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{'id': 'https://openalex.org/W2184089550', 'doi': 'https://doi.org/10.1074/mcp.m115.051938', 'title': 'Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells*', 'display_name': 'Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells*', 'publication_year': 2015, 'publication_date': '2015-10-01', 'ids': {'openalex': 'https://openalex.org/W2184089550', 'doi': 'https://doi.org/10.1074/mcp.m115.051938', 'mag': '2184089550', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26424601', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4762615'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m115.051938', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1074/mcp.m115.051938', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059973854', 'display_name': 'Margarita Villar', 'orcid': 'https://orcid.org/0000-0003-4172-9079'}, 'institutions': [{'id': 'https://openalex.org/I4210107500', 'display_name': 'Instituto de Investigación en Recursos Cinegéticos', 'ror': 'https://ror.org/0140hpe71', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210107500', 'https://openalex.org/I4210122281', 'https://openalex.org/I79189158']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Margarita Villar', 'raw_affiliation_strings': ['From the ‡SaBio. 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723, 738, 754, 948, 1073, 1167, 1212, 1254, 1291, 1388, 1448, 1489, 1532, 1615, 1660, 1698, 1795, 1863, 1952, 1956, 1979, 2052, 2208, 2256, 2264, 2273, 2300, 2388, 2447, 2471, 2587, 2607, 2642, 2846, 2866, 2909, 2934, 3019, 3046, 3109, 3177, 3288, 3580, 3667, 3821, 3839, 4020, 4114, 4153, 4191], 'both': [22, 321, 2808, 3846], 'the': [23, 27, 36, 49, 52, 67, 79, 94, 112, 174, 178, 210, 239, 259, 273, 322, 326, 335, 348, 351, 366, 378, 393, 411, 473, 477, 509, 538, 558, 572, 603, 649, 657, 713, 730, 742, 862, 866, 884, 913, 929, 1027, 1030, 1074, 1168, 1389, 1421, 1443, 1490, 1616, 1796, 1828, 1877, 1920, 2005, 2020, 2107, 2126, 2144, 2154, 2160, 2171, 2232, 2277, 2324, 2339, 2345, 2442, 2599, 2684, 2703, 2714, 2802, 2841, 2935, 2974, 2989, 3012, 3078, 3089, 3096, 3113, 3117, 3128, 3135, 3171, 3214, 3267, 3277, 3296, 3515, 3611, 3681, 3806, 3822, 3840, 3843, 3901, 3960, 3973, 3977, 3987, 4007, 4021], 'vertebrate': [24, 323], 'host': [25, 324, 707, 762], 'and': [26, 39, 69, 78, 86, 102, 136, 150, 214, 225, 284, 325, 338, 368, 377, 385, 401, 435, 449, 513, 524, 583, 611, 615, 656, 669, 712, 756, 764, 891, 905, 918, 923, 934, 953, 1010, 1106, 1338, 1386, 1446, 1545, 1557, 1745, 1793, 1870, 1895, 1901, 2022, 2106, 2114, 2149, 2188, 2194, 2211, 2226, 2260, 2267, 2276, 2318, 2404, 2438, 2463, 2474, 2482, 2574, 2594, 2628, 2678, 2722, 2732, 2810, 2891, 2968, 2971, 3002, 3005, 3024, 3033, 3052, 3056, 3061, 3086, 3095, 3134, 3162, 3195, 3235, 3249, 3263, 3322, 3598, 3627, 3631, 3637, 3670, 3724, 3731, 3761, 3783, 3811, 3882, 3898, 3911, 3941, 3979, 3999, 4111, 4183, 4187], 'tick': [28, 37, 113, 121, 155, 168, 179, 211, 240, 268, 327, 336, 412, 420, 454, 467, 478, 510, 539, 567, 717, 746, 915, 932, 989, 1075, 1092, 1169, 1213, 1256, 1345, 1390, 1422, 1444, 1491, 1534, 1546, 1617, 1661, 1752, 1797, 1829, 2130, 2163, 2233, 2265, 2278, 2287, 2325, 2448, 3014, 3629, 3639, 4185], 'vector,': [29, 328, 1391, 1798], 'Ixodes': [30, 329, 991, 1077, 1171, 1203, 1292, 1392, 1493, 1619, 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'M.S.': [621, 1112, 1560], 'Pedra': [622, 1113, 1561], 'J.H.': [623, 1114, 1562], 'F.': [624, 822, 848, 1115, 1563, 3404, 3545, 3559, 3567], 'Ayllón': [625, 1116, 1358, 1407, 1564, 1765, 1814, 4223], 'N.': [626, 1039, 1117, 1133, 1191, 1306, 1359, 1408, 1455, 1565, 1581, 1639, 1713, 1766, 1815, 1974, 2047, 3350, 3392, 3443, 3449, 4135, 4224], 'Kocan': [627, 1044, 1118, 1138, 1240, 1311, 1367, 1460, 1518, 1566, 1586, 1718, 1774, 2379], 'K.M.': [628, 1045, 1119, 1139, 1241, 1312, 1368, 1461, 1519, 1567, 1587, 1719, 1775, 2380], 'de': [629, 778, 813, 973, 1058, 1120, 1152, 1242, 1324, 1330, 1361, 1377, 1413, 1474, 1520, 1568, 1600, 1731, 1737, 1768, 1784, 1820, 1960, 2033, 3232, 4226, 4237], 'la': [630, 779, 814, 974, 1059, 1121, 1153, 1243, 1325, 1331, 1362, 1378, 1414, 1475, 1521, 1569, 1601, 1732, 1738, 1769, 1785, 1821, 2120, 2368, 4238], 'Fuente': [631, 780, 815, 