Helper <scp>NLR</scp> proteins <scp>NRC</scp>2a/b and <scp>NRC</scp>3 but not <scp>NRC</scp>1 are required for Pto‐mediated cell death and resistance in <i>Nicotiana benthamiana</i>

Name: Work Video:
Duration: 3 min 30 s
Chih‐Hang Wu; Khaoula Belhaj; Tolga O. Bozkurt; Marlène S. Birk; Sophien Kamoun
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['https://openalex.org/W4254167118', 'https://openalex.org/W4235505799', 'https://openalex.org/W4211085084', 'https://openalex.org/W3122401841', 'https://openalex.org/W3093800261', 'https://openalex.org/W2771435967', 'https://openalex.org/W2126592545', 'https://openalex.org/W2004053759', 'https://openalex.org/W1985609365', 'https://openalex.org/W1772966975'], 'abstract_inverted_index': {'Plants': [0], 'defend': [1], 'against': [2, 1691, 1846], 'pathogens': [3, 70], 'using': [4, 267, 479, 648, 1302, 1322, 1335, 1470, 1478, 1698, 1894, 1966, 3381, 3388], 'both': [5, 201, 1402, 1852, 2350, 2490], 'cell': [6, 21, 181, 197, 202, 509, 522, 537, 1076, 1117, 1185, 2211, 2268, 2288, 2357, 2368, 2388, 2405, 2430, 2462, 2477, 2484, 2487, 2525, 2583, 2590, 2640, 2670, 2722, 2735, 2827, 2860, 2914, 3061, 3195, 3251, 3287, 3307, 3335, 3567, 3578, 3590], 'surface': [7, 22, 203], 'and': [8, 28, 211, 222, 248, 417, 435, 488, 503, 511, 527, 530, 584, 656, 675, 711, 715, 717, 720, 733, 755, 766, 770, 774, 778, 794, 811, 825, 884, 918, 982, 991, 1023, 1030, 1102, 1179, 1228, 1264, 1282, 1294, 1369, 1373, 1375, 1378, 1399, 1405, 1447, 1487, 1500, 1543, 1578, 1627, 1634, 1651, 1660, 1679, 1711, 1759, 1780, 1804, 1814, 1820, 1848, 1854, 1921, 1949, 1963, 1969, 1982, 1992, 1999, 2078, 2113, 2167, 2169, 2186, 2248, 2264, 2276, 2296, 2330, 2352, 2366, 2397, 2435, 2492, 2531, 2580, 2596, 2605, 2626, 2645, 2749, 2756, 2758, 2786, 2849, 2876, 2881, 2888, 2945, 2954, 2957, 2971, 2986, 3011, 3053, 3071, 3100, 3108, 3128, 3137, 3161, 3179, 3183, 3244, 3268, 3284, 3433, 3448, 3459, 3467, 3470, 3475, 3480, 3484, 3549, 3604], 'intracellular': [9, 49, 216], 'immune': [10, 50, 204, 217, 2216, 2272, 3213], 'receptors': [11, 23, 51, 80, 205, 2273, 3214], '(Dodds': [12], '&': [13, 39, 72, 315, 1158, 1164, 1413, 1428, 2444, 3093, 3369], 'Rathjen,': [14, 1414, 1429, 3094], '2010;': [15, 74], 'Win': [16], 'et': [17, 43, 76, 98, 129, 133, 137, 165, 225, 232, 273, 296, 351, 355, 359, 363, 368, 372, 398, 414, 425, 651, 742, 803, 871, 889, 1019, 1036, 1040, 1056, 1131, 1138, 1144, 1152, 1170, 1176, 1215, 1243, 1247, 1276, 1390, 1438, 1687, 1740, 1762, 1766, 1862, 1866, 2142, 2408, 2448, 2513, 2554, 2609, 3033, 3218, 3275, 3316, 3365, 3373], 'al.,': [18, 44, 77, 99, 130, 134, 138, 166, 226, 233, 274, 297, 352, 356, 360, 364, 369, 373, 399, 415, 426, 652, 743, 804, 890, 1037, 1041, 1057, 1132, 1139, 1145, 1153, 1171, 1177, 1216, 1244, 1248, 1277, 1391, 1439, 1688, 1763, 1767, 1863, 1867, 2143, 2449, 3317, 3366, 3374], '2012).': [19, 78, 100, 168], 'Plant': [20, 1297], 'include': [24, 2023], 'receptor-like': [25, 29], 'kinases': [26], '(RLKs)': [27], 'proteins': [30, 121, 146, 153, 580, 619, 1223, 1261, 3191], '(RLPs),': [31], 'which': [32, 61, 498, 1202, 1754, 2153, 2198, 2437, 2662, 2818], 'respond': [33, 62], 'to': [34, 63, 113, 123, 332, 386, 534, 552, 565, 816, 856, 924, 1051, 1060, 1073, 1197, 1210, 1271, 1286, 1317, 1341, 1396, 1443, 1541, 1560, 1637, 1662, 1733, 1799, 1830, 1837, 1909, 2072, 2124, 2184, 2193, 2197, 2251, 2262, 2360, 2544, 2620, 2652, 2709, 2712, 2816, 2894, 2930, 2974, 2978, 3065, 3083, 3088, 3222, 3232, 3292, 3353, 3361, 3407, 3413, 3517, 3638], 'pathogen-derived': [35], 'apoplastic': [36], 'molecules': [37, 90], '(Boller': [38], 'Felix,': [40], '2009;': [41], 'Thomma': [42], '2011).': [45, 317, 805, 1249, 1392], 'By': [46, 1892], 'contrast,': [47, 1893], 'plant': [48, 286, 292, 1260], 'are': [52, 457, 505, 517, 705, 1123, 1232, 1363, 1536, 1555, 1635, 1797, 2042, 2085, 2104, 2438, 2613, 2666, 2700, 2823, 3013, 3055, 3139, 3188, 3246, 3492], 'typically': [53], 'nucleotide-binding': [54], 'leucine-rich': [55], 'repeat': [56], '(NB-LRR': [57, 175], 'or': [58, 91, 853, 1236, 1256, 1462, 1597, 2205, 2281, 2374, 2458, 2905, 2926, 3387, 3498, 3619], 'NLR)': [59], 'proteins,': [60], 'translocated': [64], 'effectors': [65], 'from': [66, 323, 725, 776, 895, 1205, 1588, 1748, 1889, 1979, 2056, 2489, 2704, 3383], 'a': [67, 191, 276, 379, 382, 403, 450, 480, 901, 925, 1198, 1684, 1707, 1749, 1770, 1781, 1899, 1977, 2419, 2648, 2870, 2975, 3175, 3208, 3384, 3389], 'diversity': [68], 'of': [69, 105, 158, 263, 301, 345, 381, 407, 464, 482, 496, 547, 598, 625, 643, 668, 679, 809, 828, 875, 928, 954, 963, 980, 1083, 1111, 1222, 1312, 1445, 1525, 1529, 1545, 1623, 1649, 1673, 1702, 1714, 1726, 1817, 1951, 2076, 2128, 2200, 2241, 2279, 2310, 2339, 2425, 2455, 2469, 2511, 2535, 2564, 2589, 2607, 2638, 2746, 2768, 2853, 2859, 2873, 2902, 2923, 2942, 3026, 3039, 3069, 