Publication Information

{'id': 'https://openalex.org/W2220848672', 'doi': 'https://doi.org/10.1016/j.molimm.2015.07.005', 'title': 'Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I', 'display_name': 'Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I', 'publication_year': 2015, 'publication_date': '2015-07-22', 'ids': {'openalex': 'https://openalex.org/W2220848672', 'doi': 'https://doi.org/10.1016/j.molimm.2015.07.005', 'mag': '2220848672', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26210183', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4678111'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molimm.2015.07.005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S92126311', 'display_name': 'Molecular Immunology', 'issn_l': '0161-5890', 'issn': ['0161-5890', '1872-9142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.molimm.2015.07.005', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058785577', 'display_name': 'Dick J. H. van den Boomen', 'orcid': 'https://orcid.org/0000-0001-6474-3661'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'D.J.H. van den Boomen', 'raw_affiliation_strings': ['Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, UK'], 'affiliations': [{'raw_affiliation_string': 'Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, UK', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075336505', 'display_name': 'Paul J. Lehner', 'orcid': 'https://orcid.org/0000-0001-9383-1054'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'P.J. Lehner', 'raw_affiliation_strings': ['Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, UK'], 'affiliations': [{'raw_affiliation_string': 'Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, UK', 'institution_ids': ['https://openalex.org/I241749']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5058785577', 'https://openalex.org/A5075336505'], 'corresponding_institution_ids': ['https://openalex.org/I241749', 'https://openalex.org/I241749'], 'apc_list': {'value': 2970, 'currency': 'USD', 'value_usd': 2970, 'provenance': 'doaj'}, 'apc_paid': {'value': 2970, 'currency': 'USD', 'value_usd': 2970, 'provenance': 'doaj'}, 'fwci': 0.643, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.576239, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '68', 'issue': '2', 'first_page': '106', 'last_page': '111'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/endoplasmic-reticulum-associated-protein-degradation', 'display_name': 'Endoplasmic-reticulum-associated protein degradation', 'score': 0.8974483}, {'id': 'https://openalex.org/keywords/ubiquitin-protein-ligases', 'display_name': 'Ubiquitin-Protein Ligases', 'score': 0.46590525}, {'id': 'https://openalex.org/keywords/protein-degradation', 'display_name': 'Protein Degradation', 'score': 0.44437262}], 'concepts': [{'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.9040563}, {'id': 'https://openalex.org/C158619295', 'wikidata': 'https://www.wikidata.org/wiki/Q21101062', 'display_name': 'Endoplasmic-reticulum-associated protein degradation', 'level': 4, 'score': 0.8974483}, {'id': 'https://openalex.org/C170627219', 'wikidata': 'https://www.wikidata.org/wiki/Q13218497', 'display_name': 'MHC class I', 'level': 4, 'score': 0.77824664}, {'id': 'https://openalex.org/C22845430', 'wikidata': 'https://www.wikidata.org/wiki/Q224879', 'display_name': 'Transporter associated with antigen processing', 'level': 5, 'score': 0.698542}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.67043483}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6609005}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6285606}, {'id': 'https://openalex.org/C207936829', 'wikidata': 'https://www.wikidata.org/wiki/Q423163', 'display_name': 'Major histocompatibility complex', 'level': 3, 'score': 0.59757805}, {'id': 'https://openalex.org/C2908868211', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin-Protein Ligases', 'level': 5, 'score': 0.46590525}, {'id': 'https://openalex.org/C2992195973', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Protein degradation', 'level': 2, 'score': 0.44437262}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.31203294}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21727428}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1374324}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.086099416}], 'mesh': [{'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D060746', 'descriptor_name': 'Endoplasmic Reticulum-Associated Degradation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D015395', 'descriptor_name': 'Histocompatibility Antigens Class I', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D014759', 'descriptor_name': 'Viral Envelope Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060746', 'descriptor_name': 'Endoplasmic Reticulum-Associated Degradation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060746', 'descriptor_name': 'Endoplasmic Reticulum-Associated Degradation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015395', 'descriptor_name': 'Histocompatibility Antigens Class I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015395', 'descriptor_name': 'Histocompatibility Antigens Class I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015395', 'descriptor_name': 'Histocompatibility Antigens Class I', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039001', 'descriptor_name': 'Integrin alpha Chains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039001', 'descriptor_name': 'Integrin alpha Chains', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D039001', 'descriptor_name': 'Integrin alpha Chains', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053646', 'descriptor_name': 'Interleukin-2 Receptor beta Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053646', 'descriptor_name': 'Interleukin-2 Receptor beta Subunit', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053646', 'descriptor_name': 'Interleukin-2 Receptor beta Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D059748', 'descriptor_name': 'Proteolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018180', 'descriptor_name': 'Thrombomodulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018180', 'descriptor_name': 'Thrombomodulin', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018180', 'descriptor_name': 'Thrombomodulin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014759', 'descriptor_name': 'Viral Envelope Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014759', 'descriptor_name': 'Viral Envelope Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molimm.2015.07.005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S92126311', 'display_name': 'Molecular Immunology', 'issn_l': '0161-5890', 'issn': ['0161-5890', '1872-9142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4678111', 'pdf_url': 'https://europepmc.org/articles/pmc4678111?