Endoplasmic Reticulum–Associated Degradation and Lipid Homeostasis

Name: Work Video:
Duration: 3 min 30 s
Julian Stevenson; Edmond Y. Huang; James A. Olzmann
{'id': 'https://openalex.org/W2213439730', 'doi': 'https://doi.org/10.1146/annurev-nutr-071715-051030', 'title': 'Endoplasmic Reticulum–Associated Degradation and Lipid Homeostasis', 'display_name': 'Endoplasmic Reticulum–Associated Degradation and Lipid Homeostasis', 'publication_year': 2016, 'publication_date': '2016-06-14', 'ids': {'openalex': 'https://openalex.org/W2213439730', 'doi': 'https://doi.org/10.1146/annurev-nutr-071715-051030', 'mag': '2213439730', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27296502', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6268005'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-nutr-071715-051030', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-nutr-071715-051030', 'source': {'id': 'https://openalex.org/S160110530', 'display_name': 'Annual Review of Nutrition', 'issn_l': '0199-9885', 'issn': ['0199-9885', '1545-4312'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-nutr-071715-051030', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054670005', 'display_name': 'Julian Stevenson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julian Stevenson', 'raw_affiliation_strings': ['Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720;'], 'affiliations': [{'raw_affiliation_string': 'Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720;', 'institution_ids': ['https://openalex.org/I95457486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114248508', 'display_name': 'Edmond Y. Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edmond Y. Huang', 'raw_affiliation_strings': ['Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720;'], 'affiliations': [{'raw_affiliation_string': 'Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720;', 'institution_ids': ['https://openalex.org/I95457486']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5014215141', 'display_name': 'James A. Olzmann', 'orcid': 'https://orcid.org/0000-0001-7751-8316'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'James A. Olzmann', 'raw_affiliation_strings': ['Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720;'], 'affiliations': [{'raw_affiliation_string': 'Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720;', 'institution_ids': ['https://openalex.org/I95457486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5014215141'], 'corresponding_institution_ids': ['https://openalex.org/I95457486'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.177, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 137, 'citation_normalized_percentile': {'value': 0.997735, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '36', 'issue': '1', 'first_page': '511', 'last_page': '542'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/endoplasmic-reticulum-associated-protein-degradation', 'display_name': 'Endoplasmic-reticulum-associated protein degradation', 'score': 0.94821477}, {'id': 'https://openalex.org/keywords/secretory-protein', 'display_name': 'Secretory protein', 'score': 0.5140025}, {'id': 'https://openalex.org/keywords/protein-degradation', 'display_name': 'Protein Degradation', 'score': 0.4289913}], 'concepts': [{'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.9530582}, {'id': 'https://openalex.org/C158619295', 'wikidata': 'https://www.wikidata.org/wiki/Q21101062', 'display_name': 'Endoplasmic-reticulum-associated protein degradation', 'level': 4, 'score': 0.94821477}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6008207}, {'id': 'https://openalex.org/C6492254', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretory pathway', 'level': 4, 'score': 0.5333184}, {'id': 'https://openalex.org/C156399914', 'wikidata': 'https://www.wikidata.org/wiki/Q7444454', 'display_name': 'Secretory protein', 'level': 3, 'score': 0.5140025}, {'id': 'https://openalex.org/C162740809', 'wikidata': 'https://www.wikidata.org/wiki/Q15334560', 'display_name': 'STIM1', 'level': 3, 'score': 