Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4

Name: Work Video:
Duration: 3 min 30 s
Lili Tian; Dachuan Shen; Xiaodong Li; Xiu Shan; Xiaoqi Wang; Qiu Yan; Jiwei Liu
{'id': 'https://openalex.org/W2191249569', 'doi': 'https://doi.org/10.18632/oncotarget.6451', 'title': 'Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4', 'display_name': 'Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4', 'publication_year': 2015, 'publication_date': '2015-12-02', 'ids': {'openalex': 'https://openalex.org/W2191249569', 'doi': 'https://doi.org/10.18632/oncotarget.6451', 'mag': '2191249569', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26636541', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4811485'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6451', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6451&path%5B%5D=17809', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6451&path%5B%5D=17809', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101400374', 'display_name': 'Lili Tian', 'orcid': 'https://orcid.org/0000-0003-0556-4449'}, 'institutions': [{'id': 'https://openalex.org/I191996457', 'display_name': 'Dalian Medical University', 'ror': 'https://ror.org/04c8eg608', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I191996457']}, {'id': 'https://openalex.org/I4210140813', 'display_name': 'First Affiliated Hospital of Dalian Medical University', 'ror': 'https://ror.org/055w74b96', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140813']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lili Tian', 'raw_affiliation_strings': ['Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China', 'institution_ids': ['https://openalex.org/I191996457', 'https://openalex.org/I4210140813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007435834', 'display_name': 'Dachuan Shen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I191996457', 'display_name': 'Dalian Medical University', 'ror': 'https://ror.org/04c8eg608', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I191996457']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dachuan Shen', 'raw_affiliation_strings': ['Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning Province, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning Province, China', 'institution_ids': ['https://openalex.org/I191996457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101563478', 'display_name': 'Xiaodong Li', 'orcid': 'https://orcid.org/0000-0002-6221-5256'}, 'institutions': [{'id': 'https://openalex.org/I191996457', 'display_name': 'Dalian Medical University', 'ror': 'https://ror.org/04c8eg608', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I191996457']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaodong Li', 'raw_affiliation_strings': ['Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning Province, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning Province, China', 'institution_ids': ['https://openalex.org/I191996457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101745766', 'display_name': 'Xiu Shan', 'orcid': 'https://orcid.org/0000-0002-4220-201X'}, 'institutions': [{'id': 'https://openalex.org/I191996457', 'display_name': 'Dalian Medical University', 'ror': 'https://ror.org/04c8eg608', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I191996457']}, {'id': 'https://openalex.org/I4210140813', 'display_name': 'First Affiliated Hospital of Dalian Medical University', 'ror': 'https://ror.org/055w74b96', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140813']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiu Shan', 'raw_affiliation_strings': ['Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China', 'institution_ids': ['https://openalex.org/I191996457', 'https://openalex.org/I4210140813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100401778', 'display_name': 'Xiaoqi Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaoqi Wang', 'raw_affiliation_strings': ['Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100668430', 'display_name': 'Qiu Yan', 'orcid': 'https://orcid.org/0000-0003-4253-4126'}, 'institutions': [{'id': 'https://openalex.org/I191996457', 'display_name': 'Dalian Medical University', 'ror': 'https://ror.org/04c8eg608', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I191996457']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiu Yan', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian Medical University, Dalian, Liaoning Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian Medical University, Dalian, Liaoning Province, China', 'institution_ids': ['https://openalex.org/I191996457']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101826858', 'display_name': 'Jiwei Liu', 'orcid': 'https://orcid.org/0000-0001-5040-6242'}, 'institutions': [{'id': 'https://openalex.org/I191996457', 'display_name': 'Dalian Medical University', 'ror': 'https://ror.org/04c8eg608', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I191996457']}, {'id': 'https://openalex.org/I4210140813', 'display_name': 'First Affiliated Hospital of Dalian Medical University', 'ror': 'https://ror.org/055w74b96', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140813']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiwei Liu', 'raw_affiliation_strings': ['Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China', 'institution_ids': ['https://openalex.org/I191996457', 