Publication Information

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'https://openalex.org/W120108273', 'https://openalex.org/W112710005'], 'abstract_inverted_index': {'Human': [0, 201, 953, 2226], 'serum': [1, 202, 954, 1166, 1674, 4100], 'albumin': [2, 17, 34, 63, 95, 203, 218, 235, 264, 296, 955, 1168, 1256, 1343, 1675, 2494, 4101], 'is': [3, 204, 403, 964, 1030, 1169, 1373, 1390, 1846, 1863, 2067, 2343, 2756, 2967, 3073], 'one': [4, 205, 957], 'of': [5, 33, 44, 58, 91, 94, 99, 105, 116, 128, 133, 146, 197, 206, 234, 245, 259, 292, 295, 300, 306, 317, 329, 334, 347, 398, 434, 516, 524, 538, 561, 588, 601, 620, 627, 651, 666, 704, 713, 787, 830, 858, 924, 936, 941, 951, 958, 1008, 1011, 1043, 1049, 1070, 1073, 1172, 1194, 1217, 1221, 1289, 1321, 1331, 1341, 1352, 1371, 1374, 1432, 1453, 1465, 1553, 1598, 1620, 1631, 1638, 1651, 1671, 1715, 1736, 1770, 1809, 1831, 1851, 1856, 1876, 1895, 1920, 1928, 1973, 1984, 2013, 2046, 2088, 2096, 2105, 2123, 2129, 2142, 2189, 2246, 2256, 2280, 2289, 2302, 2329, 2378, 2431, 2439, 2463, 2475, 2487, 2493, 2498, 2511, 2548, 2586, 2592, 2722, 2730, 2752, 2829, 2835, 2847, 2857, 2900, 2934, 2980, 3001, 3012, 3086, 3119, 3127, 3178, 3184, 3215, 3219, 3231, 3371, 3378, 3419, 3431, 3453, 3462, 3477, 3481, 3575, 3582, 3591, 3606, 3612, 3625, 3631, 3637, 3692, 3701, 3706, 3712, 3725, 3729, 3734, 3880, 3890, 3912, 4004, 4058, 4139, 4143, 4151, 4163, 4174, 4203, 4212, 4245, 4255, 4283, 4297, 4320, 4323], 'the': [6, 42, 59, 83, 97, 195, 207, 243, 260, 284, 298, 396, 450, 453, 467, 514, 536, 570, 586, 785, 791, 828, 856, 934, 949, 959, 971, 1032, 1037, 1041, 1130, 1192, 1287, 1350, 1380, 1457, 1462, 1466, 1551, 1596, 1649, 1807, 1827, 1854, 2011, 2086, 2094, 2173, 2243, 2303, 2322, 2456, 2544, 2562, 2572, 2641, 2713, 2762, 2800, 2827, 2854, 2862, 2981, 3087, 3182, 3277, 3369, 3372, 3415, 3465, 3516, 3690, 3790, 3876, 4014, 4019, 4045, 4075, 4095, 4126, 4133, 4137, 4158, 4170, 4191], 'most': [7, 208, 960, 1828, 2301], 'abundant': [8, 209, 961, 2936], 'plasma': [9, 114, 210, 315, 567, 942, 962, 972, 1255, 1262, 1938, 1945, 1981, 2130, 2148, 2174, 2194, 2497, 2615, 2673, 2724, 2739, 2790, 2814, 3224, 3463, 4285], 'proteins': [10, 211, 1717, 1950, 2080, 2131, 2171, 2191, 2386, 2440, 2973, 3079, 3225, 3252, 3283], 'that': [11, 212, 1286, 2248, 4254], 'readily': [12, 213], 'undergoes': [13, 214], 'glycation,': [14, 215, 1455], 'thus': [15, 216], 'glycated': [16, 72, 92, 130, 217, 273, 293, 331, 966, 992, 1167, 1326, 1342, 1434, 1639, 1672, 1716, 1760, 1771, 1833, 1877, 1931, 1943, 1974, 2014, 2170, 2190, 2228, 2290, 2513, 2786, 2805, 2859, 3379, 3672, 4067, 4321], 'has': [18, 122, 219, 323, 820, 983, 1135, 1521, 1539, 2507], 'been': [19, 220, 821, 984, 1136, 1522, 1540], 'suggested': [20, 221, 985, 1285], 'as': [21, 167, 222, 368, 519, 521, 575, 709, 823, 930, 932, 986, 1644, 1826, 2078, 2251, 2483, 2523, 2711, 2917, 3051, 3820, 4117], 'an': [22, 223, 987, 2264, 2464, 3622, 3851, 4054, 4148, 4199], 'additional': [23, 224, 4055, 4200], 'marker': [24, 225, 990], 'for': [25, 48, 79, 89, 164, 226, 249, 280, 290, 365, 629, 793, 995, 1309, 1349, 1393, 1429, 1535, 1550, 1848, 2010, 2044, 2120, 2253, 2277, 2403, 2455, 2469, 2485, 2624, 2745, 2773, 2785, 3026, 3123, 3181, 3194, 3246, 3263, 3279, 3311, 3368, 3515, 3689, 3768, 3773, 3939, 3967, 4000, 4136, 4157, 4217, 4225, 4237, 4262, 4318, 4351], 'monitoring': [26, 227, 996, 2795], 'glycemic': [27, 228, 997, 1038, 1127], 'status.': [28, 229], 'Hitherto,': [29, 230], 'only': [30, 231], 'Amadori-modified': [31, 49, 232, 250], 'peptides': [32, 57, 73, 93, 131, 183, 233, 258, 274, 294, 332, 384, 1652, 1677, 1761, 1772, 1878, 1897, 1932, 1975, 2245, 2435, 2492, 2514, 2520, 2787, 2806, 3321, 3380, 4063, 4322, 4342], 'were': [35, 74, 158, 236, 275, 359, 1198, 1474, 1641, 1755, 1951, 2260, 2407, 2529, 2599, 2629, 2637, 2666, 2675, 2733, 2743, 2783, 2815, 2837, 2864, 2878, 2907, 3034, 3149, 3226, 3253, 3284, 3322, 3388, 3445, 3501, 3513, 3541, 3549, 3570, 3598, 3661, 3696, 3751, 3778, 3798, 3841, 3847, 3904, 3937, 3947, 3965, 4042, 4069, 4083, 4180, 4188, 4251, 4300, 4316, 4349], 'quantified.': [36, 237], 'In': [37, 238, 772, 1190, 1279, 1999, 2109, 2239, 2316, 3460, 4123], 'this': [38, 239, 2110, 2602], 'study,': [39, 240, 2242], 'we': [40, 241, 2002, 2459], 'report': [41, 242, 2460], 'construction': [43, 244, 3370], 'fragment': [45, 84, 246, 285, 1844, 2466, 2478, 2765, 2801, 3373, 3795], 'ion': [46, 85, 247, 286, 1548, 1845, 2467, 2479, 2766, 2802, 3374, 3674, 3970, 3984, 4141], 'library': [47, 86, 248, 287, 2468, 2480, 2767, 2803, 3375], 'lysine': [50, 144, 149, 186, 251, 345, 350, 387, 1750, 2517], '(AML),': [51, 252], 'N(ε)-(carboxymethyl)lysine': [52, 253], '(CML)-,': [53, 254], 'and': [54, 77, 120, 126, 138, 156, 175, 179, 255, 278, 321, 327, 339, 357, 376, 380, 428, 486, 496, 579, 616, 625, 668, 684, 707, 783, 819, 832, 884, 918, 967, 1016, 1078, 1096, 1134, 1197, 1219, 1265, 1313, 1325, 1336, 1383, 1420, 1471, 1491, 1497, 1532, 1592, 1625, 1628, 1713, 1741, 1745, 1777, 1923, 1947, 1976, 1982, 1986, 2125, 2144, 2164, 2175, 2186, 2319, 2384, 2405, 2428, 2433, 2441, 2472, 2490, 2502, 2553, 2579, 2590, 2627, 2646, 2664, 2706, 2735, 2778, 2812, 2876, 2902, 3014, 3024, 3046, 3117, 3144, 3222, 3309, 3332, 3337, 3347, 3352, 3360, 3376, 3429, 3493, 3537, 3543, 3585, 3609, 3633, 3709, 3739, 3794, 3808, 3817, 3823, 3837, 3888, 3927, 3942, 3958, 3983, 4036, 4224, 4266, 4275, 4293], 'N(ε)-(carboxyethyl)lysine': [55, 256], '(CEL)-modified': [56, 257], 'corresponding': [60, 261, 1933], 'synthetically': [61, 262, 4066], 'modified': [62, 263, 2974, 3080], 'using': [64, 265, 1879, 1917, 2263, 2791, 2818, 3040, 3205, 3325, 3391, 3558, 3653, 3671, 3754, 3789, 3850, 4048, 4074, 4085, 4194, 4302, 4325, 4337, 4362], 'high': [65, 266, 3646], 'resolution': [66, 267, 3574, 3602, 3700, 3724], 'accurate': [67, 268], 'mass': [68, 269, 1394, 1421, 1593, 1692, 1781, 1837, 2053, 2115, 2153, 2389, 2746, 3748, 3796, 3954, 4002, 4037, 4080, 4172], 