0.497618}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.46314642}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44347733}, {'id': 'https://openalex.org/C2992195973', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Protein degradation', 'level': 2, 'score': 0.4289913}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.40826988}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3760398}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.26312095}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.19390768}], 'mesh': [{'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D060746', 'descriptor_name': 'Endoplasmic Reticulum-Associated Degradation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D055571', 'descriptor_name': 'Secretory Pathway', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008074', 'descriptor_name': 'Lipoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008074', 'descriptor_name': 'Lipoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055550', 'descriptor_name': 'Protein Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-nutr-071715-051030', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-nutr-071715-051030', 'source': {'id': 'https://openalex.org/S160110530', 'display_name': 'Annual Review of Nutrition', 'issn_l': '0199-9885', 'issn': ['0199-9885', '1545-4312'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6268005', 'pdf_url': 'https://europepmc.org/articles/pmc6268005?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/18j681rd', 'pdf_url': 'https://escholarship.org/content/qt18j681rd/qt18j681rd.pdf?t=ru3m7j', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27296502', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1146/annurev-nutr-071715-051030', 'pdf_url': 'https://www.annualreviews.org/doi/pdf/10.1146/annurev-nutr-071715-051030', 'source': {'id': 'https://openalex.org/S160110530', 'display_name': 'Annual Review of Nutrition', 'issn_l': '0199-9885', 'issn': ['0199-9885', '1545-4312'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 214, 'referenced_works': ['https://openalex.org/W1481795283', 'https://openalex.org/W1493515436', 'https://openalex.org/W1494006401', 'https://openalex.org/W1526040448', 'https://openalex.org/W1550810733', 'https://openalex.org/W1563724009', 'https://openalex.org/W1564861448', 'https://openalex.org/W1570864817', 'https://openalex.org/W1581906851', 'https://openalex.org/W1599366995', 'https://openalex.org/W1932475171', 'https://openalex.org/W1966526764', 'https://openalex.org/W1967358425', 'https://openalex.org/W1968367248', 'https://openalex.org/W1969851497', 'https://openalex.org/W1970541648', 'https://openalex.org/W1970723279', 'https://openalex.org/W1973089523', 'https://openalex.org/W1975467795', 'https://openalex.org/W1976383190', 'https://openalex.org/W1976606778', 'https://openalex.org/W1977087379', 'https://openalex.org/W1977182042', 'https://openalex.org/W1977941641', 'https://openalex.org/W1979280373', 'https://openalex.org/W1980330384', 'https://openalex.org/W1981625315', 'https://openalex.org/W1982432510', 'https://openalex.org/W1984662248', 'https://openalex.org/W1986958303', 'https://openalex.org/W1987537017', 'https://openalex.org/W1988364921', 'https://openalex.org/W1989422196', 'https://openalex.org/W1990128988', 'https://openalex.org/W1990394752', 'https://openalex.org/W1992315987', 'https://openalex.org/W1994485108', 'https://openalex.org/W1996109826', 'https://openalex.org/W1997238838', 'https://openalex.org/W1998306653', 'https://openalex.org/W2001909617', 'https://openalex.org/W2002203425', 'https://openalex.org/W2002232196', 'https://openalex.org/W2003079343', 'https://openalex.org/W2006050842', 'https://openalex.org/W2006415446', 'https://openalex.org/W2007154749', 'https://openalex.org/W2007209781', 'https://openalex.org/W2008014896', 'https://openalex.org/W2008962151', 'https://openalex.org/W2009594625', 'https://openalex.org/W2010130739', 'https://openalex.org/W2010393877', 'https://openalex.org/W2011185005', 'https://openalex.org/W2011647937', 'https://openalex.org/W2012109738', 