Title: EXPOSURE TO SODIUM FLUORIDE AFFECTS THYROID FOLLICULAR CELLS IN ALBINO RATS
Abstract:Living organisms are mainly exposed to inorganic fluorides through food, water and air; it exerts toxic effects on many soft tissues and organs. The thyroid gland has a strong capacity for absorbing a...Living organisms are mainly exposed to inorganic fluorides through food, water and air; it exerts toxic effects on many soft tissues and organs. The thyroid gland has a strong capacity for absorbing and accumulating fluoride. To accomplish this, rats were exposed to sodium fluoride in a concentration of (5, 10, 15 and 20 mg/kg bw) daily through drinking water for 15 days of duration. After the treatment period rats were sacrificed and thyroid glands were removed, weight and processed for light microscopy. The results showed that the body weight of treated rats decreases while the weight of thyroid gland increases significantly. Light microscopic examination of thyroid gland shows thyroid follicles increases and colloid volume were decreases as the dose increases. In the higher dose thyroid gland showed increasing interfollicular spaces and fusion of the follicles. These results indicate that sodium fluoride exposure exerted harmful effects on rats and the thyroid gland cells.Read More
Publication Year: 2015
Publication Date: 2015-03-05
Language: en
Type: article
Access and Citation
Cited By Count: 10
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