975, 1060, 1122, 1154, 1244, 1332, 1379, 1415, 1476, 1522, 1570, 1602, 1739, 1786, 1822, 2121, 2369, 4239], 'J.': [632, 781, 816, 844, 858, 976, 1051, 1061, 1123, 1145, 1155, 1245, 1329, 1333, 1380, 1412, 1416, 1467, 1477, 1523, 1571, 1593, 1603, 1736, 1740, 1787, 1819, 1823, 1887, 2122, 2370, 3384, 3386, 3459, 3477, 3555, 4240], 'Molecular': [633, 1124, 1572], 'Medical': [634, 1125, 1573], 'Microbiology.Academic': [635, 1126, 1574], 'Press.': [636, 678, 1127, 1575], '2015;': [637, 1080, 1128, 1174, 1496, 1576, 1622, 2099], ':': [638, 680, 1129, 1577], '2033-2042Google': [639, 1130, 1578], 'Scholar).': [640, 704, 879, 1003, 1087, 1438, 1845, 1997, 2139, 2244, 2928, 2987, 4043], 'has': [643, 1024, 1873], 'been': [644, 1549, 1874, 1946], 'reported': [645], 'be': [647, 899], 'one': [648, 2800], 'most': [650, 687], 'common': [651], 'Europe': [655], 'United': [658], 'States': [659], 'where': [660, 3907], 'it': [661], 'vectored': [663], 'I.': [665, 667, 670, 909, 1959, 2032, 2197, 2284, 2886, 3368, 3457, 3510, 3551, 3961], 'ricinus,': [666], 'scapularis,': [668], 'pacificus': [671], '(2.Goodman': [672], 'J.L.': [673, 2436, 4071], 'Tick-Borne': [674], 'Diseases': [675], 'Humans.ASM': [677], '2005;': [679, 2396], '218-238Google': [681], 'Scholar,': [682, 806, 966, 1131, 1181, 1225, 1266, 1304, 1355, 1402, 1503, 1579, 1629, 1673, 1711, 1762, 1809, 1913, 2070, 2856, 2878, 2903, 3338, 3433, 3527, 4129], '3.Stuen': [683], 'S.': [684, 856, 1185, 1633, 3358, 3372, 3453, 3469, 3549], 'phagocytophilum–The': [686], 'widespread': [688], 'animals': [692], 'Europe.Vet.': [694], 'Res.': [695, 3425, 3519, 3583], 'Commun.': [696], '2007;': [697, 959, 2871, 3426], '31:': [698, 2133, 4086], '79-84Crossref': [699], 'PubMed': [700, 802, 875, 962, 1083, 1177, 1221, 1300, 1351, 1398, 1434, 1499, 1625, 1669, 1707, 1758, 1805, 1841, 1909, 1929, 1993, 2066, 2101, 2135, 2240, 2332, 2399, 2456, 2852, 2874, 2899, 2924, 2983, 3334, 3429, 3523, 3587, 4014, 4039, 4088, 4125], 'Scopus': [701, 803, 876, 963, 1084, 1178, 1222, 1263, 1301, 1352, 1399, 1435, 1500, 1541, 1626, 1670, 1708, 1759, 1806, 1842, 1910, 1930, 1994, 2067, 2102, 2136, 2241, 2333, 2400, 2853, 2875, 2900, 2925, 2984, 3335, 3430, 3524, 3588, 4015, 4040, 4089, 4126, 4167], '(196)': [702], 'Google': [703, 805, 878, 965, 1002, 1086, 1180, 1224, 1265, 1303, 1354, 1401, 1437, 1502, 1543, 1628, 1672, 1710, 1761, 1808, 1844, 1912, 1932, 1996, 2069, 2104, 2138, 2243, 2335, 2402, 2457, 2855, 2877, 2902, 2927, 2986, 3337, 3432, 3526, 3590, 4017, 4042, 4091, 4128, 4169], 'wide': [706], 'range': [708, 2995], 'extensive': [714], 'distribution': [715], 'vector': [718, 747, 1031, 1076, 1093, 1170, 1492, 1618], 'populations': [719, 748], 'will': [720], 'likely': [721, 897], 'result': [722], 'establishment': [724], 'reservoir': [726, 761], 'hosts,': [727], 'followed': [728, 2647, 3779], 'continued': [731], 'emergence': [732], 'enzootic': [734], 'several': [739], 'regions': [740, 4116], 'world.': [743], 'In': [744, 3198], 'addition,': [745], 'expanding': [750], 'due': [751], 'changes': [753], 'climate': [755], 'interventions': [758], 'impact': [760], 'movement': [763], 'contact': [766], '(4.Estrada-Peña': [770], 'Ostfeld': [772, 829], 'R.S.': [773, 2825], 'Peterson': [774, 831], 'A.T.': [775, 1310, 1717], 'Poulin': [776, 845], 'R.': [777, 830, 842, 846, 982, 1047, 1141, 1231, 1372, 1406, 1463, 1509, 1589, 1779, 1813, 2073, 2953, 3346, 3402, 3408, 3441, 3455, 3479, 3500, 3504, 3543, 3563, 3565, 3571, 4236], 'Effects': [782], 'environmental': [784], 'change': [785], 'on': [786, 1026, 1948, 2001, 3039, 3306, 3829, 3868, 3900], 'disease': [788, 988], 'risk:': [789], 'An': [790, 1202, 1650, 3825], 'ecological': [791], 'primer.Trends': [792], 'Parasitol.': [793, 2236, 2328], '2014;': [794, 872, 999, 1926, 4164], '30:': [795], '205-214Abstract': [796], 'Full': [797, 799, 2919, 2921], 'Text': [798, 800, 2920, 2922], 'PDF': [801, 2923], '(159)': [804], '5.Gortazar': [807], 'C.': [808, 826, 836, 840, 1233, 1511, 2094, 2221, 2313, 2376, 3344, 3360, 3437, 3537, 3993, 4025, 4063, 4139], 'Reperant': [809], 'L.A.': [810], 'Kuiken': [811], 'T.': [812, 832, 1972, 2045, 3412, 3531, 3561], 'Boadella': [817], 'M.': [818, 838, 972, 1041, 1135, 1308, 1376, 1410, 1457, 1583, 1715, 1783, 1817, 1964, 2037, 2219, 2311, 2819, 2860, 