Publication Information

{'id': 'https://openalex.org/W2196475141', 'doi': 'https://doi.org/10.1148/92.3.591', 'title': 'Clinical Experience With Split-Course Radiotherapy', 'display_name': 'Clinical Experience With Split-Course Radiotherapy', 'publication_year': 1969, 'publication_date': '1969-03-01', 'ids': {'openalex': 'https://openalex.org/W2196475141', 'doi': 'https://doi.org/10.1148/92.3.591', 'mag': '2196475141', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/5779694'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1148/92.3.591', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S50280174', 'display_name': 'Radiology', 'issn_l': '0033-8419', 'issn': ['0033-8419', '1527-1315'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315931', 'host_organization_name': 'Radiological Society of North America', 'host_organization_lineage': ['https://openalex.org/P4310315931'], 'host_organization_lineage_names': ['Radiological Society of North America'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113641378', 'display_name': 'Lars R. Holsti', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Lars R. Holsti', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5113641378'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.88, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 58, 'citation_normalized_percentile': {'value': 0.971582, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '92', 'issue': '3', 'first_page': '591', 'last_page': '596'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13123', 'display_name': 'Advances in Oncology and Radiotherapy', 'score': 0.9355, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13123', 'display_name': 'Advances in Oncology and Radiotherapy', 'score': 0.9355, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10358', 'display_name': 'Advanced Radiotherapy Techniques', 'score': 0.9071, 'subfield': {'id': 'https://openalex.org/subfields/3108', 'display_name': 'Radiation'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/radiobiology', 'display_name': 'Radiobiology', 'score': 0.8175297}, {'id': 'https://openalex.org/keywords/rest', 'display_name': 'Rest (music)', 'score': 0.41202295}], 'concepts': [{'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.87986183}, {'id': 'https://openalex.org/C125118446', 'wikidata': 'https://www.wikidata.org/wiki/Q690200', 'display_name': 'Radiobiology', 'level': 3, 'score': 0.8175297}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.79547215}, {'id': 'https://openalex.org/C19527891', 'wikidata': 'https://www.wikidata.org/wiki/Q1120908', 'display_name': 'Medical physics', 'level': 1, 'score': 0.42530918}, {'id': 'https://openalex.org/C77265313', 'wikidata': 'https://www.wikidata.org/wiki/Q879844', 'display_name': 'Rest (music)', 'level': 2, 'score': 0.41202295}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.20054239}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12906972}], 'mesh': [{'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D009062', 'descriptor_name': 'Mouth Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D010610', 'descriptor_name': 'Pharyngeal Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006258', 'descriptor_name': 'Head and Neck Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008722', 'descriptor_name': 'Methods', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009062', 'descriptor_name': 'Mouth Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010610', 'descriptor_name': 'Pharyngeal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1148/92.3.591', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S50280174', 'display_name': 'Radiology', 'issn_l': '0033-8419', 'issn': ['0033-8419', '1527-1315'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315931', 'host_organization_name': 'Radiological Society of North America', 'host_organization_lineage': ['https://openalex.org/P4310315931'], 'host_organization_lineage_names': ['Radiological Society of North America'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/5779694', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.64, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4390708743', 'https://openalex.org/W4248538281', 'https://openalex.org/W4243112505', 'https://openalex.org/W2911979444', 'https://openalex.org/W2497658117', 'https://openalex.org/W2196475141', 'https://openalex.org/W2066501151', 'https://openalex.org/W2033565619', 'https://openalex.org/W1994508092', 'https://openalex.org/W1576463423'], 'abstract_inverted_index': {'IMPROVEMENT': [0], 'in': [1, 31, 43, 98, 116, 146, 200, 258, 263, 275, 303, 306, 325, 341, 347, 397, 408], 'results': [2, 42, 54, 378], 'of': [3, 24, 36, 50, 65, 72, 79, 89, 93, 108, 119, 138, 143, 170, 194, 219, 246, 288, 292, 312, 317, 331, 334, 337, 379, 394, 402, 427], 'cancer': [4, 311], 'radiotherapy': [5, 109, 166, 302, 319, 338], 'during': [6, 242], 'recent': [7, 96], 'years': [8], 'is': [9, 110, 149, 155, 178, 197, 238, 406, 416], 'due': [10], 'more': [11, 184, 365], 'to': [12, 28, 159, 248, 300], 'the': [13, 25, 41, 52, 68, 82, 86, 90, 117, 124, 136, 139, 171, 176, 198, 210, 223, 264, 286, 298, 313, 318, 332, 376, 395, 399, 403, 413, 428], 'fact': [14], 'that': [15, 360], 'patients': [16, 308], 'now': [17], 'seek': [18], 'treatment': [19, 177, 362, 420, 429], 'at': [20], 'an': [21, 156], 'earlier': [22], 'stage': [23], 'disease': [26], 'than': [27, 367], 'true': [29], 'progress': [30], 'treatment.': [32], 'Megavoltage': [33], 'therapy': [34, 128, 196, 405], 'has,': [35], 'course,': [37], 'meant': [38], 'indubitable': [39], 'progress—and': [40], 'some': [44], 'tumor': [45, 83, 206], 'groups': [46], 'have': [47, 101, 271, 430], 'improved': [48], 'because': [49], 'it—but': [51], 'better': [53], 'depend': [55], 'on': [56, 67, 123], 'physical': [57], 'benefits': [58], 'and': [59, 85, 141, 162, 164, 205, 236, 260, 346, 351, 412], 'bigger': [60], 'dose.': [61], 'The': [62, 76, 95, 106, 191], 'essential': [63], 'problems': [64, 132], 'radiotherapy,': [66], 'other': [69, 125], 'hand,': [70, 126], 'are': [71, 81], 'a': [73, 150, 188, 217, 243, 392, 434], 'biological': [74, 91], 'nature.': [75], 'most': [77], 'important': [78, 157], 'these': [80], 'characteristics': [84], 'proper': [87], 'utilization': [88], 'effects': [92], 'irradiation.': [94, 370], 'advances': [97], 'radiobiological': [99], 'research': [100], 'greatly': [102], 'stimulated': [103], 'clinical': [104, 127, 147, 373], 'radiotherapy.': [105, 293], 'aim': [107], 'practical;': [111], 'its': [112], 'achievement': [113], 'requires': [114], 'observation': [115], 'field': [118], 'basic': [120], 'research,': [121], 'and,': [122], 'repeatedly': [129], 'poses': [130], 'new': [131], 'for': [133, 152, 267], 'radiobiology.': [134], 'Testing': [135], 'validity': [137], 'observations': [140], 'hypotheses': [142], 'experimental': [144], 'radiobiology': [145], 'work': [148], 'task': [151], 'radiotherapists.': [153], 'Fractionation': [154], 'problem': [158], 'both': [160, 355], 'biologist': [161], 'therapist,': [163], 'splitcourse': [165], 'represents': [167], 'one': [168], 'form': [169], 'newer': [172], 'fractionation': [173], 'regimes.': [174], 'Here': [175], 'divided': [179], 'into': [180], 'two': [181, 247, 304, 409], 'or': [182, 421], 'perhaps': [183], 'phases': [185, 305, 426], 'separated': [186], 'by': [187, 256, 261, 323, 343, 349, 438], 'rest': [189, 211, 244], 'interval.': [190], 'theoretical': [192], 'basis': [193], 'this': [195, 234], 'difference': [199], 'cell': [201, 220], 'proliferation': [202], 'between': [203], 'normal': [204, 213], 'cells': [207, 231], '(23).': [208], 'During': [209], 'interval,': [212], 'tissue': [214], 'proliferates': [215], 'as': [216, 281, 418, 433], 'result': [218], 'loss': [221], 'stimulating': [222], 'homeostatic': [224], 'feedback,': [225], 'inducing': [226], 'rapid': [227], 'proliferation.': [228], 'In': [229, 354], 'malignant': [230], 'stimulation': [232], 'like': [233], 'fails,': [235], 'there': [237], 'very': [239], 'little': [240], 'regrowth': [241], 'interval': [245], 'three': [249, 422], 'weeks.': [250], 'This': [251], 'method': [252], 'has': [253], 'been': [254, 431], 'used': [255], 'Sambrook': [257, 324], 'England': [259], 'Scanlon': [262, 344], 'United': [265], 'States': [266], 'many': [268], 'years.': [269], 'We': [270], 'employed': [272], 'it': [273, 357], 'increasingly': [274], 'Helsinki': [276], 'since': [277], '1963.': [278], 'As': [279], 'early': [280], '1935': [282], 'Coutard': [283], '(5)': [284], 'discussed': [285], 'value': [287], 'repeated': [289], 'short': [290], 'series': [291], 'Zuppinger': [294], '(34,': [295], '35)': [296], 'was': [297, 321, 339, 358], 'first': [299, 400], 'use': [301], 'treating': [307], 'with': [309], 'advanced': [310], 'hypopharynx.': [314], 'Planned': [315], 'splitting': [316], 'course': [320], 'reported': [322, 340], '1959': [326, 342], '(21).': [327], 'A': [328], 'retrospective': [329, 380], 'study': [330], 'effect': [333], 'unplanned': [335], 'interruption': [336], '(25)': [345], '1964': [348], 'Holsti': [350], 'Taskinen': [352], '(14).': [353], 'studies': [356, 381], 'concluded': [359], 'interrupted': [361], 'might': [363], 'be': [364], 'favorable': [366], 'continuous': [368], 'daily': [369, 419], 'Afterward,': [371], 'prospective': [372], 'experiences': [374], 'confirmed': [375], 'preliminary': [377], '(9–12,': [382], '15,': [383], '22,': [384], '24,': [385], '26–32).': [386], 'Dutreix': [387], 'et': [388, 440], 'al.': [389, 441], '(7)': [390], 'presented': [391], 'modification': [393], 'treatment,': [396], 'which': [398], 'part': [401, 415], 'split-course': [404], 'given': [407, 432], 'large': [410, 436], 'fractions': [411, 437], 'second': [414], 'fractionated': [417], 'times': [423], 'weekly.': [424], 'Both': [425], 'few': [435], 'Levitt': [439], '(18).': [442]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2196475141', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-17T10:52:39.618016', 'created_date': '2016-06-24'}