'spectrometry': [69, 270, 1422, 1594, 2116], '(HR/AM).': [70, 271], 'The': [71, 272, 559, 810, 1529, 2539, 2565, 2614, 2634, 2671, 2833, 3032, 3190, 3250, 3282, 3300, 3320, 3410, 3485, 3509, 3547, 3640, 3681, 3717, 3762, 3776, 3785, 3871, 3919, 3933, 3961, 3991, 4007, 4110, 4248, 4290, 4311, 4341], 'manually': [75, 276], 'inspected': [76, 277], 'validated': [78, 279, 2784], 'their': [80, 168, 281, 369, 863, 1384, 1977], 'modification.': [81, 282, 1463, 2315], 'Further,': [82, 283, 1915, 2477, 2797], 'was': [87, 288, 1884, 2118, 2166, 2481, 2541, 2558, 2567, 2606, 2616, 2771, 2850, 2890, 2915, 2996, 3049, 3172, 3192, 3303, 3412, 3468, 3488, 3619, 3643, 3684, 3720, 3771, 3787, 3873, 3922, 3997, 4115, 4128, 4167, 4215, 4235, 4260, 4280, 4335, 4357], 'used': [88, 289, 1757, 2482, 2744, 3367, 3772, 3938, 4116, 4216, 4317], 'quantification': [90, 127, 291, 328, 1370, 2288, 2486, 2510, 2843, 3377, 4319], 'in': [96, 112, 199, 297, 313, 400, 415, 425, 437, 501, 513, 522, 540, 565, 582, 591, 659, 688, 716, 730, 827, 881, 889, 933, 978, 999, 1052, 1105, 1138, 1175, 1178, 1267, 1315, 1344, 1461, 1469, 1472, 1495, 1595, 1653, 1779, 1857, 1941, 1980, 2016, 2127, 2146, 2172, 2192, 2351, 2382, 2436, 2495, 2526, 2569, 2601, 2608, 2740, 2758, 2788, 2807, 2831, 2972, 2998, 3078, 3151, 3276, 3551, 3555, 3645, 3667, 3956, 3994, 4018, 4044, 4071, 4190, 4221, 4232, 4241], 'context': [98, 299], 'diabetes.': [100, 200, 301, 401, 952, 2527, 2832], 'Targeted': [101, 302, 2504], 'Sequential': [102, 303], 'Window': [103, 304], 'Acquisition': [104, 305], 'all': [106, 307, 2561, 4218], 'THeoretical': [107, 308], 'Mass': [108, 309, 1605, 1694, 1783, 1813, 2056], 'Spectra': [109, 310], '(SWATH)': [110, 311], 'analysis': [111, 312, 940, 1431, 1670, 1685, 1889, 2122, 2188, 2506, 2846, 4259], 'pooled': [113, 314, 2738], 'samples': [115, 316, 2674, 2725, 3033, 3500, 3548, 3946, 4286], 'control,': [117, 318, 2576, 2809, 4272], 'prediabetes,': [118, 319], 'diabetes,': [119, 320, 929, 1191], 'microalbuminuria,': [121, 322], 'led': [123, 324, 2508], 'to': [124, 160, 193, 325, 361, 394, 423, 449, 569, 887, 905, 922, 928, 970, 991, 1200, 1387, 1505, 1647, 1758, 1860, 1871, 1887, 1934, 2092, 2168, 2327, 2509, 2571, 2820, 2825, 2852, 3159, 3174, 3293, 3455, 3470, 3479, 3490, 3686, 3914, 3924, 4034, 4131, 4184, 4253], 'identification': [125, 326, 1552, 1972, 2012, 2045, 2104, 2430], '13': [129, 330, 2512], 'comprised': [132, 333], 'four': [134, 335, 2678], 'AML,': [135, 336, 2470, 2776], 'seven': [136, 337], 'CML,': [137, 338, 2471, 2777], 'two': [139, 340, 2723, 3805, 4284], 'CEL': [140, 341, 2126, 2320, 2406, 2473, 3838], 'modifications,': [141, 342], 'representing': [142, 343, 2515], 'nine': [143, 344, 2516], 'sites': [145, 150, 187, 346, 351, 388], 'albumin.': [147, 348, 2476], 'Five': [148, 349], 'namely': [151, 352], 'K549,': [152, 353], 'K438,': [153, 354], 'K490,': [154, 355], 'K88,': [155, 356], 'K375,': [157, 358], 'observed': [159, 360], 'be': [161, 189, 362, 390, 462, 1112, 1201, 1399], 'highly': [162, 363, 965], 'sensitive': [163, 364], 'glycation': [165, 198, 366, 399, 509, 653, 776, 860, 1264, 1490, 1600, 1650, 1978, 2047, 2097, 2106, 2347, 2380, 2774, 2830, 2933, 2977, 3083, 3830], 'modification': [166, 367, 1382, 1520], 'respective': [169, 370], 'm/z': [170, 371, 3675, 3688, 4145, 4153, 4156], 'showed': [171, 372], 'maximum': [172, 373, 3578, 3604, 3704, 3727], 'fold': [173, 374], 'change': [174, 375], 'had': [176, 377], 'both': [177, 378, 3940], 'AML': [178, 379, 1519, 1536, 2309, 3832], 'CML': [180, 381, 2124, 2318, 2404, 3834], 'modifications.': [181, 382], 'Thus,': [182, 383, 1378, 1839, 2091], 'involving': [184, 385], 'these': [185, 386, 1447, 2000, 2079], 'could': [188, 389, 2249, 2521], 'potential': [190, 391, 664], 'novel': [191, 392, 2524], 'markers': [192, 393, 1010, 1072, 1216, 1320, 2252, 2525], 'assess': [194, 395, 2093, 2826, 2853], 'degree': [196, 397, 2095], 'Diabetes': [402, 455, 471, 473, 480, 485, 2283, 2534, 2550], 'a': [404, 498, 597, 710, 824, 1687, 1841, 1918, 1926, 2006, 2017, 2070, 2089, 2099, 2112, 2240, 2344, 2968, 3074, 3120, 3175, 3400, 3448, 3474, 3559, 3573, 3699, 3723, 3907, 4001, 4118, 4161, 4229, 4242, 4281, 4344], 'complex': [405, 1501], 'metabolic': [406], 'disorder': [407], 'characterized': [408], 'by': [409, 452, 464, 466, 618, 855, 1401, 1476, 1525, 1557, 1678, 1683, 1718, 1835, 1899, 1916, 2022, 2050, 2150, 2195, 2262, 2284, 2387, 2410, 2543, 2618, 2817, 2839, 3019, 3201, 3241, 3267, 3305, 3324, 3334, 3390, 3670, 3753, 3849, 4359], 'prolonged': [410], 'hyperglycemia': [411, 1205, 1218], 'resulting': [412, 4240], 'from': [413, 975, 1635, 1749, 1752, 1774, 2531, 2560, 2681, 2866, 2880, 2892, 2909, 3565, 4065, 4182, 4270], 'defects': [414], 'insulin': [416, 418, 517, 614, 657, 686, 714, 736, 781, 925], 'secretion,': [417], 'action,': [419, 737], 'or': [420, 2019, 2025, 2596, 3167, 3186], 'both,': [421], 'leading': [422, 927], 'abnormalities': [424], 'carbohydrate,': [426], 'fat,': [427], 'protein': [429, 1263, 1454, 1493, 1862, 2072, 2149, 2965, 3071, 3216, 3782, 4102], 'metabolism': [430], '(1.Assoc': [431, 1046], 'A.D.': [432, 1047, 1241], 'Standards': [433, 1048], 'medical': [435, 1050], 'care': [436, 1051], 'diabetes—2014.Diabetes': [438, 1053], 'Care.': [439, 670, 1054, 1181, 1223], '2014;': [440, 546, 1055, 1117, 1511], '37:': [441, 1056, 1568], 'S14-S80Crossref': [442, 1057], 'PubMed': [443, 554, 674, 724, 805, 874, 912, 1023, 1058, 1085, 1120, 1185, 1227, 1274, 1364, 1441, 1514, 1610, 1699, 1728, 1788, 1818, 1910, 1994, 2061, 2159, 2207, 2234, 2295, 2357, 2395, 2449, 2943, 2987, 3093, 3137], 'Scopus': [444, 555, 675, 725, 806, 913, 1024, 1059, 1086, 1121, 1186, 1228, 1275, 1365, 1442, 1515, 1570, 1611, 1700, 1729, 1789, 1819, 1911, 1995, 2062, 2160, 2208, 2235, 2296, 2358, 2396, 2450, 2944, 2988, 3094], '(3680)': [445, 1060], 'Google': [446, 483, 557, 609, 677, 727, 808, 875, 915, 1026, 1061, 1088, 1123, 1188, 1230, 1277, 1334, 1367, 1444, 1517, 1572, 1613, 1702, 1731, 