3146, 3154, 3172, 3205, 3236, 3257, 3273, 3280, 3322, 3333, 3344, 3357, 3393, 3427, 3500, 3526, 3534, 3537, 3544, 3602, 3621], '(Eitas': [71], 'Dangl,': [73], 'Bonardi': [75, 132], 'These': [79, 2392, 2572, 2714, 3005], 'engage': [81], 'in': [82, 116, 149, 284, 311, 335, 339, 394, 453, 466, 476, 556, 568, 609, 613, 628, 637, 702, 820, 864, 900, 905, 957, 1078, 1093, 1116, 1120, 1224, 1254, 1359, 1401, 1493, 1533, 1550, 1594, 1640, 1675, 1696, 1776, 1787, 1801, 1822, 1839, 1851, 1877, 1903, 1938, 2016, 2033, 2081, 2099, 2136, 2333, 2403, 2415, 2496, 2552, 2569, 2622, 2629, 2657, 2668, 2676, 2762, 2777, 2795, 2811, 2825, 2907, 2961, 2990, 3102, 3126, 3197, 3296, 3330, 3430, 3569, 3580, 3592], 'microbial': [83, 117], 'perception': [84, 3025], 'either': [85], 'by': [86, 93, 200, 462, 514, 525, 540, 745, 783, 833, 869, 988, 1017, 1266, 1346, 1631, 1655, 1738, 2044, 2214, 2271, 2291, 2433, 2441, 2465, 2528, 2593, 2692, 2830, 2917, 3114, 3159, 3216, 3254, 3266, 3310, 3445, 3505, 3626], 'directly': [87], 'binding': [88], 'pathogen': [89, 106, 162], 'indirectly': [92], 'sensing': [94], 'pathogen-induced': [95], 'perturbations': [96], '(Win': [97], 'However,': [101, 235, 299, 3319], 'signaling': [102, 192, 3209], 'events': [103], 'downstream': [104], 'recognition': [107, 163], 'remain': [108], 'poorly': [109], 'understood.': [110], 'In': [111, 318, 375, 469, 1043, 3028, 3166, 3225], 'addition': [112], 'their': [114], 'role': [115, 3171], 'recognition,': [118], 'some': [119], 'NLR': [120, 145, 172, 3177], 'contribute': [122, 533], 'signal': [124], 'transduction': [125], 'and/or': [126, 2471], 'amplification': [127, 793, 1343], '(Gabriels': [128, 224, 272, 397, 2141, 3315], '2007;': [131, 228, 366, 370], '2011;': [135, 1764], 'Cesari': [136], '2014).': [139, 1217, 1768, 1868], 'An': [140], 'emerging': [141], 'model': [142, 290, 3204], 'is': [143, 254, 279, 448, 1565, 1572, 1580, 1724, 1746, 1874, 2002, 2012, 2793, 2802, 3124, 3156, 3325, 3613], 'that': [144, 160, 278, 341, 402, 1012, 1720, 1833, 1872, 2008, 2022, 2030, 2041, 2053, 2097, 2133, 2147, 2303, 2348, 2395, 2413, 2518, 2695, 2717, 2789, 2800, 2833, 2889, 2938, 2994, 3009, 3019, 3037, 3051, 3121, 3135, 3151, 3181, 3278, 3302, 3402], 'often': [147], 'function': [148, 555], 'pairs,': [150], 'with': [151, 654, 659, 685, 759, 798, 848, 892, 936, 1238, 1339, 1348, 1353, 1424, 1452, 1459, 1466, 1507, 1643, 1824, 1906, 2005, 2094, 2233, 2266, 2314, 2336, 2372, 2418, 2533, 2547, 2567, 2839, 2883, 3349, 3396, 3547, 3558], "'helper'": [152], 'required': [154, 177, 194, 256, 506, 3058, 3140, 3192, 3247], 'for': [155, 178, 186, 195, 257, 281, 392, 507, 520, 604, 791, 939, 949, 1002, 1015, 1028, 1075, 1381, 1497, 1522, 1567, 1574, 1582, 2223, 2681, 2807, 3059, 3141, 3193, 3211, 3248, 3422, 3436, 3495, 3616, 3642], 'the': [156, 196, 243, 258, 289, 307, 343, 346, 376, 387, 444, 458, 521, 535, 545, 569, 638, 696, 703, 737, 760, 826, 849, 984, 1004, 1009, 1088, 1220, 1360, 1467, 1489, 1530, 1539, 1561, 1595, 1601, 1638, 1641, 1657, 1692, 1699, 1715, 1721, 1777, 1788, 1794, 1802, 1811, 1855, 1878, 1890, 1924, 1933, 1939, 1947, 2009, 2013, 2024, 2031, 2034, 2057, 2073, 2095, 2100, 2108, 2126, 2129, 2137, 2148, 2155, 2162, 2195, 2201, 2210, 2230, 2234, 2245, 2267, 2287, 2304, 2308, 2311, 2319, 2327, 2337, 2345, 2426, 2429, 2475, 2509, 2536, 2548, 2630, 2693, 2696, 2705, 2744, 2787, 2790, 2804, 2826, 2834, 2913, 2920, 2939, 2982, 2995, 3014, 3029, 3056, 3152, 3170, 3189, 3201, 3227, 3249, 3263, 3306, 3320, 3331, 3342, 3355, 3394, 3425, 3439, 3446, 3454, 3460, 3472, 3486, 3496, 3506, 3518, 3617, 3627, 3639, 3643], 'activity': [157, 2728], "'sensors'": [159], 'mediate': [161, 3020], '(Bonardi': [164], '2011,': [167], 'Among': [169], 'previously': [170, 437, 1034, 1054, 1199, 1272, 1388, 1422, 1750, 3202], 'reported': [171, 189, 259, 459, 2412, 3313], 'helpers,': [173], 'NRC1': [174, 253, 264, 377, 445, 451, 465, 561, 1542, 1674, 1704, 1778, 1838, 1873, 2130, 2138, 2150, 2421, 2791, 2801, 3040, 3173, 3206, 3238, 3281], 'protein': [176, 571, 633, 1694, 1717, 1815, 2054, 2760, 2959, 3178, 3599], 'hypersensitive-response': [179], '(HR)-associated': [180], 'death': [182, 198, 510, 523, 538, 1077, 1118, 1186, 2212, 2269, 2289, 2358, 2369, 2389, 2431, 2463, 2478, 2488, 2526, 2584, 2591, 2641, 2736, 2828, 2861, 2915, 3022, 3196, 3252, 3288, 3308, 3336, 3568, 3579, 3591], '1)': [183], 'stands': [184], 'out': [185], 'having': [187], 'been': [188, 329, 411, 1886], 'as': [190, 207, 213, 215, 306, 707, 867, 1125, 1292, 1365, 1386, 1421, 1548, 1557, 1706, 1736, 1930, 1972, 2384, 2386, 2647, 2851, 3174, 3207, 3312, 3327, 3329], 'hub': [193, 3210], 'mediated': [199, 513, 2213, 2290, 2527, 2582, 2592, 2916], 'such': [206], 'Cf-4,': [208, 1141], 'Cf-9,': [209], 'Ve1': [210], 'LeEix2,': [212], 'well': [214, 2385], 'receptors,': [218], 'namely': [219], 'Pto,': [220, 515, 