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[74], 'SNPs': [75], 'for': [76, 327, 334, 495, 562, 579, 596, 634, 1152, 1960, 1967, 2307], 'type': [77, 103], '2': [78, 104, 746, 959], 'diabetes31': [79], 'January': [80, 139, 785], '2018': [81], '|': [82, 141, 175, 216, 264, 315, 383, 406, 451, 483, 516, 549, 570, 621, 652, 684, 707, 753, 787, 858, 883, 938, 965, 990, 1012, 1085, 1111, 1160, 1204, 1233, 1260, 1292, 1320, 1345, 1973, 2295, 2371, 2446], 'PLOS': [83], 'ONE,': [84], '13,': [86, 2139], '1Toxicity': [88], 'Insulin-Secreting': [91], 'β-CellGlucokinase': [92], 'activation': [93, 1222, 2513], 'repairs': [94], 'defective': [95], 'bioenergetics': [96], 'islets': [98, 286, 698, 1103, 1274, 1456, 1710, 1785, 1860, 1904, 1982, 2060], 'Langerhans': [100, 1105, 1862], 'isolated': [101, 2058, 2169, 2505], 'from': [102, 398, 643, 699, 768, 822, 1338, 1455, 1494, 1711, 1722, 1783, 1858, 1902, 2103, 2119, 2216, 2504, 2633], 'diabeticsNicolai': [105], 'Doliba,': [107, 202, 431], 'Wei': [108, 203, 438], 'Qin,': [109, 204, 439], 'Habiba': [110], 'Najafi,': [111], 'Chengyang': [112], 'Liu,': [113], 'Carol': [114, 440], 'W.': [115, 120, 300, 441, 444], 'Buettger,': [116, 442], 'Johanna': [117], 'Sotiris,': [118], 'Heather': [119, 443], 'Collins,': [121, 445], 'Changhong': [122], 'Li,': [123, 305], 'Charles': [124], 'A.': [125, 206, 297, 368, 2364], 'Stanley,': [126], 'David': [127, 208, 367], 'Wilson,': [129, 210], 'Joseph': [130], 'Grimsby,': [131], 'Ramakanth': [132], 'Sarabu,': [133], 'Ali': [134], 'Naji,': [135], 'andFranz': [136, 211, 446], 'Matschinsky1': [138, 213, 448], '2012': [140], 'American': [142, 176, 217, 265, 316, 384, 407, 452, 484, 550, 653, 685, 708, 939, 1205, 1234, 1261, 1293, 2296, 2372, 2447, 2648], 'Journal': [143, 177, 218, 266, 317, 385, 408, 453, 485, 517, 551, 654, 686, 709, 755, 789, 837, 885, 940, 1113, 1162, 1180, 1206, 1235, 1262, 1294, 1674, 1755, 2014, 2027, 2172, 2297, 2373, 2448], 'Physiology-Endocrinology': [145, 220, 268, 319, 387, 410, 455, 487, 656, 711, 1208, 1237, 1296, 2299, 2375, 2450], 'Metabolism,': [147, 222, 270, 321, 389, 412, 457, 489, 658, 713, 1210, 1239, 1298, 2080, 2301, 2377, 2452], '302,': [149], '1Phagocyte-like': [151], 'NADPH': [152], 'oxidase': [153], 'generates': [154], 'ROS': [155], 'INS': [157, 537], '832/13': [158, 538], 'cells': [159, 1478, 1653, 1928, 2233, 2267], 'rat': [161, 807, 1248, 1517, 1538, 1689, 1784, 1859, 1903, 2104, 2108, 2170, 2190, 2334, 2507, 2599], 'islets:': [162], 'protein': [165, 237, 580, 694, 796, 1190, 1434, 1867], 'prenylationIsmail': [166], 'Syed,': [167, 250], 'Chandrashekara': [168, 244], 'N.': [169, 245, 1284], 'Kyathanahalli,': [170], 'andAnjaneyulu': [171, 260, 545], 'Kowluru1': [172, 261, 546, 649, 704], 'March': [173, 313, 547, 1231], '2011': [174], 'Physiology-Regulatory,': [179], 'Integrative': [180], 'Comparative': [182], 'Physiology,': [183, 554, 689, 757, 887, 943, 1115, 1164, 1265], '300,': [185], '3Palmitic': [187], 'acid': [188, 1219, 1371, 1804, 1898, 2055], 'acutely': [189], 'inhibits': [190, 1473, 1820, 2162, 2432], 'acetylcholine-': [191], 'but': [192, 1451, 1669, 1878], 'not': [193, 1452, 1507, 1670, 1864, 1879], 'GLP-1-stimulated': [194], 'secretion': [196, 233, 279, 339, 613, 1440, 1450, 1475, 1553, 1708, 1721, 1765, 1782, 1841, 1857, 1901, 2039, 2091, 2350, 2503], 'mouse': [198, 2217, 2425], 'pancreatic': [199, 241, 341, 360, 427, 463, 640, 878, 1195, 1249, 1518, 1539, 