Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2189107156', 'doi': None, 'title': 'In vitro susceptibility of Plasmodium falciparum to four antimalarial drugs in the Central Province of Papua New Guinea.', 'display_name': 'In vitro susceptibility of Plasmodium falciparum to four antimalarial drugs in the Central Province of Papua New Guinea.', 'publication_year': 1998, 'publication_date': '1998-06-01', 'ids': {'openalex': 'https://openalex.org/W2189107156', 'mag': '2189107156', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10934544'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10934544', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041771193', 'display_name': 'Francis Hombhanje', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I164061489', 'display_name': 'University of Papua New Guinea', 'ror': 'https://ror.org/05jxf0p38', 'country_code': 'PG', 'type': 'education', 'lineage': ['https://openalex.org/I164061489']}], 'countries': ['PG'], 'is_corresponding': True, 'raw_author_name': 'Francis W. Hombhanje', 'raw_affiliation_strings': ['Department of Basic Medical Sciences, University of Papua New Guinea, Port Moresby.'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic Medical Sciences, University of Papua New Guinea, Port Moresby.', 'institution_ids': ['https://openalex.org/I164061489']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5041771193'], 'corresponding_institution_ids': ['https://openalex.org/I164061489'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.711833, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 75, 'max': 76}, 'biblio': {'volume': '41', 'issue': '2', 'first_page': '51', 'last_page': '8'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9868, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9686, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/halofantrine', 'display_name': 'Halofantrine', 'score': 0.97365713}, {'id': 'https://openalex.org/keywords/quinine', 'display_name': 'Quinine', 'score': 0.9126817}], 'concepts': [{'id': 'https://openalex.org/C2777199930', 'wikidata': 'https://www.wikidata.org/wiki/Q736270', 'display_name': 'Mefloquine', 'level': 4, 'score': 0.97794855}, {'id': 'https://openalex.org/C2777498558', 'wikidata': 'https://www.wikidata.org/wiki/Q947595', 'display_name': 'Halofantrine', 'level': 5, 'score': 0.97365713}, {'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.92387986}, {'id': 'https://openalex.org/C2777617192', 'wikidata': 'https://www.wikidata.org/wiki/Q189522', 'display_name': 'Quinine', 'level': 3, 'score': 0.9126817}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.8799608}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.7265082}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.5110303}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5009432}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41856253}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.36915472}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35524917}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.22166201}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.18699881}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015767', 'descriptor_name': 'Mefloquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015767', 'descriptor_name': 'Mefloquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010219', 'descriptor_name': 'Papua New Guinea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010616', 'descriptor_name': 'Phenanthrenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010616', 'descriptor_name': 'Phenanthrenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011803', 'descriptor_name': 'Quinine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011803', 'descriptor_name': 'Quinine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10934544', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1508470894', 'https://openalex.org/W1932740040', 'https://openalex.org/W1969503178', 'https://openalex.org/W1974310983', 'https://openalex.org/W1980054614', 