1127, 2274, 2918, 3255], 'Rx': [221, 526, 2295, 2365, 3267, 3283], 'Mi-1.2': [223, 2297, 2383, 2581, 3285], '2006,': [227, 365], 'Sueldo,': [229], '2014;': [230], 'Sueldo': [231], '2015).': [234, 2450], 'these': [236, 829, 2082, 2466, 2655, 2784, 3258], 'studies': [237, 340], 'did': [238, 2480, 2505, 2520, 2731, 2855, 3041, 3260, 3300], 'not': [239, 518, 2294, 2481, 2506, 2521, 2732, 2803, 2856, 3042, 3157, 3261, 3326, 3493, 3614], 'take': [240], 'into': [241, 730, 736, 780, 796, 845, 974, 993, 1234, 2038], 'account': [242], 'Nicotiana': [244, 751, 2257], 'benthamiana': [245, 294, 348, 396, 409, 574, 752, 866, 932, 1063, 1230, 1410, 1458, 1772, 1819, 1857, 1880, 2110, 2164, 2258, 2678, 2707, 2820, 2910, 3017, 3079, 3106, 3229, 3606], 'genome': [246, 349, 405, 483, 1858, 1881, 2074, 2111, 3230], 'sequence,': [247], 'it': [249, 1883], 'remains': [250], 'questionable': [251], 'whether': [252, 1793, 2453, 2741, 3067], 'indeed': [255], 'phenotypes.': [260, 2343], 'Functional': [261], 'analyses': [262, 283, 1269, 1710, 2021, 3149], 'were': [265, 602, 611, 635, 671, 728, 757, 788, 813, 831, 842, 898, 934, 944, 972, 986, 1000, 1032, 1048, 1071, 1091, 1262, 1290, 1385, 1419, 1464, 1476, 1491, 1503, 1629, 1928, 2249, 2260, 2494, 2771, 2774, 2837, 2988], 'performed': [266, 684, 832, 863, 1049, 1334, 1420, 1683, 1964, 2673, 2838, 3380, 3477], 'virus-induced': [268], 'gene': [269, 321, 384, 486, 554, 965, 1562, 1902, 1917, 2011, 2115, 2243, 2254, 2313, 2805, 2928, 3395, 3415, 3554], 'silencing': [270, 313, 393, 418, 463, 487, 558, 953, 1016, 1026, 2116, 2199, 2224, 2255, 2379, 2414, 2454, 2498, 2503, 2643, 2742, 2852, 3038, 3068, 3163, 3256, 3279, 3304, 3324, 3347, 3409, 3555], '(VIGS)': [271, 3556], '2007),': [275], 'method': [277], 'popular': [280], 'genetic': [282, 489, 549, 3350, 3403], 'several': [285], 'systems,': [287], 'particularly': [288, 338], 'solanaceous': [291, 477, 3431], 'N.': [293, 336, 347, 395, 408, 454, 467, 865, 931, 958, 1062, 1229, 1409, 1457, 1583, 1676, 1771, 1805, 1818, 1840, 1856, 1879, 2109, 2163, 2416, 2677, 2706, 2796, 2812, 2819, 2909, 3016, 3078, 3105, 3198, 3228, 3297, 3538, 3570, 3582, 3594, 3605], '(Burch-Smith': [295], '2004).': [298], 'interpretation': [300, 2007], 'VIGS': [302, 433, 861, 940, 1393, 1460, 2121, 2131, 2139, 2235, 2263, 2305, 2546, 2573, 2896, 2999], 'can': [303, 309, 429, 1591, 3378], 'be': [304, 1592, 2400, 2618, 2710, 2891, 3223, 3290, 3379, 3405, 3515, 3636], 'problematic': [305], 'experiment': [308, 2689, 3410], 'result': [310, 2649], 'off-target': [312, 3362], '(Senthil-Kumar': [314], 'Mysore,': [316], 'addition,': [319], 'heterologous': [320], 'fragments': [322, 724, 787, 808, 830, 841, 894, 985, 2332], 'other': [324, 2320, 3293], 'species': [325, 3386], '(e.g.': [326], 'tomato)': [327], 'have': [328, 421, 1885, 2060, 3048], 'frequently': [330], 'used': [331, 391, 564, 701, 790, 945, 1014, 1072, 1115, 1291, 1358, 1395, 1521, 1566, 1573, 1581, 2135, 2551, 2628], 'silence': [333, 1397], 'homologs': [334, 567, 608, 645, 670, 682, 956, 1672, 2665, 2822, 3429, 3536, 3608], 'benthamiana,': [337, 959, 1677, 1841, 2417, 2797], 'predate': [342], 'sequencing': [344, 1656], '(Burton': [350], '2000;': [353], 'Liu': [354, 870], '2002b;': [357], 'Lee': [358], '2003;': [361], 'Gabriels': [362, 1018, 2407, 2512, 2553, 2608, 3032, 3217, 3274], 'Senthil-Kumar': [367], 'Oh': [371], '2010).': [374], 'study,': [378, 471, 3031], 'fragment': [380, 855, 1011, 1978, 1989, 2132, 2179, 2422, 2550, 2566, 3546], 'tomato': [383, 674, 680, 726, 1227, 1568, 1680, 1703, 1782, 1803, 1821, 1901, 1952, 1967, 1997, 2017, 2027, 2149, 2420, 2663, 2697, 2840, 3237, 3527, 3603], 'corresponding': [385, 761, 893, 3640], 'LRR': [388, 2156], 'domain': [389], 'was': [390, 563, 646, 683, 862, 1013, 1188, 1203, 1300, 1315, 1333, 1394, 1441, 1520, 1653, 1774, 1784, 1936, 1990, 2134, 2690, 3443], '2007).': [400, 1042, 1415, 1430, 2144, 3095, 3318], 'Given': [401], 'draft': [404], 'sequence': [406, 1586, 1701, 1712, 1914, 1948, 1962, 2064, 2112, 2175, 2182, 3532], 'has': [410, 1918, 2180, 3080], 'generated': [412, 2752, 2869, 2950], '(Bombarely': [413], '2012)': [416], 'prediction': [419, 2118], 'tools': [420], 'become': [422], 'available': [423, 1812], '(Fernandez-Pozo': [424], '2015),': [427], 'we': [428, 472, 499, 1682, 1808, 1897, 1954, 2228, 2325, 2519, 2634, 2650, 2672, 2751, 2798, 2868, 2949, 3047, 3063, 3097, 3168], 'now': [430, 3049], 'design': [431, 2219, 2252], 'better': [432], 'experiments': [434, 2140, 2504, 2574, 2675, 2715, 3006, 3348], 'revisit': [436], 'published': [438], 'studies.': [439], 'Two': [440], 'questions': [441], 'arise': [442], 'about': [443], 'study.': [446], 'First,': [447], 'there': [449], 'ortholog': [452, 1773, 1783, 2015, 2792, 3235], 'benthamiana?': [455, 468], 'Second,': [456], 'phenotypes': [460], 'caused': [461], 'this': [470, 1534, 1589, 