1616, 1651, 1723, 1748, 1768, 1810, 1945, 2041, 2059, 2117, 2147, 2191, 2218, 2231, 2246, 2284, 2342, 2522, 2555], 'isletsNicolai': [200], 'Sergei': [205], 'Vinogradov,': [207], 'September': [214, 682, 705, 1109, 1158], '2010': [215, 263, 314], '299,': [224, 272], '3Regulation': [226], 'glucose-': [228], 'mitochondrial': [230, 1920], 'fuel-induced': [231], 'by': [234, 280, 820, 869, 1029, 1384, 1441, 1458, 1575, 1597, 1709, 1725, 1766, 1824, 1866, 1923, 2106, 2183, 2234, 2330, 2424, 2517, 2571, 2575], 'a': [235, 329, 825, 852, 981, 1002, 1125, 1153, 1728, 1888, 2385, 2521], 'cytosolic': [236, 1409, 2130, 2458, 2479], 'histidine': [238, 695], 'phosphatase': [239], 'β-cellsVasudeva': [242], 'Kamath*,': [243], 'Kyathanahalli*,': [246], 'Bhavaani': [247], 'Jayaram,': [248], 'Ismail': [249], 'Lawrence': [251], 'Karl': [252], 'Olson,': [253], 'Katrin': [254], 'Ludwig,': [255], 'Susanne': [256], 'Klumpp,': [257], 'Josef': [258], 'Krieglstein,': [259], 'August': [262, 936], '2PKA-dependent': [274], 'potentiation': [275], 'glucose-stimulated': [277, 337, 1526, 2089, 2202, 2308], 'Epac': [281], 'activator': [282], '8-pCPT-2′-O-Me-cAMP-AM': [283], 'human': [285], 'LangerhansOleg': [288], 'G.': [289, 292, 311], 'Chepurny,': [290], 'Grant': [291], 'Kelley,': [293], 'Igor': [294], 'Dzhura,': [295, 303], 'Colin': [296], 'Leech,': [298], 'Michael': [299], 'Roe,': [301], 'Elvira': [302], 'Xiangquan': [304], 'Frank': [306], 'Schwede,': [307], 'Hans-G.': [308], 'Genieser,': [309], 'andGeorge': [310], 'Holz1': [312], '298,': [323], '3Regulatory': [325], 'roles': [326, 578, 633], 'Tiam1,': [328], 'guanine': [330, 1566], 'nucleotide': [331, 1568], 'exchange': [332, 2229, 2282], 'factor': [333, 609], 'Rac1,': [335], 'β-cellsBiochemical': [342], 'Pharmacology,': [343, 587, 791, 1182, 1676, 1757, 2016, 2029, 2174, 2236, 2345], '77,': [345], '1Glucose': [347], 'homeostasis,': [348], 'secretion,': [350, 2589], 'islet': [352, 584, 1129, 1363, 1572, 1664, 1690, 2148, 2232, 2285, 2433], 'phospholipids': [353], 'mice': [355], 'that': [356], 'overexpress': [357], 'iPLA2β': [358], 'β-cells': [361, 1724, 2118], 'iPLA2β-null': [364], 'miceShunzhong': [365], 'Bao,': [366], 'Jacobson,': [369], 'Mary': [370], 'Wohltmann,': [371], 'Alan': [372], 'Bohrer,': [373], 'Wu': [374], 'Jin,': [375], 'Louis': [376], 'H.': [377, 1281], 'Philipson,': [378], 'andJohn': [379], 'Turk1': [380], 'February': [381, 514, 1258], '2008': [382, 1319], '294,': [391], '2ATP-sensitive': [393], 'K+': [394, 1827, 2187], 'channels': [395, 1398, 2023], 'disease:': [397], 'molecule': [399], 'maladyFrances': [401], 'Ashcroft1': [403], 'October': [404, 568, 619, 650, 1318, 1971, 2654, 2660], '2007': [405, 450, 482, 515, 548], '293,': [414], '4Metabolic': [416], 'ionic': [418], 'factors': [420], 'amino': [422], 'acid-stimulated': [423], 'release': [425, 767, 875, 1215, 1388, 1532, 1823, 2102, 2167, 2204, 2310, 2329, 2423, 2616], 'β-HC9': [428], 'cellsNicolai': [429], 'Suzanne': [432], 'L.': [433], 'Wehrli,': [434], 'Marko': [435], 'Z.': [436], 'Vatamaniuk,': [437], 'June': [449, 481, 751, 1083, 1343, 2369], '292,': [459, 491, 556], '6Stevioside': [461], 'improves': [462], 'β-cell': [464, 2343, 2523, 2619], 'function': [465], 'during': [466], 'glucotoxicity': [467], 'via': [468, 851], 'regulation': [469], 'acetyl-CoA': [471], 'carboxylaseJianguo': [472], 'Chen,': [473], 'Per': [474], 'Bendix': [475], 'Jeppesen,': [476], 'Iver': [477], 'Nordentoft,': [478], 