Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2188724532', 'doi': None, 'title': 'Changes in the activity of matrix metalloproteinases in regenerating rat liver after CCl4-induced injury.', 'display_name': 'Changes in the activity of matrix metalloproteinases in regenerating rat liver after CCl4-induced injury.', 'publication_year': 2003, 'publication_date': '2003-10-01', 'ids': {'openalex': 'https://openalex.org/W2188724532', 'mag': '2188724532', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22900326'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22900326', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019529286', 'display_name': 'Shiju Jacob', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I158338959', 'display_name': 'University of Kerala', 'ror': 'https://ror.org/05tqa9940', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I158338959']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Shiju Jacob', 'raw_affiliation_strings': ['Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695 581, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695 581, India', 'institution_ids': ['https://openalex.org/I158338959']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074037784', 'display_name': 'P. R. Sudhakaran', 'orcid': 'https://orcid.org/0000-0002-3980-612X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P R Sudhakaran', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.589478, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 74}, 'biblio': {'volume': '40', 'issue': '5', 'first_page': '324', 'last_page': '9'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9592, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9592, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mmp2', 'display_name': 'MMP2', 'score': 0.8950218}, {'id': 'https://openalex.org/keywords/zymography', 'display_name': 'Zymography', 'score': 0.821929}, {'id': 'https://openalex.org/keywords/mmp9', 'display_name': 'MMP9', 'score': 0.81502485}, {'id': 'https://openalex.org/keywords/ccl4', 'display_name': 'CCL4', 'score': 0.8126197}, {'id': 'https://openalex.org/keywords/gelatinases', 'display_name': 'Gelatinases', 'score': 0.6522373}, {'id': 'https://openalex.org/keywords/matrix', 'display_name': 'Matrix (chemical analysis)', 'score': 0.4568286}], 'concepts': [{'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.92817235}, {'id': 'https://openalex.org/C2780699576', 'wikidata': 'https://www.wikidata.org/wiki/Q15327913', 'display_name': 'MMP2', 'level': 4, 'score': 0.8950218}, {'id': 'https://openalex.org/C177430391', 'wikidata': 'https://www.wikidata.org/wiki/Q1173648', 'display_name': 'Zymography', 'level': 3, 'score': 0.821929}, {'id': 'https://openalex.org/C2775997469', 'wikidata': 'https://www.wikidata.org/wiki/Q18029196', 'display_name': 'MMP9', 'level': 4, 'score': 0.81502485}, {'id': 'https://openalex.org/C102124568', 'wikidata': 'https://www.wikidata.org/wiki/Q5009626', 'display_name': 'CCL4', 'level': 3, 'score': 0.8126197}, {'id': 'https://openalex.org/C2776637226', 'wikidata': 'https://www.wikidata.org/wiki/Q6658207', 'display_name': 'Liver injury', 'level': 2, 'score': 0.676831}, {'id': 'https://openalex.org/C2910246616', 'wikidata': 'https://www.wikidata.org/wiki/Q5530373', 'display_name': 'Gelatinases', 'level': 4, 'score': 0.6522373}, {'id': 'https://openalex.org/C2776232661', 'wikidata': 'https://www.wikidata.org/wiki/Q5530373', 'display_name': 'Gelatinase', 'level': 3, 'score': 0.58844644}, {'id': 'https://openalex.org/C2776200302', 'wikidata': 'https://www.wikidata.org/wiki/Q827450', 'display_name': 'Hepatocyte', 'level': 3, 'score': 0.5519596}, {'id': 'https://openalex.org/C2778394429', 'wikidata': 'https://www.wikidata.org/wiki/Q304956', 'display_name': 'Collagenase', 'level': 3, 'score': 0.5344405}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48775488}, {'id': 'https://openalex.org/C106487976', 'wikidata': 'https://www.wikidata.org/wiki/Q685816', 'display_name': 'Matrix (chemical analysis)', 'level': 2, 'score': 0.4568286}, {'id': 'https://openalex.org/C171056886', 'wikidata': 'https://www.wikidata.org/wiki/Q193119', 'display_name': 'Regeneration (biology)', 'level': 2, 'score': 0.43865743}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38003474}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.37322864}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34723032}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27782798}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2309809}, {'id': 'https://openalex.org/C2777359374', 'wikidata': 'https://www.wikidata.org/wiki/Q225045', 'display_name': 'Carbon tetrachloride', 'level': 2, 'score': 0.2240664}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19688153}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.18939063}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.119432}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.073245555}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0698708}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000293', 'qualifier_name': 'injuries', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D008115', 'descriptor_name': 'Liver Regeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008115', 'descriptor_name': 'Liver Regeneration', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22900326', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2313384069', 'https://openalex.org/W2188724532', 'https://openalex.org/W2106490396', 'https://openalex.org/W2074669451', 'https://openalex.org/W2061992885', 'https://openalex.org/W2045399305', 'https://openalex.org/W2044610509', 'https://openalex.org/W2004149502', 'https://openalex.org/W1986890976', 'https://openalex.org/W1986457921'], 'abstract_inverted_index': {'Molecular': [0], 'mechanisms': [1], 'involved': [2], 'in': [3, 6, 17, 24, 43, 125, 135], 'mediating': [4], 'alteration': [5], 'cell': [7], 'matrix': [8, 21, 136], 'interaction': [9], 'have': [10], 'been': [11], 'examined': [12], 'by': [13, 147], 'studying': [14], 'the': [15, 18, 44, 53, 72, 81, 94, 97, 102, 111, 119], 'changes': [16], 'activity': [19], 'of': [20, 33, 77, 88, 100, 104, 113, 122, 133], 'metalloproteinases': [22], '(MMPs)': [23], 'CCl4-induced': [25], 'regenerating': [26, 126], 'liver,': [27], 'using': [28], 'zymography': [29], 'and': [30, 39, 56, 90, 106, 138], 'ELISA.': [31], 'Activity': [32], 'MMPs': [34, 124, 134], '(72': [35], 'kD,': [36], '92': [37], 'kD': [38, 41], '130': [40], 'gelatinases)': [42], 'rat': [45], 'liver': [46, 79, 144], 'increased': [47, 108], 'progressively': [48, 109], 'during': [49, 140], 'acute': [50, 143], 'injury': [51, 145], 'till': [52], '4th': [54, 82], 'day': [55, 83], 'then': [57], 'decreased': [58], 'to': [59, 93], 'near': [60], 'normal': [61], 'level': [62], 'after': [63, 142], 'CCl4': [64], 'administration': [65], '(0.5': [66], 'ml/100': [67], 'g': [68], 'body': [69], 'wt.)': [70], 'on': [71, 80], '6th': [73], 'day.': [74], 'Hepatocyte': [75], 'lysate': [76], 'injured': [78], 'showed': [84], 'significantly': [85], 'higher': [86], 'levels': [87, 103], 'MMP2': [89, 105], 'MMP9': [91, 107], 'compared': [92], 'control.': [95], 'In': [96], 'culture': [98], 'medium': [99], 'hepatocytes,': [101], 'with': [110], 'duration': [112], 'culture,': [114], 'indicating': [115], 'that': [116], 'hepatocytes': [117], 'are': [118], 'major': [120], 'source': [121], 'these': [123], 'liver.': [127], 'These': [128], 'results': [129], 'suggest': [130], 'an': [131], 'involvement': [132], 'degradation': [137], 'remodeling': [139], 'regeneration': [141], 'induced': [146], 'CCl4.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2188724532', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-17T02:53:10.256731', 'created_date': '2016-06-24'}