1916, 2177, 2565], 'investigated': [473], 'NRC1-like': [474, 3294], 'genes': [475, 897, 1531, 2098, 2165, 2207, 2460, 2656, 2684, 2842, 3018, 3057, 3259, 3382], 'plants': [478, 933, 1064, 1411, 1475, 2259, 2679, 3091], 'combination': [481], 'annotation,': [484], 'phylogenetics,': [485], 'complementation': [490, 550, 1225, 2674, 2727, 2835, 3351, 3377, 3404], 'experiments.': [491, 559, 2631, 2659], 'We': [492, 1828, 1974, 2106, 2145, 2451, 2814, 2845, 3299, 3400], 'discovered': [493, 3180], 'three': [494, 1505, 1729, 1919, 2039, 2083, 2088], 'paralogs': [495, 2321], 'NRC1,': [497, 3187], 'termed': [500, 2878], 'NRC2a,': [501, 753], 'NRC2b': [502, 754], 'NRC3,': [504, 1953, 2646, 2850, 3184], 'hypersensitive': [508, 536, 2809, 3021, 3250], 'resistance': [512, 3082, 3123], 'but': [516, 2284, 2293, 2479, 2585, 2615, 2729, 2773], 'essential': [519], 'triggered': [524, 539, 2270, 2464], 'Mi-1.2.': [528, 2277, 3269], 'NRC2a/b': [529, 1398, 2280, 2329, 2351, 2396, 2470, 2644, 2848, 3052, 3070, 3099, 3127, 3136, 3160, 3182, 3243], 'NRC3': [531, 756, 1400, 1789, 1998, 2001, 2014, 2028, 2206, 2282, 2331, 2353, 2398, 2459, 2472, 3054, 3072, 3101, 3129, 3138, 3162, 3245, 3564], 'weakly': [532, 2473], 'Cf-4.': [541], 'Our': [542, 2501, 2688, 3339], 'results': [543, 601, 1544, 2393, 2510, 2604, 2785, 3145], 'highlight': [544], 'importance': [546, 3343], 'applying': [548], 'assays': [551, 1047, 1119, 2836, 3352], 'validate': [553, 1946], 'RNA': [557, 1299, 1311, 3346, 3408], 'Tomato': [560, 579, 3563], '(Solyc01g090430)': [562, 1705], 'identify': [566, 1670, 1831], 'predicted': [570, 577, 589, 618, 1693, 1960], 'databases': [572, 1599, 1695, 1816], '(Nicotiana': [573], 'Genome': [575], 'v0.4.4': [576], 'protein,': [578], 'ITAG': [581, 586, 615], 'release': [582, 587, 616], '2.40,': [583], 'Potato': [585, 614, 629], '1': [588, 617], 'proteins)': [590], 'on': [591, 663, 673, 1008, 1538, 1913, 1958, 2087, 2173, 2318, 2524, 2578, 2654, 2783, 2847, 3424], 'Solanaceae': [592], 'Genomics': [593], 'Network': [594], '(SGN).': [595], 'Top': [596], 'hits': [597, 1718], 'BLASTP': [599, 1685], 'search': [600, 1690], 'collected': [603], 'further': [605, 792, 950], 'analyses.': [606, 639], 'NRC2': [607, 623], 'potato': [610, 626, 676, 1575, 1910, 2000, 2077], 'missing': [612, 1775, 1786, 1795, 1876, 1937, 2794, 3512, 3633], 'database.': [620], 'Therefore,': [621, 3200], 'two': [622, 1922, 1926, 2328], 'sequences': [624, 634, 1639, 1796, 1832, 1850, 2032, 2055, 2080, 2232, 2699, 2887, 3295, 3600], 'identified': [627, 2026, 3050], 'PGSC': [630], 'DM': [631], 'v3.4': [632], 'included': [636], 'The': [640, 722, 786, 806, 839, 997, 1025, 1081, 1108, 1183, 1431, 1527, 1986, 1994, 2237, 2600, 3144, 3270, 3417, 3611], 'phylogenetic': [641, 1546], 'tree': [642], 'NRC': [644, 669, 681, 955, 1722, 1826, 2035, 2102, 2664, 2683, 2698, 2821, 2841, 3303, 3428, 3535, 3607], 'built': [647], 'Mega6-Beta2': [649], '(Tamura': [650], '2013)': [653], 'Neighbor-joining': [655], 'Maximum-likelihood': [657], 'methods': [658, 1052, 1274], 'bootstrap': [660, 2046], 'values': [661, 2047], 'based': [662, 672, 1007, 1537, 1957], '1000': [664], 'iterations.': [665], 'Chromosome': [666], 'assignments': [667], 'genomes.': [677], 'Cloning': [678, 3525], 'Gateway': [686, 746], 'cloning': [687, 704, 801], 'kit': [688], '(Invitrogen,': [689], 'Thermo': [690], 'Scientific,': [691], 'Waltham,': [692], 'MA,': [693], 'USA)': [694, 1519], 'following': [695, 998, 1602, 3023, 3345], "manufacturer's": [697], 'instruction.': [698], 'Primer': [699, 1356], 'pairs': [700, 763, 1357], 'listed': [706, 1364, 1646], 'follows:': [708, 1126, 1366], 'SlNRC1-F/R': [709], '(5′-CACCATGGTTGATGTAGGGGTTGAATTTC-3′': [710], '5′-CTAAGAAGCTGTCTGTACATCAGAATC-3′),': [712], 'SlNRC2-F/R': [713], '(5′-CACCATGGCGAACGTAGCAGTGGAATTTC-3′': [714], '5′-TCAGAGATCAGGAGGGAATATGGAAAG-3′),': [716], 'SlNRC3-F/R': [718], '(5′-CACCATGGCGGATGTAGCAGTAAAGTTCTTA-3′': [719], '5′-TTACAATCCAAGATCATGAGGGAAT-3′).': [721], 'amplified': [723, 758, 1976, 1987], 'cDNA': [727, 777, 1320, 1632, 1968, 1983, 1988], 'cloned': [729, 779, 973, 992, 1991], 'pENTR/D-TOPO': [731], '(Invitrogen)': [732, 782, 1281], 'then': [734, 789, 843, 1448, 1488], 'introduced': [735], 'pK7WG2': [738], 'destination': [739], 'vector': [740], '(Karimi': [741, 1242], '2002)': [744], 'LR': [747], 'recombination': [748], 'enzyme': [749], '(Invitrogen).': [750], 'primer': [762], '(NbNRC2a-F/R:': [764], '5′-CACCATGGCGAACGTTGCGGTGGAGTTTCTGG-3′': [765], '5′-TCAGAGATCGGGAGGGAATATAGAGAGCTT-3′;': [767], 'NbNRC2b-F/R:': [768], '5′-ATGGCGAACGTTGCGGTGGA-3′': [769], '5′-AATTGGTCTCTAAGCTTAGAGATCGGGAGGGAATATAGAG-3′;': [771], 'NbNRC3-F/R:': [772], '5′-AATTGGTCTCTAATGGCAGATGCAGTAGTGAATTTTCTGGTG-3′': [773], '5′-ATTGGTCTCGAAGCTTACTGTGTGGCCTTGGATCCAGCTTC-3′)': [775], 'pCR8/GW/TOPO': [781], 'TA': [784], 'cloning.': [785], 'subcloning': [795], 