Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2186490019', 'doi': 'https://doi.org/10.18632/oncotarget.5154', 'title': 'Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma', 'display_name': 'Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma', 'publication_year': 2015, 'publication_date': '2015-09-08', 'ids': {'openalex': 'https://openalex.org/W2186490019', 'doi': 'https://doi.org/10.18632/oncotarget.5154', 'mag': '2186490019', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26372814', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4741620'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5154', 'pdf_url': 'https://www.oncotarget.com/article/5154/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/5154/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069512606', 'display_name': 'Imran Nawaz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I20561161', 'display_name': 'University of Balochistan', 'ror': 'https://ror.org/04bf33n91', 'country_code': 'PK', 'type': 'education', 'lineage': ['https://openalex.org/I20561161']}], 'countries': ['PK', 'SE'], 'is_corresponding': False, 'raw_author_name': 'Imran Nawaz', 'raw_affiliation_strings': ['Department of Microbiology, Faculty of Life Sciences, University of Balochistan, Quetta, Pakistan', 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'Department of Microbiology, Faculty of Life Sciences, University of Balochistan, Quetta, Pakistan', 'institution_ids': ['https://openalex.org/I20561161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112003533', 'display_name': 'Li‐Fu Hu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Li-Fu Hu', 'raw_affiliation_strings': ['Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073845618', 'display_name': 'Ziming Du', 'orcid': 'https://orcid.org/0000-0003-2667-4989'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN', 'SE'], 'is_corresponding': False, 'raw_author_name': 'Zi-Ming Du', 'raw_affiliation_strings': ['Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'State Key Laboratory of Oncology in South China, and Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, and Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, P.R. China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074842353', 'display_name': 'Khalid Moumad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151823', 'display_name': 'Institut Pasteur du Maroc', 'ror': 'https://ror.org/04yb4j419', 'country_code': 'MA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151823']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Khalid Moumad', 'raw_affiliation_strings': ['Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany', 'Oncovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco'], 'affiliations': [{'raw_affiliation_string': 'Oncovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco', 'institution_ids': ['https://openalex.org/I4210151823']}, {'raw_affiliation_string': 'Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I17937529']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019534054', 'display_name': 'Ilya Ignatyev', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ilya Ignatyev', 'raw_affiliation_strings': ['Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069656959', 'display_name': 'Pavlova Tv', 'orcid': 'https://orcid.org/0000-0002-2857-5696'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Tatiana V. Pavlova', 'raw_affiliation_strings': ['Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077943146', 'display_name': 'В. И. Кашуба', 'orcid': 'https://orcid.org/0000-0001-9416-8282'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Vladimir Kashuba', 'raw_affiliation_strings': ['Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053995530', 'display_name': 'Malin Almgren', 'orcid': 'https://orcid.org/0000-0002-1526-7694'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I4210152515', 'display_name': 'Centre for Palaeogenetics', 'ror': 'https://ror.org/04sx39q13', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I161593684', 'https://openalex.org/I2801711128', 'https://openalex.org/I4210152515']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Malin