Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2219093167', 'doi': 'https://doi.org/10.1080/19420862.2015.1105416', 'title': 'Immunological evaluation of rheumatoid arthritis patients treated with itolizumab', 'display_name': 'Immunological evaluation of rheumatoid arthritis patients treated with itolizumab', 'publication_year': 2015, 'publication_date': '2015-10-15', 'ids': {'openalex': 'https://openalex.org/W2219093167', 'doi': 'https://doi.org/10.1080/19420862.2015.1105416', 'mag': '2219093167', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26466969', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4966522'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/19420862.2015.1105416', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.1080/19420862.2015.1105416?needAccess=true', 'source': {'id': 'https://openalex.org/S169123381', 'display_name': 'mAbs', 'issn_l': '1942-0862', 'issn': ['1942-0862', '1942-0870'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315740', 'host_organization_name': 'Landes Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310315740'], 'host_organization_lineage_names': ['Landes Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.1080/19420862.2015.1105416?needAccess=true', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013871206', 'display_name': 'Lazaro E. Aira', 'orcid': 'https://orcid.org/0000-0003-1753-532X'}, 'institutions': [{'id': 'https://openalex.org/I2355400', 'display_name': 'Center of Molecular Immunology (Cuba)', 'ror': 'https://ror.org/01gh7yb82', 'country_code': 'CU', 'type': 'company', 'lineage': ['https://openalex.org/I2355400']}], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Lazaro E Aira', 'raw_affiliation_strings': ['a Center of Molecular Immunology ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'a Center of Molecular Immunology ; Havana , Cuba.', 'institution_ids': ['https://openalex.org/I2355400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101600924', 'display_name': 'Patricia Hernández', 'orcid': 'https://orcid.org/0000-0003-1576-0443'}, 'institutions': [{'id': 'https://openalex.org/I2355400', 'display_name': 'Center of Molecular Immunology (Cuba)', 'ror': 'https://ror.org/01gh7yb82', 'country_code': 'CU', 'type': 'company', 'lineage': ['https://openalex.org/I2355400']}], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Patricia Hernández', 'raw_affiliation_strings': ['a Center of Molecular Immunology ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'a Center of Molecular Immunology ; Havana , Cuba.', 'institution_ids': ['https://openalex.org/I2355400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016014221', 'display_name': 'Dinorah Prada', 'orcid': None}, 'institutions': [], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Dinorah Prada', 'raw_affiliation_strings': ['b Diez de Octubre Hospital ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'b Diez de Octubre Hospital ; Havana , Cuba.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050433432', 'display_name': 'Araceli Chico', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799943988', 'display_name': 'Hermanos Ameijeiras Hospital', 'ror': 'https://ror.org/05328fn02', 'country_code': 'CU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799943988']}], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Araceli Chico', 'raw_affiliation_strings': ['c Hermanos Ameijeiras Hospital ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'c Hermanos Ameijeiras Hospital ; Havana , Cuba.', 'institution_ids': ['https://openalex.org/I2799943988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034671166', 'display_name': 'Jorge A. Gómez', 'orcid': 'https://orcid.org/0000-0001-9316-2284'}, 'institutions': [], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Jorge A Gómez', 'raw_affiliation_strings': ['b Diez de Octubre Hospital ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'b Diez de Octubre Hospital ; Havana , Cuba.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055596200', 'display_name': 'Zuyén González', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2355400', 'display_name': 'Center of Molecular Immunology (Cuba)', 'ror': 'https://ror.org/01gh7yb82', 'country_code': 'CU', 'type': 'company', 'lineage': ['https://openalex.org/I2355400']}], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Zuyén González', 'raw_affiliation_strings': ['a Center of Molecular Immunology ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'a Center of Molecular Immunology ; Havana , Cuba.', 'institution_ids': ['https://openalex.org/I2355400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053472237', 'display_name': 'Karla Fuentes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2355400', 'display_name': 'Center of Molecular Immunology (Cuba)', 'ror': 'https://ror.org/01gh7yb82', 'country_code': 'CU', 'type': 'company', 