'pICH86988': [797, 846], 'Golden': [799], 'Gate': [800], '(Weber': [802], 'synthetic': [807, 840, 2871, 2940, 3391], 'NbNRC2a/b': [810, 981, 2166, 3010], 'NbNRC3': [812, 854, 1618, 1628, 2187, 2927, 2946, 2955, 2987, 3012], 'designed': [814, 1001, 1955, 3471], 'manually': [815], 'introduce': [817], 'synonymous': [818, 2885], 'substitution': [819], 'every': [821], 'codon': [822, 2886, 3398], 'when': [823], 'possible,': [824], 'syntheses': [827], 'Genewiz': [834], '(South': [835], 'Plainfield,': [836], 'NJ,': [837], 'USA).': [838], 'subcloned': [844, 1233], 'together': [847], 'remaining': [850], 'NbNRC2a,': [851, 2874, 2924, 2943, 2952, 2984], 'NbNRC2b': [852, 1614, 1652, 3587], 'generate': [857], 'full-length': [858, 1961], 'NbNRC': [859, 2226, 2231, 2502], 'variants.': [860], 'described': [868, 1033, 1053, 1200, 1273, 1387, 1423, 1737, 1751], 'al.': [872, 1020, 1741, 2409, 2514, 2555, 2610, 3034, 3219, 3276], '(2002a).': [873], 'Suspensions': [874], 'Agrobacterium': [876], 'tumefaciens': [877, 938, 1085, 1113], 'strain': [878], 'GV3101': [879], 'harboring': [880], 'TRV': [881, 885, 975, 994], 'RNA1': [882], '(pYL155)': [883], 'RNA2': [886, 976, 995], '(pYL279)': [887], '(Liu': [888], '2002a)': [891], 'indicated': [896, 1124, 1556, 1719, 2052, 2302, 3150], 'mixed': [899], '2': [902, 1309], ':1': [903], 'ratio': [904], 'infiltration': [906, 1094, 1194], 'buffer': [907, 1095], '(10': [908, 1096], 'mM': [909, 914, 1097, 1100, 1454, 1495], 'MES': [910], '(2-[N-morpholino]ethanesulfonic': [911], 'acid),': [912], '10': [913, 1099, 1450, 1453, 1494], 'magnesium': [915], 'chloride': [916], '(MgCl2),': [917], '150': [919, 1103], 'μM': [920, 1104], 'acetosyringone,': [921, 1105], 'pH': [922, 1106], '5.6)': [923], 'final': [926, 1109], 'OD600': [927, 1444], '0.3.': [929], 'Two-week-old': [930], 'infiltrated': [935], 'A.': [937, 1084, 1112], 'assays,': [941, 1226], 'upper': [942], 'leaves': [943, 1122, 2779, 2911, 2964, 3131], '2–3': [946, 1066], 'wk': [947, 1067], 'later': [948], 'agroinfiltrations.': [951], 'For': [952, 978], '5′': [960, 2238], 'coding': [961, 1658, 2239], 'region': [962, 1659], 'each': [964, 1313, 1484, 2242], '(NbNRC2a/b,': [966], '1-429b;': [967], 'NbNRC2c,': [968, 2168], '1-426bp;': [969], 'NbNRC3,': [970, 983, 2877], '1-444bp)': [971], 'vector.': [977, 996], 'co-silencing': [979], 'fused': [987], 'overlap': [989], 'PCR': [990, 1361, 1965], 'primers': [999, 1956], 'generating': [1003], 'TRV2-SlNRC1': [1005], 'construct': [1006, 2335, 2347], 'SlNRC1': [1010, 1605, 2730], '(2007):': [1021], '5′-CACCTTAAAGTCATTCCGAAACATGTTGG-3′': [1022], '5′-TCGAGAGAACATACTCAGTGCAGC-3′.': [1024], 'constructs': [1027, 1090, 2222, 2306, 2538], 'SGT1': [1029, 2380], 'SERK3': [1031, 2497], '(Peart': [1035], '2002;': [1038, 1245], 'Heese': [1039], 'planta': [1044], 'transient': [1045], 'agroinfiltration': [1046, 1253], 'according': [1050, 1196, 1270], '(Bos': [1055, 1175], '2006).': [1058], 'Four': [1059, 1473], 'five-week-old': [1061], '(i.e.': [1065], 'after': [1068, 1252, 1843, 2642], 'virus': [1069], 'inoculation)': [1070], 'test': [1074, 2194, 2740, 3066], 'VIGSed': [1079, 1121], 'leaves.': [1080, 2765], 'concentration': [1082], 'strains': [1086], 'carrying': [1087], 'expression': [1089, 1950, 2309, 2745], 'adjusted': [1092, 1442], 'MES,': [1098], 'MgCl2,': [1101], '5.6).': [1107], 'concentrations': [1110], '(OD600)': [1114], '0.6': [1128], '(de': [1129, 1136], 'Vries': [1130, 1137], '2006);': [1133, 1140], 'AvrPto,': [1134], '0.1': [1135, 1162], '0.4': [1142, 1148], '(Liebrand': [1143], '2012),': [1146, 1172], 'AVR4,': [1147], '(Van': [1149], 'der': [1150], 'Hoorn': [1151], '2000);': [1154], 'Rx,': [1155, 2275, 2529, 2594], '0.2': [1156, 1446], '(Tameling': [1157, 1163], 'Baulcombe,': [1159, 1165], '2007);': [1160, 1166], 'CP,': [1161], 'Mi-1.2T557S,': [1167], '0.8': [1168], '(Lukasik-Shreepaathy': [1169], 'INF1,': [1173, 2436], '0.3': [1174], '2006)': [1178], 'SlNRC/NbNRC': [1180], 'variants,': [1181], '0.6.': [1182], 'HR': [1184, 1208], 'phenotype': [1187], 'scored': [1189], 'at': [1190, 1483, 1727, 2061], '7': [1191], 'd': [1192], 'post': [1193], '(dpi),': [1195], 'scale,': [1201], 'modified': [1204], 'zero': [1206], '(no': [1207], 'observed)': [1209], 'seven': [1211], '(confluent': [1212], 'necrosis)': [1213], '(Segretin': [1214], 'To': [1218, 1669, 1791, 1945, 2218, 2632, 2660, 2739, 2865, 2936], 'detect': [1219], 'accumulation': [1221, 1524, 2761, 2960, 3153], 'NRCs': [1231], 'pK7WGF2': [1235], 'pICH86966': [1237], 'N-terminal': [1239], 'GFP': [1240], 'fusion': [1241], 'Weber': [1246], 'Three': [1250], 'days': [1251], 'control': [1255, 1383, 1461, 2979], 'NRC-silenced': [1257, 3581, 3593], 'leaves,': [1258, 2992], 'total': [1259, 1298], 'extracted': [1263, 1301], 'analyzed': [1265, 2229, 3482], 'western': [1267, 3147], 'blot': [1268, 3148], '(Oh': [1275], '2009).': [1278], 