1791, 1821, 1913, 1997, 2064, 2162, 2210, 2237, 2298, 2360, 2398, 2452, 2946, 2990, 3096, 3138], 'Scholar).': [447, 484, 558, 610, 678, 728, 809, 876, 916, 1027, 1124, 1189, 1278, 1368, 1445, 1518, 1614, 1732, 1822, 1914, 1998, 2065, 2238, 2299, 2399, 2453, 2991, 3139], 'According': [448], 'projection': [451], 'International': [454, 479], 'Foundation,': [456, 2552], 'around': [457], '592': [458], 'million': [459], 'people': [460], 'will': [461], 'affected': [463], 'diabetes': [465, 617, 663, 831, 890, 1000, 1140, 1312, 2259, 2701], 'year': [468], '2040': [469], '(2.International': [470], 'Federation.IDF': [472], 'Atlas,': [474], '6th': [475], 'ed.': [476], 'Brussels,': [477], 'Belgium:': [478], 'Federation,.': [481], '2013;': [482, 909, 2292], 'its': [487, 833, 976], 'associated': [488, 1259, 1292], 'complications': [489, 526, 834], 'are': [490, 1258, 1291, 2321, 3381, 4010], 'becoming': [491], 'global': [492], 'public': [493], 'health': [494], 'problems': [495], 'posing': [497], 'serious': [499], 'challenge': [500], 'disease': [502], 'management.': [503], 'Many': [504], 'studies': [505, 1283, 2305], 'have': [506, 1284, 2003, 2081, 2306], 'implicated': [507], 'advanced': [508, 652, 775, 859, 1599, 2346, 2379, 2976, 3082, 3124], 'end': [510, 654, 777, 1601, 2978, 3084], 'products': [511, 655, 778, 1494, 1556, 2979, 3085], '(AGEs)1': [512], 'development': [515, 923, 2462], 'resistance,': [518], 'well': [520, 931, 1541], 'pathogenesis': [523, 829, 888, 935], 'diabetic': [525, 541, 566, 937, 1179, 1987, 2789], '(3.Manigrasso': [527], 'M.B.': [528], 'Juranek': [529], 'J.': [530, 633, 842, 844, 1355, 2055, 2335, 2391, 2420, 3103], 'Ramasamy': [531], 'R.': [532, 641, 1156, 1251, 1579, 1583, 1589, 1666, 1767, 1893, 2135, 2373, 2426, 2927], 'Schmidt': [533, 837, 3100], 'A.M.': [534, 838, 894, 1235, 1482, 2031, 3101], 'Unlocking': [535], 'biology': [537], 'RAGE': [539, 740, 880], 'microvascular': [542], 'complications.Trends': [543], 'Endocrin.': [544], 'Met.': [545], '25:': [547], '15-22Abstract': [548], 'Full': [549, 551, 800, 802, 871, 1361, 3134], 'Text': [550, 552, 801, 803, 872, 1362, 3135], 'PDF': [553, 804, 873, 1363, 3136], '(138)': [556], 'levels': [560, 1101, 1193, 1257, 1288], 'AGEs': [562, 589, 612, 630, 679, 734, 920, 943, 1389, 1397, 1467, 2331], 'increase': [563, 1196], 'substantially': [564], 'due': [568], 'hyperglycemic': [571], 'condition.': [572], 'Factors': [573], 'such': [574, 2737], 'oxidative': [576, 814], 'stress,': [577, 815], 'overnutrition,': [578], 'foods': [580, 1496], 'rich': [581], 'glycating': [583], 'agents': [584], 'promote': [585, 685], 'formation': [587, 786], 'even': [590], 'nondiabetic': [592], 'condition': [593, 1295], '(4.Monnier': [594], 'V.M.': [595], 'Toward': [596], 'Maillard': [598, 2982, 3088], 'reaction': [599, 904, 2794, 3302, 3354], 'theory': [600], 'aging.Prog.': [602], 'Clin.': [603, 907], 'Biol.': [604, 795, 866, 2203, 3129], 'Res.': [605, 1270, 1990, 2445], '1989;': [606, 1567], '304:': [607], '1-22PubMed': [608], 'Oral': [611], 'foster': [613], 'resistance': [615, 658, 687, 715, 926], 'down-regulation': [619], 'anti-AGE': [621], 'receptor-1(AGER1),': [622], 'sirtuin': [623], '1,': [624], 'up-regulation': [626], 'receptor': [628, 792, 3122], '(RAGE)': [631], '(5.Uribarri': [632], 'Cai': [634], 'W.': [635, 2271], 'Ramdas': [636], 'M.': [637, 1154, 1162, 1301, 1798, 2180, 2215, 2221, 2269, 2957, 3063, 3099], 'Goodman': [638], 'S.': [639, 896, 1146, 1152, 1160, 1480, 2333, 2365, 2371, 2961, 2963, 3067, 3069], 'Pyzik': [640], 'Chen': [642], 'X.': [643], 'Zhu': [644], 'L.': [645, 754, 1299, 1303, 1664], 'Striker': [646], 'G.E.': [647], 'Vlassara': [648], 'H.': [649, 2953, 3059], 'Restriction': [650], 'improves': [656], 'human': [660, 1673, 1937, 1944, 2147, 2193, 2442, 4099], 'type': [661, 1310, 2257, 2699], '2': [662, 1311, 2258, 2282, 2700, 3454, 3478, 3735], 'role': [665, 977], 'ager1': [667], 'sirt1.Diabetes': [669], '2011;': [671, 721, 1991, 2204, 2231], '34:': [672, 2355], '1610-1616Crossref': [673], '(247)': [676], 'affect': [680, 1099], 'glucose': [681, 705, 2196, 2655, 2686, 2693, 3013], 'uptake,': [682], 'transport': [683, 708], 'adipocytes': [689], '(6.Wu': [690], 'C.H.': [691], 'Huang': [692, 694], 'H.W.': [693], 'S.M.': [695, 1339], 'Lin': [696], 'J.A.': [697], 'Yeh': [698], 'C.T.': [699], 'Yen': [700], 'G.C.': [701], 'AGE-induced': [702], 'interference': [703], 'uptake': [706], 'possible': [711], 'cause': [712], 'adipocytes.J.': [717], 'Agr.': [718, 1564], 'Food': [719, 1565], 'Chem.': [720, 796, 867, 1019, 1081, 1566, 1724, 2155, 2230, 3130], '59:': [722], '7978-7984Crossref': [723], '(23)': [726], 'While': [729], 'skeletal': [731, 773], 'muscle': [732, 774], 'cells': [733, 883], 'inhibit': [735, 780], 'mediated': [738], 'through': [739], '(7.Cassese': [741], 'A.': [742, 760, 1488, 1575, 1660, 1763, 1891, 2219, 2375, 2422, 2424, 3115], 'Esposito': [743], 'I.': [744], 'Fiory': [745], 'F.': [746, 750, 756, 762, 767, 1425, 2178, 2213, 2223, 3107], 'Barbagallo': [747], 'A.P.': [748, 900, 1247], 'Paturzo': [749], 'Mirra': [751], 'P.': [752, 769, 1546, 1585, 1668, 1765, 1794], 'Ulianich': [753], 'Giacco': [755], 'Iadicicco': [757], 'C.': [758, 771, 1486, 2217], 'Lombardi': [759], 'Oriente': [761], 'Van': [763], 'Obberghen': [764], 'E.': [765, 1006, 1068, 1214, 1587], 'Beguinot': [766], 'Formisano': [768], 'Miele': [770], '(AGEs)': [779], 'action': [782], 'induce': [784], 'multimolecular': [788], 'complexes': [789], 'including': [790, 1404, 1456, 2649], 'AGEs.J.': [794], '2008;': [797, 1907, 2940], '283:': [798], '36088-36099Abstract': [799], '(87)': [807], 'AGE-RAGE': [811], 'axis': [812], 'induces': [813], 'activates': [816], 'proinflammatory': [817], 'pathways': [818], 'considered': [822, 1031, 1643, 4350], 'principal': [825], 'pathway': [826], '(8.Yan': [835], 'S.D.': [836, 2035, 3105], 'Anderson': [839], 'G.M.': [840], 'Zhang': [841], 'Brett': [843, 3102], 'Zou': [845], 'Y.S.': [846], 'Pinsky': [847], 'D.': [848, 850, 1577, 1662, 1711, 