'lineage': ['https://openalex.org/I2355400']}], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Karla Fuentes', 'raw_affiliation_strings': ['a Center of Molecular Immunology ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'a Center of Molecular Immunology ; Havana , Cuba.', 'institution_ids': ['https://openalex.org/I2355400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006318317', 'display_name': 'Carmen Viada', 'orcid': 'https://orcid.org/0000-0002-1604-3545'}, 'institutions': [{'id': 'https://openalex.org/I2355400', 'display_name': 'Center of Molecular Immunology (Cuba)', 'ror': 'https://ror.org/01gh7yb82', 'country_code': 'CU', 'type': 'company', 'lineage': ['https://openalex.org/I2355400']}], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Carmen Viada', 'raw_affiliation_strings': ['a Center of Molecular Immunology ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'a Center of Molecular Immunology ; Havana , Cuba.', 'institution_ids': ['https://openalex.org/I2355400']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067739096', 'display_name': 'Zaima Mazorra', 'orcid': 'https://orcid.org/0000-0003-3812-1767'}, 'institutions': [{'id': 'https://openalex.org/I2355400', 'display_name': 'Center of Molecular Immunology (Cuba)', 'ror': 'https://ror.org/01gh7yb82', 'country_code': 'CU', 'type': 'company', 'lineage': ['https://openalex.org/I2355400']}], 'countries': ['CU'], 'is_corresponding': False, 'raw_author_name': 'Zaima Mazorra', 'raw_affiliation_strings': ['a Center of Molecular Immunology ; Havana , Cuba.'], 'affiliations': [{'raw_affiliation_string': 'a Center of Molecular Immunology ; Havana , Cuba.', 'institution_ids': ['https://openalex.org/I2355400']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2915, 'currency': 'GBP', 'value_usd': 3575, 'provenance': 'doaj'}, 'apc_paid': {'value': 2915, 'currency': 'GBP', 'value_usd': 3575, 'provenance': 'doaj'}, 'fwci': 1.89, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.826634, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '8', 'issue': '1', 'first_page': '187', 'last_page': '195'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus and Antiphospholipid Syndrome', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.81245035}, {'id': 'https://openalex.org/keywords/immune-tolerance', 'display_name': 'Immune Tolerance', 'score': 0.448831}], 'concepts': [{'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.87452126}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.81245035}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.73642427}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.73203677}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.7174776}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.60489863}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.5955364}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.5795828}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.5216092}, {'id': 'https://openalex.org/C2780564577', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Psoriasis', 'level': 2, 'score': 0.5057733}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.4949252}, {'id': 'https://openalex.org/C2779075594', 'wikidata': 'https://www.wikidata.org/wiki/Q8084905', 'display_name': 'Autoimmune disease', 'level': 3, 'score': 0.46581176}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.40771335}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/19420862.2015.1105416', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.1080/19420862.2015.1105416?needAccess=true', 'source': {'id': 'https://openalex.org/S169123381', 'display_name': 'mAbs', 'issn_l': '1942-0862', 'issn': ['1942-0862', '1942-0870'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315740', 'host_organization_name': 'Landes Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310315740'], 'host_organization_lineage_names': ['Landes Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4966522', 'pdf_url': 'https://europepmc.org/articles/pmc4966522?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966522', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26466969', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/19420862.2015.1105416', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.1080/19420862.2015.1105416?needAccess=true', 'source': {'id': 'https://openalex.org/S169123381', 'display_name': 'mAbs', 'issn_l': '1942-0862', 'issn': ['1942-0862', '1942-0870'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315740', 'host_organization_name': 'Landes Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310315740'], 'host_organization_lineage_names': ['Landes Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1489752262', 'https://openalex.org/W1516355571', 'https://openalex.org/W161194048', 'https://openalex.org/W1631781682', 'https://openalex.org/W1807438491', 'https://openalex.org/W1816917817', 