'Commercial': [1279], 'anti-GFP': [1280], 'anti-rabbit': [1283], 'antibody': [1284, 1512], 'conjugated': [1285], 'horseradish': [1287], 'peroxidase': [1288], '(Sigma-Aldrich)': [1289], 'primary': [1293], 'secondary': [1295], 'antibody.': [1296], 'RNeasy': [1303], 'Mini': [1304], 'Kit': [1305], '(Qiagen,': [1306], 'Hilden,': [1307], 'Germany).': [1308], 'μg': [1310], 'sample': [1314, 1490], 'subject': [1316], 'first': [1318, 1925], 'strand': [1319], 'synthesis': [1321], 'Ominiscript': [1323], 'RT': [1324], 'Kit.': [1325], 'Semi-quantitative': [1326, 2300], 'reverse': [1327], 'transcription': [1328], 'polymerase': [1329], 'chain': [1330], 'reaction': [1331, 1362], '(RT-PCR)': [1332], 'DreamTaq': [1336], '(Thermo': [1337], 'Scientific)': [1338], '25': [1340], '30': [1342], 'cycles': [1344], 'followed': [1345], 'electrophoresis': [1347], '2%': [1349], 'agarose': [1350], 'gel': [1351], 'stained': [1352], 'Ethidium': [1354], 'bromide.': [1355], 'NbNRC2a/b-RT-F/R': [1367], '(5′-AGTGGATGAGAGTGTGGGTG-3′': [1368], '5′-AAGCAGGGATCTCAAAGCCT-3′),': [1370], 'NbNRC2c-RT-R/F': [1371], '(5′-TCAAAACATGCCGTGTTCAT-3′': [1372], '5′-CCTGCGGGTTTTGTACTGAT-3′)': [1374], 'NbNRC3-RT-F/R': [1376], '(5′-CCTCGAAAAGCTGAAGTTGG-3′': [1377], '5′-TGTCCCCTAAACGCATTTTC-3′).': [1379], 'Primers': [1380], 'internal': [1382], 'NbEF1α': [1384], '(Segonzac': [1389], 'wild': [1403, 3089], 'type': [1404, 3090], 'Pto/Prf': [1406, 3076, 3103], 'transgenic': [1407, 3077, 3104], '(R411B)': [1408], '(Balmuth': [1412, 1427, 3092], 'Bacteria': [1416], 'growth': [1417, 3118], 'assay': [1418, 3119, 3557], 'minor': [1425], 'modifications': [1426], 'Pseudomonas': [1432], 'syringae': [1433, 3085, 3111], 'DC3000': [1434, 3086, 3112], 'ΔhopQ1-1': [1435, 3113], 'culture': [1436, 1469], '(Wei': [1437], '2007)': [1440, 2411, 2516, 2557, 2612], 'diluted': [1449], '000-fold': [1451], 'MgCl2.': [1455], 'Five-week-old': [1456], 'NRC2a/b/3-silencing': [1463], 'inoculated': [1465, 3109], 'bacterial': [1468], 'needleless': [1471], 'syringe.': [1472], 'replicate': [1474], 'sampled': [1477], '0.33': [1479], 'cm2': [1480], 'cork': [1481], 'borer': [1482], 'time': [1485], 'points,': [1486], 'homogenized': [1492], 'MgCl2': [1496], 'serial': [1498], 'dilution': [1499], 'plating.': [1501], 'Experiments': [1502], 'repeated': [1504], 'times': [1506], 'similar': [1508, 2976], 'results.': [1509], 'Polyclonal': [1510], 'anti-myc': [1511], 'A-14': [1513], '(Santa': [1514], 'Cruz': [1515], 'Biotechnology,': [1516], 'Dallas,': [1517], 'TX,': [1518], 'detecting': [1523], 'Prf:5myc.': [1526], 'nomenclatures': [1528], 'mentioned': [1532], 'article': [1535, 1590], 'orthology': [1540], 'analysis': [1547], 'shown': [1549], 'Fig.': [1551, 1943, 2570, 3523, 3529, 3540, 3551, 3561, 3572, 3584], '1.': [1552], 'Species': [1553], 'names': [1554], 'two-letter': [1558], 'prefixes': [1559], 'names;': [1563], 'Sl': [1564], '(Solanum': [1569, 1576], 'lycopersicum),': [1570], 'St': [1571], 'tuberosum)': [1577], 'Nb': [1579], 'benthamiana.': [1584, 2813, 3199, 3298, 3539, 3571, 3583, 3595], 'DNA': [1585, 1971, 1981], 'data': [1587, 3359, 3483], 'found': [1593, 2146], 'SGN': [1596, 1697, 1823, 1853], 'GenBank/EMBL': [1598], 'under': [1600, 1664], 'accession': [1603, 1644, 1665], 'numbers:': [1604], '(Solyc01g090430,': [1606], 'NP_001234202),': [1607], 'SlNRC2': [1608, 2724], '(Solyc10g047320),': [1609], 'SlNRC3': [1610, 1626, 2718, 2757], '(XP_004238948.1),': [1611], 'NbNRC2a': [1612, 1650, 3548, 3575], '(NbS-00018282),': [1613], '(NbS00026706),': [1615], 'NbNRC2c': [1616], '(NbS000-31134),': [1617], '(NbS00011087),': [1619], 'StNRC3': [1620], '(Sotub05g007690).': [1621], 'Sequences': [1622], 'SlNRC1,': [1624, 2747, 2754], 'SlNRC2,': [1625, 2748, 2755], 'confirmed': [1630], 'sequencing,': [1633], 'identical': [1636], 'database': [1642, 1859], 'numbers': [1645, 1666], 'above.': [1647], 'Sequence': [1648], 're-annotated': [1654], 'submitted': [1661], 'NCBI': [1663], 'KT936525,': [1667], 'KT936526.': [1668], 'putative': [1671], 'potato,': [1678], 'genomes,': [1681, 1807], '(Altschul': [1686], '1990)': [1689], 'polypeptide': [1700], 'query.': [1708], 'Phylogenetic': [1709, 2020], 'comparisons': [1713, 2051], 'top': [1716], 'family': [1723, 2036], 'composed': [1725], 'least': [1728, 2062], 'subclades': [1730, 2040], '(NRC1-3)': [1731], 'belonging': [1732], 'clade': [1734, 1745, 1752], 'CNL-14': [1735], 'Andolfo': [1739, 1765], '(2014).': [1742], 'This': [1743, 2190, 2541, 3441], 'NRC/CNL-14': [1744], 'distinct': [1747], 'CCR/CNL-RPW8,': [1753], 'includes': [1755], 'helper': [1756, 3176], 'NLRs': [1757], 'ADR1': [1758], 'NRG1': [1760], '(Collier': [1761], 'Surprisingly,': [1769], 'subclade': [1779, 2059, 2103], 'also': [1785, 2561], 'subclade.': [1790], 'determine': [1792, 2817], 'due': [1798, 2619, 3291, 3360], 'misannotation': [1800], 'benthamina': [1806], 'searched': [1809], 'all': [1810], 