Publication Information

{'id': 'https://openalex.org/W2176788997', 'doi': 'https://doi.org/10.1074/mcp.m115.053272', 'title': 'Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid', 'display_name': 'Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid', 'publication_year': 2015, 'publication_date': '2015-10-24', 'ids': {'openalex': 'https://openalex.org/W2176788997', 'doi': 'https://doi.org/10.1074/mcp.m115.053272', 'mag': '2176788997', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26499837', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4762520'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m115.053272', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/1/26.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': 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'stage': [60, 69, 354, 363, 1353, 1358], 'together': [61, 355], 'with': [62, 226, 239, 253, 356, 520, 533, 547, 1634, 1644, 1654, 1683, 1805, 1831, 1848, 1884, 1950, 2031, 2064, 2222, 2247, 2277, 2310, 2327, 2340, 2348, 2725, 2745, 2793, 2877, 2938, 3085, 3121, 3139, 3256, 3299, 3341, 3421, 3432, 3459, 3483, 3624, 3674, 3693, 3707, 3765, 3849, 3917, 3962, 3988, 4071, 4076, 4112, 4163, 4212, 4221, 4241, 4386], 'late': [66, 83, 360, 377, 1357], '(24': [67, 361, 1359], 'found.': [71, 365], 'Vimentin': [72, 366], 'was': [73, 176, 244, 258, 367, 470, 538, 552, 690, 755, 1187, 1341, 1410, 1595, 1650, 1663, 1690, 1700, 1721, 1853, 1964, 1972, 1992, 2004, 2139, 2264, 2363, 2369, 2404, 2436, 2448, 2723, 2789, 2829, 3022, 3036, 3062, 3137, 3292, 3373, 3403, 3418, 3497, 3501, 3506, 3547, 3620, 3633, 3641, 3647, 3783, 3898, 3913, 3960, 3986, 4050, 4057, 4271, 4295, 4372, 4462, 4488, 4495, 4502, 4562], 'the': [74, 133, 263, 269, 368, 427, 557, 563, 605, 780, 791, 798, 813, 912, 989, 1071, 1168, 1200, 1252, 1269, 1276, 1303, 1308, 1406, 1507, 1587, 1620, 1707, 1725, 1729, 1769, 1778, 1788, 1890, 1928, 1995, 2037, 2128, 2136, 2142, 2151, 2202, 2257, 2317, 2361, 2366, 2402, 2430, 2433, 2451, 2536, 2691, 2702, 2734, 2800, 2824, 2832, 2894, 2925, 2949, 2993, 3026, 3039, 3043, 3047, 3103, 3119, 3149, 3185, 3196, 3217, 3263, 3296, 3316, 3326, 3350, 3364, 3409, 3440, 3448, 3509, 3550, 3560, 3578, 3596, 3604, 3627, 3652, 3664, 3688, 3732, 3750, 3773, 3811, 3822, 3901, 3910, 3957, 3984, 4144, 4209, 4214, 4251, 4375, 4412, 4439, 4450, 4465, 4471, 4479, 4506, 4549], 'only': [75, 369], 'protein': [77, 166, 371, 460, 597, 640, 657, 659, 661, 1209, 1236, 1239, 1241, 1371, 2453, 2471, 2612, 2740, 2922, 2944, 2958, 2973, 2989, 3019, 3069, 3080, 3218, 3666, 3719, 3763, 3896, 3903, 3912, 3937, 3982, 4128, 4147, 4451, 4499, 4528, 4533], 'found': [78, 372, 1585], 'both': [80, 87, 374, 381, 2056], 'stage.': [84, 378], 'Results': [85, 119, 181, 209, 379, 413, 475, 503], '2-DE': [88, 382, 1339, 2464, 2483, 2722, 4555], 'Western': [91, 385, 3780, 4134], 'blotting': [92, 386, 3781, 4135], 'suggested': [94, 388], 'cleavage': [95, 109, 144, 197, 389, 403, 438, 491, 1374], 'vimentin': [97, 105, 112, 134, 149, 199, 216, 243, 257, 267, 278, 391, 399, 406, 428, 443, 493, 510, 537, 551, 561, 572, 1365, 1376, 1380, 1393, 1401, 1609, 1623, 1639, 1649, 1662, 4132, 4561], 'GA.': [100, 272, 394, 566, 1204, 1338, 2803], 'MS/MS': [101, 395, 1328, 2486, 3135, 3472, 3542, 3545, 3551, 3572, 4269, 4566], 'cleaved': [104, 398], 'peptides': [106, 400, 3291, 3423, 3513, 4238], 'indicated': [107, 262, 401, 556, 1732], 'possible': [108, 402, 825, 1346, 1368, 1891, 2038, 2650, 2703, 2790, 3197, 3823], 'sites': [110, 404], 'or': [114, 408, 595, 1193, 1397, 1640, 1849, 1943, 2320, 2332, 2439, 3088, 3091, 3705, 4084], 'near': [115, 409], 'ser51': [116, 410], 'glu425.': [118, 412], 'targeted': [121, 415, 589, 1324], 'that': [125, 186, 419, 480, 1655, 2791, 3520, 3749, 3759, 4519, 4553], 'change': [128, 422], 'phosphorylation': [130, 424, 857, 1378, 1452, 1549, 4558], 'state': [131, 425, 4559], 'head': [135, 429], 'domain': [136, 430], '(aa51–64).': [137, 431], 'Caspase': [138, 432], 'inhibitors': [139, 433, 599, 2394], 'could': [140, 200, 434, 494], 'not': [141, 435, 819, 1189], 'abrogate': [142, 436], 'GA-induced': [143, 437], 'vimentin.': [146, 440], 'Over-expression': [147, 441], 'ameliorated': [150, 444], 'cytotoxicity': [151, 227, 233, 247, 270, 445, 521, 527, 541, 564, 1407, 1625, 1628, 2692, 3186, 3812], 'cells.': [156, 450, 1658], 'The': [157, 273, 451, 567, 677, 1387, 1761, 2115, 2414, 3017, 3076, 3287, 3400, 3427, 3614, 3644, 3717, 3893, 3995, 4045, 4065, 4127, 4171, 4236, 4267, 4369, 4425, 4442, 4557], 'GA-activated': [158, 452, 1413], 'signal': [159, 453, 914, 1194, 1416, 1509, 2203, 2537], 'transduction,': [160, 454], 'from': [161, 455, 669, 1692, 1744, 1759, 1787, 2396, 2457, 2608, 2960, 2992, 3071, 3118, 4040, 4059, 4346, 4537], 'p38': [162, 456, 832, 863, 1414, 1427, 1458, 1555], 'MAPK,': [163, 457], 'heat': [164, 458, 1207, 1233], 'shock': [165, 459, 639, 655, 1208, 1234], '27': [167, 461, 1210], '(HSP27),': [168, 462], 'vimentin,': [169, 463, 1594], 'dysfunction': [170, 464], 'cytoskeleton,': [172, 466], 'to': [173, 467, 603, 623, 778, 796, 959, 1275, 1332, 1343, 1666, 1706, 1728, 1924, 2245, 2304, 2480, 2491, 2765, 2780, 2811, 2816, 2858, 2979, 3064, 3251, 3529, 3622, 3662, 3681, 3722, 3731, 3761, 3943, 3951, 3979, 4121, 4280, 4348, 4504], 'death,': [175, 469], 'predicted': [177, 471, 1596], 'then': [179, 473, 1598, 1722, 2067, 2225, 2260, 2308, 2345, 2936, 3909, 3926, 4074, 4098, 4191, 4261, 4312, 4431], 'confirmed.': [180, 474, 1599], 'animal': [183, 477], 'study': [184, 478, 1254, 1277, 1333, 1589], 'treatment': [188, 482, 803, 1852], 'tumor': [190, 204, 219, 484, 498, 513, 1606], 'growth': [191, 485, 1607], 'tumor-bearing': [194, 488, 1613], 'mice': [195, 489, 1614, 2656], 'be': [201, 495, 624, 2796, 3723, 3735], 'observed': [202, 496, 3751], 'xenografts': [205, 220, 499, 514], 'GA-treated': [207, 222, 501, 516, 1382, 1962, 2994, 3074, 3097, 4540], 'animals.': [208, 223, 502, 517], 'immunohistochemical': [211, 505], 'staining': [212, 506, 2094], 'also': [213, 507, 1616, 1680, 2005, 2797], 'down-regulated': [215, 509], 'level': [217, 241, 255, 511, 535, 549, 1637, 1647], 'Furthermore,': [224, 518, 1659], 'compared': [225, 519, 1653], 'MCF-7': [237, 531, 879, 1474, 1571, 1632, 1775, 1818], 'cells': [238, 252, 532, 546, 956, 1026, 1383, 1633, 1643, 1797, 1819, 1822, 1847, 1907, 1947, 1963, 2060, 2087, 2117, 2131, 2146, 2193, 2218, 2284, 2298, 2335, 2403, 2416, 2527, 2568, 3844, 4541], 'low': [240, 534, 1635, 2412], 'weaker': [245, 539], 'whereas': [246, 540, 3540], 'MG-63': [251, 545, 1642, 1783, 1821], 'high': [254, 548, 1645], 'stronger.': [259, 553], 'These': [260, 554], 'important': [264, 558, 1334, 1369, 2195, 2529], 'role': [265, 559, 1198, 1621, 2196, 2530], 'effects': [274, 568, 1202, 1284, 1309, 1602, 1668, 2801], 'on': [277, 571, 1023, 1251, 1312, 1405, 1605, 1671, 2406, 2611, 2774, 3335, 3595, 3670, 3772, 3891, 3945, 4374], 'other': [280, 574, 1672, 1750], 'epithelial-to-mesenchymal': [281, 575, 1211], 'transition': [282, 576, 1212], '(EMT)': [283, 577], 'markers': [284, 578], 'provided': [285, 579], 'suggestion': [286, 580], 'for': [287, 581, 610, 616, 745, 766, 1159, 1940, 1984, 2083, 2110, 2253, 2329, 2354, 2423, 2463, 2467, 2889, 2916, 2969, 3107, 3238, 3437, 3476, 3534, 3541, 3739, 3931, 3973, 4048, 4091, 4187, 4203, 4309, 4421, 4527, 4545], 'better': [288, 582], 'usage': [289, 583], 'clinic.': [293, 587], 'Presently,': [588], 'therapies': [591], 'monoclonal': [593, 4003, 4009, 4019, 4025], 'antibodies': [594, 3990, 3997], 'synthetic': [596], 'kinase': [598, 662, 1242], 'are': [600], 'still': [601, 1188], 'deficient': [602], 'meet': [604], 'large': [606], 'urgent': [608], 'need': [609], 'novel': [611, 1157], 'cancer': [612, 743, 955, 2192, 2526], 'therapy': [613, 744], 'agents,': [614], 'especially': [615], 'solid': [617], 'tumors.': [618], 'Therefore,': [619], 'natural': [620, 666, 1256, 2812], 'products': [621], 'continue': [622], 'attractive': [625], 'sources': [626], 'new': [628, 1249, 1263, 1583], 'drug': [629, 1280, 1283, 2704, 3198, 3824], 'development.': [630], '1The': [634], 'abbreviations': [635], 'used': [636, 741, 1331, 1342, 1738, 1983, 2437, 2822, 3106, 3998, 4503], 'are:GAgambogic': [637], 'acidHSP27heat': [638], '27EMTepithelial-to-mesenchymal': [641], 'transitionDMSOdimethyl': [642], 'sulfoxideIEFisoelectric': [643], 'focusingCHCAα-cyano-4-hydroxycinnamic': [644], 'acidTFAtrifluoroacetic': [645], 'acidACNacetonitrileCIDcollision-induced': [646], 'dissociationFDRfalse': [647], 'discovery': [648, 1225, 4491], 'rate;': [649, 1226], 'information': [650, 1227, 1230, 4381], 'dependent': [651, 653, 1228, 1231, 4382], 'acquisitionIDAinformation': [652], 'acquisitionHSPB1heat': [654], '27kDa': [656, 1235], '1MAPKAPK2mitogen-activated': [658], 'kinase-activated': [660, 1240], '2.': [663, 1243], 'a': [665, 746, 772, 1156, 1262, 1367, 1684, 1911, 1919, 2121, 2273, 2292, 2349, 2390, 2766, 2859, 2909, 2939, 3033, 3130, 3225, 3261, 3268, 3376, 3382, 3390, 3467, 3491, 3515, 3523, 3694, 3708, 3762, 3854, 3952, 4257, 4275, 4281, 4298, 4315, 4331, 4341, 4483, 4514, 4521], 'product': [667], 'isolated': [668], 'Garcinia': [670], 'hanburyi': [671], 'tree': [672], 'grown': [673], 'Southeast': [675], 'Asia.': [676], 'structure': [678], '(C38H44O8,': [681], 'molecular': [682, 1892, 2039], 'mass': [683, 3383, 3412, 3524, 3568, 3630, 3638, 4407, 4413, 4426, 4443], '628)': [684], '(as': [685], 'shown': [686], 'Fig.': [688], '1A)': [689], 'elucidated': [691], 'detailed': [693], 'NMR': [694], 'spectroscopic': [695], 'confirmed': [698], 'x-ray': [700], 'crystallographic': [701], 'studies': [702], '(1.Ren': [703], 'Y.': [704, 710, 841, 891, 935, 1050, 1060, 1103, 1436, 1486, 1533, 2172, 2506], 'Yuan': [705], 'C.': [706, 1871, 2018, 2166, 2168, 2500, 2502, 2588, 2632], 'Chai': [707], 'H.B.': [708], 'Ding': [709], 'Li': [711, 898, 976, 1059, 1104, 1493, 2680, 3174, 3800], 'X.C.': [712], 'Ferreira': [713], 'D.': [714, 2164, 2184, 2498, 2518], 'Kinghorn': [715], 'A.D.': [716, 1286], 'Absolute': [717], 'configuration': [718], '(-)-gambogic': [720], 'acid,': [721, 1155], 'antitumor': [723, 775], 'agent.J.': [724], 'Nat.': [725], 'Products.': [726], '2011;': [727, 2575], '74:': [728], '460-463Crossref': [729], 'PubMed': [730, 885, 966, 1006, 1039, 1092, 1134, 1176, 1297, 1480, 1577, 1901, 2048, 2210, 2544, 2578, 2626, 2663, 2717, 3211, 3837], 'Scopus': [731, 886, 967, 1007, 1040, 1093, 1135, 1177, 1298, 1481, 1578, 1902, 2049, 2211, 2545, 2579, 2627, 2664, 2718, 3212, 3838], '(45)': [732], 'Google': [733, 888, 926, 969, 1009, 1042, 1095, 1137, 1179, 1300, 1483, 1521, 1580, 1904, 2051, 2213, 2547, 2581, 2629, 2666, 2720, 3214, 