Title: Reproducible and uniform cardiac ischemia: effects of antiarrhythmic drugs
Abstract: The in vivo response of cardiac tissue to ischemia is inherently nonuniform, and as a result the drug effects in the latter are subject to great variability. We therefore designed a preparation that could reproducibly respond to uniform ischemia: Langendorff-perfused rabbit hearts in which ischemia was induced by stopping the perfusion. In this preparation therapeutic concentrations of antiarrhythmic drugs have no-to-moderate effects on conduction and excitability of perfused tissue, while markedly depressing these parameters in ischemic tissue. This selectivity for depression of ischemic tissue increases as the ischemia progresses. Antiarrhythmic drugs can in this way markedly attenuate the abnormal electrical activity of the ischemic tissue (responsible for arrhythmias) while minimally affecting this activity in normal tissue.
Publication Year: 1978
Publication Date: 1978-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 15
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