'nucleotide': [1813, 2562], 'representative': [1825], 'sequences.': [1827, 3399], 'failed': [1829, 2929], 'show': [1834], 'high': [1835, 1907], 'similarity': [1836, 1908], 'even': [1842], 'blast': [1844], 'searches': [1845], 'scaffolds': [1847], 'contigs': [1849], '(http://www.benthgenome.com)': [1860], '(Naim': [1861], '2012;': [1864], 'Nakasugi': [1865], 'We,': [1869], 'therefore,': [1870], 'concluded': [1871], 'probably': [1875, 2160, 2701], 'although': [1882, 3242], 'may': [1884, 2399, 3289], 'somehow': [1887], 'omitted': [1888], 'assembly.': [1891], 'TBLASTN': [1895], 'searches,': [1896], 'detected': [1898], 'misannotated': [1900], 'contig': [1904], 'SL2.40ct02653': [1905], 'NRC3.': [1911, 3528], 'Based': [1912, 2172, 2782], 'comparisons,': [1915, 2176], 'exons': [1920, 1927], 'introns;': [1923], 'annotated': [1929], 'Solyc05g009630': [1931], 'whereas': [1932, 2378, 2486, 2919, 2981], 'third': [1934], 'exon': [1935], 'annotation': [1940], '(Supporting': [1941], 'Information': [1942], 'S1a).': [1944], 'our': [1959, 2006, 2603], 'genomic': [1970, 1980], 'template.': [1973], 'successfully': [1975], '(Fig.': [1984, 2018, 2048, 2091, 2188, 2298, 2322, 2363, 2390, 2499, 2539, 2558, 2598, 2737, 2780, 2843, 3132, 3164, 3239, 3337], 'S1b).': [1985], 'sequenced.': [1993], 'identity': [1995, 2065, 2183], 'between': [1996, 2602], '95%,': [2003], 'consistent': [2004, 2093], 'encoding': [2010], 'S1c).': [2019], 'newly': [2025], 'revealed': [2029, 2575, 2716, 3120], 'fall': [2037], 'supported': [2043], 'robust': [2045, 2342, 2636], '1).': [2049, 3240], 'Pairwise': [2050, 3542, 3598], 'same': [2058, 2101], '78%': [2063], '(Figs': [2066, 2685, 2862, 2897, 2932, 2965, 3001], '1,': [2067, 2686], 'S2;': [2068], 'Table': [2069, 3596], 'S1).': [2070], 'According': [2071], 'information': [2075, 3503, 3624], 'tomato,': [2079], 'clades': [2084], 'located': [2086], 'different': [2089, 2215, 3385], 'chromosomes': [2090], '1),': [2092], 'view': [2096], 'orthologous.': [2105], 'exploited': [2107], 'associated': [2114], 'target': [2117, 2161], 'tool': [2119], '(SGN': [2120], 'tool;': [2122], 'http://vigs.solgenomics.net)': [2123], 'analyze': [2125], 'specificity': [2127, 2247], '(SlNRC1)': [2151], 'fragment,': [2152], 'matches': [2154], 'domain,': [2157], 'would': [2158], 'most': [2159], 'possibly': [2170], 'NbNRC3.': [2171, 3550], 'pairwise': [2174], 'SlNRC1-LRR': [2178, 3545, 3559], '70–80%': [2181], 'NbNRC2a/b/c': [2185], 'S3).': [2189, 2571], 'prompted': [2191, 2542], 'us': [2192, 2543], 'degree': [2196], 'individual': [2202, 2225], 'NRC2a/b,': [2203, 2456], 'NRC2c': [2204, 2457, 2854], 'could': [2208, 2616], 'suppress': [2209], 'receptors.': [2217], 'more': [2220, 2341], 'specific': [2221], 'paralogs,': [2227], 'tool.': [2236], 'regions': [2240], 'provided': [2244], 'highest': [2246], 'selected': [2250], 'new': [2253], 'constructs.': [2256], 'subjected': [2261], 'challenged': [2265], 'Silencing': [2278, 2468], 'moderately': [2283], 'significantly': [2285], 'reduced': [2286, 2307, 2428, 2474, 2495, 2772, 3305], 'Pto': [2292, 2579, 2831, 3024], '2a).': [2299, 2391, 2540], 'RT-PCR': [2301], 'targeted': [2312], 'no': [2315, 2586], 'detectable': [2316, 2587, 2776], 'effects': [2317, 2523, 2577, 3363], '2b).': [2323, 2500], 'Next,': [2324], 'combined': [2326], 'one': [2334], 'aim': [2338], 'obtaining': [2340], 'Interestingly,': [2344], 'double-silencing': [2346], 'targets': [2349], 'dramatically': [2354], 'suppressed': [2355], 'Pto-mediated': [2356, 2387, 2404, 2639, 2669, 2734, 3044, 3060, 3074, 3122, 3142, 3194, 3334, 3577, 3589], 'close': [2359], 'background': [2361], 'levels': [2362], '2a,c).': [2364], 'Mi-1.2-mediated': [2367], 'remained': [2370], 'unaffected': [2371], 'single': [2373], 'double': [2375], 'NRC-silencing': [2376], 'constructs,': [2377], 'compromised': [2381, 3125], 'Rx-,': [2382], 'suggest': [2394], 'functionally': [2401], 'redundant': [2402], 'death.': [2406], '(2006,': [2410, 2515, 2556, 2611], 'matching': [2423], 'part': [2424], 'LRR,': [2427], 'induced': [2432, 3253, 3309], 'AVR4': [2434], 'recognized': [2439], 'extracellularly': [2440], 'RLPs': [2442], '(Rivas': [2443], 'Thomas,': [2445], '2005;': [2446], 'Du': [2447], 'tested': [2452, 2537], 'impairs': [2461], 'proteins.': [2467], 'Cf-4/AVR4': [2476, 2491], 'affect': [2482, 3043, 3158, 3262], 'INF1-triggered': [2483], 'death,': [2485, 2671, 2723, 3062], 'INF1': [2493, 2532, 2597], 'fully': [2507], 'match': [2508], 'given': [2517, 2832], 'observe': [2522, 3301], 'Mi-1.2,': [2530], 'any': [2534, 3501, 3622], 'perform': [2545], 'original': [2549, 2921, 2983], 'S4,': [2559], 'see': [2560], 'alignment': [2563, 3533, 3543], 'NbNRCs': [2568], 'moderate': [2576], 'alteration': [2588], 'Cf-4': [2595, 3311], 'S4).': [2599], 'discrepancy': [2601], 'those': [2606], 'striking': [2614], 'still': [2617, 2775], 'differences': [2621], 