3840], 'Scholar).': [734, 1301, 1905, 2052, 2214, 2721, 3215, 3841], 'Crude': [735], 'extract': [736], 'containing': [737, 1935, 2312, 2376, 2432, 3289, 3966], 'had': [739, 818, 1182, 3721], 'been': [740, 820, 1183], 'long': [747], 'time': [748], 'January': [752], '2004,': [753], 'granted': [756], 'permission': [757], 'State': [759], 'Food': [760], 'Drug': [762], 'Administration': [763], 'China': [765], 'testing': [767], 'wide': [773], 'spectrum': [774, 3456, 3480, 3537], 'candidate.': [776], 'Up': [777], 'now,': [779], 'I': [782], 'IIa': [784], 'trials': [785], 'have': [788], 'finished': [789], 'undergoing': [795], 'check': [797], 'efficacy': [799], 'nonsmall': [805], 'lung,': [807], 'renal': [808], 'colon': [810], 'cancers.': [811], 'However,': [812], 'mechanism': [815, 1253, 2693, 3187, 3813], 'fully': [821], 'clarified.': [822], 'Lots': [823], 'such': [830, 1425, 1590], 'MAPK': [833, 913, 1428, 1508, 4002], '(2.Chen': [834, 1429, 1526], 'J.': [835, 893, 899, 939, 1054, 1062, 1064, 1087, 1292, 1430, 1488, 1494, 1527], 'Gu': [836, 1431, 1528], 'H.Y.': [837, 1432, 1529], 'Lu': [838, 1433, 1530], 'N.': [839, 1434, 1531, 2552], 'Yang': [840, 1061, 1435, 1532, 1872, 2019, 2169, 2179, 2503, 2513, 2595, 2639, 2682, 3176, 3802], 'Liu': [842, 1049, 1437, 1534, 1876, 2023, 2181, 2515, 2599, 2643, 2674, 2684, 3168, 3178, 3794, 3804], 'W.': [843, 943, 1101, 1111, 1438, 1535, 2170, 2174, 2504, 2508], 'Qi': [844, 1439, 1536], 'Q.': [845, 1107, 1440, 1537], 'Rong': [846, 1441, 1538], 'J.J.': [847, 1442, 1539], 'Wang': [848, 940, 1051, 1443, 1540, 4584], 'X.T.': [849, 1444, 1541], 'You': [850, 1445, 1542], 'Q.D.': [851, 1446, 1543], 'Guo': [852, 1447, 1544, 1878, 2025, 2183, 2517, 2603, 2645, 2686, 3180, 3806], 'Q.L.': [853, 1448, 1545], 'Microtubule': [854, 1449, 1546], 'depolymerization': [855, 1450, 1547], 'c-Jun': [859, 1454, 1551], 'N-terminal': [860, 1455, 1552], 'kinase-1': [861, 1456, 1553], 'involved': [865, 1268, 1460, 1557, 2798], 'gambogic': [867, 948, 994, 1021, 1122, 1205, 1462, 1559], 'apoptosis': [874, 907, 950, 1068, 1124, 1164, 1469, 1502, 1566, 2152, 2187, 2521], 'human': [876, 1082, 1471, 1568, 1762, 1770, 1779, 3444, 3682], 'breast': [877, 1472, 1569, 1771], 'carcinoma': [878, 1473, 1570, 1764], 'cells.Life': [880, 1475, 1572], 'Sci.': [881, 1476, 1573, 1897, 2044], '2008;': [882, 1131, 1477, 1574, 1898, 2045, 2709, 3203, 3829], '83:': [883, 1478, 1575], '103-109Crossref': [884, 1479, 1576], '(67)': [887, 1482, 1579], 'Scholar,': [889, 1484, 2548, 2582, 2630, 2667], '3.Xu': [890, 1485], 'Ouyang': [892, 1487], 'Zhang': [894, 932, 1055, 1489, 2163, 2497], 'Q.G.': [895, 1490], 'Zhou': [896, 1491], 'M.': [897, 1492, 1873, 2020, 2180, 2514, 2556, 2596, 2640], 'Chen': [900, 936, 944, 1057, 1102, 1112, 1495, 4578], 'M.M.': [901, 1151, 1496], 'Xu': [902, 1497], 'Y.Y.': [903, 1498, 4577], '[Gambogic': [904, 1499], 'induces': [906, 1067, 1501], 'Jurkat': [909, 1126, 1504], 'through': [911, 1165, 1506, 3522], 'pathway].Zhongguo': [915, 1510], 'Shi': [916, 1511], 'Yan': [917, 1512], 'Xue': [918, 920, 1513, 1515], 'Ye': [919, 1514], 'Za': [921, 1516], 'Zhi.': [922, 1517], '2012;': [923, 1518], '20:': [924, 1519], '587-591PubMed': [925, 1520], 'Scholar),': [927, 970, 1010, 1043, 1096, 1138], 'transferrin': [928, 960, 1160], 'receptor': [929], '(4.Zhu': [930], 'X.': [931, 1048, 1058, 1877, 2024, 2182, 2516, 2600, 2644, 2685, 3179, 3805], 'H.': [933, 977, 1056, 2554, 2558], 'Lin': [934], 'P.': [937], 'Min': [938], 'Z.': [941, 1113], 'Xiao': [942], 'B.': [945, 1145, 2178, 2512], 'Mechanisms': [946], 'acid-induced': [949, 1123], 'non-small': [952], 'lung': [954], 'relation': [958], 'receptors.J.': [961], 'Chemother.': [962], '2009;': [963, 998, 1089, 2660], '21:': [964], '666-672Crossref': [965], '(47)': [968], 'kir2.1': [971, 990], 'K+': [972, 991], 'channel': [973, 992], '(5.Zaks-Makhina': [974], 'E.': [975], 'Grishin': [978], 'A.': [979], 'Salvador-Recatala': [980], 'V.': [981], 'Levitan': [982], 'E.S.': [983], 'Specific': [984], 'slow': [986], 'inhibition': [987], 'acid.J.': [995], 'Biol.': [996], 'Chem.': [997, 2658], '284:': [999], '15432-15438Abstract': [1000], 'Full': [1001, 1003, 2621, 2623, 2712, 2714, 3206, 3208, 3832, 3834], 'Text': [1002, 1004, 2622, 2624, 2713, 2715, 3207, 3209, 3833, 3835], 'PDF': [1005, 2625, 2716, 3210, 3836], '(24)': [1008], 'caspases': [1011], '(6.Rahman': [1012], 'M.A.': [1013], 'Kim': [1014], 'N.H.': [1015], 'Huh': [1016], 'S.O.': [1017], 'Cytotoxic': [1018], 'effect': [1019], 'SH-SY5Y': [1024], 'neuroblastoma': [1025], 'mediated': [1028], 'intrinsic': [1030], 'caspase-dependent': [1031], 'signaling': [1032, 1171], 'pathway.Mol.': [1033], 'Cell.': [1034, 2707, 3201, 3827], 'Biochem.': [1035], '2013;': [1036, 2207, 2541], '377:': [1037], '187-196Crossref': [1038], '(26)': [1041], 'Bax': [1044, 1074], 'Bcl-2': [1046, 1076], '(7.Xu': [1047], 'L.': [1052, 2162, 2496, 2677, 3171, 3797], 'He': [1053], 'Tao': [1063, 2676, 3170, 3796], 'regulating': [1070], 'expression': [1072, 1391, 1399, 1610, 1636, 1646, 2562, 2613], 'enhancing': [1078], 'caspase-3': [1079], 'activity': [1080], 'malignant': [1083], 'melanoma': [1084], 'A375': [1085], 'cells.Int.': [1086], 'Dermatol.': [1088], '48:': [1090], '186-192Crossref': [1091], '(63)': [1094], 'nucleophosmin': [1097, 1118], 'nucleoporins': [1099, 1120], '(8.Shu': [1100], 