Publication Information

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'abstract_inverted_index': {'Phototransduction': [0, 168], 'is': [1, 95, 121, 169, 263, 289, 486, 544, 910, 1081, 1098, 1176, 1290, 1294, 1829, 1898, 2096, 2145, 2271, 2332, 2348, 2356, 2419, 2448, 2533, 2601, 2785, 3102, 3304, 3390, 3576, 3648, 3712, 3888, 3946, 4313], 'initiated': [2, 170, 431, 3833], 'by': [3, 97, 114, 171, 265, 282, 432, 459, 540, 1076, 1083, 1557, 1719, 1900, 2206, 2631, 2787, 2791, 3022, 3030, 3170, 3652, 3701, 3834, 3861, 3942], 'the': [4, 28, 32, 70, 172, 196, 200, 238, 371, 385, 454, 473, 483, 541, 592, 774, 786, 790, 798, 863, 869, 981, 993, 996, 1000, 1007, 1046, 1056, 1067, 1111, 1120, 1124, 1152, 1169, 1173, 1316, 1345, 1348, 1471, 1671, 1687, 1761, 1768, 1771, 1781, 1792, 1803, 1851, 1863, 1901, 1919, 1932, 1940, 1955, 1959, 1975, 2075, 2086, 2128, 2140, 2143, 2187, 2193, 2197, 2267, 2285, 2299, 2316, 2324, 2350, 2354, 2378, 2381, 2386, 2416, 2424, 2427, 2442, 2460, 2469, 2549, 2572, 2577, 2591, 2618, 2624, 2632, 2636, 2653, 2828, 2830, 3010, 3015, 3018, 3031, 3095, 3110, 3113, 3248, 3309, 3369, 3381, 3412, 3415, 3453, 3579, 3670, 3677, 3680, 3733, 3738, 3773, 3787, 3856, 3875, 3885, 3943, 3995, 4177, 4189, 4193, 4201, 4266, 4272], 'photoisomerization': [5, 173, 460, 1074, 3862], 'of': [6, 35, 73, 111, 132, 135, 155, 174, 203, 241, 279, 300, 303, 323, 370, 381, 461, 470, 537, 572, 769, 776, 789, 866, 980, 984, 988, 995, 1009, 1045, 1078, 1085, 1151, 1168, 1207, 1288, 1315, 1341, 1350, 1553, 1627, 1689, 1704, 1748, 1763, 1765, 1770, 1783, 1802, 1823, 1850, 1853, 1857, 1867, 1910, 1934, 1943, 1961, 2074, 2088, 2110, 2125, 2142, 2152, 2196, 2269, 2298, 2342, 2353, 2372, 2380, 2441, 2446, 2463, 2472, 2478, 2548, 2574, 2581, 2590, 2620, 2638, 2643, 2827, 2832, 2836, 2839, 2846, 2878, 2913, 3012, 3034, 3112, 3118, 3180, 3239, 3259, 3311, 3362, 3383, 3388, 3414, 3427, 3450, 3456, 3483, 3581, 3583, 3609, 3672, 3682, 3698, 3727, 3742, 3772, 3783, 3863, 3872, 3939, 3975, 4172, 4179, 4192, 4269], 'rhodopsin': [7, 175, 337, 338, 434, 573, 1041, 1628, 3836, 3976], '(Rho)': [8, 176], 'chromophore': [9, 177, 485, 543, 791, 2129, 2198, 3451, 3887, 3945, 4194], '11-cis-retinylidene': [10, 178], 'to': [11, 160, 179, 328, 376, 445, 468, 793, 800, 924, 992, 1100, 1108, 1118, 1237, 1296, 1694, 1752, 1918, 1953, 2070, 2091, 2130, 2208, 2358, 2385, 2422, 2535, 2587, 2641, 2977, 3007, 3097, 3124, 3399, 3606, 3688, 3692, 3778, 3847, 3870, 4196, 4203, 4327], 'all-trans-retinylidene.': [12, 180], 'Here,': [13, 181], 'using': [14, 182, 577, 858, 930, 1983, 3182, 3980, 4261, 4333], 'Rho': [15, 148, 183, 316, 462, 538, 867, 1086, 1705, 1728, 1766, 1815, 2126, 2144, 2557, 2578, 3429, 3584, 3864, 3940, 4270], 'regenerated': [16, 184, 1629, 1653, 1816], 'with': [17, 20, 139, 185, 188, 307, 729, 1055, 1087, 