Title: ANTICANCER AND ANTIMICROBIAL ACTIVITY OF 1-((5- SUBSTITUTED-1,3,4 OXADIAZOL-2-YL) METHYL)-4- BENZYLPIPERAZINES
Abstract:The synthesis of 1-[(5-sustituted-1,3,4-oxadiazol-2 -yl) methyl]-4-benzylpiperazines VIa-j was carried out by refluxing the 1-benzylpiperazine II with ethylchloroacetate III in dry acetone in the pres...The synthesis of 1-[(5-sustituted-1,3,4-oxadiazol-2 -yl) methyl]-4-benzylpiperazines VIa-j was carried out by refluxing the 1-benzylpiperazine II with ethylchloroacetate III in dry acetone in the presence of potassium carbon ate and subsequent hydrazinolysis with hydrazine hydrate. F inally 2-(4-benzylpiperazin-1-yl)aceto- hydrazide V was treated with appropriate carboxylic acids in the presence of pho sphorous oxy chloride to produce title compounds. All the title compounds (VIa-j) were screened for anticancer activity using HBL-100 cell lines by MTT method and antibacterial activity against B. subtiliis , S.aureus , E.coli and P.vulgaris .The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, 1 H NMR and mass spectral data.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 3
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