Abstract: Cyclopropane having alkane and alkene properties plays an important role in many reactions and its intermediates. There has been numerous researches done on the reactions of Donor-Acceptor cyclopropane (D-A cyclopropane) (Reisig & Zimmer, 2003), otherwise known as di-activated cyclopropane. However, only a little attention was focused on the chemistry of mono-activated cyclopropane. It is hypothesized that mono-activated cyclopropane can also achieve the same results as that of a di-activated one. This can be actualized by employing a highly ring strain hydrocarbon, and a mono-substituent. With the development of methodology for the mono-activated cyclopropane, simplification to the synthetic steps of complex organic structures can be made. Until now, it can be concluded that SnCl 4 seemed to be a suitable catalyst for this reaction. A good reactive rigid carbonyl cyclopropane may be bicyclo[3.1.0]hexanone while 2,3-dihydropyran is not a good olefin (substrate). Although the development of this methodology is still at its infancy, successful advancement in this area of research will allow us to experiment with the concept on dynamic combinatorial chemistry.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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