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/249122', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstream/1810/249122/4/van%20den%20Boomen%20and%20Lehner%202015%20Molecular%20Immunology.pdf', 'source': {'id': 'https://openalex.org/S4306401777', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678111', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26210183', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molimm.2015.07.005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S92126311', 'display_name': 'Molecular Immunology', 'issn_l': '0161-5890', 'issn': ['0161-5890', '1872-9142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1596555978', 'https://openalex.org/W1966526764', 'https://openalex.org/W1976601347', 'https://openalex.org/W1978518924', 'https://openalex.org/W1981625315', 'https://openalex.org/W1987428238', 'https://openalex.org/W1989422196', 'https://openalex.org/W1989665460', 'https://openalex.org/W1992315987', 'https://openalex.org/W1994260424', 'https://openalex.org/W1995852844', 'https://openalex.org/W2008014896', 'https://openalex.org/W2019525085', 'https://openalex.org/W2022931463', 'https://openalex.org/W2030723839', 'https://openalex.org/W2032715845', 'https://openalex.org/W2033218317', 'https://openalex.org/W2035349696', 'https://openalex.org/W2045407060', 'https://openalex.org/W2068309688', 'https://openalex.org/W2071852328', 'https://openalex.org/W2073321713', 'https://openalex.org/W2093827098', 'https://openalex.org/W2094770279', 'https://openalex.org/W2102235137', 'https://openalex.org/W2103749584', 'https://openalex.org/W2105159408', 'https://openalex.org/W2112121098', 'https://openalex.org/W2116064456', 'https://openalex.org/W2117313136', 'https://openalex.org/W2142491346', 'https://openalex.org/W2149368193', 'https://openalex.org/W2159684743', 'https://openalex.org/W2168316603', 'https://openalex.org/W4232689224'], 'related_works': ['https://openalex.org/W760197577', 'https://openalex.org/W2220848672', 'https://openalex.org/W2143023706', 'https://openalex.org/W2132207019', 'https://openalex.org/W2085107982', 'https://openalex.org/W2083481270', 'https://openalex.org/W2057739562', 'https://openalex.org/W2016359645', 'https://openalex.org/W1989376179', 'https://openalex.org/W1592776416'], 'abstract_inverted_index': {'The': [0, 25], 'human': [1], 'cytomegalovirus': [2], '(HCMV)': [3], 'US2': [4, 173], 'and': [5, 57, 100, 123, 174, 188, 201, 212], 'US11': [6, 144, 155, 175], 'gene': [7], 'products': [8], 'hijack': [9], 'mammalian': [10, 177], 'ER-associated': [11], 'degradation': [12, 17, 56, 65, 117, 120, 214], '(ERAD)': [13], 'to': [14, 33, 59, 72, 147], 'induce': [15], 'rapid': [16], 'of': [18, 37, 66, 108, 152, 204, 215], 'major': [19], 'histocompatibility': [20], 'class': [21], 'I': [22], '(MHC-I)': [23], 'molecules.': [24], 'rate-limiting': [26], 'step': [27], 'in': [28, 149, 208], 'this': [29], 'pathway': [30], 'is': [31, 121, 161, 191], 'thought': [32], 'be': [34, 60], 'the': [35, 50, 63, 86, 96, 101, 165, 179, 194, 199, 216], 'polyubiquitination': [36], 'MHC-I': [38, 55, 159, 180, 190, 217], 'by': [39, 164, 193], 'distinct': [40], 'host': [41], 'ERAD': [42], 'E3': [43, 132, 167, 205], 'ubiquitin': [44, 206], 'ligases.': [45], 'TRC8': [46], 'was': [47], 'identified': [48, 77, 127], 'as': [49, 134], 'ligase': [51, 168], 'responsible': [52, 135], 'for': [53, 62, 85, 136], 'US2-mediated': [54], 'shown': [58], 'required': [61], 'cleavage-dependent': [64], 'some': [67], 'tail-anchored': [68], 'proteins.': [69], 'In': [70, 139], 'addition': [71], 'MHC-I,': [73], 'plasma': [74], 'membrane': [75], 'profiling': [76], 'further': [78], 'immune': [79], 'receptors,': [80], 'which': [81], 'are': [82], 'also': [83, 182], 'substrates': [84], 'US2/TRC8': [87], 'complex.': [88, 169, 196], 'These': [89], 'include': [90], 'at': [91], 'least': [92], 'six': [93], 'α': [94], 'integrins,': [95], 'coagulation': [97], 'factor': [98], 'thrombomodulin': [99], 'NK': [102], 'cell': [103], 'ligand': [104], 'CD112.': [105], 'US2’s': [106], 'use': [107], 'specific': [109], 'HCMV-encoded': [110], 'adaptors': [111], 'makes': [112], 'it': [113], 'an': [114, 129], 'adaptable': [115], 'viral': [116, 213], 'hub.': [118], 'US11-mediated': [119, 137], 'MHC-I-specific': [122], 'genetic': [124], 'screens': [125], 'have': [126], 'TMEM129,': [128], 'uncharacterised': [130], 'RING-C2': [131], 'ligase,': [133], 'degradation.': [138], 'a': [140], 'unique': [141], 'auto-regulatory': [142], 'loop,': [143], 'readily': [145], 'responds': [146], 'changes': [148], 'cellular': [150, 185], 'expression': [151], 'MHC-I.': [153], 'Free': [154], 'either': [156], 'rebinds': [157], 'more': [158], 'or': [160], 'itself': [162], 'degraded': [163, 192], 'HRD1/SEL1L': [166, 195], 'While': [170], 'virally': [171], 'encoded': [172], 'appropriate': [176], 'ERAD,': [178], 'complex': [181], 'undergoes': [183], 'stringent': [184], 'quality': [186, 210], 'control': [187, 211], 'misfolded': [189], 'We': [197], 'discuss': [198], 'identification': [200], 'central': [202], 'role': [203], 'ligases': [207], 'ER': [209], 'chain.': [218]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2220848672', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-01T20:49:48.307818', 'created_date': '2016-06-24'}