'R.': [1105, 1288], 'Wu': [1106, 2173, 2507, 2593, 2637, 2678, 3172, 3798, 4586], 'Cui': [1108, 2601], 'G.': [1109], 'Ke': [1110], 'Involvement': [1114], 'regulations': [1116], 'cells.Basic': [1127], 'Clin.': [1128], 'Pharmacol.': [1129], 'Toxicol.': [1130, 2659], '103:': [1132], '530-537Crossref': [1133], '(22)': [1136], 'NF-kappa': [1139], 'B': [1140, 4352], 'pathway': [1141, 1195], '(9.Pandey': [1142], 'M.K.': [1143], 'Sung': [1144], 'Ahn': [1146], 'K.S.': [1147], 'Kunnumakkara': [1148], 'A.B.': [1149], 'Chaturvedi': [1150], 'Aggarwal': [1152], 'B.B.': [1153], 'ligand': [1158], 'receptor,': [1161], 'potentiates': [1162], 'TNF-induced': [1163], 'modulation': [1166], 'nuclear': [1169], 'factor-kappaB': [1170], 'pathway.Blood.': [1172], '2007;': [1173], '110:': [1174], '3517-3525Crossref': [1175], '(237)': [1178], 'Scholar)': [1180, 1522, 1581], 'etc.,': [1181], 'reported.': [1184], 'But,': [1185], 'it': [1186], 'clear': [1190], 'which': [1191, 1267, 1419, 3556, 4056], 'target': [1192, 2705, 3199, 3321, 3825], 'played': [1196], 'critical': [1197], 'dimethyl': [1213, 1703], 'sulfoxide': [1214, 1704], 'isoelectric': [1215, 2726], 'focusing': [1216, 2727], 'α-cyano-4-hydroxycinnamic': [1217], 'trifluoroacetic': [1219], 'acetonitrile': [1221, 3257], 'collision-induced': [1222], 'dissociation': [1223], 'false': [1224, 4509], 'acquisition': [1229, 1232, 2267, 4383], '1': [1237, 2756, 2841, 3623, 3882, 3974, 4092, 4156, 4158, 4188], 'mitogen-activated': [1238], 'Development': [1244], 'systems': [1246, 1272], 'biology': [1247, 1273], 'shed': [1248], 'light': [1250], 'products.': [1257], 'Systems': [1258, 1289], 'pharmacology': [1259], 'appeared': [1260], 'branch': [1264], 'pharmacology,': [1266], 'application': [1270], 'approaches': [1274], 'drugs,': [1279], 'targets,': [1281], '(10.Boran': [1285], 'Iyengar': [1287], 'pharmacology.Mount': [1290], 'Sinai': [1291], 'Med.': [1293], '2010;': [1294, 2618], '77:': [1295], '333-344Crossref': [1296], '(31)': [1299], 'present': [1304, 1588, 2825], 'study,': [1305], 'after': [1306, 2054, 2216, 3323, 4567], 'checking': [1307], 'methods': [1316], 'including': [1317], 'method': [1320, 1326, 4551], '(2-DE': [1321], 'analysis)': [1322, 1329], '(nanoHPLC-ESI': [1327], 'unbiasedly': [1344], 'search': [1345, 3469, 3493, 3580, 3605, 3646, 3654], 'treatment.': [1362], 'After': [1363, 2077, 2325, 2352, 2851, 3254, 3842, 3956, 4206], 'finding': [1364], 'GA,': [1373, 1627], 'further': [1385, 3108], 'studied.': [1386], 'influence': [1388], 'increased': [1390, 3090], '(by': [1394, 1402], 'plasmid': [1395], 'transfection)': [1396, 1404], 'decreased': [1398, 3092], 'siRNA': [1403], 'checked.': [1411, 1681], 'MAPK-HSP27-vimentin-cytoskeleton': [1415], 'cascade': [1417], 'pathway,': [1418], 'included': [1420], 'published': [1421, 3157], 'targets': [1422, 1584, 1893, 2040], 'cytoskeleton': [1524], 'HSP27': [1592], 'vivo': [1601], 'observed.': [1617], 'To': [1618], 'confirm': [1619], 'checked': [1651, 4563], 'because': [1660, 2805], 'cellular': [1661, 2807], 'closely': [1664], 'related': [1665], 'EMT,': [1667], 'EMT': [1673], 'makers': [1674], 'fibronectin,': [1675], 'β-catenin,': [1676], 'E-cadherin': [1678], 'purity': [1685], 'more': [1687, 3089, 3724, 3736], 'than': [1688, 3725, 3737], '97%': [1689], 'purchased': [1691, 1743, 1758], 'Sigma-Aldrich': [1693], 'Chemical': [1694], 'Co.': [1695], '(St.': [1696], 'Louis,': [1697], 'MO).': [1698], 'dissolved': [1701], '(DMSO)': [1705], 'concentration': [1708, 1731, 1989, 2445, 3894], '0.1': [1710], 'm': [1711, 2378, 2381, 2749, 2871], 'stock': [1713], 'solution': [1714, 2095, 3227, 3273], 'kept': [1716], '−20': [1718], '°C.': [1719, 2076, 2443, 3286, 3994, 4405], 'It': [1720, 2788], 'diluted': [1723, 3308], 'culture': [1726], 'medium': [1727, 1803, 1829, 2311], 'final': [1730, 2767], 'every': [1734], 'experiment.': [1735], 'All': [1736, 2921, 4106], 'reagents': [1737], 'Bio-Rad': [1745, 2452, 2910, 3902], 'Laboratories': [1746], '(Hercules,': [1747], 'CA)': [1748], 'chemical': [1751], 'reagents,': [1752], 'except': [1753], 'where': [1754], 'specially': [1755], 'noted,': [1756], 'Sigma-Aldrich.': [1760], 'cervical': [1763], 'line': [1766, 1774, 1782], '(CCL-2),': [1768], 'adenocarcinoma': [1772], '(HTB-22)': [1776], 'osteosarcoma': [1780], '(CRL-1407)': [1784], 'obtained': [1786, 2991, 3380], 'American': [1789], 'Type': [1790], 'Culture': [1791], 'Collection': [1792], '(ATCC,': [1793], 'Rockville,': [1794], 'MD).': [1795, 4290], 'cultured': [1799, 1824, 2286], 'minimum': [1801, 1827], 'essential': [1802, 1828], 'supplemented': [1804, 1830], '10%': [1806, 1832, 3880, 3970], 'fetal': [1807, 1833], 'bovine': [1808, 1834], 'serum,': [1809, 1835], '100': [1810, 1814, 1836, 1840, 2080, 3229, 3634, 3929, 4167, 4178, 4194], 'U/ML': [1811, 1837], 'penicillin,': [1812, 1838], 'mg/L': [1815, 1841], 'streptomycin': [1816, 1842], '(Invitrogen).': [1817, 1843], "Eagle's": [1826], 'Cell': [1844, 1959, 2914, 4041, 4082, 4089, 4118], 'viability': [1845, 1960], 'without': [1850], 'measured': [1854], 'described': [1859, 3152, 3786], 'our': [1861, 2492, 3154], 'previous': [1862, 2493, 3155], 'report': [1863, 3156], '(11.Yue': [1864, 2011], 'Q.X.': [1865, 2012, 2584, 2634, 2669, 3163, 3789], 'Xie': [1866, 2013], 'F.B.': [1867, 2014], 'Guan': [1868, 2015, 2175, 2509, 2591, 2635, 2672, 3166, 3792], 