2880, 3314, 3364, 3388, 3390, 3485, 3494, 3535, 3995, 4067, 4104, 4220, 4222, 4234], 'Martínez-Lopez': [819], 'B.': [820, 1183, 1631, 2432, 3445, 3991, 4131], 'Ruiz-Fons': [821], 'Estrada-Peña': [823, 977], 'Drosten': [825], 'Medley': [827], 'G.': [828, 1270, 1677, 2955, 3378], 'VerCauteren': [833], 'K.C.': [834], 'Menge': [835], 'Artois': [837], 'Schultsz': [839], 'Delahay': [841], 'Serra-Cobo': [843], 'Keck': [847], 'Aguirre': [849], 'A.A.': [850], 'Henttonen': [851], 'H.': [852, 1268, 1675, 1915], 'Dobson': [853], 'A.P.': [854], 'Kutz': [855], 'Lubroth': [857], 'Mysterud': [859], 'Crossing': [861], 'interspecies': [863], 'barrier:': [864], 'Opening': [865], 'door': [867], 'pathogens.PLoS': [870], 'Pathog.': [871], '10:': [873, 4012], 'e1004129Crossref': [874], '(106)': [877], 'All': [880, 3031, 3220], 'these': [881], 'factors': [882], 'increase': [883], 'risk': [885], 'acquiring': [887], 'thus': [892], 'growing': [901], 'concern': [902], 'animal': [906], 'health.': [907], 'scapularis': [910, 1204, 1293, 1652, 1700, 2198, 2285, 3962], 'genome': [911, 916, 949, 3964, 3975], 'only': [914], 'sequenced': [917, 3912], 'assembled': [919], '(GenBank': [920], 'accession': [921], 'ABJB010000000)': [922], 'constitutes': [924], 'valuable': [926], 'resource': [927], '(6.Geraci': [937], 'N.S.': [938], 'Johnston': [939], 'J.S.': [940], 'Robinson': [941], 'J.P.': [942], 'Wikel': [943], 'S.K.': [944], 'Hill': [945], 'C.A.': [946, 3467], 'Variation': [947], 'size': [950, 3743], 'argasid': [952], 'ixodid': [954], 'ticks.Insect.': [955], 'Biochem.': [956, 2870], 'Mol.': [957, 996, 2097], 'Biol.': [958, 2098, 4010, 4162], '37:': [960, 2454, 3521], '399-408Crossref': [961], '(65)': [964], '7.Genomic': [967], 'Resources': [968, 994], 'Development': [969], 'Consortium': [970], 'Contreras': [971], 'Grubhoffer': [979], 'L.': [980, 1966, 2039, 2084, 2086, 2418, 2947, 3362, 3410, 3418, 3461, 3475, 3506, 4027, 4069, 4073, 4230], 'Tobes': [981, 4235], 'Transcriptome': [983], 'sequence': [984, 3145, 3176, 3218, 3965], 'divergence': [985], 'between': [986, 2966, 3635], 'Lyme': [987], 'vectors,': [990], 'scapularisIxodes': [992], 'ricinus.Genomic': [993], 'Notes': [995], 'Ecol.': [997], 'Resour.': [998], '14:': [1000], '1095PubMed': [1001], 'Postgenomic': [1004], 'approaches': [1006], 'transcriptomics': [1009, 2731], 'increased': [1013], 'our': [1014, 1022], 'understanding': [1015, 2155], 'Recent': [1019], 'research': [1020, 1850], 'group': [1023], 'focused': [1025], 'characterization': [1028], 'competency': [1032, 1094], '(8.Ayllón': [1038, 1454], 'Villar': [1040, 1134, 1307, 1375, 1456, 1582, 1714, 1782], 'Galindo': [1042, 1136, 1317, 1365, 1458, 1584, 1724, 1772, 4231], 'R.C.': [1043, 1137, 1318, 1366, 1459, 1585, 1725, 1773, 4232], 'Šíma': [1046, 1140, 1405, 1462, 1588, 1812], 'López': [1048, 1142, 1464, 1590], 'J.A.': [1049, 1143, 1465, 1591, 3463], 'Vázquez': [1050, 1144, 1466, 1592], 'Alberdi': [1052, 1146, 1321, 1373, 1468, 1594, 1728, 1780], 'P.': [1053, 1057, 1147, 1151, 1322, 1374, 1418, 1469, 1473, 1595, 1599, 1729, 1781, 1825, 2372, 3370, 3376, 3471, 3473, 3557], 'Cabezas-Cruz': [1054, 1148, 1470, 1596], 'Kopáček': [1056, 1150, 1472, 1598], 'Systems': [1062, 1156, 1478, 1604], 'tissue-specific': [1065, 1159, 1481, 1607], 'reveals': [1070, 1164, 1486, 1612, 4108], 'differentiated': [1071, 1165, 1487, 1613], 'scapularis.PLoS': [1078, 1172, 1393, 1494, 1620, 1800], 'Genet.': [1079, 1173, 1495, 1621], '11:': [1081, 1175, 1497, 1623], 'e1005120Crossref': [1082, 1176, 1498, 1624], '(100)': [1085, 1179, 1501, 1627], 'demonstrated': [1090], 'involves': [1095], 'ensure': [1099, 3835], 'infect,': [1104], 'develop,': [1105], 'transmitted': [1108, 1426, 1833], '8.Ayllón': [1132, 1580], '9.Sukumaran': [1182, 1630], 'Narasimhan': [1184, 1632], 'Anderson': [1186, 1634], 'J.F.': [1187, 1635], 'DePonte': [1188, 1636], 'K.': [1189, 1637, 2077, 3354, 3374, 4100], 'Marcantonio': [1190, 1638], 'Krishnan': [1192, 1640], 'M.N.': [1193, 1641], 'Fish': [1194, 1275, 1642, 1682], 'D.': [1195, 1276, 1643, 1683, 1970, 2043, 3342, 3352, 3356, 3380, 3406, 3481, 3483, 3498, 3553], 'Telford': [1196, 1644], 'S.R.': [1197, 1645], 'Cantor': [1198, 1646], 'F.S.': [1199, 1272, 1647, 1679], 'Fikrig': [1200, 1279, 1648, 1686], 'E.': [1201, 1280, 1316, 1649, 1687, 1723, 