'experimental': [2623], 'set': [2624], 'up': [2625], 'materials': [2627], 'summarize,': [2633], 'observed': [2635], 'reduction': [2637, 2858], 'decided': [2651, 3064], 'focus': [2653], 'follow-up': [2658], 'clarify': [2661], 'implicated': [2667, 2824], 'silenced': [2680, 2764, 2963, 2991, 3098, 3130], 'endogenous': [2682], '2).': [2687, 3338], 'motivated': [2691], 'observation': [2694, 2788], 'divergent': [2702, 2892], 'enough': [2703, 2893], 'ones': [2708], 'resilient': [2711], 'silencing.': [2713], 'partially': [2719], 'rescued': [2720, 2912], 'Pto-elicited': [2721, 2808], 'showed': [2725, 3036], 'weak': [2726], 'rescue': [2733], 'S5a).': [2738], 'affects': [2743], 'SlNRC3,': [2750], 'GFP-tagged': [2753, 2951], 'assessed': [2759, 2958], 'NRC2a/b/3': [2763, 2962], 'Protein': [2766, 3531], 'level': [2767, 2977], 'SlNRC': [2769], 'variants': [2770, 2941, 2956], 'NRC2a/b/3-silenced': [2778, 2908], 'S5b).': [2781], 'reasoned': [2799], 'responsible': [2806, 3494, 3615], 'response': [2810, 3264], 'aimed': [2815], 'elicited': [2829, 3265], 'S5).': [2844], 'focused': [2846], 'yield': [2857], '2,': [2863], 'S2).': [2864], 'achieve': [2866], 'this,': [2867], 'version': [2872, 3392], 'NbNRC2b,': [2875, 2925, 2944, 2953, 2985], 'NbNRC2asyn,': [2879, 2903, 2969], 'NbNRC2bsyn,': [2880, 2904, 2970], 'NbNRC3syn,': [2882], 'shuffled': [2884, 2996, 3397], 'should': [2890, 3514, 3635], 'evade': [2895, 2947], '3a,': [2898], 'S6a,': [2899], 'S7a).': [2900], 'Expression': [2901], 'NbNRC3syn': [2906, 2972], 'versions': [2922], 'complement': [2931], '3b,': [2933], 'S6b,': [2934], 'S7b).': [2935], 'confirm': [2937], 'VIGS,': [2948], '3c,': [2966, 3002], 'S6c,': [2967, 3003], 'S7c).': [2968, 3004], 'accumulated': [2973], 'treatments': [2980], 'undetectable': [2989], 'indicating': [2993], 'codons': [2997], 'enabled': [2998], 'evasion': [3000], 'clearly': [3007], 'demonstrate': [3008], 'causal': [3015, 3190], 'AvrPto.': [3027], 'previous': [3030, 3271], '(2007)': [3035, 3220, 3277], 'resistance.': [3045, 3075, 3143], 'Since': [3046], 'compromise': [3073], 'higher': [3081], 'P.': [3084, 3110], 'compared': [3087], 'Hence,': [3096], '(R411B),': [3107], 'syringe': [3115], 'infiltration.': [3116], 'Bacterial': [3117], '4a),': [3133], 'demonstrating': [3134], 'Prf': [3155], '4b).': [3165], 'summary,': [3167], 'revisited': [3169], 'rather': [3185], 'than': [3186, 3511, 3632], 'proposed': [3203], 'multiple': [3212], 'postulated': [3215], 'needs': [3221], 'revised.': [3224], 'fact,': [3226], 'appears': [3231], 'lack': [3233], 'an': [3234], 'Furthermore,': [3241], 'finding': [3272], 'suppresses': [3282], '–mediated': [3286], 'earlier': [3314], 'effect': [3321], 'NRC2/NRC3': [3323], 'dramatic': [3328], 'case': [3332], 'findings': [3340], 'emphasize': [3341], 'minimize': [3354], 'risk': [3356], 'misinterpreting': [3358], '(Kumar': [3364], '2006;': [3367], 'Jonchere': [3368], 'Bennett,': [3370], '2013;': [3371], 'Pliego': [3372], '2013).': [3375], 'Genetic': [3376], 'silencing-resilient': [3390], 'recommend': [3401], 'applied': [3406], 'whenever': [3411], 'possible': [3412], 'avoid': [3414], 'misidentification.': [3416], 'authors': [3418], 'thank': [3419], 'Florian': [3420], 'Jupe': [3421], 'discussion': [3423], 'identification': [3426], 'plants,': [3432], 'Lida': [3434], 'Derevnina': [3435], 'carefully': [3437], 'reading': [3438], 'manuscript.': [3440, 3487], 'project': [3442], 'funded': [3444], 'Biotechnology': [3447], 'Biological': [3449], 'Science': [3450], 'Research': [3451, 3456], 'Council': [3452, 3457], '(BBSRC),': [3453], 'European': [3455], '(ERC),': [3458], 'Gatsby': [3461], 'Charitable': [3462], 'Foundation.': [3463], 'C-H.W.,': [3464], 'K.B.,': [3465], 'T.O.B.': [3466], 'S.K.': [3468, 3481], 'planned': [3469], 'research.': [3473], 'C-H.W.': [3474, 3479], 'M.S.B.': [3476], 'experiments,': [3478], 'wrote': [3485], 'Please': [3488, 3609], 'note:': [3489, 3610], 'Wiley': [3490], 'Blackwell': [3491], 'content': [3497, 3618], 'functionality': [3499, 3620], 'supporting': [3502, 3623], 'supplied': [3504, 3625], 'authors.': [3507, 3628], 'Any': [3508, 3629], 'queries': [3509, 3630], '(other': [3510, 3631], 'material)': [3513], 'directed': [3516, 3637], 'New': [3519], 'Phytologist': [3520], 'Central': [3521], 'Office.': [3522], 'S1': [3524, 3597], 'S2': [3530], 'S3': [3541], 'S4': [3552], 'Virus-induced': [3553], 'fragment.': [3560], 'S5': [3562], 'mediates': [3565], 'Pto-induced': [3566], 'S6': [3573], 'Synthetic': [3574, 3586], 'rescues': [3576, 3588], 'S7': [3585], 'comparison': [3601], 'publisher': [3612], 'content)': [3634], 'author': [3641], 'article.': [3644]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2173011848', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 10}], 'updated_date': '2024-12-30T06:35:13.637233', 'created_date': '2016-06-24'}
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