1964, 2182, 3113], 'Stern': [849, 3112], 'Enhanced': [851], 'cellular': [852, 2383], 'oxidant': [853], 'stress': [854], 'interaction': [857], 'end-products': [861, 3126], 'with': [862, 879, 1013, 1075, 1204, 1260, 1293, 2199, 2698, 2708, 2726, 2768, 2975, 3038, 3081, 3203, 3228, 3256, 3269, 3286, 3399, 3417, 3447, 3473, 3562, 3577, 3603, 3663, 3703, 3804, 3860, 3878, 3906, 4022, 4053, 4094, 4198, 4287, 4343], 'receptors': [864], 'binding-proteins.J.': [865], '1994;': [868], '269:': [869], '9889-9897Abstract': [870], 'AGE': [877, 2314], 'interacts': [878], 'different': [882, 1526], 'tissues,': [885], 'contributing': [886], '(9.Kulkarni': [891], 'M.J.': [892, 1253, 1709, 2039, 2929], 'Korwar': [893, 1234, 2030], 'Mary': [895], 'Bhonsle': [897], 'H.S.': [898, 1233, 1705, 2029, 2921], 'Giri': [899, 1246], 'Glycated': [901, 4062], 'proteome:': [902], 'From': [903], 'intervention.Proteom.': [906], 'Appl.': [908], '7:': [910], '155-170Crossref': [911], '(26)': [914], 'By': [917], 'large,': [919], 'contribute': [921], 'complications.': [938], 'Therefore,': [939, 1369, 1870], 'can': [944, 1398, 2073], 'possibly': [945], 'provide': [946], 'information': [947], 'about': [948], 'severity': [950], '(HSA),': [956], 'proteins,': [963, 1939, 1946], 'contributes': [968], 'predominantly': [969], 'AGEs.': [973], 'Apart': [974], 'pathogenesis,': [979], 'AGE-modified': [980, 1859, 3220], 'HSA': [981, 1654, 2247, 2993, 3048, 3141, 3221, 3781, 4068, 4324], '(AGE-HSA)': [982], 'alternative': [988, 1009, 1071], 'diagnostic': [989, 1533, 2647, 2769], 'hemoglobin': [993, 1014, 1076, 1106], '(HbA1c)': [994], 'status': [998, 1039, 1128], '(10.Juraschek': [1001], 'S.P.': [1002, 1064, 1207], 'Steffes': [1003, 1065, 1208], 'M.W.': [1004, 1066, 1209], 'Selvin': [1005, 1067, 1213], 'Associations': [1007, 1069], 'glycemia': [1012, 1074], 'A(1c)': [1015, 1077], 'fasting': [1017, 1079, 2650, 2672], 'glucose.Clin.': [1018, 1080], '2012;': [1020, 1082, 1224, 1271, 2058], '58:': [1021, 1083], '1648-1655Crossref': [1022, 1084], '(69)': [1025, 1087], 'Although': [1028], 'HbA1c': [1029, 1100, 1266, 2728], '"gold': [1033], 'standard"': [1034], 'marker,': [1035], 'reflecting': [1036], 'over': [1040, 1129], 'period': [1042], '8–10': [1044], 'weeks': [1045, 1133], 'Scholar,': [1062, 1231, 1573, 1703, 1792, 2211, 2361, 2947, 3097], '10.Juraschek': [1063], 'Scholar),': [1089, 2163], 'factors': [1090], 'like': [1091], 'anemia,': [1092], 'blood': [1093, 2605, 2651, 2659], 'loss,': [1094], 'splenomegaly,': [1095], 'iron': [1097, 1173], 'deficiency': [1098, 1174], '(11.Radin': [1102], 'M.S.': [1103], 'Pitfalls': [1104], 'A1c': [1107], 'measurement:': [1108], 'When': [1109], 'results': [1110, 2834, 3518], 'may': [1111], 'misleading.J.': [1113], 'Gen.': [1114], 'Intern.': [1115], 'Med.': [1116], '29:': [1118], '388-394Crossref': [1119], '(161)': [1122], 'AGE-HSA': [1125, 1195, 1290, 1372, 2763, 2914], 'reflects': [1126], 'preceding': [1131], '3–4': [1132], 'recommended': [1137], 'gestational': [1139], '(12.Hashimoto': [1141], 'K.': [1142, 1150, 1796, 2949, 3055, 3111], 'Osugi': [1143], 'T.': [1144, 1158, 2133, 2882, 2885, 2951, 2959, 3057, 3065], 'Noguchi': [1145], 'Morimoto': [1147], 'Y.': [1148, 2955, 3061], 'Wasada': [1149], 'Imai': [1151], 'Waguri': [1153], 'Toyoda': [1155], 'Fujita': [1157], 'Kasayama': [1159], 'Koga': [1161], 'A1C': [1163], 'but': [1164], 'not': [1165], 'elevated': [1170], 'because': [1171], 'late': [1176], 'pregnancy': [1177], 'women.Diabetes': [1180], '2010;': [1182], '33:': [1183, 1512], '509-511Crossref': [1184], '(84)': [1187], 'found': [1199], 'positively': [1202], 'correlated': [1203], '(13.Juraschek': [1206], 'Miller': [1210], '3rd,': [1211], 'E.R.': [1212], 'Alternative': [1215], 'risk': [1220], 'diabetes.Diabetes': [1222], '35:': [1225, 2985, 3091], '2265-2270Crossref': [1226], '(66)': [1229, 1276], '14.Bhonsle': [1232], 'Kote': [1236], 'S.S.': [1237], 'Golegaonkar': [1238], 'S.B.': [1239, 2037], 'Chougale': [1240], 'Shaik': [1242], 'M.L.': [1243], 'Dhande': [1244], 'N.L.': [1245], 'Shelgikar': [1248], 'K.M.': [1249], 'Boppana': [1250, 2926], 'Kulkarni': [1252, 2038, 2928], 'Low': [1254], 'increased': [1261], 'diabetes.J.': [1268], 'Proteome': [1269, 1989, 2444, 3755], '11:': [1272], '1391-1396Crossref': [1273], 'addition,': [1280], 'several': [1281], 'recent': [1282, 2241], 'prediabetic': [1294, 4273], '(15.Chan': [1296], 'C.L.': [1297], 'Pyle': [1298], 'Kelsey': [1300], 'Newnes': [1302], 'Zeitler': [1304], 'P.S.': [1305], 'Nadeau': [1306], 'K.J.': [1307, 2337], 'Screening': [1308, 1712], 'prediabetes': [1314], 'obese': [1316], 'youth:': [1317], 'Evaluating': [1318], 'alternate': [1319], 'glycemia—1,5': [1322], 'anhydroglucitol,': [1323], 'fructosamine,': [1324], 'albumin.Pediatr.': [1327], 'Diabetes.': [1328], 'Epub': [1329], 'ahead': [1330], 'print.': [1332], '2015;': [1333, 2446], 'Scholar)': [1335], 'microalbuminuria': [1337, 2580, 2709, 2813], '(16.Donnelly': [1338], 'Accumulation': [1340], 'end-stage': [1345], 'renal': [1346], 'failure:': [1347], 'Evidence': [1348], 'principle': [1351], '"physiological': [1353], 'microalbuminuria.".Am.': [1354], 'Kidney': [1356], 'Dis.': [1357], '1996;': [1358, 2984, 3090], '28:': [1359, 1439], '62-66Abstract': [1360], '(14)': [1366, 2063], 'utmost': [1375], 'clinical': [1376, 2496, 3223], 'significance.': [1377], 'understanding': [1379], 'site-specific': [1381, 2429], 'dynamic': [1385, 2075, 3634], 'transformation': [1386], 'heterogeneous': [1388, 2076], 'quite': [1391], 'critical': [1392], 'spectrometric': [1395, 2747, 3749, 4081], 'quantification.': [1396, 4352], 'quantified': [1400, 2261, 2816, 2858], 'various': [1402], 'approaches,': [1403, 1448], 'colorimetric': [1405], 'assay,': [1406, 1409, 1419], 'ketoamine': [1407], 'oxidase': [1408], 'enzyme-linked': [1410], 'boronate': [1411, 1880], 'immunoassay,': [1412], 'fluorescence': [1413], 'spectroscopy,': [1414], 'boronic': [1415, 1900], 'acid': [1416, 1459, 1901, 3163, 3427], 'affinity': [1417, 1881, 1902], 