Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2177471073', 'doi': 'https://doi.org/10.1016/j.archoralbio.2015.11.015', 'title': 'Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α', 'display_name': 'Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α', 'publication_year': 2016, 'publication_date': '2016-02-01', 'ids': {'openalex': 'https://openalex.org/W2177471073', 'doi': 'https://doi.org/10.1016/j.archoralbio.2015.11.015', 'mag': '2177471073', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26655749'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.archoralbio.2015.11.015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44717366', 'display_name': 'Archives of Oral Biology', 'issn_l': '0003-9969', 'issn': ['0003-9969', '1879-1506'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086676643', 'display_name': 'Tsuyoshi Miyakawa', 'orcid': 'https://orcid.org/0000-0003-0137-8200'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tsuyoshi Miyagawa', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101742390', 'display_name': 'Tsuyoshi Fujita', 'orcid': 'https://orcid.org/0000-0002-3094-5510'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Tsuyoshi Fujita', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059349346', 'display_name': 'Hiromichi Yumoto', 'orcid': 'https://orcid.org/0000-0002-8659-9776'}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiromichi Yumoto', 'raw_affiliation_strings': ['Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017174154', 'display_name': 'Tetsuya Yoshimoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuya Yoshimoto', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029830408', 'display_name': 'Mikihito Kajiya', 'orcid': 'https://orcid.org/0000-0001-6652-0007'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mikihito Kajiya', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040863675', 'display_name': 'Kazuhisa Ouhara', 'orcid': 'https://orcid.org/0000-0001-6796-884X'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhisa Ouhara', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002033800', 'display_name': 'Shinji Matsuda', 'orcid': 'https://orcid.org/0000-0002-4281-3216'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shinji Matsuda', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033901129', 'display_name': 'Hideki Shiba', 'orcid': 'https://orcid.org/0000-0003-3177-0764'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideki Shiba', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103030255', 'display_name': 'Takashi Matsuo', 'orcid': 'https://orcid.org/0000-0003-3805-7224'}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi Matsuo', 'raw_affiliation_strings': ['Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070040943', 'display_name': 'Hidemi Kurihara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}, {'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hidemi Kurihara', 'raw_affiliation_strings': ['Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontal Medicine, Division of Applied Life Science, Institute of Biomedical & Health Sciences, Hiroshima University, Japan', 'institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5101742390'], 'corresponding_institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210111488'], 'apc_list': {'value': 3920, 'currency': 'USD', 'value_usd': 3920, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.4, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.999688, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '62', 'issue': None, 'first_page': '64', 'last_page': '69'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10257', 'display_name': 'Periodontal Diseases and Oral Microbiome', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3506', 'display_name': 'Periodontics'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10257', 'display_name': 'Periodontal Diseases and Oral Microbiome', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3506', 'display_name': 'Periodontics'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13768', 'display_name': 'Risk Factors for Gingival Overgrowth in Medication Use', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/3611', 'display_name': 'Pharmacy'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11872', 'display_name': 'Blood-Brain Barrier and Neurovascular Interactions', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/connective-tissue-growth-factor', 'display_name': 'Connective Tissue Growth Factor', 'score': 0.451721}], 'concepts': [{'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.6992911}, {'id': 'https://openalex.org/C51551487', 'wikidata': 'https://www.wikidata.org/wiki/Q2043632', 'display_name': 'p38 mitogen-activated protein kinases', 'level': 4, 'score': 0.6019222}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.58853793}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.57055545}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.5662961}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3506027}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.33878905}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.23159519}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2153804}], 'mesh': [{'descriptor_ui': 'D017963', 'descriptor_name': 'Azithromycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017963', 'descriptor_name': 'Azithromycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005891', 