'andKjeld': [479], 'Hermansen1': [480], '6Immunohistochemical': [493], 'Evidence': [494], 'Presence': [497], 'Glucokinase': [499], 'Gonadotropes': [502], 'Thyrotropes': [504], 'Anterior': [507], 'Pituitary': [508], 'Gland': [509], 'Rat': [511], 'Monkey20': [513], 'Histochemistry': [519], '&': [520, 2643], 'Cytochemistry,': [521], '55,': [523], '6Biologically': [525], 'active': [526], 'lipids': [527, 724], 'promote': [528], 'trafficking': [529], 'membrane': [531, 616], 'association': [532], 'Rac1': [534], 'insulin-secreting': [536, 782, 920, 1927, 2025], 'cellsPhillip': [539], 'McDonald,': [540], 'Rajakrishnan': [541], 'Veluthakal,': [542], 'Hitchintan': [543], 'Kaur,': [544], 'Physiology-Cell': [553, 688, 942, 1264], '3PKA-Dependent': [558], 'PKA-Independent': [560], 'Pathways': [561], 'cAMP-Regulated': [563], 'ExocytosisSusumu': [564], 'Seino,': [565], 'andTadao': [566], 'Shibasaki1': [567], '2005': [569], 'Physiological': [571, 2649], 'Reviews,': [572], '85,': [574], '4Novel': [576], 'regulatory': [577], 'phosphatase-2A': [581], 'β': [585, 879, 1652], 'cellBiochemical': [586], '69,': [589], '12AMP': [591], 'kinase': [592, 762, 797, 1191, 1435], 'malonyl-CoA:': [594], 'targets': [595], 'therapy': [597], 'metabolic': [600], 'syndromeNature': [601], 'Reviews': [602, 1952], 'Drug': [603], 'Discovery,': [604], '3,': [606, 2274], '4ADP-ribosylation': [608], '6': [610], 'regulates': [611, 663, 800], 'through': [614, 668, 1218, 1393, 1479], 'plasma': [615], 'phosphatidylinositol': [617, 1884], '4,5-bisphosphate29': [618], '2003': [620, 651, 683, 706, 752], 'Proceedings': [622], 'National': [625], 'Academy': [626], 'Sciences,': [628, 910, 1603, 1891, 2112, 2427], '100,': [630], '23Regulatory': [632], 'small': [635], 'G': [636], 'proteins': [637, 1570], 'β-cell:': [641], 'lessons': [642], 'models': [644], 'impaired': [646, 1146, 1426], 'secretionAnjaneyulu': [648], '285,': [660, 691, 715], '4Glucose': [662], 'cortical': [665], 'actin': [666], 'network': [667], 'modulation': [669, 1762], 'Cdc42': [671], 'cycling': [672], 'stimulate': [674, 1881], 'secretionAngela': [676], 'K.': [677], 'Nevins,': [678], 'andDebbie': [679], 'C.': [680, 2356, 2361], 'Thurmond1': [681], '3Defective': [693], 'phosphorylation': [696], 'Goto-Kakizaki': [701], 'diabetic': [702, 1657], 'ratAnjaneyulu': [703], '3Insulin': [717, 1840, 2349], 'Gene': [718], 'Expression': [719], 'Biosynthesis1': [721], 'July': [722, 881, 988], '2003Letting': [723], 'go:': [725], 'hormone-sensitive': [726], 'lipaseCurrent': [727], 'Opinion': [728], 'Lipidology,': [730], '14,': [732, 1040], '3A': [734], 'Reappraisal': [735], 'Blood': [738], 'Glucose': [739], 'Homeostat': [740], 'which': [741], 'Comprehensively': [742], 'Explains': [743], 'Type': [745], 'Diabetes': [747], 'Mellitus–Syndrome': [748], 'X': [749], 'Complex1': [750], 'The': [754, 884, 1112, 1161], '549,': [759], '2Protein': [761], 'A-': [763], 'C-induced': [765], 'Ca2+-insensitive': [769], 'poolsCellular': [770], 'Signalling,': [771, 2272], '15,': [773], '5Loperamide': [775], 'mobilizes': [776, 1492], 'intracellular': [777, 1387, 1495], 'Ca': [778, 870, 873, 2611], '2+': [779, 871, 874, 2612], 'stores': [780, 1365, 1496, 2263], 'HIT-T15': [783, 1414, 1498, 1601, 2466], 'cells29': [784], '2009': [786], 'British': [788], '139,': [793], '2Ca2+/calmodulin-dependent': [795], 'II': [798, 1192], 'δ2': [799], 'gene': [801], 'expression': [802, 1611], 'INS-1': [806, 877, 1035], 