Title: FMS-LIKE TYROSINE KINASE (FLT3) GENE ITD MUTATION IN ACUTE MYELOID LEUKEMIA MUTACIJA GENA FLT3 PRI AKUTNI MIELOBLASTNI LEVKEMIJI
Abstract:Background. FLT3 is a class III receptor tyrosine kinase expressed in normal stem cells and blasts of myeloid leukemia. Internal tandem duplication (ITD) of the FLT3 ge- ne affecting the exons 14 and ...Background. FLT3 is a class III receptor tyrosine kinase expressed in normal stem cells and blasts of myeloid leukemia. Internal tandem duplication (ITD) of the FLT3 ge- ne affecting the exons 14 and 15 leads to ligand-independent FLT3 dimerization and constitutive activation. This stimula- tes proliferation and induces inhibition of apoptosis which contributes to leukemogenesis. We have screened a panel of acute myeloid leukemia (AML) patients for the occurrence of FLT3/ITD mutation and correlated this mutation to patients' survival and basic hematological parameters.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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