Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2203231406', 'doi': 'https://doi.org/10.1007/s13277-015-4432-9', 'title': 'Methylation-mediated repression of potential tumor suppressor miR-203a and miR-203b contributes to esophageal squamous cell carcinoma development', 'display_name': 'Methylation-mediated repression of potential tumor suppressor miR-203a and miR-203b contributes to esophageal squamous cell carcinoma development', 'publication_year': 2015, 'publication_date': '2015-11-17', 'ids': {'openalex': 'https://openalex.org/W2203231406', 'doi': 'https://doi.org/10.1007/s13277-015-4432-9', 'mag': '2203231406', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26577858'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s13277-015-4432-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S12644804', 'display_name': 'Tumor Biology', 'issn_l': '1010-4283', 'issn': ['1010-4283', '1423-0380'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007203749', 'display_name': 'Yibing Liu', 'orcid': 'https://orcid.org/0000-0001-9218-8108'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yibing Liu', 'raw_affiliation_strings': ['Department of Internal Medicine-Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine-Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101047069', 'display_name': 'Zhiming Dong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhiming Dong', 'raw_affiliation_strings': ['Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102855990', 'display_name': 'Jia Liang', 'orcid': 'https://orcid.org/0000-0002-3868-1724'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jia Liang', 'raw_affiliation_strings': ['Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101835286', 'display_name': 'Yanli Guo', 'orcid': 'https://orcid.org/0000-0001-6931-7696'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanli Guo', 'raw_affiliation_strings': ['Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100666448', 'display_name': 'Xin Guo', 'orcid': 'https://orcid.org/0000-0001-6789-3139'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin Guo', 'raw_affiliation_strings': ['Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087610998', 'display_name': 'Supeng Shen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Supeng Shen', 'raw_affiliation_strings': ['Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076590004', 'display_name': 'Gang Kuang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gang Kuang', 'raw_affiliation_strings': ['Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057370077', 'display_name': 'Wei Guo', 'orcid': 'https://orcid.org/0000-0001-9690-161X'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}, {'id': 'https://openalex.org/I4210106405', 'display_name': 'Fourth Hospital of Hebei Medical University', 'ror': 'https://ror.org/01mdjbm03', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106405']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wei Guo', 'raw_affiliation_strings': ['Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China', 'institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5057370077'], 'corresponding_institution_ids': ['https://openalex.org/I111381250', 'https://openalex.org/I4210106405'], 'apc_list': {'value': 2000, 'currency': 'USD', 'value_usd': 2000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.94, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.768374, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '37', 'issue': '4', 'first_page': '5621', 'last_page': '5632'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Protein Arginine Methylation in Mammals', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cpg-site', 'display_name': 'CpG site', 'score': 0.611802}, {'id': 'https://openalex.org/keywords/dna-methylation', 'display_name': 'DNA Methylation', 'score': 0.571467}, {'id': 'https://openalex.org/keywords/demethylating-agent', 'display_name': 'Demethylating agent', 'score': 0.48516995}], 'concepts': [{'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.7676364}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7552065}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.7535664}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.6764093}, {'id': 'https://openalex.org/C140173407', 'wikidata': 'https://www.wikidata.org/wiki/Q1138358', 'display_name': 'CpG site', 'level': 5, 'score': 0.611802}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.555418}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.52012026}, {'id': 'https://openalex.org/C2779277951', 'wikidata': 'https://www.wikidata.org/wiki/Q5255196', 'display_name': 'Demethylating agent', 'level': 5, 'score': 0.48516995}, {'id': 'https://openalex.org/C2778264664', 'wikidata': 'https://www.wikidata.org/wiki/Q422445', 'display_name': 'Tumor suppressor gene', 'level': 4, 'score': 0.47858596}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.47068197}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4406545}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.4255276}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.27396345}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.26952195}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.19881186}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14679796}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06245011}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018899', 'descriptor_name': 'CpG Islands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018899', 'descriptor_name': 'CpG Islands', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000077277', 'descriptor_name': 'Esophageal Squamous