Publication Information

{'id': 'https://openalex.org/W2173782486', 'doi': 'https://doi.org/10.1667/0033-7587(2001)155[0402:tbeiro]2.0.co;2', 'title': 'The Bystander Effect in Radiation Oncogenesis: II. A Quantitative Model', 'display_name': 'The Bystander Effect in Radiation Oncogenesis: II. A Quantitative Model', 'publication_year': 2001, 'publication_date': '2001-03-01', 'ids': {'openalex': 'https://openalex.org/W2173782486', 'doi': 'https://doi.org/10.1667/0033-7587(2001)155[0402:tbeiro]2.0.co;2', 'mag': '2173782486', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11182790'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1667/0033-7587(2001)155[0402:tbeiro]2.0.co;2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S152208300', 'display_name': 'Radiation Research', 'issn_l': '0033-7587', 'issn': ['0033-7587', '1938-5404'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315745', 'host_organization_name': 'Radiation Research Society', 'host_organization_lineage': ['https://openalex.org/P4310315745'], 'host_organization_lineage_names': ['Radiation Research Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048201953', 'display_name': 'David J. Brenner', 'orcid': 'https://orcid.org/0000-0002-0926-1210'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D. J. Brenner', 'raw_affiliation_strings': ['aCenter for Radiological Research, Columbia University, New York, New York 10032'], 'affiliations': [{'raw_affiliation_string': 'aCenter for Radiological Research, Columbia University, New York, New York 10032', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050473614', 'display_name': 'John B. Little', 'orcid': 'https://orcid.org/0000-0003-1458-3131'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. B. Little', 'raw_affiliation_strings': ['bDepartment of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115'], 'affiliations': [{'raw_affiliation_string': 'bDepartment of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009898650', 'display_name': 'Rainer K. Sachs', 'orcid': 'https://orcid.org/0000-0002-9300-374X'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. K. Sachs', 'raw_affiliation_strings': ['cDepartment of Mathematics, University of California, Berkeley, California 94720'], 'affiliations': [{'raw_affiliation_string': 'cDepartment of Mathematics, University of California, Berkeley, California 94720', 'institution_ids': ['https://openalex.org/I95457486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 17.151, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 216, 'citation_normalized_percentile': {'value': 0.999896, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '155', 'issue': '3', 'first_page': '402', 'last_page': '408'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11176', 'display_name': 'Radiation Therapy and Dosimetry', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10358', 'display_name': 'Advanced Radiotherapy Techniques', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/3108', 'display_name': 'Radiation'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bystander-effect', 'display_name': 'Bystander effect', 'score': 0.98232776}, {'id': 'https://openalex.org/keywords/alpha-particle', 'display_name': 'Alpha particle', 'score': 0.6643785}], 'concepts': [{'id': 'https://openalex.org/C19106626', 'wikidata': 'https://www.wikidata.org/wiki/Q230749', 'display_name': 'Bystander effect', 'level': 2, 'score': 0.98232776}, {'id': 'https://openalex.org/C66385817', 'wikidata': 'https://www.wikidata.org/wiki/Q103517', 'display_name': 'Alpha particle', 'level': 2, 'score': 0.6643785}, {'id': 'https://openalex.org/C18231593', 'wikidata': 'https://www.wikidata.org/wiki/Q186161', 'display_name': 'Ionizing radiation', 'level': 3, 'score': 0.62314487}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.5584674}, {'id': 'https://openalex.org/C111337013', 'wikidata': 'https://www.wikidata.org/wiki/Q2737837', 'display_name': 'Irradiation', 'level': 2, 'score': 0.4972327}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.44028032}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.39539135}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3910993}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.38095033}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.34474498}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33731163}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32815528}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.18118948}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17855856}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.17662805}, {'id': 'https://openalex.org/C185544564', 'wikidata': 'https://www.wikidata.org/wiki/Q81197', 'display_name': 'Nuclear physics', 'level': 1, 'score': 0.10306141}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009381', 'descriptor_name': 'Neoplasms, Radiation-Induced', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009381', 'descriptor_name': 'Neoplasms, Radiation-Induced', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1667/0033-7587(2001)155[0402:tbeiro]2.0.co;2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S152208300', 