2079, 3451, 3465, 3547], 'required': [1206, 1654], 'salivary': [1214, 1662], 'glands.J.': [1215, 1663], 'Exp.': [1216, 1295, 1664, 1702], 'Med.': [1217, 1296, 1665, 1703], '2006;': [1218, 1666], '203:': [1219, 1667], '1507-1517Crossref': [1220, 1668], '(93)': [1223, 1671], '10.Zivkovic': [1226, 1504], 'Z.': [1227, 1505], 'Blouin': [1228, 1313, 1369, 1506, 1720, 1776, 2373], 'E.F.': [1229, 1314, 1370, 1507, 1721, 1777, 2374], 'Manzano-Roman': [1230, 1508], 'Almazán': [1232, 1510, 2375], 'Naranjo': [1234, 1512, 2377], 'V.': [1235, 1357, 1513, 1764, 2075, 2378, 2416, 3569], 'Massung': [1236, 1514], 'R.F.': [1237, 1515], 'Jongejan': [1238, 1516], 'F': [1239, 1517], 'phagocytophilumA.': [1247, 1525], 'marginale': [1248, 1526], 'elicit': [1249, 1527], 'different': [1250, 1528], 'gene': [1251, 1289, 1529, 1696, 2760, 4077, 4109, 4152], 'expression': [1252, 1530, 2382, 4110], 'responses': [1253, 1531], 'cultured': [1255, 1533, 2299], 'cells.Comp.': [1257, 1535], 'Funct.': [1258, 1536], 'Genomics.': [1259, 1537], '2009;': [1260, 1538, 3520, 4011, 4036], '2009:': [1261, 1539], '705034Crossref': [1262, 1540], '(30)': [1264, 1542], '11.Sultana': [1267, 1674], 'Neelakanta': [1269, 1676], 'Kantor': [1271, 1678], 'Malawista': [1273, 1680], 'S.E.': [1274, 1681], 'Montgomery': [1277, 1684], 'R.R.': [1278, 1685], 'actin': [1284, 1691], 'phosphorylation': [1285, 1692], 'selectively': [1287, 1694], 'regulate': [1288, 1695], 'transcription': [1290, 1697], 'ticks.J.': [1294, 1701], '2010;': [1297, 1704, 2896, 2916], '207:': [1298, 1705], '1727-1743Crossref': [1299, 1706], '(59)': [1302, 1709], '12.Ayllón': [1305, 1712], 'Busby': [1309, 1716], 'Bonzon-Kulichenko': [1315, 1722], 'Mangold': [1319, 1726], 'A.J.': [1320, 1727], 'Pérez': [1323, 1360, 1730, 1767], 'Lastra': [1326, 1363, 1733, 1770], 'J.M.': [1327, 1364, 1734, 1771, 2422], 'Vazquez': [1328, 1735], 'inhibits': [1336, 1743], 'promotes': [1339, 1746], 'cytoskeleton': [1340, 1747], 'rearrangement': [1341, 1748], 'cells.Infect.': [1346, 1753], 'Immun.': [1347, 1754], '2013;': [1348, 1395, 1431, 1755, 1802, 1838, 2132, 3584, 4085], '81:': [1349, 1756], '2415-2425Crossref': [1350, 1757], '(56)': [1353, 1760], '13.Naranjo': [1356, 1763], 'Mitra': [1371, 1778], 'Reciprocal': [1381, 1788], 'regulation': [1382, 1789, 4078], 'NF-kB': [1384, 1791], '(Relish)': [1385, 1792], 'Subolesin': [1387, 1794], 'ONE.': [1394, 1801, 4121], '8:': [1396, 1803], 'e65915Crossref': [1397, 1804], '(36)': [1400, 1807], '14.Hajdušek': [1403, 1810], 'O.': [1404, 1811, 2124, 2829], 'Jalovecká': [1409, 1816], 'Perner': [1411, 1818], 'Kopacek': [1417, 1824], 'Interaction': [1419, 1826], 'system': [1424, 1831], 'pathogens.Front.': [1427, 1834], 'Cell.': [1428, 1835], 'Infect.': [1429, 1836], 'Microbiol.': [1430, 1837, 1904, 2395, 2452], '3:': [1432, 1839], '26Crossref': [1433, 1840], '(150)': [1436, 1843], 'Two': [1439, 4174], 'Scholar)': [1544, 2105, 2403, 2458, 4018, 4092, 4170], 'proteins': [1547], 'identified': [1550, 3665], 'mediate': [1552], 'multiplication,': [1556], 'transmission': [1558], 'Metabolomics': [1846, 1872, 2861], 'field': [1851], 'concerned': [1852], 'developing': [1854], 'methods': [1855, 3880, 4147], 'analysis': [1857, 2842, 2942, 4049, 4075, 4206], 'low': [1859, 2814], 'weight': [1861, 2816], 'compounds': [1862, 3115, 3616], 'cells,': [1868, 2200, 3630, 4186], 'organs,': [1869], 'organisms.': [1871], 'diseases': [1881, 1978, 2051, 2118], '(15.Fuchs': [1882], 'T.M.': [1883], 'Eisenreich': [1884], 'W.': [1885, 1889, 2082], 'Heesemann': [1886], 'Goebel': [1888], 'Metabolic': [1890], 'adaptation': [1891], 'pathogenic': [1894], 'related': [1896], 'nonpathogenic': [1897], 'extra-': [1900], 'habitats.FEMS': [1903], 'Rev.': [1905], '2012;': [1906, 1990, 2063], '36:': [1907], '435-462Crossref': [1908], '(82)': [1911], '16.Eoh': [1914], 'Metabolomics:': [1916], 'window': [1918], 'into': [1919], 'adaptive': [1921], 'physiology': [1922], 'Mycobacterium': [1924], 'tuberculosis.Tuberculosis.': [1925], '94:': [1927], '538-543Crossref': [1928], '(16)': [1931], 'Scholar),': [1933, 2336], 'not': [1937], 'ticks.': [1940], 'Only': [1941], 'few': [1943], 'published': [1947, 3307], 'selected': [1949, 4198], 'grown': [1955], 'culture': [1957, 2888], '(17.Marcelino': [1958, 2031], 'Almeida': [1961, 2034], 'A.M.': [1962, 