'https://openalex.org/I4210140813']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.688, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 125, 'citation_normalized_percentile': {'value': 0.856575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '7', 'issue': '2', 'first_page': '1619', 'last_page': '1632'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11889', 'display_name': 'Ginseng Biological Effects and Applications', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11889', 'display_name': 'Ginseng Biological Effects and Applications', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11316', 'display_name': 'Mycobacterium research and diagnosis', 'score': 0.9579, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glycobiology', 'display_name': 'Glycobiology', 'score': 0.6382022}, {'id': 'https://openalex.org/keywords/fucosyltransferase', 'display_name': 'Fucosyltransferase', 'score': 0.4621677}], 'concepts': [{'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.73880935}, {'id': 'https://openalex.org/C204641814', 'wikidata': 'https://www.wikidata.org/wiki/Q899224', 'display_name': 'Glycobiology', 'level': 4, 'score': 0.6382022}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.5896831}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.56807023}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5629453}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.53413296}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.51903284}, {'id': 'https://openalex.org/C147447768', 'wikidata': 'https://www.wikidata.org/wiki/Q411624', 'display_name': 'Vimentin', 'level': 3, 'score': 0.4812493}, {'id': 'https://openalex.org/C2777762822', 'wikidata': 'https://www.wikidata.org/wiki/Q5507035', 'display_name': 'Fucosyltransferase', 'level': 3, 'score': 0.4621677}, {'id': 'https://openalex.org/C67082663', 'wikidata': 'https://www.wikidata.org/wiki/Q3523816', 'display_name': 'Molecular medicine', 'level': 4, 'score': 0.4263841}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.3398009}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3272035}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3134834}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29966247}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28734055}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.18907747}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.15709883}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.11061451}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.081033975}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.078935236}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C206212055', 'wikidata': 'https://www.wikidata.org/wiki/Q2553138', 'display_name': 'Glycan', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005647', 'descriptor_name': 'Fucosyltransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D036145', 'descriptor_name': 'Ginsenosides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016256', 'descriptor_name': 'Lewis X Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D000072283', 'descriptor_name': 'A549 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005647', 'descriptor_name': 'Fucosyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005647', 'descriptor_name': 'Fucosyltransferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D036145', 'descriptor_name': 'Ginsenosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016256', 'descriptor_name': 'Lewis X Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016256', 'descriptor_name': 'Lewis X Antigen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014746', 'descriptor_name': 'Vimentin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014746', 'descriptor_name': 'Vimentin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014746', 'descriptor_name': 'Vimentin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6451', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6451&path%5B%5D=17809', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4811485', 'pdf_url': 'https://europepmc.org/articles/pmc4811485?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811485', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26636541', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6451', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6451&path%5B%5D=17809', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.63, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1517723427', 'https://openalex.org/W1575738715', 'https://openalex.org/W1957403168', 'https://openalex.org/W1963501822', 'https://openalex.org/W1974248844', 'https://openalex.org/W1979907716', 'https://openalex.org/W1980457341', 'https://openalex.org/W1983411073', 'https://openalex.org/W1990090167', 'https://openalex.org/W1993358064', 'https://openalex.org/W1999427915', 'https://openalex.org/W2018341118', 'https://openalex.org/W2028593825', 'https://openalex.org/W2043797012', 'https://openalex.org/W2045867270', 'https://openalex.org/W2057967638', 'https://openalex.org/W2058493425', 'https://openalex.org/W2076202104', 'https://openalex.org/W2078628823', 'https://openalex.org/W2083416941', 'https://openalex.org/W2084645564', 'https://openalex.org/W2086976855', 'https://openalex.org/W2091728033', 'https://openalex.org/W2094049925', 'https://openalex.org/W2095217252', 'https://openalex.org/W2100206806', 'https://openalex.org/W2119684461', 'https://openalex.org/W2121604649', 