'insulinoma': [808, 2483], 'cellsCell': [809, 1402, 1415, 2193, 2467], 'Calcium,': [810, 1403, 1416, 1486, 1520, 1541, 2137, 2194, 2468], '33,': [812], '3Decreased': [814], 'Cholinergic': [815], 'Stimulation': [816], 'Insulin': [818, 849, 906, 951, 978, 1172, 1312, 1336], 'Secretion': [819, 850, 1313], 'Islets': [821], 'Rats': [823], 'Fed': [824], 'Low': [826], 'Protein': [827, 833], 'Diet': [828], 'Is': [829], 'Associated': [830], 'with': [831, 1361, 1425], 'Reduced': [832], 'Kinase': [834, 847], 'Cα': [835], 'ExpressionThe': [836], 'Nutrition,': [839], '133,': [841, 1142], '3Leptin': [843], 'Constrains': [844], 'Phospholipase': [845], 'C-Protein': [846], 'C-Induced': [848], 'Phosphatidylinositol': [853], '3-Kinase-Dependent': [854], 'Pathway6': [855], 'December': [856, 1010, 2293, 2444], '2016': [857, 964], 'Experimental': [859, 966], 'Biology': [860, 967], 'Medicine,': [862, 969, 1140], '228,': [864], '2Amplification': [866], 'exocytosis': [868], '-induced': [872], 'cells19': [880], '2004': [882, 1110, 1159], '546,': [889], '1New': [891], 'Aspects': [892], 'Neurotransmitter': [894], 'Release': [895, 1337], 'Exocytosis:': [897], 'Involvement': [898], 'Ca2+/Calmodulin-Dependent': [900], 'Phosphorylation': [901], 'Synapsin': [903], 'I': [904], 'ExocytosisJournal': [907], 'Pharmacological': [909], '93,': [912, 1774], '1Regulation': [914, 1564], 'secretory': [916, 1733, 2546], 'granule': [917], 'pH': [918, 2340, 2480], 'cellsLinda': [921], 'S.': [922, 931], 'Tompkins,': [923], 'Kevin': [924], 'D.': [925, 1286], 'Nullmeyer,': [926], 'Sean': [927], 'Murphy,': [929], 'Craig': [930], 'Weber,': [932], 'andRonald': [933], 'Lynch1': [935], '2002': [937], '283,': [945], '2Leptin-Deficient': [947], 'Mice': [948], 'Commence': [949], 'Hypersecreting': [950], 'Response': [953], 'Acetylcholine': [955, 1333], 'between': [956, 1095], '1': [957, 2653, 2659], 'Weeks': [960], 'Age29': [962], 'November': [963], '226,': [971], '10Molecular': [973], 'Cloning': [974], 'Porcine': [977], 'cDNA': [979], 'Using': [980], 'Monolayer': [982], 'Culture': [983], 'Pancreatic': [985, 1177], 'Endocrine': [986], 'Cells7': [987], '2017': [989, 1084, 1344], 'Cell': [991, 1014, 1067, 1079, 1086, 1346, 1588, 1794, 1835, 1913, 1936, 2049, 2257, 2492, 2532], 'Transplantation,': [992, 1087, 1347], '10,': [994, 1977, 2470], '4-5Mitochondrial': [996], 'dysfunction': [997, 1421], 'diabetes': [999], 'mellituscAMP-GEFII': [1000], 'is': [1001, 1223, 1863, 2573], 'direct': [1003], 'target': [1004], 'cAMP': [1006, 1246, 2389], 'regulated': [1008], 'exocytosis6': [1009], '2000': [1011], 'Nature': [1013, 1974], 'Biology,': [1015, 2561], '2,': [1017], '11Essentiality': [1019], 'intron': [1021], 'control': [1022], 'induction': [1025], 'c-': [1027], 'fos': [1028], 'glucose': [1030, 1374, 1427, 1463, 1649, 1880, 2318, 2569, 2597, 2607], 'glucoincretin': [1032], 'peptides': [1033], 'β-cellsThe': [1036], 'FASEB': [1037], 'Journal,': [1038], '1EFFECTS': [1042], 'OF': [1043, 1053], 'CRYOPRESERVATION': [1044], 'ON': [1045], 'IN': [1046, 1049], 'VITRO': [1047], 'AND': [1048], 'VIVO': [1050], 'LONG-TERM': [1051], 'FUNCTION': [1052], 'HUMAN': [1054], 'ISLETS1Transplantation,': [1055], '68,': [1057], '5Forskolin-Stimulated': [1059], 'Adenylylcyclase': [1060], 'Activity:': [1061], 'A': [1062], 'Marker': [1063], 'Assess': [1065], 'Islet': [1066, 1078, 1339], 'Viability': [1068], 'Following': [1069], 'Cold': [1070], 'Storage': [1071], 'Different': [1073], 