'S.H.': [1869, 2016, 2592, 2636, 2673, 3167, 3793], 'Ma': [1870, 2017, 2167, 2501, 2587], 'Jiang': [1874, 2021, 2177, 2511, 2597, 2641], 'B.H.': [1875, 2022, 2598, 2642], 'D.A.': [1879, 2026, 2604, 2646, 2687, 3181, 3807], 'Interaction': [1880, 2027], 'Ganoderma': [1882, 1895, 2029, 2042, 2609], 'triterpenes': [1883, 2030, 2607], 'doxorubicin': [1885, 2032], 'characterization': [1888, 2035, 2689, 3183, 3809], 'triterpenes.Cancer': [1896, 2043], '99:': [1899, 2046], '1461-1470Crossref': [1900, 2047], '(62)': [1903, 2050], 'Briefly,': [1906, 2053, 2215, 3216, 4143], 'plated': [1909], 'density': [1912, 2293], '9': [1914], '×': [1915, 2081, 2296, 2359, 2421, 4157, 4327], '102': [1916], 'cells/well': [1917], '96-well': [1920, 3131], 'plate': [1921, 3298], 'let': [1923, 2244, 2303], 'grow': [1925, 2305], 'overnight.': [1926], 'Then,': [1927], 'media': [1929, 1934], 'changed': [1931], 'into': [1932, 3129, 3589, 4153], 'fresh': [1933], 'various': [1936], 'amount': [1937], '24,': [1941], '48,': [1942], '72': [1944], 'h.': [1945], 'Control': [1946], 'treated': [1949, 2309], '0.1%': [1951, 2321, 3310, 3874, 3967, 4246, 4264, 4358, 4366], 'DMSO': [1952, 2322], '(dose': [1953], '0': [1957], 'μm).': [1958], 'presented': [1965], '%': [1967], 'control.': [1969], 'Each': [1970, 4291], 'experiment': [1971], 'performed': [1973, 2271, 2479, 2830, 2978, 3011, 3063, 3575, 4373, 4496], 'triplicate': [1975, 2476, 2975], 'three': [1979, 2338, 2458, 2961, 3847, 4069], 'independent': [1980, 2459, 2962], 'experiments': [1981, 2460, 2963], 'statistical': [1985], 'Half-maximal': [1987], 'inhibitory': [1988], '(IC50': [1990], 'value)': [1991, 2319], 'calculated': [1993], 'Logit': [1996], 'method.': [1997], 'Flow': [1998, 2125, 2275], 'carried': [2006, 3333, 3648, 4272], 'out': [2007, 3101, 3334, 3649, 3770, 4273], 'reported': [2009, 2159], 'before': [2010, 2160, 3787], 'treatment,': [2055, 2217, 3843], 'adherent': [2057], 'detached': [2059], 'collected,': [2062, 2220], 'washed': [2063, 2221, 2337, 3846, 4068, 4161, 4308], 'PBS': [2065, 2223, 2343], 'fixed': [2068, 2086], 'ice-cold': [2070], '70%': [2071], 'ethanol': [2072], 'overnight': [2073, 2306, 3283, 3991, 4220], '4': [2075, 2295, 2427, 2779, 2815, 3993], 'centrifugation': [2078, 2353], 'g': [2082, 2422], '2': [2084, 2313, 2380, 3239, 3877, 4008], 'min,': [2085, 2891, 4311], 'resuspended': [2089, 2226, 2370], 'hypotonic': [2091], 'propidium': [2092, 2106, 2251], 'iodide': [2093, 2107, 2252], '(0.1%': [2096], 'Triton': [2097], 'X-100,': [2098], '10': [2099, 2233, 2254, 3860, 4181, 4222, 4225], 'μg/ml': [2100, 2105, 3275, 3886, 3889], 'DNase-free': [2101], 'RNase': [2102], 'A,': [2103], '50': [2104, 3247, 3481, 3484, 4230], 'PBS)': [2109], '30': [2111, 2424, 2837, 3234, 3738], 'min': [2112, 2255, 2356, 2425, 3240, 4343], 'dark.': [2114], 'stained': [2116], 'analyzed': [2119, 2965, 4140], 'Becton': [2122], 'Dickinson': [2123], 'FACSCalibur': [2124, 2274], 'Cytometer': [2126, 2276], 'percentage': [2129], 'each': [2133, 2468, 2970, 3030, 3535], 'quantitated': [2140], 'ModFit': [2143], 'software.': [2144, 2279], 'Apoptotic': [2145], 'quantified': [2148, 2947, 3899], 'detection': [2153, 3000], 'kit': [2154], '(Calbiochem,': [2155], 'Gibbstown,': [2156], 'NJ)': [2157], '(12.Feng': [2161, 2495], 'Fan': [2165, 2499], 'Meng': [2171, 2505], 'S.': [2176, 2510], 'ER': [2185, 2519], 'stress-mediated': [2186, 2520], 'celastrol': [2190, 2524], 'glycogen': [2198, 2532], 'synthase': [2199, 2533], 'kinase-3beta': [2200, 2534], 'network.Cell': [2204, 2538], 'Death': [2205, 2539], 'Dis.': [2206, 2540], '4:': [2208, 2542], 'e715Crossref': [2209, 2543], '(43)': [2212, 2546], 'binding': [2228], 'buffer': [2229, 2375, 2747, 2864, 3865, 3924, 3964], '(2.5': [2230], 'mm': [2231, 2234, 2238, 2754, 2757, 2866, 3230, 3235, 3248, 3278, 3867, 3872, 3878, 3883, 4168, 4182, 4198, 4231], 'CaCl2,': [2232], 'HEPES,': [2235], '140': [2237], 'NaCl,': [2239, 3873], 'pH': [2240, 2778, 2814, 2853, 2875, 3252, 3869], '7.5).': [2241], 'Cells': [2242, 2301], 'incubate': [2246], 'Annexin': [2248], 'V-FITC': [2249], 'dark': [2258], 'conducted.': [2265], 'Data': [2266], 'CellQuest': [2278], 'For': [2280, 2733, 2893, 3452, 4458, 4530], 'sample': [2281, 3297, 3922, 4292, 4531], 'preparation,': [2282, 4532], '75': [2288, 4322], 'cm2': [2289], 'flasks': [2290], '105': [2297], 'per': [2299, 3462, 3486], 'flask.': [2300], 'μm': [2314, 4304, 4323, 4326, 4543], '(about': [2316], 'IC50': [2318], '(solvent': [2323], 'control).': [2324], 'incubation': [2326], '3': [2330, 4546], 'h': [2331, 3975, 4093, 4189], '24': [2333], 'h,': [2334], 'times': [2339, 3848, 4070], 'ice': [2341, 2407], 'cold': [2342, 3850, 3863], 'scraped': [2346], 'off': [2347], 'scraper.': [2351], '5': [2355, 2845, 3885, 3888, 3932, 4306, 4325], '1500': [2358], 'g,': [2360], 'supernatant': [2362, 2431, 3288, 3911], 'discarded': [2364], 'pellet': [2368], '200': [2372, 3394], 'μl': [2373, 4165, 4179, 4195, 4223], 'lysis': [2374, 3864], '7': [2377, 2781, 2817, 2870], 'urea,': [2379, 2750, 2872], 'thiourea,': [2382], '2%': [2383, 2751, 2873, 4356], 'CHAPS,': [2384, 2752], '1%': [2385, 2878, 4522], 'DTT,': [2386], '0.8%': [2387], 'Pharmalyte,': [2388], 'mixture': [2391], 'Protease': [2393], '(all': [2395], 'Bio-Rad,': [2397], 'Hercules,': [2398], 'CA).': [2399], 'Homogenization': [2400], 'achieved': [2405], 