'https://openalex.org/W2124052283', 'https://openalex.org/W2125000518', 'https://openalex.org/W2129860749', 'https://openalex.org/W2135609376', 'https://openalex.org/W2136526650', 'https://openalex.org/W2154127669', 'https://openalex.org/W2160222685', 'https://openalex.org/W2161817637', 'https://openalex.org/W2174059881', 'https://openalex.org/W2345363516'], 'related_works': ['https://openalex.org/W4255855377', 'https://openalex.org/W3042521424', 'https://openalex.org/W3032018168', 'https://openalex.org/W2991110581', 'https://openalex.org/W2784579557', 'https://openalex.org/W2343703378', 'https://openalex.org/W2304480144', 'https://openalex.org/W2099293728', 'https://openalex.org/W2092051801', 'https://openalex.org/W1513049384'], 'abstract_inverted_index': {'//': [0, 108, 112], 'Lili': [1], 'Tian': [2], '1,*': [3], ',': [4, 8, 12, 16, 20], 'Dachuan': [5], 'Shen': [6], '2,*': [7], 'Xiaodong': [9], 'Li': [10], '2': [11, 43], 'Xiu': [13], 'Shan': [14], '1': [15, 27, 28], 'Xiaoqi': [17], 'Wang': [18], '3': [19, 56], 'Qiu': [21, 105], 'Yan': [22], '4': [23, 72], 'and': [24, 76, 85, 149, 160, 193, 215, 219, 236, 244, 255, 282, 292, 298, 316, 327, 330], 'Jiwei': [25, 109], 'Liu': [26], 'Department': [29, 57, 73], 'of': [30, 35, 45, 58, 64, 70, 74, 83, 195, 269, 318, 344], 'Oncology,': [31], 'First': [32], 'Affiliated': [33], 'Hospital': [34], 'Dalian': [36, 49, 87], 'Medical': [37, 50, 88], 'University,': [38, 51, 89], 'Dalian,': [39, 52, 90], 'Liaoning': [40, 53, 79, 91], 'Province,': [41, 54, 92], 'China': [42, 55, 93], 'Institute': [44], 'Cancer': [46], 'Stem': [47], 'Cell,': [48], 'Dermatology,': [59], 'Northwestern': [60], 'University': [61], 'Feinberg': [62], 'School': [63], 'Medicine,': [65], 'Chicago,': [66], 'Illinois,': [67], 'United': [68], 'States': [69], 'America': [71], 'Biochemistry': [75], 'Molecular': [77], 'Biology,': [78], 'Provincial': [80], 'Core': [81], 'Lab': [82], 'Glycobiology': [84], 'Glycoengineering,': [86], '*': [94], 'These': [95], 'authors': [96], 'have': [97], 'contributed': [98], 'equally': [99], 'to': [100, 186, 191], 'this': [101, 176], 'work': [102], 'Correspondence': [103], 'to:': [104], 'Yan,': [106], 'email:': [107, 111], 'Liu,': [110], 'Keywords': [113], ':': [114, 122, 127, 132], 'Rg3,': [115], 'EMT,': [116], 'FUT4,': [117], 'EGFR,': [118], 'lung': [119, 146, 196, 248, 305, 319, 345], 'cancer': [120, 147, 163, 197, 249, 320], 'Received': [121], 'May': [123], '05,': [124], '2015': [125, 130, 135], 'Accepted': [126], 'November': [128], '21,': [129], 'Published': [131], 'December': [133], '02,': [134], 'Abstract': [136], 'The': [137], 'epithelial-mesenchymal': [138], 'transition': [139], '(EMT)': [140], 'is': [141, 152, 198], 'an': [142], 'important': [143], 'factor': [144], 'in': [145, 172, 247, 294, 304], 'metastasis,': [148], 'targeting': [150], 'EMT': [151, 192, 226, 262, 315], 'a': [153, 178, 337], 'potential': [154], 'therapeutic': [155], 'strategy.': [156], 'Fucosyltransferase': [157], 'IV': [158], '(FUT4)': [159], 'its': [161, 189], 'synthetic': [162], 'sugar': [164], 'antigen': [165], 'Lewis': [166], 'Y': [167], '(LeY)': [168], 'was': [169, 184, 263, 275], 'abnormally': [170], 'elevated': [171], 'many': [173], 'cancers.': [174], 'In': [175, 286, 311], 'study,': [177], 'traditional': [179], 'Chinese': [180], 'medicine': [181], 'ginsenoside': [182], 'Rg3': [183, 206, 222, 239, 288, 313, 334], 'used': [185], 'investigate': [187], 'whether': [188], 'inhibition': [190], 'invasion': [194, 216, 317], 'by': [199, 217, 251, 307, 321], 'the': [200, 267, 279, 342], 'glycobiology': [201], 'mechanism.': [202], 'We': [203], 'found': [204], 'that': [205], 'treatment': [207, 343], '(25,': [208], '50,': [209], '100': [210], '&mu;g/ml)': [211], 'inhibited': [212], 'cell': [213], 'migration': [214], 'wound-healing': [218], 'transwell': [220], 'assays.': [221], 'could': [223], 'significantly': [224, 299], 'alter': [225], 'marker': [227], 'proteins': [228], 'with': [229, 260], 'increased': [230], 'E-cadherin,': [231], 'but': [232], 'decreased': [233, 272, 300], 'Snail,': [234], 'N-cadherin': [235], 'Vimentin': [237], 'expression.': [238], 'also': [240], 'down-regulated': [241, 259], 'FUT4': [242, 258, 323], 'gene': [243], 'protein': [245], 'expression': [246], 'cells': [250], 'qPCR,': [252], 'Western': [253], 'blot': [254], 'immunofluorescence.': [256], 'After': [257], 'shFUT4,': [261], 'obviously': [264], 'inhibited.': [265], 'Furthermore,': [266], 'activation': [268], 'EGFR': [270, 325], 'through': [271], 'LeY': [273], 'biosynthesis': [274], 'inhibited,': [276], 'which': [277], 'blocked': [278], 'downstream': [280], 'MAPK': [281, 329], 'NF-&kappa;B': [283, 331], 'signal': [284, 332], 'pathways.': [285, 333], 'addition,': [287], 'reduced': [289], 'tumor': [290, 301], 'volume': [291], 'weight': [293], 'xenograft': [295], 'mouse': [296], 'model,': [297], 'metastasis': [302], 'nodules': [303], 'tissues': [306], 'tail': [308], 'vein': [309], 'injection.': [310], 'conclusion,': [312], 'inhibits': [314], 'down-regulating': [322], 'mediated': [324], 'inactivation': [326], 'blocking': [328], 'may': [335], 'be': [336], 'potentially': [338], 'effective': [339], 'agent': [340], 'for': [341], 'cancer.': [346]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2191249569', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 8}], 'updated_date': '2024-12-24T13:14:41.474229', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