Almgren', 'raw_affiliation_strings': ['Centre for Molecular Medicine, Stockholm, Sweden', 'Department Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'Centre for Molecular Medicine, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I4210152515']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009191282', 'display_name': 'Eugene R. Zabarovsky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I102134673', 'display_name': 'Linköping University', 'ror': 'https://ror.org/05ynxx418', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I102134673']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Eugene R. Zabarovsky', 'raw_affiliation_strings': ['Department of Clinical & Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden', 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'Department of Clinical & Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden', 'institution_ids': ['https://openalex.org/I102134673']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032129206', 'display_name': 'Ingemar Ernberg', 'orcid': 'https://orcid.org/0000-0001-6518-1648'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ingemar Ernberg', 'raw_affiliation_strings': ['Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.758, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.772241, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '6', 'issue': '31', 'first_page': '31493', 'last_page': '31507'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bisulfite-sequencing', 'display_name': 'Bisulfite sequencing', 'score': 0.45157993}], 'concepts': [{'id': 'https://openalex.org/C2778997737', 'wikidata': 'https://www.wikidata.org/wiki/Q1693598', 'display_name': 'Nasopharyngeal carcinoma', 'level': 3, 'score': 0.7481425}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.65923274}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.6193366}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.60732955}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.596754}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.5722102}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.56709445}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.47992903}, {'id': 'https://openalex.org/C189235521', 'wikidata': 'https://www.wikidata.org/wiki/Q4087270', 'display_name': 'Bisulfite sequencing', 'level': 5, 'score': 0.45157993}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.36458024}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2675388}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.24177685}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17901361}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13365534}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D039001', 'descriptor_name': 'Integrin alpha Chains', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016023', 'descriptor_name': 'Integrins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009305', 'descriptor_name': 'Nasopharynx', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077209', 'descriptor_name': 'Decitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077274', 'descriptor_name': 'Nasopharyngeal Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5154', 'pdf_url': 'https://www.oncotarget.com/article/5154/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4741620', 'pdf_url': 'https://europepmc.org/articles/pmc4741620?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741620', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122660', 'pdf_url': 'https://liu.diva-portal.org/smash/get/diva2:871717/FULLTEXT01', 'source': {'id': 'https://openalex.org/S4306400837', 'display_name': 'DiVA (Linkoping University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26372814', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5154', 'pdf_url': 'https://www.oncotarget.com/article/5154/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.69, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 80, 'referenced_works': ['https://openalex.org/W102511770', 'https://openalex.org/W1504197144', 'https://openalex.org/W1517481525', 'https://openalex.org/W1552528612', 'https://openalex.org/W1593940291', 