'ultrasonication': [2409], '(10': [2410, 3274], 'strokes,': [2411], 'amplitude).': [2413], 'lysed': [2415, 3858], 'centrifuged': [2418, 3907], '15,000': [2420], '°C': [2428, 3930, 3978, 4096, 4186], 'solubilized': [2434], 'immediately': [2438], 'stored': [2440], '−80': [2442], 'Protein': [2444, 2455, 3684], 'samples': [2447, 2456, 2472, 2959, 3897, 3938, 4252, 4534], 'determined': [2449], 'assay.': [2454, 2465, 3904], 'harvested': [2462, 3852], 'And,': [2466], 'pair': [2469, 2971], '(control': [2473, 2955, 3007], 'GA-treated),': [2475], 'electrophoreses': [2477, 2976], 'ensure': [2481, 2980], 'reproducibility.': [2482, 2981], 'identification': [2487, 3109, 3686, 3774], 'conducted': [2489, 2724, 3138, 3374, 3784], 'similar': [2490], 'reports': [2494], '13.Yoshikawa': [2549], 'T.': [2550], 'Ogata': [2551], 'Izuta': [2553], 'Shimazawa': [2555], 'Hara': [2557], 'Takahashi': [2559], 'K.': [2560], 'Increased': [2561], 'tight': [2564], 'junctions': [2565], 'ARPE-19': [2567], 'under': [2569, 3325], 'endoplasmic': [2570], 'reticulum': [2571], 'stress.Curr.': [2572], 'Eye': [2573], 'Res.': [2574], '36:': [2576], '1153-1163Crossref': [2577], '(28)': [2580], '14.Yue': [2583], 'Song': [2585], 'X.Y.': [2586], 'Feng': [2589], 'L.X.': [2590], 'W.Y.': [2594, 2638, 2679, 3173, 3799], 'Y.J.': [2602], 'Effects': [2605], 'lucidum': [2610], 'profile': [2614], 'cells.Phytomedicine.': [2617], '17:': [2619], '606-613Abstract': [2620], '(85)': [2628], '15.Ma': [2631], 'Yue': [2633], 'Proteomic': [2647], 'cyclophosphamide': [2654], 'thymus.Food': [2657], '47:': [2661], '1841-1847Crossref': [2662], '(14)': [2665], '16.Yue': [2668], 'Cao': [2670, 3164, 3790], 'Z.W.': [2671, 3165, 3791], 'X.H.': [2675, 3169, 3795], 'Y.X.': [2681, 3175, 3801], 'P.Y.': [2683, 3177, 3803], 'Proteomics': [2688, 3144, 3161, 3182, 3339, 3808], 'ganoderic': [2695, 3189, 3815], 'D': [2697, 3191, 3817], 'computer-automated': [2699, 3193, 3819], 'estimation': [2700, 3194, 3820], 'network.Mol.': [2706, 3200, 3826], 'Proteomics.': [2708, 3202, 3828], '7:': [2710, 3204, 3830], '949-961Abstract': [2711, 3205, 3831], '(164)': [2719, 3213, 3839], '(IEF)': [2728], 'electrophoresis': [2730, 2917, 3944], 'units': [2731], '(Bio-Rad).': [2732, 2953, 3955], 'first': [2735, 2881, 3428], 'dimensional': [2736, 2896], 'separation,': [2737], 'whole': [2738], 'lysates': [2741], '(150': [2742], 'μg),': [2743], 'mixed': [2744], 'rehydration': [2746], '(8': [2748], '65': [2753], 'dithiothreitol,': [2755], 'phenylmethylsulfonyl': [2758], 'fluoride,': [2759], '0.2%': [2761], 'pI': [2762], '3–10': [2763], 'ampholytes)': [2764], 'volume': [2768, 3270, 3861, 3919], '300': [2770, 4303, 4335], 'μl,': [2771], 'applied': [2773, 3294], '17': [2775], 'cm': [2776], 'immobilized': [2777], 'linear': [2782, 2818], 'gradient': [2783, 2819, 2854, 4344], 'strips': [2784, 2820, 2855, 2899], '(Bio-Rad)': [2785, 2942, 3126], 'focused.': [2787], 'pI>7': [2794], 'might': [2795], 'Although,': [2804], 'most': [2806], 'acidic': [2810], 'proteins,': [2813], 'study.': [2826], 'IEF': [2827], 'protocol': [2828], 'following': [2833], 'conditions:': [2834], '250V,': [2835], 'linear,': [2836, 2844], 'min;': [2838], '1000V,': [2839], 'rapid,': [2840, 2848], 'h;': [2842, 2846], '10000V,': [2843], '10,000V,': [2847], '60,000': [2849], 'Vh.': [2850], 'IEF,': [2852], 'subjected': [2857, 3942], 'two-step': [2860], 'equilibration': [2861, 2863], '(50': [2865, 3866, 3939], 'Tris-HCL,': [2867], '30%': [2868], 'glycerol;': [2869], 'SDS,': [2874], '8.8)': [2876], 'dithiothreitol': [2879], '(the': [2880, 2886], 'step)': [2882, 2888], '4%': [2884], 'iodoacetamide': [2885, 4199], 'second': [2887, 2895], '15': [2890, 4328], 'respectively.': [2892], 'separation': [2897], '(SDS-PAGE),': [2898], 'transferred': [2901, 3950], 'onto': [2902, 3295, 3315, 4297, 4314], '1.0': [2903], 'mm-thick': [2904], '12%': [2905, 3946], 'polyacrylamide': [2906], 'gels': [2907, 2926, 2934, 3006, 3070, 3104, 3120], 'PROTEAN': [2911], 'II': [2912], 'xi': [2913], 'system': [2915, 4285, 4379], 'room': [2919, 3242, 4201, 4234], 'temperature.': [2920, 4235], 'spots': [2923, 2945, 3045, 3081, 3219, 3264], 'visualized': [2928, 4099], 'Coomassie': [2930], 'blue': [2931], 'staining.': [2932], 'Stained': [2933], 'scanned': [2937], 'Densitometer': [2940], 'GS-800': [2941], 'PDQuest': [2950], '7.4.1': [2951], 'software': [2952, 3368], 'Paired': [2954], 'GA-treated)': [2957, 3009], '2-DE.': [2967], 'And': [2968], 'samples,': [2974], 'Comparisons': [2982], 'made': [2984], 'between': [2985, 3003, 3068, 3094], 'gel': [2986, 3035, 3948, 4146, 4210, 4219], 'images': [2987], 'profiles': [2990], 'group': [2995, 3098], 'control': [2997, 3072, 3095, 4538], 'group.': [2998, 3075], 'Spot': [2999], 'matching': [3002], 'pairs': [3004], 'automatically,': [3012], 'followed': [3013], 'manual': [3015], 'matching.': [3016], 'individual': [3018, 3510, 3740], 'spot': [3020, 3031, 3051, 3124], 'quantity': [3021, 3028, 3041], 'normalized': [3023, 3050], 'follows:': [3025], 'raw': [3027], 'member': [3034], 'divided': [3037], 'total': [3040], 'valid': [3044], 'gel,': [3048], 'intensities': [3052], 'expressed': [3054, 3079], 'ppm.': [3056], 'A': [3057], 'two-tailed': [3058], "Student's": [3059], 't': [3060], 'test': [3061], 'perform': [3065], 'quantitative': [3066], 'significantly': [3077], 'differentially': [3078], '(p': [3082, 