2035, 3400], 'Ventosa': [1963, 2036], 'Pruneau': [1965, 2038], 'Meyer': [1967, 2040], 'D.F.': [1968, 2041], 'Martinez': [1969, 2042], 'Lefrançois': [1971, 2044], 'Vachiéry': [1973, 2046], 'Coelho': [1975, 2048], 'A.V.': [1976, 2049], 'Tick-borne': [1977, 2050], 'cattle:': [1980, 2053], 'Applications': [1981, 2054], 'develop': [1985, 2058], 'generation': [1987, 2060], 'vaccines.J.': [1988, 2061], 'Proteomics.': [1989, 2062], '75:': [1991, 2064, 2850], '4232-4350Crossref': [1992, 2065], '(62)': [1995, 2068, 2137, 2401], 'Rather': [1998], 'than': [1999], 'focusing': [2000], 'single': [2002], 'studies,': [2004], '18.Van': [2071], 'Assche': [2072], 'Broeckx': [2074], 'Boonen': [2076], 'Maes': [2078], 'De': [2080, 3488], 'Haes': [2081], 'Schoofs': [2083], 'Temmerman': [2085], 'Integrating': [2087], '-omics:': [2088], 'explored': [2092], 'elegans': [2095], 'research.J.': [2096], 'Crossref': [2100], '(26)': [2103], '(19.de': [2119], 'Merino': [2123], 'Vaccinomics,': [2125], 'roads': [2128], 'vaccines.Vaccine.': [2131], '5923-5929Crossref': [2134], 'Our': [2140], 'objective': [2141], 'was': [2142, 2182, 2298, 2342, 2461, 2550, 2681, 2698, 2728, 3092, 3101, 3131, 3146, 3156, 3304, 3700, 3710, 3728, 3737, 3759, 3764, 3831, 3853, 3865, 4053, 4211], 'expand': [2153], 'playing': [2166], 'critical': [2168], 'role': [2169], 'at': [2170, 2496, 2554, 2568, 2663, 3049, 3053, 3205, 3845, 4079], 'interface.': [2173], 'To': [2174], 'address': [2175], 'objective,': [2177], 'developed': [2183], 'integrate': [2185], 'collected': [2191, 2677], 'uninfected': [2193, 2479, 3626, 3636, 4182], 'phagocytophilum-infected': [2196], '(20.Munderloh': [2214, 2306], 'U.G.': [2215, 2307, 2412], 'Liu': [2216, 2308, 3472, 3538, 3556], 'Y.': [2217, 2309, 3394, 3496, 3539, 3541], 'Wang': [2218, 2310], 'Chen': [2220, 2312], 'Kurtti': [2222, 2314, 2427], 'T.J.': [2223, 2315, 2428], 'Establishment,': [2224, 2316], 'maintenance': [2225, 2317], 'description': [2227, 2319], 'lines': [2230, 2322], 'scapularis.J.': [2235, 2327], '1994;': [2237, 2329], '80:': [2238, 2330], '533-543Crossref': [2239, 2331], '(201)': [2242, 2334], '(ER)': [2259], 'coevolved': [2270], 'embryo-derived': [2286], 'line': [2289], 'ISE6,': [2290], 'provided': [2291], 'Ulrike': [2293], 'Munderloh,': [2294], 'University': [2295], 'Minnesota,': [2297], 'l-15B300': [2301], 'medium': [2302], 'described': [2304, 4057], 'previously': [2305], 'except': [2337], 'osmotic': [2340], 'pressure': [2341], 'lowered': [2343], 'addition': [2346, 3612], 'one-fourth': [2348], 'sterile': [2349], 'water': [2350], 'volume.': [2352], 'were': [2356, 2469, 2494, 2566, 2577, 2605, 2637, 2661, 2676, 2718, 3017, 3037, 3067, 3075, 3107, 3140, 3168, 3187, 3203, 3211, 3222, 3253, 3261, 3273, 3286, 3608, 3621, 3633, 3675, 3777, 3896, 3909, 3928, 3957, 3970, 4177, 4197], 'inoculated': [2358], '(human': [2362], 'NY18': [2363], 'isolate)-infected': [2364], 'HL-60': [2365], '(21.de': [2367], 'Ayoubi': [2371], 'Gene': [2381, 4203], 'profiling': [2383], 'promyelocytic': [2386], 'phagocytophilum.Cell.': [2394], '7:': [2397], '549-559Crossref': [2398], 'maintained': [2405], 'according': [2406, 3793], 'Munderloh': [2408], 'et': [2409, 4060], 'al.': [2410, 4061], '(22.Munderloh': [2411], 'Jauron': [2413], 'S.D.': [2414], 'Fingerle': [2415], 'Leitritz': [2417], 'Hayes': [2419], 'S.F.': [2420], 'Hautman': [2421], 'Nelson': [2423], 'C.M.': [2424], 'Huberty': [2425], 'B.W.': [2426], 'Ahlstrand': [2429], 'G.G.': [2430], 'Greig': [2431], 'Mellencamp': [2433], 'M.A.': [2434, 3366], 'Goodman': [2435], 'Invasion': [2437], 'development': [2440], 'ehrlichiosis': [2445], 'culture.J.': [2450], 'Clin.': [2451], '1999;': [2453], '2518-2524Crossref': [2455], 'until': [2459, 2590], 'established': [2462], 'routinely': [2464], 'passaged.': [2465], 'Infected': [2466], 'frozen': [2470, 2586], 'liquid': [2472, 2588], 'nitrogen': [2473, 2589], 'served': [2475], 'inoculum': [2477], 'Uninfected': [2481], 'cultures': [2484, 2489, 2706], '(n': [2485], '=': [2486, 3649], '3': [2487, 2572], 'independent': [2488], '∼107': [2491], 'each)': [2493], 'sampled': [2495], '7': [2497], 'days': [2498], 'postinfection': [2499], '(percentage': [2500], '71–77%': [2503], '(Ave': [2504], '1The': [2505], 'abbreviations': [2506], 'are:AveaverageBPbiological': [2508], 