issue 3 p. 502-503 Letters/Replies Ineffective quinidine therapy in early onset epileptic encephalopathy with KCNT1 mutation Pin Fee Chong MD, Pin Fee Chong MD Department of Pediatric Neurology, Fukuoka Children's Hospital, FukuokaSearch for more papers by this authorRyoko Nakamura MD, Ryoko Nakamura MD Department of Pediatric Neurology, Fukuoka Children's Hospital, FukuokaSearch for more papers by this authorHirotomo Saitsu MD, PhD, Hirotomo Saitsu MD, PhD Department of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, JapanSearch for more papers by this authorNaomichi Matsumoto MD, PhD, Naomichi Matsumoto MD, PhD Department of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, JapanSearch for more papers by this authorRyutaro Kira MD, PhD, Ryutaro Kira MD, PhD Department of Pediatric Neurology, Fukuoka Children's Hospital, FukuokaSearch for more papers by this author Pin Fee Chong MD, Pin Fee Chong MD Department of Pediatric Neurology, Fukuoka Children's Hospital, FukuokaSearch for more papers by this authorRyoko Nakamura MD, Ryoko Nakamura MD Department of Pediatric Neurology, Fukuoka Children's Hospital, FukuokaSearch for more papers by this authorHirotomo Saitsu MD, PhD, Hirotomo Saitsu MD, PhD Department of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, JapanSearch for more papers by this authorNaomichi Matsumoto MD, PhD, Naomichi Matsumoto MD, PhD Department of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, JapanSearch for more papers by this authorRyutaro Kira MD, PhD, Ryutaro Kira MD, PhD Department of Pediatric Neurology, Fukuoka Children's Hospital, FukuokaSearch for more papers by this author First published: 09 January 2016 https://doi.org/10.1002/ana.24598Citations: 61Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Bearden D, Strong A, Ehnot J, et al. Targeted treatment of migrating partial seizures of infancy with quinidine. Ann Neurol 2014; 76: 457–461. 10.1002/ana.24229 CASPubMedWeb of Science®Google Scholar 2Milligan CJ, Li M, Gazina EV, et al. KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine. Ann Neurol 2014; 75: 581–590. 10.1002/ana.24128 CASPubMedWeb of Science®Google Scholar 3Ohba C, Kato M, Takahashi N, et al. De novo KCNT1 mutations in early-onset epileptic encephalopathy. Epilepsia 2015; 56: e121–e128. 10.1111/epi.13072 CASPubMedWeb of Science®Google Scholar 4Mikati MA, Jiang YH, Carboni M, et al. Quinidine in the treatment of KCNT1 positive epilepsies. Ann Neurol doi:10.1002/ana.24520. 10.1002/ana.24520 Google Scholar 5Ben-Ari Y, Holmes GL. Effects of seizures on developmental processes in the immature brain. Lancet Neurol 2006; 5: 1055–1063. 10.1016/S1474-4422(06)70626-3 PubMedWeb of Science®Google Scholar Citing Literature Volume79, Issue3March 2016Pages 502-503 ReferencesRelatedInformation
Publication Year: 2016
Publication Date: 2016-02-12
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 69
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