'Solutions': [1074], 'Predict': [1077], 'Function': [1080], 'following': [1081], 'Transplantation22': [1082], '8,': [1089], '4Homologous': [1091], 'heterologous': [1093], 'asynchronicity': [1094], 'identified': [1096], 'α‐,': [1097], 'β‐': [1098], 'δ‐cells': [1100], 'within': [1101, 1925], 'intact': [1102], 'mouse8': [1108], '517,': [1117], '1Preoperative': [1119], 'assessment': [1120, 2314], 'adenylylcyclase': [1122], 'as': [1124], 'functional': [1126], 'marker': [1127], 'cell': [1130, 2566], 'quality': [1131], 'after': [1132, 2270], 'transplantation': [1133], 'ratsJournal': [1135], 'Laboratory': [1137], 'Clinical': [1139, 1559, 2580], '4Gastrectomy': [1144], 'induces': [1145], 'glucagon': [1149, 1437, 1682], 'secretion:': [1150, 2384], 'evidence': [1151], 'gastro‐insular': [1154], 'axis': [1155], 'mice8': [1157], '514,': [1166], '2Ca2+': [1168], 'Signaling': [1169], 'Secretory': [1173], 'Cascade': [1174], 'th': [1176], 'Beta-Cell.The': [1178], 'Japanese': [1179], '80,': [1184], '3Ca2+-induced': [1186], 'loss': [1187], 'Ca2+/calmodulin-dependent': [1189], 'β-cellsPeter': [1196], 'Jones,': [1198], 'andShanta': [1199], 'J.': [1200], 'Persaud1': [1201], 'April': [1202], '1998': [1203, 1232, 1259], '274,': [1212, 1241, 1267], '4Insulin': [1214], 'transduction': [1216], 'mechanism': [1217, 1777], 'glucan': [1220], '1,4-α-glucosidase': [1221], 'Ca2+': [1224, 1382, 1392, 1514, 1527, 1531, 1646, 1924, 1942, 1996, 2022, 2132, 2515], 'regulatedAlbert': [1225], 'Salehi,': [1226], 'Henrik': [1227], 'Mosén,': [1228], 'andIngmar': [1229], 'Lundquist1': [1230], '3[Ca2+]i-reducing': [1243], 'action': [1244], 'β-cells:': [1250], 'involvement': [1251], 'thapsigargin-sensitive': [1253], 'storesKazuro': [1254], 'Yaekura,': [1255], 'andToshihiko': [1256], 'Yada1': [1257], '2Impaired': [1269], 'phosphoinositide': [1270, 1453, 1595], 'metabolism': [1271, 1980, 2056, 2464], 'glucose-incompetent': [1273], 'neonatally': [1276], 'streptozotocin-diabetic': [1277], 'ratsL.': [1278], 'Morin,': [1279], 'Giroix,': [1282], 'Gangnerau,': [1285], 'Bailbe,': [1287], 'andB.': [1288], 'Portha1': [1289], 'May': [1290], '1997': [1291], '272,': [1300], '5Effect': [1302], 'Activators': [1304], 'Inhibitors': [1306], 'K': [1308], '+': [1309], 'Channels': [1310], 'on': [1311, 1334, 1356, 1373, 1551, 1684, 1703, 1899, 1953, 1998, 2088, 2201, 2244, 2319, 2405, 2418, 2478, 2501, 2543, 2608], 'Amphibian': [1316], 'Pancreas3': [1317], 'Archives': [1321], 'Physiology': [1323], 'Biochemistry,': [1325], '105,': [1327], '1Effects': [1329, 2537], 'Caffeine': [1331], 'Glucose-Stimulated': [1335], 'Transplants': [1340], 'Mice22': [1342], '6,': [1349], '1Inhibitory': [1351], 'effects': [1352, 1608, 1726], 'fatty': [1354, 1370], 'acids': [1355], 'glucose-regulated': [1357], 'b-cell': [1358], 'function:': [1359], 'Association': [1360], 'increased': [1362, 2576], 'triglyceride': [1364], 'altered': [1367], 'effect': [1368, 1546, 1699, 2085, 2498, 2605], 'oxidation': [1372], 'metabolismMetabolism,': [1375], '45,': [1377, 1430, 1444, 1470], '8Generation': [1379], 'repetitive': [1381], 'transients': [1383], 'bombesin': [1385], 'requires': [1386], 'influx': [1390, 2516], 'voltage-dependent': [1394], 'voltage': [1396], 'independent': [1397], 'single': [1400, 1767, 2189], 'HIT': [1401], '19,': [1405, 1418, 1488], '6Oscillations': [1407], 'free': [1410, 2131, 2610], 'calcium': [1411, 1493, 1704, 2404, 2459], 'bombesin-stimulated': [1413], '6Islet': [1420], 