Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2182487661', 'doi': 'https://doi.org/10.1212/wnl.0000000000002260', 'title': 'Oxidative phosphorylation and lacunar stroke', 'display_name': 'Oxidative phosphorylation and lacunar stroke', 'publication_year': 2015, 'publication_date': '2015-12-17', 'ids': {'openalex': 'https://openalex.org/W2182487661', 'doi': 'https://doi.org/10.1212/wnl.0000000000002260', 'mag': '2182487661', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26674331', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4731691'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1212/wnl.0000000000002260', 'pdf_url': 'https://n.neurology.org/content/neurology/86/2/141.full.pdf', 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://n.neurology.org/content/neurology/86/2/141.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011294322', 'display_name': 'Matthew Traylor', 'orcid': 'https://orcid.org/0000-0001-6624-8621'}, 'institutions': [{'id': 'https://openalex.org/I51532219', 'display_name': 'University of Lincoln', 'ror': 'https://ror.org/03yeq9x20', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I51532219']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Matthew Traylor', 'raw_affiliation_strings': ['From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'School of Life Science (S.B.), University of Lincoln, UK'], 'affiliations': [{'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'institution_ids': ['https://openalex.org/I51532219', 'https://openalex.org/I241749', 'https://openalex.org/I4210087915']}, {'raw_affiliation_string': 'School of Life Science (S.B.), University of Lincoln, UK', 'institution_ids': ['https://openalex.org/I51532219']}, {'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006140547', 'display_name': 'Christopher D. Anderson', 'orcid': 'https://orcid.org/0000-0002-0053-2002'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I51532219', 'display_name': 'University of Lincoln', 'ror': 'https://ror.org/03yeq9x20', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I51532219']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Christopher D. Anderson', 'raw_affiliation_strings': ['From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'School of Life Science (S.B.), University of Lincoln, UK'], 'affiliations': [{'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I51532219', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}, {'raw_affiliation_string': 'School of Life Science (S.B.), University of Lincoln, UK', 'institution_ids': ['https://openalex.org/I51532219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026853539', 'display_name': 'Robert Hurford', 'orcid': 'https://orcid.org/0000-0002-4226-7681'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I51532219', 'display_name': 'University of Lincoln', 'ror': 'https://ror.org/03yeq9x20', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I51532219']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Robert Hurford', 'raw_affiliation_strings': ['From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'School of Life Science (S.B.), University of Lincoln, UK'], 'affiliations': [{'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I51532219', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'School of Life Science (S.B.), University of Lincoln, UK', 'institution_ids': ['https://openalex.org/I51532219']}, {'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049405504', 'display_name': 'Steve Bevan', 'orcid': 'https://orcid.org/0000-0003-0490-6830'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I51532219', 'display_name': 'University of Lincoln', 'ror': 'https://ror.org/03yeq9x20', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I51532219']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Steve Bevan', 'raw_affiliation_strings': ['From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'School of Life Science (S.B.), University of Lincoln, UK'], 'affiliations': [{'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'institution_ids': ['https://openalex.org/I241749', 'https://openalex.org/I4210087915', 'https://openalex.org/I51532219']}, {'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}, {'raw_affiliation_string': 'School of Life Science (S.B.), University of Lincoln, UK', 'institution_ids': ['https://openalex.org/I51532219']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091235988', 'display_name': 'Markus M. Nöthen', 'orcid': 'https://orcid.org/0000-0002-8770-2464'}, 'institutions': [{'id': 'https://openalex.org/I51532219', 'display_name': 'University of Lincoln', 'ror': 'https://ror.org/03yeq9x20', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I51532219']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Hugh S. Markus', 'raw_affiliation_strings': ['From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'School of Life Science (S.B.), University of Lincoln, UK'], 'affiliations': [{'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK; School of Life Science (S.B.), University of Lincoln, UK; and the Center for Human Genetic Research (C.D.A.), Department of Neurology, Massachusetts General Hospital, Boston.', 'institution_ids': ['https://openalex.org/I51532219', 'https://openalex.org/I241749', 'https://openalex.org/I4210087915']}, {'raw_affiliation_string': 'School of Life Science (S.B.), University of Lincoln, UK', 'institution_ids': ['https://openalex.org/I51532219']}, {'raw_affiliation_string': 'From Clinical Neurosciences (M.T., R.H., H.S.M.), University of Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': {'value': 3757, 'currency': 'EUR', 'value_usd': 4051, 'provenance': 'openapc'}, 'fwci': 1.403, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.695922, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '86', 'issue': '2', 'first_page': '141', 'last_page': '145'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10261', 'display_name': 'Genomic Studies and Association Analyses', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10261', 'display_name': 'Genomic Studies and Association Analyses', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10816', 'display_name': 'Diagnosis and Treatment of Carotid Artery Disease', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12747', 'display_name': 'Moyamoya Disease and Syndrome', 'score': 0.9712, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lacunar-stroke', 'display_name': 'Lacunar stroke', 'score': 0.92817897}, {'id': 'https://openalex.org/keywords/leukoaraiosis', 'display_name': 'Leukoaraiosis', 'score': 0.80039823}, {'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke (engine)', 'score': 0.63320315}, {'id': 'https://openalex.org/keywords/pathophysiology', 'display_name': 'Pathophysiology', 'score': 0.5230035}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.49004185}, {'id': 'https://openalex.org/keywords/polygenic-risk-scores', 'display_name': 'Polygenic Risk Scores', 'score': 0.468362}], 'concepts': [{'id': 'https://openalex.org/C2779285336', 'wikidata': 'https://www.wikidata.org/wiki/Q6469117', 'display_name': 'Lacunar stroke', 'level': 4, 'score': 0.92817897}, {'id': 'https://openalex.org/C2776191500', 'wikidata': 'https://www.wikidata.org/wiki/Q2123166', 'display_name': 'Leukoaraiosis', 'level': 4, 'score': 0.80039823}, {'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.63320315}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5643006}, {'id': 'https://openalex.org/C10162356', 'wikidata': 'https://www.wikidata.org/wiki/Q1135939', 'display_name': 'Pathophysiology', 'level': 2, 'score': 0.5230035}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.49004185}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.47564384}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.46061632}, {'id': 'https://openalex.org/C57600042', 'wikidata': 'https://www.wikidata.org/wiki/Q227564', 'display_name': 'Oxidative phosphorylation', 'level': 2, 'score': 0.44491684}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42641538}, {'id': 'https://openalex.org/C3020199598', 'wikidata': 'https://www.wikidata.org/wiki/Q12202', 'display_name': 'Ischemic stroke', 'level': 3, 'score': 0.3403657}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.32350636}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21849346}, {'id': 'https://openalex.org/C2779483572', 'wikidata': 'https://www.wikidata.org/wiki/Q83030', 'display_name': 'Dementia', 'level': 3, 'score': 0.21670422}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.14243808}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08213502}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014644', 'descriptor_name': 'Genetic Variation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D055106', 'descriptor_name': 'Genome-Wide Association Study', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D049292', 'descriptor_name': 'Leukoaraiosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010085', 'descriptor_name': 'Oxidative Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D059409', 'descriptor_name': 'Stroke, Lacunar', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002544', 'descriptor_name': 'Cerebral Infarction', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049292', 'descriptor_name': 'Leukoaraiosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059409', 'descriptor_name': 'Stroke, Lacunar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059409', 'descriptor_name': 'Stroke, Lacunar', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1212/wnl.0000000000002260', 'pdf_url': 'https://n.neurology.org/content/neurology/86/2/141.full.pdf', 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4731691', 'pdf_url': 'https://europepmc.org/articles/pmc4731691?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731691', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://eprints.lincoln.ac.uk/id/eprint/27839/1/27839%20Neurology-2016-Traylor-141-5.pdf', 'pdf_url': 'http://eprints.lincoln.ac.uk/id/eprint/27839/1/27839%20Neurology-2016-Traylor-141-5.pdf', 'source': {'id': 'https://openalex.org/S4377196275', 'display_name': 'Lincoln Repository (University of Lincoln)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I51532219', 'host_organization_name': 'University of Lincoln', 'host_organization_lineage': ['https://openalex.org/I51532219'], 'host_organization_lineage_names': ['University of Lincoln'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26674331', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1212/wnl.0000000000002260', 'pdf_url': 'https://n.neurology.org/content/neurology/86/2/141.full.pdf', 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1527874749', 'https://openalex.org/W1900670142', 'https://openalex.org/W1965180269', 'https://openalex.org/W1972526012', 'https://openalex.org/W1985477573', 'https://openalex.org/W1992436001', 'https://openalex.org/W2003283154', 'https://openalex.org/W2037394994', 'https://openalex.org/W2043274957', 'https://openalex.org/W2061014177', 'https://openalex.org/W2067395123', 'https://openalex.org/W2078103827', 'https://openalex.org/W2080544548', 'https://openalex.org/W2092590432', 'https://openalex.org/W2096791516', 'https://openalex.org/W2109708024', 'https://openalex.org/W2130410032', 'https://openalex.org/W2138595885', 'https://openalex.org/W2140551822', 'https://openalex.org/W2157752701', 'https://openalex.org/W2163799428'], 'related_works': ['https://openalex.org/W4251924720', 'https://openalex.org/W2753564871', 'https://openalex.org/W2473428648', 'https://openalex.org/W2461530514', 'https://openalex.org/W2312858636', 'https://openalex.org/W2303603544', 'https://openalex.org/W2182487661', 'https://openalex.org/W2148455094', 'https://openalex.org/W2108293654', 'https://openalex.org/W2069528320'], 'abstract_inverted_index': {'<h3>Objective:</h3>': [0], 'We': [1], 'investigated': [2, 47], 'whether': [3], 'oxidative': [4], 'phosphorylation': [5], '(OXPHOS)': [6], 'abnormalities': [7], 'were': [8, 66, 166], 'associated': [9, 20], 'with': [10, 23, 72, 80, 114, 128, 194], 'lacunar': [11, 25, 34, 58, 82, 116, 163, 184, 204, 219], 'stroke,': [12, 185], 'hypothesizing': [13], 'that': [14, 200, 214], 'these': [15], 'would': [16], 'be': [17], 'more': [18], 'strongly': [19], 'in': [21, 110, 133, 139, 148, 156, 180], 'patients': [22, 193], 'multiple': [24, 73], 'infarcts': [26, 74, 83, 91], 'and': [27, 37, 57, 78, 92, 118, 186, 212], 'leukoaraiosis': [28], '(LA).': [29], '<h3>Methods:</h3>': [30], 'In': [31], '1,012': [32], 'MRI-confirmed': [33], 'stroke': [35, 59, 117, 164, 205, 220], 'cases': [36], '964': [38], 'age-matched': [39], 'controls': [40], 'recruited': [41], 'from': [42], 'general': [43], 'practice': [44], 'surgeries,': [45], 'we': [46, 104], 'associations': [48], 'between': [49], 'common': [50], 'genetic': [51], 'variants': [52], 'within': [53], 'the': [54, 87, 97, 111, 119, 134, 140, 149, 157, 161, 177, 181, 188, 195], 'OXPHOS': [55, 112, 178], 'pathway': [56, 113, 179], 'using': [60, 68, 96], 'a': [61, 125], 'permutation-based': [62], 'enrichment': [63, 107, 132], 'approach.': [64], 'Cases': [65], 'phenotyped': [67], 'MRI': [69], 'into': [70, 209], 'those': [71, 79], 'or': [75], 'LA': [76], '(MLI/LA)': [77], 'isolated': [81], '(ILI)': [84], 'based': [85], 'on': [86], 'number': [88], 'of': [89, 94, 108, 131, 137, 183, 203, 218], 'subcortical': [90], 'degree': [93], 'LA,': [95], 'Fazekas': [98], 'grading.': [99], 'Using': [100], 'gene-level': [101], 'association': [102, 127, 189], 'statistics,': [103], 'tested': [105], 'for': [106, 160], 'genes': [109, 138], 'all': [115, 162], '2': [120], 'subtypes.': [121], '<h3>Results:</h3>': [122], 'There': [123], 'was': [124], 'specific': [126, 191], 'strong': [129], 'evidence': [130], 'top': [135, 158], '1%': [136], 'MLI/LA': [141, 196], '(subtype': [142], '<i>p</i>': [143], '=': [144, 153, 171], '0.0017)': [145], 'but': [146], 'not': [147, 167], 'ILI': [150], 'subtype': [151], '(<i>p</i>': [152, 170], '1).': [154], 'Genes': [155], 'percentile': [159], 'analysis': [165], 'significantly': [168], 'enriched': [169], '0.07).': [172], '<h3>Conclusions:</h3>': [173], 'Our': [174], 'results': [175], 'implicate': [176], 'pathogenesis': [182], 'show': [187, 199], 'is': [190], 'to': [192], 'subtype.': [197], 'They': [198], 'MRI-based': [201], 'subtyping': [202], 'can': [206], 'provide': [207], 'insights': [208], 'disease': [210], 'pathophysiology,': [211], 'imply': [213], 'different': [215], 'radiologic': [216], 'subtypes': [217, 221], 'have': [222], 'distinct': [223], 'underlying': [224], 'pathophysiologic': [225], 'processes.': [226]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2182487661', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-17T16:56:40.720901', 'created_date': '2016-06-24'}