'chromatography': [1418, 1681, 1882], '(MS)': [1423], '(17.Capote': [1424], 'Sanchez': [1426, 2183, 2224], 'J.C.': [1427, 2184, 2225], 'Strategies': [1428], 'proteomic': [1430, 1507, 3287], 'non-enzymatically': [1433], 'proteins.Mass': [1435], 'Spectrom.': [1436, 1509, 1606, 1695, 1784, 1814, 2057], 'Rev.': [1437, 1510], '2009;': [1438, 1815], '135-146Crossref': [1440], '(39)': [1443], 'Among': [1446], 'MS': [1449, 1527, 1558, 1888, 3568, 3694, 4020], 'offers': [1450], 'precise': [1451, 1849, 2103], 'characterization': [1452, 1850], 'amino': [1458], 'involved': [1460], 'Most': [1464], 'reported': [1468, 2005, 2408, 2918, 3052], 'vitro': [1470, 1942], 'vivo': [1473, 1858], 'discovered': [1475], 'MS-based': [1477, 2265], 'techniques': [1478, 1559], '(18.Arena': [1479], 'Salzano': [1481], 'Renzone': [1483], 'G.': [1484, 2925], "D'Ambrosio": [1485], 'Scaloni': [1487], 'Non-enzymatic': [1489], 'glycoxidation': [1492], 'diseases:': [1498], 'An': [1499, 4207], 'interconnected,': [1500], 'scenario': [1502], 'fully': [1503], 'open': [1504], 'innovative': [1506], 'studies.Mass': [1508], '49-77Crossref': [1513], '(63)': [1516], 'extensively': [1523, 3036], 'studied': [1524], 'approaches.': [1528], 'fragmentation': [1530, 1808, 3642, 3719], 'pattern': [1531], 'ions': [1534, 1619, 1646, 1744, 1747, 1824, 2402, 2770, 2782, 4009, 4017], 'rearrangement': [1537, 1555], 'product': [1538], 'established': [1542, 2772], '(19.Yaylayan': [1543], 'V.': [1544, 3990], 'Sporns': [1545], 'Diagnostic': [1547, 1823, 2400, 2780], 'series': [1549], 'Amadori': [1554, 1811, 1896], 'based': [1560, 2798, 4012], 'on': [1561, 1686, 1806, 2308, 2799, 3364, 3503, 3949, 4013], 'electron-impact': [1562], 'ionization.J.': [1563], '978-981Crossref': [1569], '(13)': [1571, 1820], '20.Lapolla': [1574], 'Fedele': [1576, 1661], 'Reitano': [1578], 'Aricò': [1580], 'N.C.': [1581], 'Seraglia': [1582, 1665], 'Traldi': [1584, 1667], 'Marotta': [1586], 'Tonani': [1588], 'Enzymatic': [1590], 'digestion': [1591, 3301], 'study': [1597, 1805, 2540, 2563, 2566, 2754], 'products/peptides.J.': [1602], 'Am.': [1603], 'Soc.': [1604], '2004;': [1607, 2156], '15:': [1608, 2941], '496-509Crossref': [1609], '(155)': [1612], 'Further': [1615], 'specific': [1616], 'neutral': [1617, 1719], 'loss': [1618, 1630, 1720, 1738], '162': [1621], 'Da,': [1622, 1624, 3802], '120': [1623, 3471, 3583, 3607, 3707, 3730, 3869, 3908, 4026], '84': [1626], 'Da': [1627, 1633], 'water': [1629, 1737], '36': [1632], 'arising': [1634, 1751], 'hexose': [1636], 'moiety': [1637], 'peptide': [1640, 1754, 1834, 2015, 2823, 3641, 3673, 3718, 3774, 4120, 4312], 'also': [1642, 1756], 'signature': [1645, 2781], 'validate': [1648], '(21.Brancia': [1655], 'F.L.': [1656], 'Bereszczak': [1657], 'J.Z.': [1658], 'Lapolla': [1659], 'Baccarin': [1663], 'Comprehensive': [1669, 1971], 'tryptic': [1676, 2437, 3211], 'off-line': [1679], 'liquid': [1680], 'followed': [1682, 3200, 3240, 3266], 'MALDI': [1684], 'time-of-flight/curved': [1688], 'field': [1689], 'reflectron': [1690], 'tandem': [1691, 1780, 1836, 2052, 2114, 2152, 2388], 'spectrometer.J.': [1693], '2006;': [1696, 1785], '41:': [1697, 1786], '1179-1185Crossref': [1698], '(31)': [1701], '22.Gadgil': [1704], 'Bondarenko': [1706], 'P.V.': [1707], 'Treuheit': [1708], 'Ren': [1710], 'Sequencing': [1714], 'scan': [1721, 3563, 3996, 4021, 4231], 'LC/MS/MS': [1722], 'method.Anal.': [1723], '2007;': [1725], '79:': [1726], '5991-5999Crossref': [1727], '(64)': [1730], 'Similar': [1733], 'characteristic': [1734], 'patterns': [1735], '(18,': [1739], '36,': [1740], '54': [1742], 'Da)': [1743, 3840], 'immonium': [1746], 'derived': [1748, 1773, 4064], 'AML-modified': [1753], 'identify': [1759], '(23.Frolov': [1762], 'Hoffmann': [1764, 1766, 1892, 2425], 'Fragmentation': [1768], 'behavior': [1769], 'D-glucose,': [1775], 'D-fructose': [1776], 'D-ribose': [1778], 'spectrometry.J.': [1782], '1459-1469Crossref': [1787], '(94)': [1790], '24.Stefanowicz': [1793], 'Kapczynska': [1795], 'Jaremko': [1797, 1799], 'Ł.': [1800], 'Szewczuk': [1801], 'Z.': [1802], 'A': [1803, 2274, 3422, 3883], 'mechanistic': [1804], 'peptide-derived': [1810], 'products.J.': [1812], '44:': [1816], '1500-1508Crossref': [1817], 'serve': [1825, 2250, 2522], 'reliable': [1829], 'way': [1830], 'identifying': [1832], 'spectrometry.': [1838], 'having': [1840], 'good': [1842], 'MS/MS': [1843, 2024, 2465, 2764, 3596, 4178], 'key': [1847], 'glycation.': [1852], 'However,': [1853, 2300], 'ratio': [1855, 3295, 3630], 'unmodified': [1861], 'significantly': [1864], 'low,': [1865], 'which': [1866, 3160], 'limits': [1867], 'better': [1868, 3517, 3968], 'MS/MS.': [1869], 'achieve': [1872], 'efficient': [1873], 'identification,': [1874], 'enrichment': [1875, 1922], '(BAC)': [1883], 'adopted': [1885], 'prior': [1886, 2554], '(25.Frolov': [1890], 'Analysis': [1894], 'enriched': [1898], 'chromatography.Ann,': [1903], 'NY': [1904], 'Acad.': [1905], 'Sci.': [1906], '1126:': [1908], '253-256Crossref': [1909], '(43)': [1912], 'combination': [1919], 'immunodepletion,': [1921], 'fractionation': [1924], 'strategies,': [1925], 'total': [1927, 2330, 4338], '7,749': [1929], 'unique': [1930], '1,095': [1935], 'native': [1936], '1,592': [1940], '1,664': [1948], 'erythrocyte': [1949], 'identified': [1952], '(26.Zhang': [1953], 'Q.': [1954], 'Monroe': [1955], 'M.E.': [1956], 'Schepmoes': [1957], 'A.A.': [1958], 'Clauss': [1959], 'T.R.': [1960], 'Gritsenko': [1961], 'M.A.': [1962], 'Meng': [1963], 'Petyuk': [1965], 'V.A.': [1966], 'Smith': [1967], 'R.D.': [1968], 'Metz': [1969], 'T.O.': [1970], 'motifs': [1979], 'erythrocytes': [1983, 2176], 'control': [1985, 2683, 3588], 'subjects.J.': [1988], '10:': [1992], '3076-3088Crossref': [1993], '(83)': [1996], 'lines,': [2001], 'previously': [2004], 'database': [2007, 2042, 3769, 3783, 4103], 'search': [2008, 2043, 3786], 'approach': [2009], 'crude': [2018], 'nonenriched': [2020], 'sample': [2021, 2642, 3411, 3872], 'untargeted': [2023, 2051], 'data-independent': [2026], 'workflow': [2027, 