Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2203446178', 'doi': 'https://doi.org/10.1016/j.plipres.2015.09.002', 'title': 'Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate', 'display_name': 'Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate', 'publication_year': 2016, 'publication_date': '2016-01-01', 'ids': {'openalex': 'https://openalex.org/W2203446178', 'doi': 'https://doi.org/10.1016/j.plipres.2015.09.002', 'mag': '2203446178', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26703189'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.plipres.2015.09.002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108758393', 'display_name': 'Progress in Lipid Research', 'issn_l': '0163-7827', 'issn': ['0163-7827', '1873-2194'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025551442', 'display_name': 'Antonio Gómez‐Muñoz', 'orcid': 'https://orcid.org/0000-0002-2539-016X'}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Antonio Gomez-Muñoz', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072158541', 'display_name': 'Natalia Presa', 'orcid': 'https://orcid.org/0000-0002-1667-1672'}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Natalia Presa', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030937137', 'display_name': 'Ana Gómez-Larrauri', 'orcid': 'https://orcid.org/0000-0002-0434-2476'}, 'institutions': [{'id': 'https://openalex.org/I4210125364', 'display_name': 'Osakidetza', 'ror': 'https://ror.org/02g7qcb42', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210125364']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ana Gomez-Larrauri', 'raw_affiliation_strings': ['Department of Pneumology, University Hospital of Alava (Osakidetza), Vitoria-Gasteiz, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Pneumology, University Hospital of Alava (Osakidetza), Vitoria-Gasteiz, Spain', 'institution_ids': ['https://openalex.org/I4210125364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083307993', 'display_name': 'Io-Guané Rivera', 'orcid': 'https://orcid.org/0000-0001-5040-0246'}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Io-Guané Rivera', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004402701', 'display_name': 'Miguel Trueba', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Miguel Trueba', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077259584', 'display_name': 'Marta Ordoñez', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Marta Ordoñez', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain', 'institution_ids': ['https://openalex.org/I169108374']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5025551442'], 'corresponding_institution_ids': ['https://openalex.org/I169108374'], 'apc_list': {'value': 4800, 'currency': 'USD', 'value_usd': 4800, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.069, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 179, 'citation_normalized_percentile': {'value': 0.999734, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '61', 'issue': None, 'first_page': '51', 'last_page': '62'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11078', 'display_name': 'Molecular Mechanisms of Inflammasome Activation and Regulation', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol Metabolism and Atherosclerosis', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sphingolipid', 'display_name': 'Sphingolipid', 'score': 0.9188974}, {'id': 'https://openalex.org/keywords/inflammation', 'display_name': 'Inflammation', 'score': 0.593269}, {'id': 'https://openalex.org/keywords/sphingosine-kinase', 'display_name': 'Sphingosine kinase', 'score': 0.5294423}, {'id': 'https://openalex.org/keywords/inflammasome', 'display_name': 'Inflammasome', 'score': 0.525439}, {'id': 'https://openalex.org/keywords/sphingosine-1-phosphate', 'display_name': 'Sphingosine-1-Phosphate', 'score': 0.52152}], 'concepts': [{'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.9660183}, {'id': 'https://openalex.org/C61705674', 'wikidata': 'https://www.wikidata.org/wiki/Q410395', 'display_name': 'Sphingolipid', 'level': 2, 'score': 0.9188974}, {'id': 'https://openalex.org/C180899940', 'wikidata': 'https://www.wikidata.org/wiki/Q117982', 'display_name': 'Lipid signaling', 'level': 3, 'score': 0.8592099}, {'id': 