Cell Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s13277-015-4432-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S12644804', 'display_name': 'Tumor Biology', 'issn_l': '1010-4283', 'issn': ['1010-4283', '1423-0380'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26577858', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1504099216', 'https://openalex.org/W1507528762', 'https://openalex.org/W1511630185', 'https://openalex.org/W1517535303', 'https://openalex.org/W1598789331', 'https://openalex.org/W1941981220', 'https://openalex.org/W1964184380', 'https://openalex.org/W1967920636', 'https://openalex.org/W1969628021', 'https://openalex.org/W1977560532', 'https://openalex.org/W1982433045', 'https://openalex.org/W1986120469', 'https://openalex.org/W1992106366', 'https://openalex.org/W1994517596', 'https://openalex.org/W1997137459', 'https://openalex.org/W2000608287', 'https://openalex.org/W2000873902', 'https://openalex.org/W2004512437', 'https://openalex.org/W2014053566', 'https://openalex.org/W2014783179', 'https://openalex.org/W2018116818', 'https://openalex.org/W2018179657', 'https://openalex.org/W2018336169', 'https://openalex.org/W2024505981', 'https://openalex.org/W2027690135', 'https://openalex.org/W2034249826', 'https://openalex.org/W2039164708', 'https://openalex.org/W2042016774', 'https://openalex.org/W2044962228', 'https://openalex.org/W2045109499', 'https://openalex.org/W2045709370', 'https://openalex.org/W2060132371', 'https://openalex.org/W2065661738', 'https://openalex.org/W2069095648', 'https://openalex.org/W2069567885', 'https://openalex.org/W2082363749', 'https://openalex.org/W2091396041', 'https://openalex.org/W2093203570', 'https://openalex.org/W2094531416', 'https://openalex.org/W2107277218', 'https://openalex.org/W2118121377', 'https://openalex.org/W2120208667', 'https://openalex.org/W2125855796', 'https://openalex.org/W2135314242', 'https://openalex.org/W2139056019', 'https://openalex.org/W2147057201', 'https://openalex.org/W2150597604', 'https://openalex.org/W2151804259', 'https://openalex.org/W2162344899', 'https://openalex.org/W2165801694', 'https://openalex.org/W2170326371', 'https://openalex.org/W3147148312', 'https://openalex.org/W4237473415', 'https://openalex.org/W4240849279'], 'related_works': ['https://openalex.org/W3152305951', 'https://openalex.org/W2921336251', 'https://openalex.org/W2902329290', 'https://openalex.org/W2169344098', 'https://openalex.org/W2151182744', 'https://openalex.org/W2128056428', 'https://openalex.org/W2107880877', 'https://openalex.org/W2052355316', 'https://openalex.org/W2046964473', 'https://openalex.org/W2045854104'], 'abstract_inverted_index': {'MiRNAs': [0, 11], 'regulate': [1], 'gene': [2], 'expression': [3, 200, 236], 'and': [4, 33, 38, 45, 53, 75, 82, 99, 113, 148, 159, 174, 178, 187, 196, 220, 234, 237], 'play': [5], 'pivotal': [6], 'roles': [7], 'in': [8, 40, 61, 77, 115, 138, 155, 193, 244], 'biological': [9], 'processes.': [10], 'can': [12], 'be': [13, 153, 240], 'inactivated': [14, 229], 'by': [15], 'epigenetic': [16, 104], 'mechanisms,': [17], 'such': [18], 'as': [19, 224], 'DNA': [20], 'hypermethylation': [21, 163, 175, 204, 233], 'of': [22, 36, 58, 64, 73, 87, 106, 111, 135, 146, 164, 176, 201, 205], 'CpG': [23, 26, 144], 'sites': [24, 145], 'within': [25], 'islands.': [27], 'Here,': [28], 'we': [29], 'investigated': [30], 'the': [31, 56, 62, 103, 131, 142, 160], 'role': [32, 57, 134], 'methylation': [34, 238], 'status': [35], 'miR-203a': [37, 74, 98, 126, 147, 177, 202, 206, 219, 235], 'miR-203b': [39, 76, 100, 128, 149, 179, 221], 'esophageal': [41, 47, 78, 88, 116, 139], 'cancer': [42, 79, 89, 117], 'cell': [43, 49, 80], 'lines': [44, 81], 'primary': [46, 83], 'squamous': [48], 'carcinoma': [50], '(ESCC)': [51], 'tumors': [52], 'further': [54], 'elucidate': [55], 'both': [59, 107, 136, 165], 'miRNAs': [60, 137, 166, 226], 'prognosis': [63], 'ESCC.': [65], 'The': [66, 109], 'present': [67], 'study': [68], 'revealed': [69], 'a': [70], 'strong': [71], 'downregulation': [72], 'ESCC': [84, 191, 245], 'samples.': [85], 'Treatment': [86], 'cells': [90, 118], 'with': [91, 121, 125, 182, 198], 'demethylating': [92], 'agent': [93], '5-Aza-dC': [94, 122], 'led': [95], 'to': [96, 152, 169], 'increased': [97], 'expression,': [101], 'confirming': [102], 'regulation': [105], 'miRNAs.': [108], 'inhibition': [110], 'proliferation': [112], 'invasiveness': [114], 'after': [119], 'treated': [120], 'or': [123, 127, 203, 207], 'transfected': [124], 'mimics,': [129], 'suggesting': [130], 'tumor': [132], 'suppressor': [133], 'cancer.': [140], 'Furthermore,': [141], 'critical': [143], 'were': [150, 180], 'found': [151, 168], 'located': [154], 'proximal': [156, 161, 231], 'promoter': [157, 162, 232], 'region,': [158], 'was': [167], 'influence': [170], 'transcriptional': [171], 'activity.': [172], 'Downregulation': [173], 'associated': [181], 'TNM': [183], 'stage,': [184], 'pathological': [185], 'differentiation,': [186], 'lymph': [188], 'node': [189], 'metastasis.': [190], 'patients': [192], 'stages': [194], 'III': [195], 'IV,': [197], 'reduced': [199], 'miR-203b,': [208], 'demonstrated': [209], 'poor': [210], 'patient': [211], 'survival.': [212], 'In': [213], 'summary,': [214], 'our': [215], 'results': [216], 'suggest': [217], 'that': [218, 227], 'may': [222, 239], 'function': [223], 'tumor-suppressive': [225], 'are': [228], 'through': [230], 'useful': [241], 'prognostic': [242], 'marker': [243], 'patients.': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2203231406', 'counts_by_year': [{'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-17T10:15:12.240864', 'created_date': '2016-06-24'}