4361], '(27.Bhonsle': [2028], 'Kesavan': [2032], 'S.K.': [2033, 2923], 'Bhosale': [2034], 'Bansode': [2036], '"Zoom-In"—A': [2040], 'targeted': [2041, 2792, 4294], 'modifications': [2048, 2474, 2775, 3819, 3831], 'analyzed': [2049, 3502, 3948, 4358], 'spectrometry.Eur.': [2054], '18:': [2059], '475-481Crossref': [2060], 'Glycation': [2066], 'chronic': [2068], 'process;': [2069], 'given': [2071, 2100], 'undergo': [2074], 'transformations': [2077], 'varying': [2082], 'biological': [2083, 4264, 4278], 'lifespans,': [2084], 'influencing': [2085], 'function': [2087], 'protein.': [2090], 'at': [2098, 2620, 2631, 3029, 3197, 3243, 3260, 3273, 3290, 3297, 3314, 3339, 3439, 3496, 3572, 3600, 3621, 3656, 3698, 3722, 3742, 3898, 3930, 3977, 3988, 4105], 'pathophysiological': [2101], 'condition,': [2102], 'becomes': [2107], 'critical.': [2108], 'regard,': [2111], 'stable-isotope-dilution': [2113, 2151], 'method': [2117, 3467, 3561], 'employed': [2119], 'simultaneous': [2121], 'hydrolysates': [2128], '(28.Teerlink': [2132], 'Barto': [2134], 'Ten': [2136], 'Brink': [2137], 'H.J.': [2138], 'Schalkwijk': [2139], 'C.G.': [2140], 'Measurement': [2141], 'N-epsilon-(carboxymethyl)lysine': [2143, 2342, 2964, 3070], 'N-epsilon-(carboxyethyl)lysine': [2145], 'spectrometry.Clin.': [2154], '50:': [2157], '1222-1228Crossref': [2158], '(114)': [2161], '13C6-glucose': [2165], 'utilized': [2167], 'quantify': [2169], '(29.Priego-Capote': [2177], 'Ramírez-Boo': [2179], 'Hochstrasser': [2181], 'Qualitative': [2185], 'quantitative': [2187], 'isotopic': [2197], 'labeling': [2198], '13C6-reducing': [2200], 'sugars.Methods': [2201], 'Mol.': [2202], '728:': [2205], '219-232Crossref': [2206], '(3)': [2209], '30.Priego-Capote': [2212], 'Ramirez-Boo': [2214], 'Hoogland': [2216], 'Scherl': [2218], 'Mueller': [2220], 'Lisacek': [2222], 'hemolysate': [2227], 'proteome.Anal.': [2229], '83:': [2232], '5673-5680Crossref': [2233], '(17)': [2236], 'glycation-sensitive': [2244], 'early': [2254], 'diagnosis': [2255], '18O-labeling': [2266], 'technique': [2267], '(31.Zhang': [2268], 'Xu': [2270], 'Deng': [2272], 'Y.L.': [2273], 'New': [2275], 'Strategy': [2276], 'Early': [2278], 'Diagnosis': [2279], 'Type': [2281], 'standard-free,': [2285], 'label-free': [2286, 2842], 'LC-MS/MS': [2287], 'peptides.Diabetes.': [2291], '62:': [2293], '3936-3942Crossref': [2294], '(30)': [2297, 2451], 'previous': [2304], 'focused': [2307], 'modification,': [2310], 'rather': [2311], 'than': [2312, 2583, 4025], 'other': [2313, 2582], 'fact,': [2317], 'predominant': [2323], 'AGEs,': [2324], 'constituting': [2325], 'up': [2326], '80%': [2328], '(32.Reddy': [2332], 'Bichler': [2334], 'Wells-Knecht': [2336], 'Thorpe': [2338], 'S.R.': [2339], 'Baynes': [2340], 'J.W.': [2341], 'dominant': [2345], 'end-product': [2348], '(AGE)': [2349], 'antigen': [2350], 'tissue': [2352], 'proteins.Biochemistry.': [2353], '1995;': [2354], '10872-10878Crossref': [2356], '(465)': [2359], '33.Thornalley': [2362], 'P.J.': [2363], 'Battah': [2364], 'Ahmed': [2366], 'N.': [2367, 2369], 'Karachalias': [2368], 'Agalou': [2370], 'Babaei-Jadidi': [2372], 'Dawnay': [2374], 'Quantitative': [2376], 'screening': [2377], 'endproducts': [2381], 'extracellular': [2385], 'spectrometry.Biochem.': [2390], '2003;': [2392], '375:': [2393], '581-592Crossref': [2394], '(0)': [2397], 'reporter': [2401], 'recently': [2409], 'Prof.': [2411], 'Ralf': [2412], "Hoffmann's": [2413], 'group': [2414, 2742], '(34.Greifenhagen': [2415], 'U.': [2416], 'Nguyen': [2417], 'V.D.': [2418], 'Moschner': [2419], 'Giannis': [2421], 'Frolov': [2423], 'Sensitive': [2427], 'carboxymethylated': [2432], 'carboxyethylated': [2434], 'digests': [2438, 3385, 3660, 3844], 'plasma.J.': [2443], '14:': [2447], '768-777Crossref': [2448], 'Here,': [2454], 'first': [2457], 'time,': [2458], 'comprehensive': [2461], 'reference': [2484], 'AML-,': [2488], 'CML-,': [2489], 'CEL-modified': [2491, 3047, 3187], 'healthy,': [2499], 'prediabetic,': [2500, 2577, 2810], 'diabetic,': [2501, 2578, 2811, 4274], 'microalbuminuria.': [2503, 4276], 'SWATH': [2505, 2819, 2836, 3943, 4177, 4258], 'sites.': [2518], 'These': [2519], 'Subjects': [2528], 'recruited': [2530], 'Dr.': [2532], "Mohan's": [2533], 'Specialties': [2535], 'Centre,': [2536], 'Chennai,': [2537], 'India.': [2538], 'approved': [2542], 'institutional': [2545], 'ethics': [2546], 'committee': [2547], 'Madras': [2549], 'Research': [2551], 'written': [2555], 'informed': [2556], 'consent': [2557], 'obtained': [2559], 'subjects.': [2564], 'performed': [2568, 2638, 2851, 3620, 3644, 3721, 3788, 4261, 4301, 4336], 'accordance': [2570], 'Helsinki': [2573], 'Declaration.': [2574], 'Healthy': [2575], 'patients': [2581, 2697], 'known': [2584, 2594], 'history': [2585, 2591], 'cancer,': [2587], 'hematuria,': [2588], 'hypothyroidism,': [2589], 'any': [2593], 'infection': [2595], 'inflammatory': [2597], 'diseases': [2598], 'included': [2600, 3815], 'study.': [2603], 'Peripheral': [2604], 'collected': [2607, 4181], 'EDTA': [2609], 'vacutainers': [2610], '(BD': [2611], 'Biosciences,': [2612], 'USA).': [2613, 2870, 2888, 2897, 2913, 4310, 4333], 'separated': [2617, 3389, 3848], 'centrifugation': [2619], '1500': [2621], '×': [2622, 3593, 3614, 3714, 3736], 'g': [2623], '15': [2625, 3264, 3638, 4060, 4205], 'min': [2626, 3313, 3450, 3472, 3909], 'aliquots': [2628], 'stored': [2630, 3338], '−80': [2632], '°C.': [2633, 3031, 3299, 3498, 3932], 'biochemical': [2635], 'analyses': [2636], 'immediately': [2639], 'after': [2640], 'collection.': [2643], 'Descriptive': [2644], 'characters': [2645], 'parameters,': [2648], 'glucose,': [2652], 'HbA1c,': [2653], 'oral': [2654], 'tolerance': [2656, 2687, 2694, 3797, 4038], 'test,': [2657], 'postprandial': [2658], 'sugar,': [2660], 'lipids,': [2661], 'urea,': [2662], 'creatinine,': [2663], 'microalbumin': [2665], 'measured': [2667], '(Supplemental': [2668, 3678], 'Table': [2669, 3679], '1).': [2670], 'categorized': [2676], 'into': [2677], 'groups,': [2679], 'viz.,': [2680], 