'https://openalex.org/W1906437207', 'https://openalex.org/W1977137008', 'https://openalex.org/W1978117435', 'https://openalex.org/W1994030928', 'https://openalex.org/W1999140409', 'https://openalex.org/W2003290529', 'https://openalex.org/W2006566716', 'https://openalex.org/W2010210784', 'https://openalex.org/W2011733498', 'https://openalex.org/W2014381340', 'https://openalex.org/W2024148297', 'https://openalex.org/W2029106619', 'https://openalex.org/W2029968450', 'https://openalex.org/W2031390865', 'https://openalex.org/W2031785853', 'https://openalex.org/W2035469701', 'https://openalex.org/W2037107779', 'https://openalex.org/W2040375528', 'https://openalex.org/W2040817201', 'https://openalex.org/W2041616856', 'https://openalex.org/W2056712334', 'https://openalex.org/W2059109668', 'https://openalex.org/W2062770015', 'https://openalex.org/W2066290397', 'https://openalex.org/W2070011436', 'https://openalex.org/W2071249922', 'https://openalex.org/W2074132402', 'https://openalex.org/W2076044376', 'https://openalex.org/W2089708032', 'https://openalex.org/W2091140574', 'https://openalex.org/W2094277829', 'https://openalex.org/W2096349837', 'https://openalex.org/W2101436588', 'https://openalex.org/W2102647446', 'https://openalex.org/W2103187999', 'https://openalex.org/W2105294056', 'https://openalex.org/W2110623161', 'https://openalex.org/W2116956799', 'https://openalex.org/W2117738981', 'https://openalex.org/W2117839723', 'https://openalex.org/W2124060758', 'https://openalex.org/W2125389744', 'https://openalex.org/W2129671292', 'https://openalex.org/W2129903115', 'https://openalex.org/W2130789834', 'https://openalex.org/W2136550752', 'https://openalex.org/W2137096190', 'https://openalex.org/W2137809958', 'https://openalex.org/W2138675753', 'https://openalex.org/W2141826840', 'https://openalex.org/W2147971828', 'https://openalex.org/W2158058290', 'https://openalex.org/W2166732840', 'https://openalex.org/W2259025595', 'https://openalex.org/W2336588424', 'https://openalex.org/W2396206508', 'https://openalex.org/W3006080604', 'https://openalex.org/W4241917186', 'https://openalex.org/W4248269869', 'https://openalex.org/W81609256'], 'related_works': ['https://openalex.org/W4379052364', 'https://openalex.org/W4210767205', 'https://openalex.org/W2802816389', 'https://openalex.org/W2418145303', 'https://openalex.org/W2416795054', 'https://openalex.org/W2392126385', 'https://openalex.org/W2391784904', 'https://openalex.org/W2347638186', 'https://openalex.org/W2137251947', 'https://openalex.org/W14566330'], 'abstract_inverted_index': {'Rheumatoid': [0], 'arthritis': [1, 64], 'is': [2], 'an': [3], 'autoimmune': [4], 'disease': [5], 'characterized': [6], 'by': [7, 65], 'joint': [8], 'inflammation': [9], 'that': [10], 'affects': [11], 'approximately': [12], '1%': [13], 'of': [14, 39, 56, 89, 107, 118, 125, 152, 163], 'the': [15, 24, 53, 90, 116, 150, 153, 161], 'general': [16], 'population.': [17], 'Itolizumab,': [18], 'a': [19, 75, 113, 129, 157], 'monoclonal': [20], 'antibody': [21, 97, 143], 'specific': [22], 'for': [23, 160], 'human': [25], 'CD6': [26, 154], 'molecule': [27, 155], 'mainly': [28], 'expressed': [29], 'on': [30], 'T': [31, 40, 78, 119], 'lymphocytes,': [32], 'has': [33], 'been': [34], 'shown': [35], 'to': [36, 99, 112, 133], 'inhibit': [37], 'proliferation': [38], 'cells': [41], 'and': [42, 79, 95, 109, 122], 'proinflammatory': [43, 126], 'cytokine': [44, 93], 'production': [45], 'in': [46, 58, 62, 74, 115], 'psoriasis': [47], 'patients.': [48], 'We': [49], 'have': [50], 'now': [51], 'assessed': [52], 'immunological': [54], 'effect': [55], 'itolizumab': [57, 100, 108], 'combination': [59], 'with': [60], 'methotrexate': [61, 110], 'rheumatoid': [63], 'analyzing': [66], 'clinical': [67, 76], 'samples': [68], 'taken': [69], 'from': [70], '30': [71], 'patients': [72], 'enrolled': [73], 'trial.': [77], 'B': [80], 'cell': [81, 120], 'subpopulations': [82], 'were': [83, 101], 'measured': [84], 'at': [85, 134], 'different': [86], 'time': [87], 'points': [88], 'study.': [91], 'Plasma': [92], 'levels': [94, 124], 'anti-idiotypic': [96, 142], 'response': [98, 144], 'also': [102], 'evaluated.': [103], 'The': [104], 'combined': [105], 'treatment': [106, 139, 162], 'led': [111], 'reduction': [114], 'frequency': [117], 'subpopulations,': [121], 'plasma': [123], 'cytokines': [127], 'showed': [128], 'significant': [130], 'decrease': [131], 'up': [132], 'least': [135], '12': [136], 'weeks': [137], 'after': [138], 'ended.': [140], 'No': [141], 'was': [145], 'detected.': [146], 'These': [147], 'results': [148], 'support': [149], 'relevance': [151], 'as': [156], 'therapeutic': [158], 'target': [159], 'this': [164], 'disease.': [165]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2219093167', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-08-15T04:06:25.114686', 'created_date': '2016-06-24'}