'processCtPCR': [2509], 'cycle': [2510, 2749], 'thresholdDNAdeoxyribonucleic': [2511], 'acidERendoplasmic': [2512], 'reticulumFDRfalse': [2513], 'rateFITCfluorescein': [2515], 'isothiocyanateGOgene': [2516], 'ontologyHRPhorseradish': [2517], 'peroxidaseHspheat': [2518], 'shock': [2519, 2765], 'proteinIgGimmunoglobulin': [2520], 'GMKKmitogen-activated': [2521], 'kinaseMMmethyl': [2523], 'methanesulfonatemRNAmessenger': [2524], 'RNANMRnuclear': [2525], 'magnetic': [2526, 2582, 2777, 3714, 3769], 'resonancePEPCKphosphoenolpyruvate': [2527], 'carboxykinaseppmparts': [2528], 'per': [2529, 2782, 3660, 3948], 'millionPSMpeptide-spectrum': [2530], 'matchesrDNAribosomal': [2531], 'DNARNAribonucleic': [2532], 'acidRNAiRNA': [2533], 'interferencerRNAribosomal': [2534], 'RNASDstandard': [2535], 'deviation.': [2536, 2795], '±': [2537, 2540], 'SD,': [2538], '74': [2539], '3).': [2541], 'percentage': [2543], 'calculated': [2551], 'examining': [2553], 'least': [2555], '200': [2556, 2664], 'using': [2558, 2683, 2707, 2835, 3116, 3159, 3680, 3712, 3766, 3887, 3913, 3976, 4093], '100x': [2560], 'oil': [2561], 'immersion': [2562], 'objective.': [2563], 'centrifuged': [2567, 2662], '10,000': [2569], 'g': [2570, 2666], 'min,': [2573], 'pellets': [2576], 'lyophilized': [2578, 3013], '1H': [2580, 2930, 3060, 3072, 3270, 3299, 3321, 3656], 'nuclear': [2581, 2776, 3181], 'resonance': [2583, 2778], '(NMR)': [2584], 'or': [2585], 'RNA': [2595, 2697, 2727, 2775, 2790, 2793, 3686, 3699, 3709, 3717, 3727], 'extraction.': [2596], 'Cells': [2597], 'three': [2600, 2654], 'replicates': [2601, 3620, 4176], 'each': [2603, 3280, 3624, 4180], 'condition': [2604], 'pooled': [2606], '500': [2608, 3020, 3043], 'μl': [2609, 3021], 'lysis': [2610], 'buffer': [2611], '(phosphate': [2612], 'buffered': [2613], 'saline': [2614], '(PBS),': [2615], '1%': [2616], 'Triton': [2617], 'X-100,': [2618], 'supplemented': [2619], 'Complete': [2621], 'protease': [2622], 'inhibitor': [2623], 'mixture': [2624], '(Roche,': [2625], 'Basel,': [2626], 'Switzerland),': [2627], 'homogenized': [2629], 'passing': [2631], 'needle': [2634], '(27G).': [2635], 'Samples': [2636], 'sonicated': [2638], '1': [2640, 3696, 3951], 'min': [2641, 2669], 'ultrasonic': [2644], 'cooled': [2645], 'bath,': [2646], 'vortexing': [2649], '10': [2651], 's.': [2652], 'After': [2653], 'cycles': [2655, 3852], 'sonication–vortex,': [2657], 'total': [2658, 3698], 'extracts': [2660], '×': [2665, 3924, 3952], '5': [2668, 3027], 'remove': [2671], 'debris.': [2673], 'supernatants': [2675], 'concentration': [2680], 'determined': [2682], 'BCA': [2685], 'Protein': [2686], 'Assay': [2687], '(Life': [2688], 'Technologies,': [2689], 'Carlsbad,': [2690], 'CA)': [2691], 'BSA': [2693], 'standard.': [2695, 3892], 'Total': [2696, 2726, 3163], 'extracted': [2699], 'aliquots': [2701], 'same': [2704], 'TriReagent': [2708], '(Sigma,': [2709], 'St.': [2710], 'Louis,': [2711], 'MO)': [2712], 'following': [2713, 3118, 3185], "manufacturer's": [2715], 'recommendations.': [2716], 'Proteins': [2717], 'Western': [2723], 'blot': [2724], 'analyses.': [2725], 'real-time': [2733, 2743, 3885], 'RT-PCR.': [2734, 2744], 'Supplemental': [2735, 3651], 'Table': [2736, 3652], 'I': [2737], 'contains': [2738, 3654], 'all': [2739, 3009, 3199, 3655, 3664, 3837, 3858], 'genes': [2740, 4188], 'average': [2745], 'process': [2747, 4209], 'PCR': [2748, 3830, 3851, 3886], 'threshold': [2750], 'deoxyribonucleic': [2751], 'acid': [2752, 2789], 'false': [2755], 'rate': [2757], 'fluorescein': [2758], 'isothiocyanate': [2759], 'ontology': [2761, 4204], 'horseradish': [2762], 'peroxidase': [2763], 'heat': [2764], 'immunoglobulin': [2767], 'G': [2768], 'mitogen-activated': [2769], 'kinase': [2771], 'methyl': [2772], 'methanesulfonate': [2773], 'messenger': [2774], 'phosphoenolpyruvate': [2779], 'carboxykinase': [2780], 'parts': [2781], 'million': [2783, 3945], 'peptide-spectrum': [2784], 'matches': [2785], 'ribosomal': [2786, 2792], 'DNA': [2787, 3763, 4004], 'ribonucleic': [2788], 'interference': [2791], 'standard': [2794, 3215, 3615], 'NMR': [2796, 2831, 2907, 2931, 2960, 3010, 3029, 3035, 3073, 3105, 3271, 3324, 3603, 3657], 'recognized': [2798], 'main': [2803, 3114], 'analytical': [2804], 'methodologies': [2805], 'obtain': [2807, 3740, 3931], 'qualitative': [2809], 'quantitative': [2811, 2941, 3006], 'information': [2812], 'metabolites': [2817, 2845, 3666], '(23.Spraul': [2818], 'Freund': [2820], 'A.S.': [2821, 2884], 'Nast': [2822], 'R.E.': [2823], 'Withers': [2824], 'Maas': [2826], 'W.E.': [2827], 'Corcoran': [2828], 'Advancing': [2830], 'sensitivity': [2832], 'LC-NMR-MS': [2834], 'cryoflow': [2837], 'probe:': [2838], 'Application': [2839], 'acetaminophen': [2844], 'urine.Anal.': [2847], 'Chem.': [2848, 3330], '2003;': [2849], '1536-1541Crossref': [2851], '(132)': [2854], '24.Khoo': [2857], 'S.H.': [2858], 'Al-Rubeai': [2859], 'complementary': [2864], 'tool': [2865, 3988], 'culture.Biotechnol.': [2868], 'Appl.': [2869], '47:': [2872], '71-84Crossref': [2873], '(68)': [2876], '25.Cuperlović-Culf': [2879], 'Barnett': [2881], 'D.A.': [2882], 'Culf': [2883], 'Chute': [2885], 'Cell': [2887], 'metabolomics:': [2889], 'applications': [2890], 'future': [2892], 'directions.Drug.': [2893], 'Discov.': [2894], 'Today.': [2895], '15:': [2897], '610-621Crossref': [2898], '(166)': [2901], '26.Holzgrabe': [2904], 'U.': [2905], 'Quantitative': [2906], 'spectroscopy': [2908, 2932, 2961, 3325], 'pharmaceutical': [2910], 'applications.Prog.': [2911], 'Nucl.': [2912], 'Magn.': [2913], 'Reson.': [2914], 'Spectrosc.': [2915], '57:': [2917], '229-240Abstract': [2918], '(251)': [2926], 'present': [2936], 'rapid': [2940], 'complex': [2944], 'matrices': [2945], '(27.Bala': [2946], 'Sharma': [2948], 'Yellapa': [2950], 'R.K.': [2951], 'Roy': [2952], 'Choudhuri': [2954], 'Khetrapal': [2956], 'C.L.': [2957, 4133], '(1)': [2958], 'H': [2959], 'ascitic': [2963], 'fluid:': [2964], 'Discrimination': [2965], 'malignant': [2967], 'benign': [2969], 'ascites': [2970], 'comparison': [2972], 'conventional': [2977], 'methods.NMR': [2978], 'Biomed.': [2979], '2008;': [2980], '21:': [2981], '606-614Crossref': [2982], '(22)': [2985], 'Furthermore,': [2988], '13C': [2990, 3062, 3104], 'nucleus': [2991], 'sweeps': [2992], 'wider': [2994], 'chemical': [2997], 'shifts,': [2998], 'therefore': [2999], 'improving': [3000], 'resolution': [3001, 4081], 'facilitating': [3003], 'assignments': [3004], 'analysis.': [3007], 'For': [3008, 3893], 'spectra,': [3011], 'samples': [3016, 3669, 3776], 'dissolved': [3018], 'deuterium': [3022, 3047], 'oxide': [3023, 3048], 'transferred': [3025], 'mm': [3028], 'tubes.': [3030], 'proton': [3032, 3149], 'carbon': [3034], 'spectra': [3036, 3155, 3167, 3221, 3260, 3272, 3658], 'recorded': [3038, 3076], 'Varian': [3041, 3216], 'Inova': [3042], 'MHz': [3044, 3055, 3058, 3320], 'spectrometer': [3045], '278': [3050], '°K': [3051], '499.769': [3054], '125.678': [3057], 'NMR,': [3063], 'respectively.': [3064], 'Chemical': [3065], 'shifts': [3066], 'referenced': [3068], 'trimethylsilyl': [3070], 'propionate.': [3071], 'experiments': [3074], 'spectral': [3079, 3120, 3189, 3300], 'width': [3080, 3121], '7,000': [3082], 'Hz,': [3083, 3123], '90°': [3084, 3124], 'pulse': [3085, 3175, 3209, 3217], '256': [3087, 3126], 'scans,': [3088, 3127], 'relaxation': [3090, 3129], 'delay': [3091, 3130], '25': [3093, 3132, 3206], 's,': [3094, 3133, 3194], 'number': [3097, 3136, 3849], 'points': [3100, 3139], '30,256.': [3102], 'acquired': [3108, 3169], 'order': [3110, 3178, 3289], 'conditions:': [3119], '20,000': [3122], 'pulse,': [3125], '81,726;': [3141], 'inverse': [3142, 3172], 'gated': [3143, 3173], 'decoupling': [3144, 3150, 3174], 'applied': [3147, 3738], 'during': [3151], 'acquisition.': [3152], 'Assignment': [3153], 'carried': [3157], 'out': [3158, 3292], 'NOESY-1D,': [3160], 'g-COSY': [3161], 'Correlation': [3164], 'Spectroscopy.': [3165], 'employing': [3170], 'suppress': [3180], 'overhauser': [3182], 'effects.': [3183], 'parameters': [3186], 'used:': [3188], 'width,': [3190], 'acquisition': [3191], 'time': [3192], '0.64': [3193], '160': [3196], 'scans.': [3197], 'cases,': [3200], 'probe': [3201], 'temperatures': [3202], 'adjusted': [3204, 3854], '°C.': [3207], 'programs': [3210], 'taken': [3212], 'library.': [3219], 'Fourier-transformed': [3223], 'MestReNova': [3225], '8.1': [3226], 'software': [3227, 3238, 3601, 4215], '(Mestrelab': [3228], 'Research': [3229], 'S.L.,': [3230], 'Santiago': [3231], 'Compostela,': [3233], 'Spain)': [3234], 'ACD/Specmanager': [3236], '7.00': [3237], '(Advanced': [3239], 'Chemistry,': [3240], 'Inc.,': [3241], 'Toronto,': [3242], 'ON,': [3243], 'Canada).': [3244, 3606], 'Apodization': [3245], '0.2': [3247], 'Hz': [3248], 'zero': [3250], 'filling': [3251], '(32,000)': [3252], 'prior': [3255], 'Fourier': [3257], 'transformation.': [3258], 'phased': [3262], 'baseline': [3264], 'corrected': [3265], 'Whittaker': [3268], 'smoother.': [3269], 'integrated': [3274, 4019], 'manually,': [3275], 'choosing': [3276], 'area': [3278], 'peak': [3281, 3302], 'interest.': [3283], 'integrals': [3285], 'normalized': [3287], 'carry': [3291], 'relative': [3293], 'quantification': [3294], 'interesting': [3297], 'compounds.': [3298], 'resonances': [3301], 'assignment': [3303], 'based': [3305, 3828], '(28.Nicholson': [3309], 'J.K.': [3310], 'Foxall': [3311], 'P.J.': [3312], 'Spraul': [3313], 'Farrant': [3315], 'R.D.': [3316], 'Lindon': [3317], 'J.C.': [3318], '750': [3319], '1H-13C': [3323], 'blood': [3328], 'plasma.Anal.': [3329], '1995;': [3331], '67:': [3332], '793-811Crossref': [3333], '(943)': [3336], '29.Wishart': [3339], 'D.S.': [3340, 3435, 3529], 'Tzur': [3341, 3482], 'Knox': [3343, 3436, 3536], 'Eisner': [3345, 3440, 3564], 'Guo': [3347, 3391, 3438, 3532], 'A.C.': [3348, 3439, 3533], 'Young': [3349, 3442], 'Cheng': [3351, 3480, 4144], 'Jewell': [3353], 'Arndt': [3355, 3552], 'Sawhney': [3357], 'Fung': [3359], 'Nikolai': [3361], 'Lewis': [3363, 3486], 'Coutouly': [3365], 'Forsythe': [3367, 3509], 'Tang': [3369], 'Shrivastava': [3371, 3468], 'Jeroncic': [3373], 'Stothard': [3375], 'Amegbey': [3377], 'Block': [3379], 'Hau': [3381, 3446], 'D.D.': [3382, 3447], 'Wagner': [3383], 'Miniaci': [3385], 'Clements': [3387, 3484], 'Gebremedhin': [3389], 'Zhang': [3393, 4140], 'Duggan': [3395], 'G.E.': [3396], 'Macinnis': [3397], 'G.D.': [3398], 'Weljie': [3399], 'Dowlatabadi': [3401], 'Bamforth': [3403], 'Clive': [3405, 3497], 'Greiner': [3407, 3499, 3570], 'Li': [3409, 3505, 4136], 'Marrie': [3411], 'Sykes': [3413], 'B.D.': [3414], 'Vogel': [3415, 3507], 'H.J.': [3416, 3508], 'Querengesser': [3417], 'HMDB:': [3419, 3511], 'Human': [3421, 3577, 3592], 'Metabolome': [3422, 3578, 3593], 'Database.Nucleic': [3423], 'Acids': [3424, 3518, 3582], '35:': [3427], 'D521-D526Crossref': [3428], '(2176)': [3431], '30.Wishart': [3434], 'Gautam': [3444], 'Psychogios': [3448], 'Dong': [3450, 3546], 'Bouatra': [3452, 3548], 'Mandal': [3454, 3542], 'Sinelnikov': [3456, 3550], 'Xia': [3458, 3554], 'Jia': [3460], 'Cruz': [3462], 'Lim': [3464], 'Sobsey': [3466], 'Huang': [3470], 'Fang': [3474], 'Peng': [3476], 'Fradette': [3478], 'Souza': [3489], 'Zuniga': [3491], 'Dawe': [3493], 'Xiong': [3495], 'Nazyrova': [3501], 'Shaykhutdinov': [3503], 'A': [3512, 3733, 4241], 'knowledgebase': [3513], 'metabolome.Nucleic': [3517], 'D603-D610Crossref': [3522], '(1497)': [3525], '31.Wishart': [3528], 'Jewison': [3530], 'Wilson': [3534], 'Djoumbou': [3540], 'Aziat': [3544], 'Yallou': [3558], 'Bjorndahl': [3560], 'Perez-Pineiro': [3562], 'Allen': [3566], 'Neveu': [3568], 'Scalbert': [3572], 'HMDB': [3574], '3.0.': [3575], 'Database': [3579, 3594], '2013.Nucleic': [3581], '41:': [3585], 'D801-D807Crossref': [3586], '(2280)': [3589], 'Scholar;': [3591], 'version': [3595], '3.0,': [3596], 'http://www.hmdb.ca)': [3597], 'Chenomx': [3599], 'Profiler': [3600], '(Chenomx': [3602], 'Suite,': [3604], 'Edmonton,': [3605], 'Assignments': [3607], 'confirmed': [3609], 'pure': [3614], '(Sigma).': [3617], 'Three': [3618], 'compared': [3634], "Student's": [3642], 't': [3643], 'test': [3644], 'unequal': [3646], 'variance': [3647], '(p': [3648], '.05).': [3650], 'II': [3653], '(parts': [3659], 'million;': [3661], 'ppm)': [3662], 'analyzed': [3668], 'quantitation.': [3672], 'Purified': [3673], 'RNAs': [3674], 'library': [3678, 3706, 3801, 3841, 3864, 3890], 'preparation': [3679], 'TruSeq-based': [3682], 'NEB-Next': [3683, 3795], 'Ultra': [3684], 'Directional': [3685], 'Library': [3687], 'Prep': [3688], 'kit': [3689], '(New': [3690], 'England': [3691, 3722], 'Biolabs,': [3692], 'Ipswick,': [3693], 'MA).': [3694], 'Briefly,': [3695], 'μg': [3697], 'starting': [3703], 'material': [3704], 'preparation.': [3707], 'Messenger': [3708], 'captured': [3711], 'oligo-dT': [3713], 'beads': [3715, 3770], '(Poly(A)': [3716], 'Magnetic': 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