'https://openalex.org/W1986212668', 'https://openalex.org/W1990074634', 'https://openalex.org/W1998937714', 'https://openalex.org/W2037042007', 'https://openalex.org/W2040085542', 'https://openalex.org/W2060203512', 'https://openalex.org/W2062780202', 'https://openalex.org/W2072578147', 'https://openalex.org/W2079445122', 'https://openalex.org/W2082533641', 'https://openalex.org/W2094313233', 'https://openalex.org/W2097339869', 'https://openalex.org/W2104934338', 'https://openalex.org/W2106801704', 'https://openalex.org/W2134591885', 'https://openalex.org/W2141766819', 'https://openalex.org/W2169541516', 'https://openalex.org/W2172163121', 'https://openalex.org/W2244488606', 'https://openalex.org/W2296453872', 'https://openalex.org/W2297723510', 'https://openalex.org/W2395357050', 'https://openalex.org/W2396351265', 'https://openalex.org/W2410977256', 'https://openalex.org/W2412321772', 'https://openalex.org/W2412901577', 'https://openalex.org/W2413147287', 'https://openalex.org/W2415396064', 'https://openalex.org/W2415986179', 'https://openalex.org/W2416571181', 'https://openalex.org/W2424672000', 'https://openalex.org/W2427687468', 'https://openalex.org/W2471536955', 'https://openalex.org/W65850468', 'https://openalex.org/W91525599'], 'related_works': ['https://openalex.org/W49352801', 'https://openalex.org/W2410056375', 'https://openalex.org/W2394565064', 'https://openalex.org/W2232851504', 'https://openalex.org/W2089765100', 'https://openalex.org/W2084090088', 'https://openalex.org/W2057305837', 'https://openalex.org/W2051072666', 'https://openalex.org/W1972177048', 'https://openalex.org/W1477469345'], 'abstract_inverted_index': {'The': [0, 36, 111, 176], 'susceptibility': [1, 57], 'of': [2, 17, 66, 79, 94, 114, 146, 153, 156, 164, 166, 171, 178, 184], 'Plasmodium': [3], 'falciparum': [4, 158], 'to': [5, 61, 71, 123, 128, 132, 139], 'chloroquine,': [6], 'quinine,': [7], 'mefloquine': [8, 107, 179], 'and': [9, 24, 77, 87, 97, 121, 134, 169], 'halofantrine': [10, 88, 135, 172], 'was': [11, 30, 45], 'investigated': [12], 'in': [13, 33, 41, 47], 'the': [14, 34, 48, 51, 144, 162], 'Central': [15], 'Province': [16], 'Papua': [18], 'New': [19], 'Guinea': [20], 'between': [21, 118], 'March': [22], '1995': [23], 'September': [25], '1996,': [26], 'when': [27], 'chloroquine': [28, 56, 62, 124, 147, 185], 'resistance': [29, 91, 148, 168, 173], 'widely': [31], 'present': [32], 'country.': [35], 'standard': [37], 'World': [38], 'Health': [39], 'Organization': [40], 'vitro': [42], 'microtest': [43], 'methodology': [44], 'used': [46], 'study.': [49], 'Of': [50], '30': [52], 'isolates': [53, 82, 104, 119, 127], 'tested': [54, 105], 'for': [55, 84, 106], 'all': [58, 102], 'were': [59, 108], 'resistant': [60, 120], 'with': [63, 150], 'median': [64, 115], 'IC50': [65, 116], '1.15': [67], 'mumol/l': [68, 96], '(range': [69], '0.54': [70], '4.24),': [72], 'indicating': [73], 'a': [74], 'high': [75], 'prevalence': [76], 'degree': [78], 'resistance.': [80, 186], 'Three': [81], 'each': [83], 'quinine': [85, 133, 154, 167], '(3/31)': [86], '(3/28)': [89], 'showed': [90, 125], 'at': [92], 'concentrations': [93], '51.2': [95], '10': [98], 'nM': [99], 'respectively,': [100], 'while': [101, 136], '31': [103], 'fully': [109, 137], 'susceptible.': [110], 'comparative': [112], 'analysis': [113], 'values': [117], 'susceptible': [122, 131, 138], 'chloroquine-resistant': [126], 'be': [129], 'less': [130], 'mefloquine.': [140], 'It': [141], 'seems': [142], 'that': [143], 'evolution': [145], 'together': [149], 'increased': [151], 'use': [152], 'treatment': [155], 'P.': [157], 'malaria': [159], 'may': [160], 'increase': [161], 'risk': [163], 'emergence': [165], 'possibly': [170], 'as': [174], 'well.': [175], 'development': [177], 'resistance,': [180], 'however,': [181], 'is': [182], 'independent': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2189107156', 'counts_by_year': [{'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T00:28:21.262020', 'created_date': '2016-06-24'}