Title: CHRONOPHARMACOTHERAPY: A NIGHT TIME THERAPY
Abstract: Historically, extended release dosage forms were developed, which release the drug continuously over longer periods of time. Recently, however, delivery systems with a pulsatile-release pattern are receiving increasing interest for the development of drugs for which conventional continuous release systems are not ideal. This system is designed for chronopharmacotherapy which is based on circadian rhythm. A pulsatile-release profile is characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not desired. These systems are beneficial for the drugs having chronopharmacological behaviour where night time dosing is required.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 1
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