'https://openalex.org/W2015086970', 'https://openalex.org/W2015227829', 'https://openalex.org/W2015357935', 'https://openalex.org/W2016676112', 'https://openalex.org/W2017152530', 'https://openalex.org/W2019261756', 'https://openalex.org/W2022345195', 'https://openalex.org/W2023311735', 'https://openalex.org/W2024141615', 'https://openalex.org/W2025869401', 'https://openalex.org/W2027706325', 'https://openalex.org/W2030266364', 'https://openalex.org/W2030901818', 'https://openalex.org/W2031058047', 'https://openalex.org/W2031426969', 'https://openalex.org/W2032719065', 'https://openalex.org/W2034597340', 'https://openalex.org/W2035251713', 'https://openalex.org/W2040468164', 'https://openalex.org/W2040550235', 'https://openalex.org/W2041092523', 'https://openalex.org/W2041810719', 'https://openalex.org/W2042170759', 'https://openalex.org/W2042885556', 'https://openalex.org/W2044728907', 'https://openalex.org/W2045151558', 'https://openalex.org/W2045612646', 'https://openalex.org/W2046422846', 'https://openalex.org/W2046933512', 'https://openalex.org/W2048969348', 'https://openalex.org/W2049732271', 'https://openalex.org/W2049881558', 'https://openalex.org/W2050312512', 'https://openalex.org/W2050561023', 'https://openalex.org/W2051881845', 'https://openalex.org/W2053437868', 'https://openalex.org/W2056967236', 'https://openalex.org/W2057680047', 'https://openalex.org/W2057739562', 'https://openalex.org/W2058001278', 'https://openalex.org/W2058169488', 'https://openalex.org/W2058743922', 'https://openalex.org/W2061635298', 'https://openalex.org/W2064254630', 'https://openalex.org/W2064609154', 'https://openalex.org/W2064875837', 'https://openalex.org/W2065114693', 'https://openalex.org/W2065278356', 'https://openalex.org/W2065394018', 'https://openalex.org/W2068306128', 'https://openalex.org/W2068688570', 'https://openalex.org/W2068689195', 'https://openalex.org/W2072443332', 'https://openalex.org/W2072519673', 'https://openalex.org/W2073376872', 'https://openalex.org/W2073726493', 'https://openalex.org/W2074394032', 'https://openalex.org/W2076100752', 'https://openalex.org/W2077345144', 'https://openalex.org/W2079261384', 'https://openalex.org/W2079944785', 'https://openalex.org/W2080378383', 'https://openalex.org/W2080429010', 'https://openalex.org/W2080508595', 'https://openalex.org/W2083255287', 'https://openalex.org/W2083345819', 'https://openalex.org/W2086024671', 'https://openalex.org/W2086462010', 'https://openalex.org/W2089086088', 'https://openalex.org/W2089324007', 'https://openalex.org/W2089931377', 'https://openalex.org/W2091557924', 'https://openalex.org/W2093827098', 'https://openalex.org/W2094402929', 'https://openalex.org/W2094770279', 'https://openalex.org/W2094852275', 'https://openalex.org/W2096153672', 'https://openalex.org/W2096320478', 'https://openalex.org/W2097058674', 'https://openalex.org/W2099582088', 'https://openalex.org/W2105159408', 'https://openalex.org/W2106690639', 'https://openalex.org/W2108653811', 'https://openalex.org/W2110310839', 'https://openalex.org/W2110876464', 'https://openalex.org/W2111415532', 'https://openalex.org/W2114081556', 'https://openalex.org/W2114366341', 'https://openalex.org/W2115420718', 'https://openalex.org/W2116064456', 'https://openalex.org/W2116199219', 'https://openalex.org/W2116404848', 'https://openalex.org/W2119840692', 'https://openalex.org/W2121233961', 'https://openalex.org/W2121854747', 'https://openalex.org/W2122333565', 'https://openalex.org/W2122550753', 'https://openalex.org/W2122976461', 'https://openalex.org/W2123844682', 'https://openalex.org/W2126453322', 'https://openalex.org/W2126842666', 'https://openalex.org/W2127772281', 'https://openalex.org/W2128484647', 'https://openalex.org/W2129200728', 'https://openalex.org/W2129744834', 'https://openalex.org/W2130016382', 'https://openalex.org/W2130530752', 'https://openalex.org/W2130716475', 'https://openalex.org/W2130820087', 'https://openalex.org/W2132102175', 'https://openalex.org/W2135845161', 'https://openalex.org/W2136018257', 'https://openalex.org/W2136260469', 'https://openalex.org/W2137300408', 