'https://openalex.org/W1609687385', 'https://openalex.org/W1620198905', 'https://openalex.org/W1646424808', 'https://openalex.org/W171400472', 'https://openalex.org/W1831033366', 'https://openalex.org/W1927648082', 'https://openalex.org/W1938323833', 'https://openalex.org/W1969445397', 'https://openalex.org/W1970541895', 'https://openalex.org/W1972733724', 'https://openalex.org/W1973867913', 'https://openalex.org/W1976788864', 'https://openalex.org/W1976845229', 'https://openalex.org/W1996776072', 'https://openalex.org/W2009327119', 'https://openalex.org/W2015201933', 'https://openalex.org/W2020695247', 'https://openalex.org/W2025453886', 'https://openalex.org/W2030061155', 'https://openalex.org/W2032004540', 'https://openalex.org/W2033940835', 'https://openalex.org/W2034879676', 'https://openalex.org/W2035717945', 'https://openalex.org/W2036986058', 'https://openalex.org/W2041345810', 'https://openalex.org/W2041795914', 'https://openalex.org/W2041889626', 'https://openalex.org/W2042397015', 'https://openalex.org/W2043330124', 'https://openalex.org/W2044170819', 'https://openalex.org/W2045292924', 'https://openalex.org/W2046313481', 'https://openalex.org/W2049174408', 'https://openalex.org/W2049641805', 'https://openalex.org/W2058009094', 'https://openalex.org/W2059243506', 'https://openalex.org/W2060690036', 'https://openalex.org/W2061006217', 'https://openalex.org/W2070727491', 'https://openalex.org/W2074788931', 'https://openalex.org/W2077213730', 'https://openalex.org/W2079043502', 'https://openalex.org/W2090154286', 'https://openalex.org/W2090757807', 'https://openalex.org/W2090810603', 'https://openalex.org/W2094230188', 'https://openalex.org/W2095430690', 'https://openalex.org/W2096600031', 'https://openalex.org/W2097403031', 'https://openalex.org/W2104181329', 'https://openalex.org/W2104673149', 'https://openalex.org/W2111247797', 'https://openalex.org/W2116297115', 'https://openalex.org/W2127086165', 'https://openalex.org/W2128497892', 'https://openalex.org/W2131465172', 'https://openalex.org/W2139122477', 'https://openalex.org/W2147517893', 'https://openalex.org/W2147623206', 'https://openalex.org/W2152654856', 'https://openalex.org/W2158659430', 'https://openalex.org/W2159664205', 'https://openalex.org/W2161706255', 'https://openalex.org/W2165035655', 'https://openalex.org/W2166525889', 'https://openalex.org/W2168967764', 'https://openalex.org/W2184787439', 'https://openalex.org/W2353788233', 'https://openalex.org/W2409528752', 'https://openalex.org/W2409713416', 'https://openalex.org/W2411593237', 'https://openalex.org/W2463321210', 'https://openalex.org/W27236305', 'https://openalex.org/W4211156657', 'https://openalex.org/W4251025034'], 'related_works': ['https://openalex.org/W3212149434', 'https://openalex.org/W2902329290', 'https://openalex.org/W2291484187', 'https://openalex.org/W2214376880', 'https://openalex.org/W2151182744', 'https://openalex.org/W2139872319', 'https://openalex.org/W2107880877', 'https://openalex.org/W2073893804', 'https://openalex.org/W2052355316', 'https://openalex.org/W2046964473'], 'abstract_inverted_index': {'//': [0], 'Imran': [1], 'Nawaz': [2], '1,': [3, 9, 14, 45, 51], '2': [4, 65], '*': [5, 16, 26, 151], ',': [6, 11, 17, 22, 27, 32, 36, 41, 48], 'Li-Fu': [7, 179], 'Hu': [8], '#': [10, 52, 160], 'Zi-Ming': [12], 'Du': [13], '3': [15, 78, 228, 256], 'Khalid': [18], 'Moumad': [19], '4,': [20], '5': [21, 112], 'Ilya': [23], 'Ignatyev': [24], '1': [25, 31, 35, 53], 'Tatiana': [28], 'V.': [29], 'Pavlova': [30], 'Vladimir': [33], 'Kashuba': [34], 'Malin': [37], 'Almgren': [38], '6,': [39], '7': [40, 129], 'Eugene': [42], 'R.': [43], 'Zabarovsky': [44], '8': [46, 136], '†': [47, 170], 'Ingemar': [49, 175], 'Ernberg': [50], 'Department': [54, 66, 88, 100, 122, 137], 'of': [55, 67, 70, 74, 82, 89, 101, 138, 144, 207, 224, 231, 272, 285, 293, 334, 359, 387, 397], 'Microbiology,': [56, 68], 'Tumor': [57], 'and': [58, 87, 261, 274, 291, 317], 'Cell': [59, 145], 'Biology,': [60, 146], 'Karolinska': [61, 125], 'Institutet,': [62, 126], 'Stockholm,': [63, 127, 134], 'Sweden': [64, 128, 135, 150], 'Faculty': [69], 'Life': [71], 