'https://openalex.org/C2778703144', 'wikidata': 'https://www.wikidata.org/wiki/Q46298', 'display_name': 'Sphingosine', 'level': 3, 'score': 0.827097}, {'id': 'https://openalex.org/C2776596873', 'wikidata': 'https://www.wikidata.org/wiki/Q418267', 'display_name': 'Sphingosine-1-phosphate', 'level': 4, 'score': 0.82461137}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.6093848}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5734421}, {'id': 'https://openalex.org/C2777700496', 'wikidata': 'https://www.wikidata.org/wiki/Q7576797', 'display_name': 'Sphingosine kinase', 'level': 5, 'score': 0.5294423}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48995844}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48480454}, {'id': 'https://openalex.org/C61322309', 'wikidata': 'https://www.wikidata.org/wiki/Q423143', 'display_name': 'Sphingomyelin', 'level': 3, 'score': 0.47756678}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.42045087}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3403852}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16875777}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.06577256}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.060196012}], 'mesh': [{'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.plipres.2015.09.002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108758393', 'display_name': 'Progress in Lipid Research', 'issn_l': '0163-7827', 'issn': ['0163-7827', '1873-2194'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26703189', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 220, 'referenced_works': ['https://openalex.org/W1107678296', 'https://openalex.org/W1514747902', 'https://openalex.org/W1516047133', 'https://openalex.org/W1517647708', 'https://openalex.org/W1524055105', 'https://openalex.org/W1536331044', 'https://openalex.org/W1543554758', 'https://openalex.org/W1555026559', 'https://openalex.org/W1561695121', 'https://openalex.org/W1566441785', 'https://openalex.org/W1569922252', 'https://openalex.org/W1584468263', 'https://openalex.org/W1673043020', 'https://openalex.org/W1773327886', 'https://openalex.org/W1775924518', 'https://openalex.org/W1805604755', 'https://openalex.org/W1874766814', 'https://openalex.org/W1900480423', 'https://openalex.org/W1956142364', 'https://openalex.org/W1964781367', 'https://openalex.org/W1966223886', 'https://openalex.org/W1966411711', 'https://openalex.org/W1966452335', 'https://openalex.org/W1967690338', 'https://openalex.org/W1967802627', 'https://openalex.org/W1968956158', 'https://openalex.org/W1969322346', 'https://openalex.org/W1970911936', 'https://openalex.org/W1977371793', 'https://openalex.org/W1977569037', 'https://openalex.org/W1979145580', 'https://openalex.org/W1980092613', 'https://openalex.org/W1981819567', 'https://openalex.org/W1982140990', 'https://openalex.org/W1982277787', 'https://openalex.org/W1982965514', 'https://openalex.org/W1983522217', 'https://openalex.org/W1983852016', 'https://openalex.org/W1984007392', 'https://openalex.org/W1984927266', 'https://openalex.org/W1985224052', 'https://openalex.org/W1986074611', 'https://openalex.org/W1986411839', 'https://openalex.org/W1986426214', 'https://openalex.org/W1987664136', 'https://openalex.org/W1988517411', 'https://openalex.org/W1989023368', 'https://openalex.org/W1989050444', 'https://openalex.org/W1989934289', 'https://openalex.org/W1990723931', 'https://openalex.org/W1990834174', 'https://openalex.org/W1990858807', 'https://openalex.org/W1991190121', 'https://openalex.org/W1992031993', 'https://openalex.org/W1992495544', 'https://openalex.org/W1992630084', 'https://openalex.org/W1992678282', 'https://openalex.org/W1993918137', 'https://openalex.org/W1994928797', 'https://openalex.org/W1996870265', 'https://openalex.org/W1997524534', 'https://openalex.org/W1997848675', 'https://openalex.org/W1998249059', 'https://openalex.org/W1999876234', 'https://openalex.org/W1999951314', 'https://openalex.org/W2001026082', 'https://openalex.org/W2001312856', 'https://openalex.org/W2001687686', 'https://openalex.org/W2001752971', 'https://openalex.org/W2001956269', 'https://openalex.org/W2002148098', 'https://openalex.org/W2002940566', 'https://openalex.org/W2002988594', 'https://openalex.org/W2005271761', 