Title: Protective effects of xanthoceraside on learning and memory impairment induced by Aβ1-42 in mice.
Abstract: Objective To investigate the effects of Xanthoceraside on the learning and memory impairment induced in mice by intracere-broventricular injection of aggregated amyloid β peptide 1-42 (Aβ1-42). Methods Learning and memory functions in mice were examined using step-through test and water maze test. Biochemical determination of acetylcholinesterase (AchE)and choline acetyl transferase(ChAT) were measured with spectrophotometric method. Results Administration of Xanthoceraside reduced number of error and prolonged the latency in step-through test in mice impaired by Aβ1-42 (P 0.05,P 0.01,respectively). In water maze test,the swimming time decreased in mice treated with Xanthoceraside compared with the model mice impaired by Aβ1-42 (P 0.05,P 0.01,respectively). The results of bio-chemical determination showed that decrease level of AchE and ChAT in mice impaired by Aβ1-42 were significantly ameliorated by Xantho-ceraside administration(P 0.05 and P 0.01). Conclusion Xanthoceraside has the effect of improving learning and memory impairment in mice induced by intracerebroventricular injection of Aβ1-42 via enhancing the cholinergic system functions.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 2
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