3755], '<': [3083, 3756], '0.05)': [3084], '1.5': [3086], 'fold': [3087], 'intensity': [3093, 3434], 'punched': [3100], 'MALDI-TOF': [3111, 3134], 'MS/MS.': [3112, 4142], 'Proteins': [3113, 3758], 'interest': [3115, 3221, 4150], 'excised': [3117], 'EXQuest': [3123], 'cutter': [3125], 'placed': [3128], 'microtiter': [3132], 'plate.': [3133], 'Applied': [3141], 'Biosystems': [3142], '4700': [3143, 3338], 'Analyzer': [3145, 3340], '(Framingham,': [3146], 'MA)': [3147], 'parameters': [3150, 3360], 'Molecular': [3159], 'Cellular': [3160], '(16.Yue': [3162, 3788], 'destained': [3223], '1:1': [3226], 'sodium': [3231], 'thiosulfate': [3232], 'potassium': [3236], 'ferricyanide': [3237], 'temperature': [3243, 4202], 'equilibrated': [3245], 'ammonium': [3249, 3279], 'bicarbonate': [3250], '8.0.': [3253], 'dehydrating': [3255], 'drying': [3259], 'SpeedVac,': [3262], 'rehydrated': [3266], 'minimal': [3269], 'trypsin': [3272, 3441, 3625, 4227, 4469], '25': [3277, 3457], 'bicarbonate)': [3280], 'incubated': [3282, 3961, 3987, 4075], '37': [3285, 3977, 4095], 'extracted': [3290, 4240, 4536], 'directly': [3293], 'equal': [3300, 3918, 4123], 'amounts': [3301, 3935], 'MALDI': [3303, 3320], 'matrix': [3304, 3449], '(5': [3305, 4293], 'mg/ml': [3306], 'CHCA': [3307], 'TFA/50%': [3311], 'ACN)': [3312], 'spotted': [3314], '192-well': [3317], 'stainless': [3318], 'steel': [3319], 'plates': [3322], 'dried': [3324, 4255], 'protection': [3327], 'N2.': [3329], 'MS': [3330, 3371, 3416, 3455, 3479, 3536, 4370], 'measurements': [3331], 'ABI': [3337], 'delayed': [3342], 'ion': [3343, 3411, 3450, 3474, 4389, 4397], 'extraction': [3344], '(Applied': [3345, 3369, 3593], 'Biosystems,': [3346], 'Fredrick,': [3347], 'MD)': [3348], 'Institutes': [3351], 'Biomedical': [3353], 'Sciences,': [3354], 'Fudan': [3355], 'University,': [3356], 'Shanghai,': [3357], 'Instrument': [3359], 'set': [3362, 3621, 3632, 3640], '4000': [3365, 4282, 4376], 'Series': [3366], 'Explorer': [3367], 'Biosystems).': [3370], 'Mass': [3377], 'spectra': [3378, 3413, 4408], 'range': [3384, 4414], '700–3200': [3386], 'Da': [3387], 'laser': [3391], '(355': [3392], 'nm,': [3393], 'Hz)': [3395], 'desorption': [3397], 'ionization': [3398], 'source.': [3399], 'accelerated': [3401], 'voltage': [3402], 'operated': [3404], '20': [3406, 3519, 4204, 4310], 'kV,': [3407], 'positive': [3410, 3473, 4510], 'recorded.': [3415], 'accuracy': [3417, 3546], 'internally': [3419], 'calibrated': [3420, 3548], 'trypsin-digested': [3422], 'horse': [3425], 'myoglobin.': [3426], 'five': [3429], 'precursor': [3430], 'ions': [3431, 3742], 'highest': [3433], 'selected': [3436, 4463, 4477], 'fragmentation,': [3438], 'excluding': [3439], 'autolysis': [3442], 'peptides,': [3443], 'keratin': [3445], 'peaks,': [3446], 'signals.': [3451], 'one': [3453, 3477, 3558], 'main': [3454, 3478], 'subspectra': [3458, 3482], '125': [3460], 'shots': [3461, 3485, 3533], 'subspectrum': [3463, 3487], 'accumulated': [3465, 3489], 'random': [3468, 3492], 'pattern.': [3470, 3494], 'mode,': [3475], 'Collision': [3495], 'energy': [3496, 4420], '1kV,': [3498], 'collision': [3499, 4419], 'gas': [3500], 'air': [3502], 'default': [3504], 'calibration': [3505], 'set.': [3507], 'Using': [3508], 'PMF': [3511, 3570, 3729], 'spectra,': [3512, 3747], 'exceeding': [3514, 3697, 3711], 'signal-to-noise': [3516], 'ratio': [3517], 'passed': [3521, 4520], 'exclusion': [3525], 'filter': [3526], 'submitted': [3528], 'fragmentation': [3530], 'Total': [3532], '2000': [3539], '3000': [3543], 'shots.': [3544], 'against': [3549, 4448], 'fragments': [3552], 'm/z': [3554, 4415], '1606.85,': [3555], 'peaks': [3561], 'generated': [3562, 4237], 'myoglobin': [3564], 'PMF.': [3565], 'Combined': [3566], 'peptide': [3567, 3741, 3745, 4423], 'fingerprinting': [3569], 'queries': [3573], 'MASCOT': [3579, 3653], 'engine': [3581, 3655], '2.2': [3582, 3656], '(Matrix': [3583, 3657], 'Science,': [3584, 3658], 'London,': [3585, 3659], 'United': [3586, 3660], 'Kingdom)': [3587, 3661], 'embedded': [3588], 'GPS-Explorer': [3590], 'Software': [3591], '3.6': [3592], 'Biosystems)': [3594], 'NCBI': [3597, 3665], 'database.': [3598, 4457], 'Peptide': [3599, 3629], 'differential': [3600], 'modifications': [3601], 'allowed': [3602], 'during': [3603], 'oxidation': [3607], 'methionines': [3609], 'carbamidomethylation': [3611], 'cysteines.': [3613], 'maximum': [3615], 'number': [3616, 4507], 'missed': [3618], 'cleavages': [3619], 'protease.': [3628], 'tolerance': [3631, 3639], 'ppm': [3635], 'fragment': [3637], '0.4': [3642], 'Da.': [3643], 'database': [3645, 3668, 3733], 'screen': [3663], 'sequence': [3667, 3746, 4452], '(updated': [3669], 'June': [3671], '27,': [3672], '2007,': [3673], '4182491': [3675], 'sequences': [3676, 4500], '1439956234': [3678], 'residues)': [3679], 'restricted': [3680], 'taxonomy.': [3683], 'homology': [3685], 'top': [3689], 'hit': [3690], '(first': [3691], 'rank)': [3692], 'relative': [3695, 3709], 'score': [3696, 3710, 3720], '95%': [3698, 4515], 'probability': [3699, 3713], 'additional': [3701], 'hits': [3702], '(second': [3703], 'rank': [3704], 'more)': [3706], '98%': [3712, 4364], 'threshold': [3714, 4524], 'retained.': [3716], 'probability-based': [3718], '64': [3726], 'when': [3727, 3743], 'submitting': [3728, 3744], 'data': [3730, 4428, 4445], 'assuming': [3748], 