Title: Corticosterone strongly increases the a⁄nity of dorsal raphe 5-HT1A receptors
Abstract: The eiects of corticosterone (10mg/kg, s.c., 6 h) on dorsal raphe 5-HT1A autoreceptors have been studied in adrenalectomized rats with or without porcine galanin modulation. Adrenalectomy diminishes 5-HT1A autoreceptors a⁄nity. Corticosterone increases 5-HT1A autoreceptor agonist a⁄nity (+90%, po0.001) in adrenalectomized rats. Galanin (10nM) increases dorsal raphe 5-HT1A autoreceptor density (+65%, po0.05) and its Kd value (+248%, po0.05) only in adrenalectomized rats treated with corticosterone. Dorsal raphe glucocorticoid receptors activation by corticosterone may therefore lead to an increased signalling of 5-HT1A autoreceptors thatmay become counteractedby galanin receptor activation. Glucocorticoids, by enhancing dorsal raphe 5-HT1A autoreceptor function, may therefore cause reduced 5-HT neuronal activity and thus lead to a depressive state. NeuroReport 15:1457^1459 c 2004 LippincottWilliams &Wilkins.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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