'https://openalex.org/W2137559379', 'https://openalex.org/W2138486337', 'https://openalex.org/W2138799891', 'https://openalex.org/W2140009513', 'https://openalex.org/W2140073846', 'https://openalex.org/W2140187466', 'https://openalex.org/W2140435480', 'https://openalex.org/W2140577289', 'https://openalex.org/W2141284487', 'https://openalex.org/W2141484937', 'https://openalex.org/W2142083551', 'https://openalex.org/W2142491346', 'https://openalex.org/W2146467407', 'https://openalex.org/W2146544786', 'https://openalex.org/W2147294235', 'https://openalex.org/W2147506734', 'https://openalex.org/W2147833903', 'https://openalex.org/W2147917253', 'https://openalex.org/W2149761960', 'https://openalex.org/W2151049734', 'https://openalex.org/W2151390847', 'https://openalex.org/W2152114560', 'https://openalex.org/W2153158283', 'https://openalex.org/W2153693056', 'https://openalex.org/W2158157260', 'https://openalex.org/W2158494234', 'https://openalex.org/W2158671081', 'https://openalex.org/W2159684743', 'https://openalex.org/W2160886926', 'https://openalex.org/W2161573536', 'https://openalex.org/W2162599839', 'https://openalex.org/W2164798613', 'https://openalex.org/W2164985707', 'https://openalex.org/W2165019570', 'https://openalex.org/W2165554981', 'https://openalex.org/W2170292082', 'https://openalex.org/W2174130773', 'https://openalex.org/W2177108444', 'https://openalex.org/W2220848672', 'https://openalex.org/W2236878792', 'https://openalex.org/W2273299625', 'https://openalex.org/W2335514186', 'https://openalex.org/W4230336193', 'https://openalex.org/W4252021281'], 'related_works': ['https://openalex.org/W939715917', 'https://openalex.org/W67268079', 'https://openalex.org/W4211044652', 'https://openalex.org/W2953355091', 'https://openalex.org/W2775405637', 'https://openalex.org/W2732286909', 'https://openalex.org/W2371834241', 'https://openalex.org/W2148528360', 'https://openalex.org/W2140327417', 'https://openalex.org/W1985289297'], 'abstract_inverted_index': {'The': [0, 86], 'endoplasmic': [1, 32, 67], 'reticulum': [2, 33], 'is': [3, 34], 'the': [4, 11, 15, 31, 45, 66, 92, 100, 106, 113], 'port': [5], 'of': [6, 17, 40, 50, 75, 102, 108, 119, 122], 'entry': [7], 'for': [8, 19], 'proteins': [9], 'into': [10], 'secretory': [12], 'pathway': [13, 71], 'and': [14, 26, 48, 52, 82, 116], 'site': [16], 'synthesis': [18], 'several': [20], 'important': [21], 'lipids,': [22], 'including': [23], 'cholesterol,': [24], 'triacylglycerol,': [25], 'phospholipids.': [27], 'Protein': [28], 'production': [29], 'within': [30], 'tightly': [35, 76], 'regulated': [36], 'by': [37, 98], 'a': [38, 73], 'cohort': [39], 'resident': [41], 'machinery': [42, 89], 'that': [43], 'coordinates': [44], 'folding,': [46], 'modification,': [47], 'deployment': [49], 'secreted': [51], 'integral': [53], 'membrane': [54], 'proteins.': [55], 'Proteins': [56], 'failing': [57], 'to': [58, 105], 'attain': [59], 'their': [60], 'native': [61], 'conformation': [62], 'are': [63], 'degraded': [64], 'through': [65, 94], 'reticulum-associated': [68], 'degradation': [69], '(ERAD)': [70], 'via': [72], 'series': [74], 'coupled': [77], 'steps:': [78], 'substrate': [79], 'recognition,': [80], 'dislocation,': [81], 'ubiquitin-dependent': [83], 'proteasomal': [84], 'destruction.': [85], 'same': [87], 'ERAD': [88], 'also': [90], 'controls': [91], 'flux': [93], 'various': [95], 'metabolic': [96, 103], 'pathways': [97], 'coupling': [99], 'turnover': [101], 'enzymes': [104], 'levels': [107], 'key': [109], 'metabolites.': [110], 'We': [111], 'review': [112], 'current': [114], 'understanding': [115], 'biological': [117], 'significance': [118], 'ERAD-mediated': [120], 'regulation': [121], 'lipid': [123], 'metabolism': [124], 'in': [125], 'mammalian': [126], 'cells.': [127]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2213439730', 'counts_by_year': [{'year': 2024, 'cited_by_count': 19}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 27}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-08T01:57:09.449926', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