'match': [3752], 'significant': [3754], '0.05).': [3757], 'belonged': [3760], 'family': [3764], 'multiple': [3766], 'members': [3767], 'singled': [3769], 'based': [3771], 'unique': [3776], 'diagnostic': [3778], 'peptides.': [3779], 'TBS,': [3851], 'scraper,': [3856], 'Tris-HCl,': [3868], '7.2,': [3870], '250': [3871], 'Nonidet': [3875], 'P-40,': [3876], 'EDTA,': [3879], 'glycerol,': [3881], 'PMSF,': [3884], 'Aprotinin,': [3887], 'Leupeptin)': [3890], 'ice.': [3892], 'Lysates': [3905], 'denatured': [3914], 'mixing': [3916], '2×': [3921], 'loading': [3923, 4124], 'boiling': [3927], 'min.': [3933, 4205], 'Equal': [3934], 'μg)': [3940], 'SDS-polyacrylamide': [3947], 'nitrocellulose': [3953, 3958], 'membrane': [3954, 3959, 3985], 'TBST': [3963, 4072], '(TBS': [3965], 'Tween-20)': [3968], 'nonfat': [3971], 'milk': [3972], 'block': [3980], 'nonspecific': [3981], 'binding,': [3983], 'primary': [3989, 3996, 4046], 'rabbit': [4000, 4006, 4012, 4028, 4033, 4051, 4113], 'antiphospho(Thr180/Tyr182)-p38': [4001], 'antibody': [4004, 4010, 4015, 4020, 4026, 4031, 4036, 4047, 4054, 4116], '(1:500),': [4005, 4011, 4016, 4021, 4027], 'antiphospho(Thr334)-MAPKAPK': [4007], 'antiphospho(Ser82)-HSP27': [4013], 'polyclonal': [4014, 4030, 4035, 4053, 4115], 'mouse': [4017, 4022], 'anti-HSP27': [4018], 'anti-vimentin': [4023], '(5G3F10)': [4024], 'anti-β-catenin': [4029], '(1:1000),': [4032], 'anti-E-cadherin': [4034], '(1:600),': [4037], 'all': [4038, 4449], 'bought': [4039, 4058], 'Signaling,': [4042, 4119], 'Boston,': [4043], 'MA.': [4044], 'fibronectin': [4049], 'anti-fibronectin': [4052], '(1:200),': [4055], 'Santa': [4060], 'Cruz': [4061], 'Biotechnology,': [4062, 4103], 'Dallas,': [4063], 'TX.': [4064], 'blots': [4066, 4107], 'HRP-conjugated': [4077], 'goat': [4078, 4085], 'anti-rabbit': [4079], 'IgG': [4080, 4087], '(1:2000,': [4081, 4088], 'Signaling)': [4083, 4090], 'anti-mouse': [4086], 'chemiluminescence': [4101], '(Pierce': [4102], 'Waltham,': [4104], 'MA).': [4105], 'stripped': [4109], 'reprobed': [4111], 'anti-GAPDH': [4114], '(1:1000,': [4117], 'USA)': [4120], 'ascertain': [4122], 'protein.': [4126], 'bands': [4129, 4148, 4211], 'identified': [4130], 'cut': [4138, 4152], '1-D': [4145], 'cubes': [4154], '(ca.': [4155], 'mm)': [4159], 'twice': [4162], '400': [4164], 'NH4HCO3/ACN': [4169], '(30%v/v).': [4170], 'Cys': [4172], 'residues': [4173], 'firstly': [4175], 'reduced': [4176], 'DTT': [4183], '56': [4185], 'alkylated': [4192], '60': [4197], 'dehydration': [4207], 'ACN,': [4213], 'digested': [4217], 'ng/μl': [4226], '(Promega)': [4228], 'NH4HCO3': [4232], '60%': [4242], 'v/v': [4243, 4247], 'ACN': [4244], 'formic': [4248, 4265, 4359, 4367], 'acid.': [4249, 4266], 'Afterward,': [4250], 'completely': [4254], 'vacuum': [4258], 'centrifuge': [4259], 'reconstituted': [4262], 'nanoHPLC-ESI': [4268, 4565], 'Tempo': [4276], 'nanoMDLC': [4277], 'System': [4278], 'coupled': [4279], 'Q': [4283, 4377], 'TRAP': [4284, 4378], '(AB': [4286, 4436], 'Sciex': [4287], 'Inc.,': [4288], 'Baltimore,': [4289], 'μl)': [4294], 'loaded': [4296], 'trap': [4299], 'column': [4300, 4319], '(PepMap™': [4301], '100,': [4302], 'x': [4305, 4324], 'mm),': [4307], 'eluted': [4313], 'C18': [4316], 'reversed': [4317, 4498], '(PepMap100': [4320], 'C18,': [4321], 'cm)': [4329], 'rate': [4333, 4492], 'nL/min.': [4336], 'Peptides': [4337, 4518], 'separated': [4339], '120': [4342], 'ranging': [4345], '5%': [4347], '50%': [4349], 'mobile': [4350, 4361], '(mobile': [4353], 'A:': [4355], 'acetonitrile,': [4357, 4365], 'acid;': [4360], 'B:': [4363], 'acid).': [4368], '(IDA)': [4384], 'mode': [4385], 'setting': [4387], 'parameters:': [4388], 'spray': [4390], 'voltage:': [4391], '2300': [4392], 'V;': [4393], 'curtain': [4394], 'gas:': [4395, 4399], '20;': [4396], 'source': [4398], '15;': [4400], 'heated': [4402], 'interface:': [4403], '150': [4404], 'Tandem': [4406], 'acquired': [4410], 'over': [4411], '375–1500': [4416], 'rolling': [4418], 'optimum': [4422], 'fragmentation.': [4424], 'spectrometry': [4427, 4444], 'files': [4429], 'processed': [4432], 'ProteinPilot': [4434, 4459], '3.0': [4435], 'Sciex)': [4437], 'Paragon': [4440], 'algorithm.': [4441], 'Homo': [4453], 'sapiens': [4454], 'Uniprot_sprot_20100309': [4456], 'Paragon,': [4460], 'Iodoacetamide': [4461], 'cysteine': [4466], 'modification': [4467], 'agent,': [4468], 'digestion': [4472], 'enzyme,': [4473], '"biological': [4474], 'modifications"': [4475], '"ID': [4480], 'focus"': [4481], '"Thorough': [4484], 'ID': [4485], 'Search': [4486], 'Effort"': [4487], 'selected.': [4489], 'False': [4490], '(FDR)': [4493], 'calculate': [4505], 'expected': [4512], 'confidence': [4516], 'level.': [4517], 'FDR': [4523], 'considered': [4526], 'identification.': [4529], '(2': [4542], 'same': [4550], 'enrichment': [4568, 4589], 'phosphopeptides.': [4570], 'Phosphopeptides': [4571], 'enriched': [4573], 'TiO2': [4575], '(17.Zeng': [4576], 'H.J.': [4579], 'Shiau': [4580], 'K.J.': [4581], 'Hung': [4582], 'S.U.': [4583], 'Y.S.': [4585], 'C.C.': [4587], 'Efficient': [4588], 'phosphopeptides': [4591], 'magnetic': [4593], 'TiO(2)-coated': [4594], 'carbon-encap': [4595]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2176788997', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 9}], 'updated_date': '2025-01-12T18:50:38.977971', 'created_date': '2016-06-24'}