'healthy': [2682, 2808, 4271], 'subjects': [2684], '(normal': [2685], '(NGT)': [2688], '],': [2689, 2696, 2705], 'prediabetics': [2690], '[': [2691, 2703], 'impaired': [2692], '(IGT)': [2695], 'mellitus': [2702], 'T2DM': [2704], 'diabetics': [2707], '[MIC)': [2710], 'per': [2712, 4028], 'World': [2714], 'Health': [2715], 'Organization': [2716], 'Consulting': [2717], 'Group': [2718], 'Criteria.': [2719], 'Equal': [2720, 3213], 'volumes': [2721], 'similar': [2727, 4252, 4288], '(deviation': [2729], '<': [2731], '0.2%)': [2732], 'pooled,': [2734], 'three': [2736, 4263], 'each': [2741, 4226, 4269], 'technical': [2748, 4072, 4267], 'triplicate': [2749, 4073], 'analysis.': [2750], 'Overview': [2751], 'complete': [2753, 3247], 'design': [2755], 'shown': [2757], 'Fig.': [2759], '1.': [2760], 'First,': [2761], 'CEL.': [2779], 'parallel': [2793, 3353], 'workflow.': [2796], 'information,': [2804], 'discover': [2821], 'candidate': [2822], 'biomarkers': [2824], 'extent': [2828], 'verified': [2838], 'MSE,': [2840], 'another': [2841], 'method.': [2844, 4078], 'Two-way': [2845], 'variance': [2848], '(ANOVA)': [2849], 'statistical': [2855], 'significance': [2856], 'peptides.': [2860], 'All': [2861, 3499, 3945], 'chemicals': [2863], 'procured': [2865, 2879, 2891, 2908], 'Sigma-Aldrich': [2867], '(Sigma-Aldrich,': [2868], 'MO,': [2869], 'MS-grade': [2871], 'solvents': [2872], '(acetonitrile': [2873], '(ACN),': [2874], 'water,': [2875, 3424, 3885], 'methanol)': [2877], 'J': [2881], 'Baker': [2883], '(J': [2884], 'Baker,': [2886], 'PA,': [2887], 'RapiGest': [2889], 'Waters': [2893], '(Waters': [2894], 'Corporation,': [2895], 'MA,': [2896, 2912, 3330, 4092, 4309, 4332], 'Membrane': [2898], 'filters': [2899], '3': [2901, 3626, 3867, 3913], '30': [2903, 3041, 3206, 3280, 3542, 3657, 3743], 'KDa': [2904], 'cut': [2905], 'off': [2906], 'Millipore': [2910], '(Millipore,': [2911, 3329], 'synthesized': [2916, 3050], 'elsewhere': [2919, 3053], '(35.Bhonsle': [2920], 'Singh': [2922], 'Srivastava': [2924], 'Albumin': [2930], 'competitively': [2931], 'inhibits': [2932], 'less': [2935], 'proteins.Protein': [2937], 'Peptide': [2938, 3384, 3659, 3793, 3843], 'Letters.': [2939], '663-667Crossref': [2942], '(22)': [2945], '36.Ikeda': [2948], 'Higashi': [2950, 3056], 'Sano': [2952, 3058], 'Jinnouchi': [2954, 3060], 'Yoshida': [2956, 3062], 'Araki': [2958, 3064], 'Ueda': [2960, 3066], 'Horiuchi': [2962, 3068], 'adduct': [2966, 3072], 'major': [2969, 3075], 'immunological': [2970, 3076], 'epitope': [2971, 3077], 'reaction.Biochemistry.': [2983, 3089], '8075-8083Crossref': [2986, 3092], '(412)': [2989, 3095], 'Briefly,': [2992, 3140], '(50': [2994, 3142, 3235], 'mg/ml)': [2995, 3143], 'dissolved': [2997, 3150], '10': [2999, 3179, 3312, 3799], 'ml': [3000, 3180], '0.2': [3002, 3152], 'm': [3003, 3011, 3153], 'sodium': [3004, 3016, 3145, 3154], 'phosphate': [3005, 3155], 'buffer': [3006, 3156, 3234], '(pH': [3007, 3157], '7.4)': [3008], 'containing': [3009, 3237], '0.5': [3010, 3801], '0.05%': [3015], 'azide,': [3017], 'sterilized': [3018], 'ultrafiltration': [3020], '(0.22': [3021], 'μm': [3022], 'filter),': [3023], 'incubated': [3025, 3193, 3310], '7': [3027], 'days': [3028], '37': [3030, 3198, 3298, 3315], 'then': [3035, 3254], 'washed': [3037], 'PBS': [3039, 3204], 'kDa': [3042, 3207], 'cut-off': [3043, 3208], 'filters.': [3044, 3209], 'CML-': [3045, 3185], '(36.Ikeda': [3054], '37.Neeper': [3098], 'Yan': [3104], 'Wang': [3106], 'Pan': [3108], 'Y.C.': [3109], 'Elliston': [3110], 'Shaw': [3114], 'Cloning': [3116], 'expression': [3118], 'cell-surface': [3121], 'glycosylation': [3125], 'proteins.J.': [3128], '1992;': [3131], '267:': [3132], '14998-15004Abstract': [3133], 'cyanoborohydride': [3146], '(0.15': [3147], 'm)': [3148, 3166, 3171, 3259, 3272], '7.4),': [3158], 'either': [3161], 'glyoxylic': [3162], '(GA)': [3164], '(0.045': [3165], 'methylglyoxal': [3168], '(MG)': [3169], '(0.05': [3170], 'added': [3173], 'final': [3176], 'volume': [3177], 'synthesis': [3183], 'HSA,': [3188], 'respectively.': [3189, 3546, 3826], 'solution': [3191], '24': [3195], 'h': [3196], '°C,': [3199, 3527, 3531, 3982], 'washing': [3202], 'In-solution': [3210], 'digestion:': [3212], 'amounts': [3214], '(100': [3217], 'μg)': [3218, 3387, 3846], 'diluted': [3227], '100': [3229, 4183, 4238], 'μl': [3230], 'ammonium': [3232], 'bicarbonate': [3233], 'mm)': [3236], '0.1%': [3238, 3425, 3437, 3886, 3896], 'RapiGest,': [3239], 'incubation': [3242], '80': [3244], '°C': [3245, 3262, 3316, 3341, 3492, 3926], 'proteome': [3248], 'solubilization.': [3249], 'denatured': [3251], 'reduced': [3255], 'DTT': [3257], '(0.1': [3258], '60': [3261], 'min,': [3265], 'alkylation': [3268], 'iodoacetamide': [3270], '(0.2': [3271], 'room': [3274], 'temperature': [3275, 3487, 3525, 3529, 3921, 3980], 'dark': [3278], 'min.': [3281], 'digested': [3285], 'grade': [3288], 'trypsin': [3289], '1:50': [3291], 'enzyme': [3292], 'substrate': [3294], 'overnight': [3296], 'stopped': [3304], 'adding': [3306], 'concentrated': [3307, 3333], 'HCl': [3308], 'before': [3317], 'being': [3318], 'centrifuged.': [3319], 'desalted': [3323], 'C18': [3326], 'Zip': [3327], 'tip': [3328], 'USA)': [3331, 4093], 'vacuum': [3335], 'centrifuge': [3336], '−20': [3340], 'until': [3342], 'further': [3343], 'use.': [3344], 'Instrument-specific': [3345], 'methods': [3346], 'settings': [3348, 4135], '[(LC-HR/AM': [3349], 'Q-Exactive': [3350, 3506, 3746], 'Orbitrap': [3351, 3507, 3747], 'monitoring),': [3355], '(Triple': [3356], 'TOF': [3357, 3953], '5600': [3358, 3951], '(DDA': [3359], 'SWATH-MS),': [3361], '(label-free': [3362], 'LC-MSE': [3363, 4360], 'SYNAPT': [3365], 'HDMS)]': [3366], 'described': [3382], 'below.': [3383], '(1.5': [3386], 'Accela': [3392], '1250': [3393], 'UHPLC': [3394], '(Thermo': [3395, 3759], 'Fisher': [3396, 3760], 'Scientific)': [3397], 'equipped': [3398, 3859], 'Hypersil': [3401], 'Gold': [3402], 'C18-reverse': [3403, 3862], 'phase': [3404, 3421, 3433, 3458, 3483, 3863, 3882, 3892, 