'obese': [1423], 'women': [1424], 'toleranceMetabolism,': [1428], '4Inhibition': [1432], 'A—Induced': [1436], 'synthesis': [1438, 2593], 'glucoseMetabolism,': [1442], '3Glucagon-like': [1446], 'peptide-1': [1447], 'stimulates': [1448, 1719], 'hydrolysis': [1454, 1596, 1882], 'desensitized': [1457], 'prior': [1459], 'exposure': [1460], 'high': [1462], 'or': [1464], 'muscarinic': [1466], 'agonist': [1467], 'carbacholMetabolism,': [1468], '2Pancreastatin': [1472], 'RINm5F': [1477], 'obstruction': [1480], 'G-protein': [1482], 'mediated,': [1483], 'calcium-directed': [1484], 'exocytosisCell': [1485], '2Gastrin-releasing': [1490], 'peptide': [1491], 'cellsPeptides,': [1499], '17,': [1501, 1543], '6A': [1503], 'cADP-ribose': [1504], 'antagonist': [1505], 'does': [1506], 'inhibit': [1508], 'secretagogue-,': [1509], 'caffeine-': [1510], 'nitric': [1512], 'oxide-induced': [1513], 'responses': [1515], 'β-cellsCell': [1519, 1540], '18,': [1522], '5Interplay': [1524], 'sequestration': [1528], 'acetylcholine-induced': [1530, 1999], 'at': [1533, 1727], 'endoplasmic': [1535], 'reticulum': [1536], '1Bimodal': [1545], 'transforming': [1548], 'growth': [1549], 'factor-β': [1550], 'MIN6': [1555], 'cellsDiabetes': [1556], 'Practice,': [1560, 2581], '26,': [1562], '—': [1567], 'binding': [1569], 'subcellular': [1573], 'fractions': [1574], 'phospholipase-derived': [1576], 'lipid': [1577, 2434, 2463], 'mediators': [1578], 'secretionBiochimica': [1581], 'et': [1582, 1788, 1829, 1907, 1930, 1947, 1985, 2043, 2072, 2251, 2486, 2526], 'Biophysica': [1583, 1789, 1830, 1908, 1931, 1948, 1986, 2044, 2073, 2252, 2487, 2527], 'Acta': [1584, 1790, 1831, 1909, 1932, 1949, 1987, 2045, 2074, 2253, 2488, 2528], '(BBA)': [1585, 1791, 1832, 1910, 1933, 1950, 1988, 2046, 2075, 2254, 2489, 2529], '-': [1586, 1792, 1833, 1911, 1934, 1951, 1989, 2047, 2076, 2255, 2490, 2530], 'Molecular': [1587, 1793, 1834, 1912, 1935, 2048, 2256, 2491, 2531, 2560], 'Research,': [1589, 1795, 1836, 1914, 1937, 2050, 2258, 2493, 2533], '1222,': [1591], '3Stimulation': [1593], 'glyceraldehyde-3-phosphate': [1598], 'electroporated': [1600], 'cellsLife': [1602], '54,': [1605, 2563], '2Functional': [1607], 'transgenic': [1610], 'cholera': [1613], 'toxin': [1614], 'beta-cellsMolecular': [1617], 'Cellular': [1619, 1693, 1736, 1771, 1813, 1849, 1870, 2154, 2221, 2393], '98,': [1622], '1The': [1624, 1776], 'Incretin': [1625], 'Notion': [1626], 'its': [1628], 'Relevance': [1629], 'DiabetesEndocrinology': [1631], 'Metabolism': [1633], 'Clinics': [1634], 'North': [1636], 'America,': [1637], '22,': [1639], '4Selective': [1641], 'impairment': [1642], 'cytoplasmic': [1645, 2609], 'response': [1647, 2134, 2248], 'streptozocin-induced': [1655], 'non-insulin-dependent': [1656], 'ratsMetabolism,': [1658], '42,': [1660], '11Changes': [1662], 'glucan-1,4-α-glucosidase': [1665], 'modulate': [1667], 'sulphonylurea-induced': [1668], 'cholinergic': [1671], 'secretionEuropean': [1673, 1754], '243,': [1678], '2Effects': [1680, 2398], 'like-1(7–36)amide': [1683], 'ctoplasmic': [1686], 'Ca2+-concentration': [1687], 'cellsMolecular': [1691], '96,': [1696], '1-2Stimulatory': [1698], '1,25-dihydroxyvitamin': [1701], 'D3': [1702], 'handling': [1705], 'vitamin': [1712], 'D3-deficient': [1713], 'ratsSteroids,': [1714], '58,': [1716], '7Mastoparan': [1718], 'late': [1729], 'stage': [1730], 'pathwayMolecular': [1734], '94,': [1739], '1Different': [1741], 