Title: Impaired leptin‐induced hypothalamic leptin receptor expression with age
Abstract: We previously reported that the overweight aged F344/BN rats were resistant to the anorexic and metabolic effects of leptin. The aim of this study was to determine whether the development of age‐related leptin resistant was mediated by the impaired hypothalamic leptin receptor expression. Young (4–6mo) and old (24–28mo) male F344/BN rats were treated with either saline or leptin (1mg/Kg; ip; n=8). Leptin markedly reduced 24 hr food consumption in young rats (−5.4±0.8g) as compared with aged rats (−3.6±0.8g). To examine the hypothalamic OB‐Rb expression, rats were fasted overnight and treated with either saline or leptin (1 mg/Kg; iv; n=4/age/treatment) for 1 hr. Basal OB‐Rb protein expression was significantly reduced by 45±5% in aged rat hypothalamus (p<0.05). Leptin treatment significantly induced hypothalamic OB‐Rb protein expression by 34±2% (p<0.05) in young rats whereas leptin failed to induce hypothalamic OB‐Rb expression in aged rats. In conclusion, the impaired anorexic effect of leptin with age may be mediated in part by the inability of leptin to up‐regulate hypothalamic OB‐Rb protein expression in aged rats.
Publication Year: 2008
Publication Date: 2008-03-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot