Title: CNS depressant and sedative effects of Andrographis paniculata
Abstract: Andrographis paniculata aerial parts methanol extract (aerial parts) at 200 and 400 mg/kg (p.o) was administered in the mice to study CNS depressant effect. Different models for CNS depressant activity viz. open field, hole cross and thiopental sodium induced sleeping time tests were used. In hole cross and open field tests, the number of squares traversed decreased significantly. In the thiopental sodium induced sleeping time test, the extract at 400 mg/kg showed a remarkable decrease in onset of action and increased the duration of sleep in comparison with controls. The behavioral studies on mice indicate CNS depressant activity of the methanol extract of A. paniculata.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 2
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