'Sciences,': [72], 'University': [73, 93], 'Balochistan,': [75], 'Quetta,': [76], 'Pakistan': [77], 'State': [79], 'Key': [80], 'Laboratory': [81], 'Oncology': [83], 'in': [84, 220, 234, 246, 254, 276, 288, 304, 336, 346, 357, 376, 381], 'South': [85], 'China,': [86], 'Pathology,': [90], 'Sun': [91], 'Yat-Sen': [92], 'Cancer': [94, 106], 'Center,': [95], 'Guangzhou,': [96], 'P.R.': [97], 'China': [98], '4': [99], 'Molecular': [102, 132], 'Genetic': [103], 'Epidemiology,': [104], 'German': [105], 'Research': [107], 'Center': [108], '(DKFZ),': [109], 'Heidelberg,': [110], 'Germany': [111], 'Oncovirology': [113], 'Laboratory,': [114], 'Institut': [115], 'Pasteur': [116], 'du': [117], 'Maroc,': [118], 'Casablanca,': [119], 'Morocco': [120], '6': [121], 'Clinical': [123, 139], 'Neuroscience,': [124], 'Centre': [130], 'for': [131, 327, 394], 'Medicine,': [133, 142], '&': [140], 'Experimental': [141], 'Division': [143], 'Linköping': [147], 'University,': [148], 'Linköping,': [149], 'These': [152, 161], 'authors': [153, 163], 'have': [154, 164], 'contributed': [155, 165], 'equally': [156, 166], 'to': [157, 167, 343], 'this': [158, 168, 368], 'work': [159, 169], 'senior': [162], 'Deceased': [171], '2013': [172], 'Correspondence': [173], 'to:': [174], 'Ernberg,': [176], 'e-mail:': [177, 181], '[email protected]': [178], 'Hu,': [180], '[email protected]': [182], 'Keywords:': [183], 'nasopharyngeal': [184, 239, 296], 'carcinoma,': [185], 'ITGA9,': [186], 'DNA': [187], 'methylation,': [188], 'notI': [189], 'microarrays,': [190], 'epigenetics': [191], 'Received:': [192], 'March': [193], '15,': [194], '2015': [195, 199, 203], 'Accepted:': [196], 'August': [197], '27,': [198], 'Published:': [200], 'September': [201], '08,': [202], 'ABSTRACT': [204], 'Epigenetic': [205], 'silencing': [206], 'tumor': [208, 306, 316, 382], 'suppressor': [209], 'genes': [210, 287], '(TSGs)': [211], 'by': [212, 352], 'promoter': [213, 310], 'methylation': [214, 314, 323, 349, 353, 390], 'can': [215], 'be': [216, 264, 325, 373, 401], 'an': [217], 'early': [218, 395], 'event': [219], 'the': [221, 242, 270, 289, 328, 344], 'multi-step': [222], 'process': [223], 'carcinogenesis.': [225], 'Human': [226], 'chromosome': [227, 255], 'contains': [229], 'clusters': [230], 'TSGs': [232, 252], 'involved': [233, 380], 'many': [235], 'cancer': [236, 245], 'types': [237], 'including': [238], 'carcinoma': [240], '(NPC),': [241], 'most': [243], 'common': [244], 'Southern': [247], 'China.': [248], 'Among': [249], 'ten': [250], 'candidate': [251], 'identified': [253], 'using': [257, 388], 'NotI': [258], 'microarray,': [259], 'ITGA9': [260, 273, 309, 335, 348, 371, 389], 'WNT7A': [262, 275, 329], 'could': [263, 324], 'validated.': [265], '5′-aza-2′': [266], 'deoxycytidine': [267], 'treatment': [268], 'restored': [269], 'expression': [271, 284, 332, 345], 'two': [277], 'NPC': [278, 305, 337, 377, 398], 'cell': [279, 383], 'lines.': [280], 'Immunostaining': [281], 'showed': [282, 311], 'strong': [283], 'these': [286], 'membrane': [290], 'cytoplasm': [292], 'adjacent': [294], 'control': [295, 318], 'epithelium': [297], 'cells,': [298], 'while': [299], 'they': [300], 'were': [301], 'weakly': [302], 'expressed': [303], 'cells.': [307], 'The': [308, 331, 385], 'marked': [312], 'differentially': [313, 322], 'between': [315], 'tissue,': [319], 'whereas': [320], 'no': [321], 'detected': [326, 351], 'promoter.': [330], 'level': [333], 'tumors': [338], 'was': [339, 350], 'downregulated': [340], '4.9-fold,': [341], 'compared': [342], 'control.': [347], 'specific': [354], 'PCR': [355], '(MSP)': [356], '56%': [358], 'EBV': [360], 'positive': [361], 'NPC-cases': [362], 'with': [363], '100%': [364], 'specificity.': [365], 'Taken': [366], 'together,': [367], 'suggests': [369], 'that': [370, 378], 'might': [372], 'a': [374, 392], 'TSG': [375], 'is': [379], 'biology.': [384], 'possibility': [386], 'as': [391], 'marker': [393], 'detection': [396], 'should': [399], 'further': [400], 'explored.': [402]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2186490019', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-12T07:39:27.680502', 'created_date': '2016-06-24'}