'https://openalex.org/W2008119775', 'https://openalex.org/W2008969264', 'https://openalex.org/W2009021880', 'https://openalex.org/W2010601216', 'https://openalex.org/W2011345944', 'https://openalex.org/W2012660133', 'https://openalex.org/W2016182128', 'https://openalex.org/W2016760783', 'https://openalex.org/W2018759292', 'https://openalex.org/W2019209482', 'https://openalex.org/W2020466852', 'https://openalex.org/W2022153601', 'https://openalex.org/W2024538127', 'https://openalex.org/W2024952986', 'https://openalex.org/W2025303906', 'https://openalex.org/W2030364807', 'https://openalex.org/W2030384997', 'https://openalex.org/W2031143643', 'https://openalex.org/W2032167584', 'https://openalex.org/W2032451465', 'https://openalex.org/W2032984448', 'https://openalex.org/W2035353955', 'https://openalex.org/W2036130962', 'https://openalex.org/W2038315060', 'https://openalex.org/W2038562158', 'https://openalex.org/W2039506763', 'https://openalex.org/W2040300892', 'https://openalex.org/W2041697003', 'https://openalex.org/W2042753405', 'https://openalex.org/W2042851093', 'https://openalex.org/W2044097637', 'https://openalex.org/W2044232250', 'https://openalex.org/W2045068620', 'https://openalex.org/W2045459429', 'https://openalex.org/W2045621756', 'https://openalex.org/W2045852899', 'https://openalex.org/W2046914457', 'https://openalex.org/W2047324343', 'https://openalex.org/W2047607345', 'https://openalex.org/W2047786354', 'https://openalex.org/W2049209190', 'https://openalex.org/W2050254589', 'https://openalex.org/W2051698951', 'https://openalex.org/W2052863900', 'https://openalex.org/W2053638660', 'https://openalex.org/W2054275443', 'https://openalex.org/W2055047552', 'https://openalex.org/W2058888096', 'https://openalex.org/W2059712756', 'https://openalex.org/W2062163667', 'https://openalex.org/W2062880614', 'https://openalex.org/W2063358157', 'https://openalex.org/W2064179212', 'https://openalex.org/W2064210924', 'https://openalex.org/W2065094485', 'https://openalex.org/W2067796353', 'https://openalex.org/W2069412624', 'https://openalex.org/W2070325049', 'https://openalex.org/W2071156482', 'https://openalex.org/W2073554187', 'https://openalex.org/W2073647995', 'https://openalex.org/W2073656642', 'https://openalex.org/W2074322827', 'https://openalex.org/W2074814583', 'https://openalex.org/W2076091755', 'https://openalex.org/W2076738925', 'https://openalex.org/W2078015812', 'https://openalex.org/W2078957898', 'https://openalex.org/W2078985662', 'https://openalex.org/W2080325435', 'https://openalex.org/W2080475643', 'https://openalex.org/W2082622955', 'https://openalex.org/W2082762041', 'https://openalex.org/W2083397512', 'https://openalex.org/W2083571191', 'https://openalex.org/W2084619132', 'https://openalex.org/W2085165280', 'https://openalex.org/W2085246663', 'https://openalex.org/W2085649523', 'https://openalex.org/W2088302139', 'https://openalex.org/W2089648706', 'https://openalex.org/W2089676334', 'https://openalex.org/W2090629337', 'https://openalex.org/W2092330976', 'https://openalex.org/W2092717485', 'https://openalex.org/W2093581003', 'https://openalex.org/W2093676869', 'https://openalex.org/W2093816724', 'https://openalex.org/W2093869445', 'https://openalex.org/W2100198908', 'https://openalex.org/W2101828725', 'https://openalex.org/W2105017519', 'https://openalex.org/W2105646576', 'https://openalex.org/W2106302419', 'https://openalex.org/W2111631843', 'https://openalex.org/W2112940161', 'https://openalex.org/W2112987667', 'https://openalex.org/W2114827607', 'https://openalex.org/W2115491025', 'https://openalex.org/W2116113293', 'https://openalex.org/W2120078064', 'https://openalex.org/W2120478897', 'https://openalex.org/W2121753693', 'https://openalex.org/W2122753291', 'https://openalex.org/W2126544407', 'https://openalex.org/W2127141986', 'https://openalex.org/W2127624074', 'https://openalex.org/W2131705782', 'https://openalex.org/W2135415664', 'https://openalex.org/W2135984449', 'https://openalex.org/W2138459238', 'https://openalex.org/W2139171483', 'https://openalex.org/W2139432714', 'https://openalex.org/W2139753251', 'https://openalex.org/W2140053474', 'https://openalex.org/W2140165859', 'https://openalex.org/W2145661466', 'https://openalex.org/W2145876349', 'https://openalex.org/W2149340180', 