'are': [1743], 'involved': [1744], 'neuropeptide': [1746], 'Y-induced': [1747], 'vasoconstriction': [1749], 'inhibition': [1751, 2099, 2420], '236,': [1759], '1Muscarinic': [1761], 'β-cellsMolecular': [1769], 'arachidonic': [1779, 1803, 1846], 'acid-induced': [1780, 1855], 'LangerhansBiochimica': [1787, 1906, 1984], '1176,': [1797], '1-2Fuel': [1799], 'secretagogue': [1800], 'stimulation': [1801], 'accumulation': [1805], 'fresh': [1807], 'cultured': [1809, 2332, 2482], 'isletsMolecular': [1811, 2219], '92,': [1816], '1Sodium': [1818], 'nitroprusside': [1819], 'glucose-induced': [1821], 'activating': [1825], 'ATP-sensitive': [1826], 'channelsBiochimica': [1828], '1175,': [1838, 1916, 1939], 'without': [1842], 'participation': [1844], 'acidMolecular': [1847], '91,': [1852, 1873], '1-2Arachidonic': [1854], 'mediated': [1865], 'phosphorylationMolecular': [1868], '1-2Vasopressin': [1875], 'oxytocin': [1877], 'phosphatidylcholine': [1886], 'hamster': [1889], 'insulinomaLife': [1890], '53,': [1893], '15Effects': [1895], 'okadaic': [1897], '2Regulation': [1918], 'glycerol-phosphate': [1921], 'dehydrogenase': [1922], 'electropermeabilized': [1926, 2265], '(INS-1)Biochimica': [1929], '1Cytoplasmic': [1941], 'oscillations': [1943], 'ß-cellsBiochimica': [1946], 'Biomembranes,': [1954], '1113,': [1956], '3-4Cellular': [1958], 'Engineering': [1959], 'Treatment': [1962], 'Metabolic': [1964], 'Disorders:': [1965], 'Prospects': [1966], 'Therapy': [1968], 'Diabetes1': [1970], '1992': [1972], 'Biotechnology,': [1975], '10Energy': [1979], 'Bioenergetics,': [1990], '1101,': [1992], '3Effect': [1994], 'modulators': [1997], 'phasic': [2000], 'tonic': [2002], 'contractions': [2003, 2006], 'A23187-induced': [2005], 'ileal': [2008], 'longitudinal': [2009], 'muscle': [2010], 'IP3': [2012], 'productionEuropean': [2013], '218,': [2018], '1ω-Conotoxin-sensitive,': [2020], 'voltage-operated': [2021], 'cellsEuropean': [2026], '216,': [2031], '3Inhibition': [2033, 2226], 'phospholipase': [2035, 2150, 2213], 'A2': [2036], 'isletsBiochimica': [2042], '1135,': [2052], '2Arachidonic': [2054], 'VI.': [2061], 'Carbohydrate': [2062], 'secretagogues': [2064, 2401], 'must': [2065], 'be': [2066], 'metabolized': [2067], 'induce': [2069], 'eicosanoid': [2070], 'releaseBiochimica': [2071], 'Lipids': [2077], 'Lipid': [2079], '1125,': [2082], '3Inhibitory': [2084], 'D-myo-inositol-1,2,6-trisphosphate': [2087], 'mouseNeuropeptides,': [2094], '21,': [2096], '3Stimulus-specific': [2098], 'pancreas': [2105], 'both': [2107], 'porcine': [2110], 'galaninLife': [2111], '51,': [2114], '25Single': [2116], 'normal': [2120], 'rats': [2121], 'exhibit': [2122], 'an': [2123], 'initial': [2124], 'decrease': [2125], 'subsequent': [2127], 'increase': [2128], 'glucoseCell': [2136], '1Ca2+-': [2141], 'ATP-dependent': [2143], 'reversible': [2144], 'inactivation': [2145], 'phosphoinositide-specific': [2149, 2212], 'C': [2151, 2214], 'activityMolecular': [2152], '82,': [2157], '1CCKA': [2159], 'receptor': [2160], 'antagonism': [2161], 'underlying': [2164], 'CCK-8-stimulated': [2165], 'isletsEuropean': [2171], '202,': [2176], '2Heterogeneous': [2178], 'changes': [2179], '[Ca2+]i': [2181], 'induced': [2182, 2570], 'glucose,': [2184], 'tolbutamide': [2185], 'B': [2192], '12,': [2196], '8Influence': [2198], 'gliclazide': [2200], 'manMetabolism,': [2206], '40,': [2208, 2347], '7Characteristics': [2210], '78,': [2224], 