Title: EFFECT OF METHAOLIC EXTRACT OF VICA ROSEA LEAVES O GLYCEMIC COTROL AD ATIOXIDAT STATUS I ALLOXA IDUCED DIABETES I RATS 1 Dinesh Kumar Sharma, Chandresh varshneya, Babasaheb Suryabhan More,
Abstract: Summary In the present study, methanolic extract of vinca rosea (v.rosea) leaves was administered orally @ 100 & 200mg/kg body weight to alloxan induced diabetic rats for 15 days. This resulted in significant reduction (p<0.01) in blood glucose level in alloxan diabetic rats. The levels of blood glycosylated hemoglobin (HbA1c), serum AST & ALT significantly (p<0.01) increased in alloxan induced diabetic rats however, these levels returned to normal in V.rosea (100&200) treated rats. There was a significant (p<0.01) increase in LPO and reduction in the activities of antioxidant enzymes CAT & SOD in alloxan diabetic rats. The administration of methanolic extracts of V.rosea @ 100 & 200mg/kg significantly decreased the LPO in alloxan diabetic rats. CAT level elevated significantly by V.rosea (200).However, glibenclamide restored blood glucose, HbA1c, ALT, AST, LPO, CAT and SOD and the restoration was greater than the treated groups. The studies therefore indicated that V.rosea possesses antidiabetic activities along with good antioxidant properties and can be used as an adjunct therapy in diabetes.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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