'descriptor_name': 'Gingivitis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005891', 'descriptor_name': 'Gingivitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016209', 'descriptor_name': 'Interleukin-8', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016209', 'descriptor_name': 'Interleukin-8', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016209', 'descriptor_name': 'Interleukin-8', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.archoralbio.2015.11.015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44717366', 'display_name': 'Archives of Oral Biology', 'issn_l': '0003-9969', 'issn': ['0003-9969', '1879-1506'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26655749', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.76, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1532257786', 'https://openalex.org/W1925725099', 'https://openalex.org/W1967389480', 'https://openalex.org/W1969887412', 'https://openalex.org/W1970129984', 'https://openalex.org/W1970638674', 'https://openalex.org/W1972889587', 'https://openalex.org/W1980059877', 'https://openalex.org/W1982518012', 'https://openalex.org/W1994953316', 'https://openalex.org/W1996809975', 'https://openalex.org/W1997072139', 'https://openalex.org/W2000344153', 'https://openalex.org/W2000476027', 'https://openalex.org/W2009776096', 'https://openalex.org/W2024687369', 'https://openalex.org/W2027282602', 'https://openalex.org/W2030385962', 'https://openalex.org/W2031719686', 'https://openalex.org/W2039343606', 'https://openalex.org/W2040665828', 'https://openalex.org/W2041983669', 'https://openalex.org/W2042192715', 'https://openalex.org/W2044996387', 'https://openalex.org/W2047243501', 'https://openalex.org/W2051901005', 'https://openalex.org/W2059078722', 'https://openalex.org/W2060839308', 'https://openalex.org/W2069274385', 'https://openalex.org/W2071451674', 'https://openalex.org/W2075256290', 'https://openalex.org/W2087096548', 'https://openalex.org/W2090648579', 'https://openalex.org/W2109619688', 'https://openalex.org/W2131455890', 'https://openalex.org/W2141941125', 'https://openalex.org/W2148837652', 'https://openalex.org/W2156742440', 'https://openalex.org/W2157133445', 'https://openalex.org/W2163595135', 'https://openalex.org/W2166453119', 'https://openalex.org/W2168987929', 'https://openalex.org/W2171574454', 'https://openalex.org/W645558247'], 'related_works': ['https://openalex.org/W4239892895', 'https://openalex.org/W3005630266', 'https://openalex.org/W2376631516', 'https://openalex.org/W2243167688', 'https://openalex.org/W2130234269', 'https://openalex.org/W2092574818', 'https://openalex.org/W2068905608', 'https://openalex.org/W2056415482', 'https://openalex.org/W2053622195', 'https://openalex.org/W1981680830'], 'abstract_inverted_index': {'The': [0, 116], 'gingival': [1, 19, 60, 78, 182, 200], 'epithelium': [2], 'plays': [3], 'an': [4], 'important': [5], 'role': [6], 'in': [7, 25, 35, 48, 59, 85, 95, 134, 159, 167, 170, 199], 'protecting': [8], 'against': [9], 'the': [10, 16, 26, 36, 64, 69, 74, 96, 139, 151, 165, 197], 'invasion': [11], 'of': [12, 18, 28, 38, 71, 76, 98, 118, 153], 'periodontal': [13], 'pathogens,': [14], 'and': [15, 104, 124, 136, 138, 143, 155, 189, 192], 'permeability': [17, 75, 184], 'epithelial': [20, 50, 61, 79, 183], 'cells': [21, 80], 'has': [22, 32], 'been': [23, 33], 'implicated': [24], 'initiation': [27], 'periodontitis.': [29], 'Azithromycin': [30], '(AZM)': [31], 'used': [34], 'treatment': [37], 'chronic': [39], 'inflammatory': [40, 83], 'airway': [41, 49], 'diseases': [42], 'because': [43], 'it': [44], 'regulates': [45], 'cell–cell': [46], 'contact': [47], 'cells.': [51, 62], 'Therefore,': [52], 'AZM': [53, 72, 99, 137, 149, 163, 180], 'may': [54, 193], 'also': [55], 'regulate': [56], 'barrier': [57], 'function': [58], 'In': [63], 'present': [65], 'study,': [66], 'we': [67], 'examined': [68], 'effects': [70], 'on': [73, 111], 'human': [77], '(HGEC)': [81], 'under': [82], 'conditions': [84], 'vitro.': [86], 'HGEC': [87, 171], 'were': [88], 'stimulated': [89, 172], 'by': [90, 128], 'tumor': [91], 'necrosis': [92], 'factor-α': [93], '(TNF-α)': [94], 'presence': [97], 'or': [100], 'p38': [101, 121, 140, 156, 186], 'MAP': [102, 122, 141, 157, 187], 'kinase': [103, 142, 158, 188], 'ERK': [105, 125, 144, 154, 190], 'inhibitors.': [106], 'Permeability': [107], 'was': [108, 126], 'assessed': [109], 'based': [110], 'transepithelial': [112], 'electrical': [113], 'resistance': [114], '(TER).': [115], 'expression': [117, 169], 'E-cadherin,': [119], 'phosphorylated': [120], 'kinase,': [123], 'analyzed': [127], 'Western': [129], 'blotting.': [130], 'TNF-α': [131], 'decreased': [132], 'TER': [133], 'HGEC,': [135], 'inhibitors': [145], 'recovered': [146, 164], 'this': [147], 'decrease.': [148], 'inhibited': [150], 'phosphorylation': [152], 'TNF-α-stimulated': [160], 'HGEC.': [161], 'Furthermore,': [162], 'decrease': [166], 'E-cadherin': [168], 'with': [173], 'TNF-α.': [174], 'Conclusions:': [175], 'These': [176], 'results': [177], 'suggested': [178], 'that': [179], 'regulated': [181], 'through': [185], 'signaling,': [191], 'contribute': [194], 'to': [195], 'suppress': [196], 'inflammation': [198], 'tissue.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2177471073', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-08-15T13:48:33.744135', 'created_date': '2016-06-24'}