'display_name': 'Radiation Research', 'issn_l': '0033-7587', 'issn': ['0033-7587', '1938-5404'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315745', 'host_organization_name': 'Radiation Research Society', 'host_organization_lineage': ['https://openalex.org/P4310315745'], 'host_organization_lineage_names': ['Radiation Research Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11182790', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1526797885', 'https://openalex.org/W1562671095', 'https://openalex.org/W1772090058', 'https://openalex.org/W1906714136', 'https://openalex.org/W1965620353', 'https://openalex.org/W1968029748', 'https://openalex.org/W1969921553', 'https://openalex.org/W1974860118', 'https://openalex.org/W1980055028', 'https://openalex.org/W1981797176', 'https://openalex.org/W1993735535', 'https://openalex.org/W2006558097', 'https://openalex.org/W2043218028', 'https://openalex.org/W2049573558', 'https://openalex.org/W2058810537', 'https://openalex.org/W2060158170', 'https://openalex.org/W2066693401', 'https://openalex.org/W2070139779', 'https://openalex.org/W2072524042', 'https://openalex.org/W2073759134', 'https://openalex.org/W2079966048', 'https://openalex.org/W2081564285', 'https://openalex.org/W2084205200', 'https://openalex.org/W2087870236', 'https://openalex.org/W2098705416', 'https://openalex.org/W2101331356', 'https://openalex.org/W2111554139', 'https://openalex.org/W2128625175', 'https://openalex.org/W2132305988', 'https://openalex.org/W2138297556', 'https://openalex.org/W2144318283', 'https://openalex.org/W2154166333', 'https://openalex.org/W2155946551', 'https://openalex.org/W2164856505', 'https://openalex.org/W2167245973', 'https://openalex.org/W2168212159', 'https://openalex.org/W2316909623', 'https://openalex.org/W2317141171', 'https://openalex.org/W2329559081', 'https://openalex.org/W4256434740'], 'related_works': ['https://openalex.org/W2620667791', 'https://openalex.org/W2372296322', 'https://openalex.org/W2370719635', 'https://openalex.org/W2359636035', 'https://openalex.org/W2167349817', 'https://openalex.org/W2083162155', 'https://openalex.org/W2060232277', 'https://openalex.org/W2053004761', 'https://openalex.org/W2015652414', 'https://openalex.org/W1979091441'], 'abstract_inverted_index': {'Brenner,': [0], 'D.': [1], 'J.,': [2], 'Little,': [3], 'J.': [4], 'B.': [5], 'and': [6, 104], 'Sachs,': [7], 'R.': [8], 'K.': [9], 'The': [10, 82, 131, 161], 'Bystander': [11], 'Effect': [12], 'in': [13, 64, 78, 97, 123, 139, 154], 'Radiation': [14], 'Oncogenesis:': [15], 'II.': [16], 'A': [17, 67], 'Quantitative': [18], 'Model.There': [19], 'is': [20, 74, 90, 133], 'strong': [21], 'evidence': [22], 'that': [23, 36, 85, 105], 'biological': [24], 'response': [25, 58, 89], 'to': [26, 38, 60, 115, 135, 196], 'ionizing': [27], 'radiation': [28], 'has': [29], 'a': [30, 50, 56, 91, 98, 124], 'contribution': [31], 'from': [32, 107, 118, 203], 'unirradiated': [33], '"bystander"': [34], 'cells': [35, 106], 'respond': [37], 'signals': [39], 'emitted': [40], 'by': [41, 144], 'irradiated': [42], 'cells.': [43], 'We': [44], 'discuss': [45], 'here': [46], 'an': [47, 197], 'approach': [48, 73], 'incorporating': [49], 'radiobiological': [51], 'bystander': [52, 88, 171, 187], 'response,': [53, 193], 'superimposed': [54], 'on': [55, 71, 138], 'direct': [57, 61, 116, 207], 'due': [59], 'energy': [62], 'deposition': [63], 'cell': [65, 128], 'nuclei.': [66], 'quantitative': [68], 'model': [69, 83, 132], 'based': [70], 'this': [72, 108], 'described': [75], 'for': [76, 158, 167], 'α-particle-induced': [77, 168], 'vitro': [79, 140], 'oncogenic': [80, 87, 141, 169], 'transformation.': [81], 'postulates': [84], 'the': [86, 156, 191], 'binary': [92], '"all': [93], 'or': [94, 146], 'nothing"': [95], 'phenomenon': [96], 'small': [99, 177], 'sensitive': [100, 109, 114, 127], 'subpopulation': [101, 110], 'of': [102, 199], 'cells,': [103], 'are': [111, 152, 173], 'also': [112], 'very': [113], 'hits': [117], 'α': [119], 'particles,': [120], 'generally': [121], 'resulting': [122], 'directly': [125], 'hit': [126], 'being': [129], 'inactivated.': [130], 'applied': [134], 'recent': [136], 'data': [137, 157], 'transformation': [142, 159], 'produced': [143], 'broad-beam': [145], 'microbeam': [147], 'α-particle': [148], 'irradiation.': [149], 'Two': [150], 'parameters': [151], 'used': [153], 'analyzing': [155], 'frequency.': [160], 'analysis': [162], 'suggests': [163], 'that,': [164], 'at': [165, 176], 'least': [166], 'transformation,': [170], 'effects': [172, 188, 208], 'important': [174], 'only': [175], 'doses—here': [178], 'below': [179], 'about': [180], '0.2': [181], 'Gy.': [182], 'At': [183], 'still': [184], 'lower': [185], 'doses,': [186, 205], 'may': [189], 'dominate': [190], 'overall': [192], 'possibly': [194], 'leading': [195], 'underestimation': [198], 'low-dose': [200], 'risks': [201], 'extrapolated': [202], 'intermediate': [204], 'where': [206], 'dominate.': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2173782486', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-14T14:29:44.782324', 'created_date': '2016-06-24'}