'https://openalex.org/W2150541225', 'https://openalex.org/W2150691476', 'https://openalex.org/W2151603054', 'https://openalex.org/W2156069059', 'https://openalex.org/W2156164763', 'https://openalex.org/W2157240187', 'https://openalex.org/W2158353135', 'https://openalex.org/W2158972319', 'https://openalex.org/W2159808743', 'https://openalex.org/W2160615924', 'https://openalex.org/W2162770335', 'https://openalex.org/W2162940414', 'https://openalex.org/W2166640187', 'https://openalex.org/W2166825241', 'https://openalex.org/W2168065734', 'https://openalex.org/W2168853304', 'https://openalex.org/W2169082359', 'https://openalex.org/W2170793173', 'https://openalex.org/W2330568889', 'https://openalex.org/W2370602662', 'https://openalex.org/W26705282', 'https://openalex.org/W4313333879', 'https://openalex.org/W4361868714', 'https://openalex.org/W563899680', 'https://openalex.org/W57763528', 'https://openalex.org/W67524005', 'https://openalex.org/W73040139'], 'related_works': ['https://openalex.org/W3031778006', 'https://openalex.org/W2889205449', 'https://openalex.org/W2417105649', 'https://openalex.org/W2356739021', 'https://openalex.org/W2127552316', 'https://openalex.org/W2084654786', 'https://openalex.org/W2014239065', 'https://openalex.org/W2009993180', 'https://openalex.org/W1996192399', 'https://openalex.org/W114681587'], 'abstract_inverted_index': {'Inflammation': [0], 'is': [1, 137], 'a': [2, 8], 'network': [3], 'of': [4, 10, 34, 90, 109, 127, 152, 178], 'complex': [5], 'processes': [6], 'involving': [7], 'variety': [9], 'metabolic': [11], 'and': [12, 18, 42, 53, 92, 113, 115, 121, 139, 141, 158, 167, 180], 'signaling': [13], 'pathways': [14], 'aiming': [15], 'at': [16], 'healing': [17], 'repairing': [19], 'damage': [20], 'tissue,': [21], 'or': [22, 85], 'fighting': [23], 'infection.': [24], 'However,': [25, 62, 123], 'inflammation': [26, 179], 'can': [27], 'be': [28, 149], 'detrimental': [29], 'when': [30, 79], 'it': [31, 75, 144], 'becomes': [32], 'out': [33], 'control.': [35], 'Inflammatory': [36], 'mediators': [37], 'involve': [38], 'cytokines,': [39], 'bioactive': [40], 'lipids': [41], 'lipid-derived': [43], 'metabolites.': [44], 'In': [45], 'particular,': [46], 'the': [47, 124, 176, 190], 'simple': [48, 184], 'sphingolipids': [49, 100], 'ceramides,': [50], 'sphingosine': [51, 93, 116, 156], '1-phosphate,': [52], 'ceramide': [54, 64, 128, 159, 194], '1-phosphate': [55, 65, 94, 117, 129, 136, 157, 160, 195], 'have': [56, 95, 101, 130], 'been': [57, 96, 132, 146], 'widely': [58], 'implicated': [59, 163], 'in': [60, 81, 164, 196], 'inflammation.': [61], 'although': [63], 'was': [66], 'first': [67], 'described': [68], 'as': [69], 'pro-inflammatory,': [70], 'recent': [71], 'studies': [72], 'show': [73], 'that': [74], 'has': [76, 145], 'anti-inflammatory': [77], 'properties': [78], 'produced': [80], 'specific': [82], 'cell': [83, 110, 119, 153, 181], 'types': [84], 'tissues.': [86], 'The': [87, 169], 'biological': [88, 125], 'functions': [89], 'ceramides': [91, 105], 'extensively': [97], 'studied.': [98], 'These': [99], 'opposing': [102], 'effects': [103], 'with': [104, 186], 'being': [106], 'potent': [107], 'inducers': [108], 'cycle': [111], 'arrest': [112], 'apoptosis,': [114], 'promoting': [118], 'growth': [120, 166], 'survival.': [122], 'actions': [126], 'only': [131], 'partially': [133], 'described.': [134], 'Ceramide': [135], 'mitogenic': [138], 'anti-apoptotic,': [140], 'more': [142], 'recently,': [143], 'demonstrated': [147], 'to': [148, 189], 'key': [150], 'regulator': [151], 'migration.': [154], 'Both': [155], 'are': [161], 'also': [162], 'tumor': [165], 'dissemination.': [168], 'present': [170], 'review': [171], 'highlights': [172], 'new': [173], 'aspects': [174], 'on': [175], 'control': [177], 'migration': [182], 'by': [183, 193], 'sphingolipids,': [185], 'special': [187], 'emphasis': [188], 'role': [191], 'played': [192], 'controlling': [197], 'these': [198], 'actions.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2203446178', 'counts_by_year': [{'year': 2024, 'cited_by_count': 20}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 28}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 12}], 'updated_date': '2024-09-01T04:54:31.702546', 'created_date': '2016-06-24'}