3917], 'column': [3405, 3416, 3486, 3864, 3877, 3920], '(150*2.1': [3406], 'mm,': [3407, 3866], '1.9': [3408], 'μm).': [3409], 'loaded': [3413, 3874], 'onto': [3414, 3875], '98%': [3418], 'mobile': [3420, 3432, 3457, 3482, 3881, 3891, 3916], '(100%': [3423, 3435, 3884, 3894], 'formic': [3426], '(FA))': [3428], '2%': [3430], 'B': [3434, 3893], 'ACN,': [3436, 3895], 'FA)': [3438, 3887, 3897], '350': [3440], 'μl/min': [3441, 3900], 'flow': [3442, 3901], 'rate.': [3443, 3812, 3902, 4109], 'Peptides': [3444, 3903], 'eluted': [3446, 3905], '45': [3449], 'linear': [3451, 3475, 3910], 'gradient': [3452, 3476, 3911], '40%': [3456], 'B.': [3459, 3484, 3918], 'case': [3461], 'samples,': [3464], 'LC': [3466], 'extended': [3469], '50%': [3480, 3915], 'set': [3489, 3685, 3923, 4162], '40': [3491, 3925], 'auto': [3494, 3928], 'sampler': [3495, 3929], '4': [3497, 3931], 'hybrid': [3504], 'quadruple': [3505], 'MS.': [3508], 'instrument': [3510, 4127], 'tune': [3511, 3665], 'parameters': [3512, 3666, 3964, 4250], 'optimized': [3514, 3664, 3966], 'as:': [3519], 'spray': [3520, 3985], 'voltage': [3521, 3986], '4,200': [3522], 'V,': [3523], 'capillary': [3524], '320': [3526], 'heater': [3528], '200': [3530, 3854, 3981], 'S-lens': [3532], 'RF': [3533], 'value': [3534, 3590, 3611, 3711, 3733, 4346], '55,': [3535], 'sheath': [3536], 'auxiliary': [3538], 'gases': [3539, 3972], 'pressure': [3540], '8': [3544, 3899], 'psi,': [3545, 3979], 'acquired': [3550, 3571, 3599, 3662, 3697, 4070, 4236], 'positive': [3552, 3957], 'ionization': [3553], 'mode': [3554, 3669, 4234], 'data-dependent': [3556], 'manner': [3557], 'top-five': [3560], 'range': [3564, 4003, 4173], '350–1,800': [3566, 4005], 'm/z.': [3567, 4006, 4176, 4186], 'spectra': [3569, 3597, 3695, 4179], '70,000': [3576, 3702], 'injection': [3579], 'time': [3580, 3636, 3993, 4209], '(IT)': [3581], 'ms': [3584, 3608, 3708, 3999, 4214], 'automatic': [3586], 'gain': [3587], '(AGC)': [3589], '1': [3592, 3613, 3687, 4155], 'e6': [3594], 'ions;': [3595], '17,500': [3601], 'IT': [3605, 3705, 3728], 'AGC': [3610, 3710, 3732], 'e5': [3615], 'ions.': [3616, 3716], "Precursor's": [3617], 'selectivity': [3618], 'isolation': [3623, 3682, 4149], 'width': [3624, 3683, 4150], 'm/z,': [3627], 'under': [3628], 'fill': [3629], '0.3%,': [3632], 'exclusion': [3635], 's.': [3639, 4247], 'energy': [3647, 4051, 4197], 'collision': [3648, 4046, 4050, 4192, 4196], 'induced': [3649], 'dissociation': [3650], '(HCD)': [3651], 'cell': [3652, 4047, 4193], 'normalized': [3654, 3740], 'HCD': [3655, 3741], 'eV.': [3658, 3744, 4061, 4206], 'targeted/dd-MS2': [3668], 'inclusion': [3676], 'list': [3677], '2).': [3680], 'selection': [3691, 4138], 'precursor.': [3693], '5': [3713], 'e4': [3715, 3737], '17,500,': [3726], 'ms,': [3731, 4239], 'ions,': [3738], 'LC-HR/AM': [3745], 'data': [3750, 3777, 4295, 4299, 4313], 'processed': [3752], 'Discoverer,': [3756], 'Version': [3757, 4088, 4305, 4328], '1.4.0.288,': [3758], 'Scientific).': [3761], 'SEQUEST': [3763], 'HT': [3764], '(a': [3765], 'computer': [3766], 'algorithm': [3767, 4097], 'search)': [3770], 'identification.': [3775], 'searched': [3779, 4084], 'against': [3780, 4098], '(P02768-UniProt).': [3784], 'following': [3791, 4015], 'parameters:': [3792], 'ppm,': [3800], 'respectively,': [3803], 'missed': [3806], 'cleavages': [3807], '1%': [3809, 4106], 'false': [3810, 4107], 'discovery': [3811, 4108], 'Search': [3813], 'criteria': [3814], 'fixed': [3816], 'variable': [3818, 3828], 'carbamidomethylation': [3821], '(C)': [3822], 'oxidation': [3824], '(M),': [3825], 'Additional': [3827], 'lysine-specific': [3829], '(+162.02);': [3833], '(+58.005': [3835], 'Da),': [3836], '(+72.021': [3839], 'considered.': [3842], '(3': [3845], 'Eksigent': [3852, 3861], 'MicroLC': [3853], 'system': [3855], '(Eksigent,': [3856], 'Dublin,': [3857], 'CA)': [3858], '(100*0.3': [3865], 'μm,': [3868], 'Å).': [3870], '97%': [3879], '3%': [3889], 'same': [3934], 'chromatographic': [3935], 'conditions': [3936], 'DDA': [3941, 4077, 4079, 4256], 'acquisition.': [3944, 4257], 'AB-SCIEX': [3950], 'Triple': [3952], 'spectrometer': [3955], 'high-sensitivity': [3959, 4222], 'mode.': [3960], 'dual': [3962], 'source': [3963, 3971, 4249], 'results:': [3969], 'GS1,': [3973], 'GS2,': [3974], 'curtain': [3975], 'gas': [3976], '25': [3978, 4144], 'floating': [3987], '5,500': [3989], 'accumulation': [3992, 4208], 'full': [3995], '250': [3998], 'parent': [4008], 'selected': [4011], 'criteria:': [4016], 'intensity': [4023], 'more': [4024], 'counts': [4027], 'second,': [4029], 'charge': [4030], 'stage': [4031], 'between': [4032], '+2': [4033], '+5,': [4035], '50': [4039], 'mDa.': [4040], 'Ions': [4041, 4187], 'fragmented': [4043, 4189], 'rolling': [4049, 4195], '(CE)': [4052], 'CE': [4056, 4201], 'spread': [4057, 4202], '±': [4059, 4204], 'above-mentioned': [4076], 'files': [4082, 4315], 'ProteinPilot': [4086, 4111], 'software,': [4087, 4304, 4327], '4.0.8085': [4089], '(AB': [4090, 4307, 4330], 'SCIEX,': [4091, 4308, 4331], 'Paragon': [4096], '(P02768-UniProt)': [4104], 'output': [4112], 'file': [4113], '(.group)': [4114], 'standard': [4119], 'spectral': [4121, 4291], 'library.': [4122], 'SWATH-MS': [4124, 4227, 4298], 'mode,': [4125, 4223], 'specifically': [4129], 'tuned': [4130], 'optimize': [4132], 'quadrupole': [4134], 'precursor': [4140, 4171], 'window': [4142, 4159], 'wide.': [4146], 'Using': [4147], '26': [4152], '(containing': [4154], 'overlap),': [4160], '34': [4164], 'overlapping': [4165], 'windows': [4166], 'constructed': [4168], 'covering': [4169], '400–1,250': [4175], '2,000': [4185], '(dwell': [4210], 'time)': [4211], '96': [4213], 'fragment-ion': [4219], 'scans': [4220], 'cycle': [4228, 4244], 'survey': [4230], 'high-resolution': [4233], 'duty': [4243], '3.33': [4246], 'replicates': [4265], 'triplicates': [4268], 'Each': [4277], 'replicate': [4279], 'pool': [4282], 'HbA1c.': [4289], 'alignment': [4292], 'extraction': [4296], 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