'Na/Ca': [2228], '3′,4′-dichlorobenzamilBiochemical': [2235], '41,': [2238], '11Effects': [2240], 'chloride': [2242], 'deficiency': [2243], 'B-cell': [2247], 'acetylcholineBiochimica': [2250], '1092,': [2260], '2Calcium': [2262], 'HL-60': [2266], 'before': [2268], 'differentiationCellular': [2271], '1Characterization': [2276], 'process': [2279], 'sodium-calcium': [2281], 'cellsP.': [2286], 'O.': [2287], 'Plasman,': [2288], 'P.': [2289], 'Lebrun,': [2290], 'andA.': [2291], 'Herchuelz1': [2292], '1990': [2294, 2370], '259,': [2303], '6Dose-response': [2305], 'characteristics': [2306], 'man': [2312], 'influence': [2316, 2414], 'arginine-stimulated': [2320], 'releaseMetabolism,': [2322], '39,': [2324], '12Regulation': [2326], 'TRH': [2328], 'neonate': [2333], 'pancreasPeptides,': [2335], '11,': [2337], '6Cytosolic': [2339], 'functionBiochemical': [2344], 'Walker': [2352], '256': [2353], 'tumor': [2354], 'cachexiaL.': [2355], 'Fernandes,': [2357], 'U.': [2358], 'Machado,': [2360], 'R.': [2362, 2365], 'Nogueira,': [2363], 'Carpinelli,': [2366], 'andR.': [2367], 'Curi1': [2368], '258,': [2379], '6Control': [2381], 'model': [2386], 'involving': [2387], 'Ca2+,': [2388], 'diacylglycerolMolecular': [2391], '70,': [2396], 'combined': [2400], 'extracellular': [2403, 2518], 'neonatal': [2406, 2544], 'releaseRegulatory': [2408], 'Peptides,': [2409, 2548], '27,': [2411], '2The': [2413, 2497], 'sodium': [2416], 'omission': [2417], 'α2-adrenergic': [2419], 'isletsLife': [2426], '47,': [2429], '4Norepinephrine': [2431], 'metabolism,': [2435], '45Ca2+': [2436], 'uptake,': [2437], 'secretionE.': [2440], 'Vara,': [2441], 'andJ.': [2442], 'Tamarit-Rodriguez1': [2443], '1989': [2445], '257,': [2454], '6Glucose': [2456], 'increases': [2457], 'concentration': [2460, 2613], 'inositol': [2462], '8Effects': [2472], 'nutrient': [2474], 'non-nutrient': [2476], 'stimuli': [2477], '(HIT-T15)': [2484], 'cellsBiochimica': [2485], '1012,': [2495, 2535], 'monooleoylglycerol': [2500], 'perifused': [2506], 'isletsDiabetologia,': [2508, 2600], '32,': [2510], '6Selective': [2512], 'ATP': [2519], 'line': [2524], '(HIT)Biochimica': [2525], 'cholecystokinin': [2539], 'octapeptide': [2540], 'carbachol': [2542], 'dynamicsRegulatory': [2547], '25,': [2550], '3Electrophysiology': [2552], 'β-cellProgress': [2556], 'Biophysics': [2558], '2Beta': [2565], 'desensitization': [2567], 'hyperglycemia': [2572], 'augmented': [2574], 'calciumDiabetes': [2577], '7,': [2583], '3Palmitate': [2585], 'dependence': [2586], '?de': [2590], 'novo?': [2591], 'phospholipid': [2592], '45Ca2+-turnover': [2595], 'stimulated': [2598], '31,': [2602], '9Dual': [2604], 'reflects': [2617], 'being': [2620], 'deprived': [2621], 'fuelBiochemical': [2623], 'Biophysical': [2625], 'Communications,': [2627], '153,': [2629], '3': [2631], 'More': [2632], 'this': [2634], 'issue': [2635], '>': [2636], 'Volume': [2637], '67Issue': [2638], '4October': [2639], '1987Pages': [2640], '1185-1248': [2641], 'Copyright': [2642], 'PermissionsCopyright': [2644], '©': [2645], '1987': [2646, 2655, 2661], 'Societyhttps://doi.org/10.1152/physrev.1987.67.4.1185PubMed2825225History': [2650], 'Published': [2651, 2656], 'online': [2652], 'print': [2658], 'Metrics': [2662]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2218148748', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 20}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 29}], 'updated_date': '2024-12-13T14:42:35.312529', 'created_date': '2016-06-24'}