Title: Coronary Hemodynamics and Myocardial Metabolism in Septic Shock
Abstract: In recent years, increasing effort has been devoted to the study of the hemodynamic and metabolic alterations accompanying septic shock. The hemodynamic pattern of septic shock in humans is generally characterized by a high cardiac output and a low systemic vascular resistance [1, 2]. The hyperdynamic circulation is not likely due to peripheral arterio-venous shunts, since, in skeletal muscle at least, capillary blood flow is increased, and varies directly with cardiac index [3]. Such an hyperdynamic circulatory state seems to be related to profound metabolic abnormalities, resulting in a rapid catabolism rather than changes in oxygen transport. However, there is strong evidence that myocardial dysfunction can occur early in experimental [4] and human [5] septic shock, even in the presence of an elevated cardiac output, and may contribute to the deterioration of the condition. It is likely that both altered cardiac performance and peripheral vascular and cellular function combine to produce inadequate tissue flow, progressive organ failure, and ultimately death of the patient.
Publication Year: 1987
Publication Date: 1987-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 3
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot