Title: Changes in lactate dehydrogenase activity in Carassius Auratus Gibelio (L. Pysces) kidney, gills and intestine induced by acute exposure to copper
Abstract: Copper is a metal with a significant impact on the environment. We report the effects of two sublethal concentrations (100 µg/l respectively 250 µg/l) of copper (II), in Carassius auratus gibelio gills, intestine and kidney. LDH specific activity changes were studied after 24, 48 and 72 hours of copper acute intoxication. Our researches revealed that gills (100 µgCu 2+ /l and 250 µgCu 2+ /l) and intestine (250 µgCu 2+ /l) LDH activity decreased after exposure to copper. Significant increase in LDH activity were observed in the intestine and kidney after 24 and 48 hours at 100 µgCu 2+ /l and after 24 hours of treatment at 250 µgCu 2+ /l in kidney. The inhibition of LDH activity may reflect an important stress, while a stimulation of this enzyme may indicate an increased dependence on anaerobic carbohydrate metabolism. It seems that the short term exposure of crucian carp to sublethal levels of copper sulphate affected the carbohydrate metabolism in a tissue and concentration manner. Our results provide evidence that LDH activity could be a sensitive indicator for toxicological studies.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 17
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