1203, 1241, 1305, 1571, 1630, 1654, 1817, 1862, 1931, 2082, 2148, 2279, 2596, 2662, 3556, 3578, 3590, 3707, 4132], 'retinal': [18, 107, 165, 186, 275, 333, 341, 366, 578, 589, 860, 919, 990, 1068, 1632, 1745, 2325, 2575, 2640, 2718, 3768, 3981, 3992, 4263, 4322], 'analogs': [19, 187, 579, 920, 1633, 1773, 3982, 4323], 'different': [21, 189, 1756, 2883], 'ring': [22, 190, 584, 788, 2195, 3987, 4191], 'sizes,': [23, 191], 'which': [24, 192, 3173], 'prevent': [25, 193], 'isomerization': [26, 98, 125, 194, 266, 293, 369, 772, 1317, 1669, 1678, 1695, 2117, 2573, 3771, 4175], 'around': [27, 195, 591, 1670, 2127, 3994], 'C11=C12': [29, 197, 770, 4173], 'double': [30, 62, 101, 198, 230, 269, 594, 1698, 1949, 3997], 'bond,': [31, 199, 1673], 'activation': [33, 94, 120, 149, 201, 262, 288, 317, 539, 775, 1729, 1764, 1793, 1865, 1960, 2094, 2132, 2141, 2181, 2270, 3941, 4178], 'mechanism': [34, 202, 536, 1762, 2268, 3938], 'this': [36, 204, 908, 1646, 1749, 2599, 3125, 3235, 3344, 3394, 3699, 3704, 4311], 'G-protein-coupled': [37, 205], 'receptor': [38, 206, 2425], 'was': [39, 207, 781, 1566, 2134, 2306, 3081, 3086, 3232, 4184], 'investigated.': [40, 208], 'We': [41, 209, 1795], 'demonstrate': [42, 210], 'that': [43, 55, 65, 92, 211, 223, 233, 260, 580, 783, 906, 1059, 1308, 1470, 1568, 1634, 1651, 1667, 1709, 1733, 1896, 1928, 2095, 2116, 2192, 2284, 2321, 2331, 2349, 2368, 2571, 2593, 3091, 3229, 3251, 3316, 3603, 3722, 3983, 4186, 4309], '11-cis-7-ring-Rho': [44, 212], 'does': [45, 57, 126, 213, 225, 294, 1674], 'not': [46, 58, 122, 127, 214, 226, 290, 295, 1675, 2146, 3103, 3597, 3649, 3702], 'activate': [47, 215], 'G-protein': [48, 216, 441, 3843], 'in': [49, 52, 87, 103, 117, 163, 217, 220, 255, 271, 285, 331, 773, 868, 928, 999, 1050, 1102, 1110, 1113, 1128, 1172, 1299, 1344, 1347, 1424, 1561, 1624, 1683, 1713, 1715, 1741, 1774, 1832, 1915, 1958, 1969, 1974, 2067, 2072, 2079, 2308, 2328, 2365, 2553, 2576, 2617, 2623, 2635, 2648, 2652, 2659, 2841, 3003, 3017, 3176, 3234, 3247, 3320, 3343, 3377, 3392, 3571, 3585, 3676, 3679, 3720, 3736, 3745, 3748, 3755, 3761, 4176, 4271, 4331], 'vivo': [50, 82, 218, 250, 929, 1625, 1681, 1970, 3721, 3746, 4332], 'and': [51, 54, 83, 109, 141, 150, 219, 222, 251, 277, 309, 318, 436, 482, 488, 862, 986, 1066, 1104, 1161, 1473, 1564, 1658, 1665, 1679, 1700, 1730, 1735, 1767, 1808, 1811, 1838, 1860, 1912, 1925, 1947, 1973, 1986, 2078, 2120, 2191, 2302, 2335, 2377, 2433, 2455, 2555, 2603, 2610, 2634, 2645, 2752, 2843, 2906, 2991, 3083, 3242, 3335, 3364, 3567, 3663, 3740, 3747, 3838, 3884, 3890, 4265], 'vitro,': [53, 221], 'it': [56, 66, 224, 234, 780, 1293, 1565, 1828, 1894, 2569, 3397, 4183], 'isomerize': [59, 227], 'along': [60, 99, 228, 267, 1696, 1945, 2118], 'other': [61, 100, 229, 268, 1697], 'bonds,': [63, 231], 'suggesting': [64, 232, 766, 4169], 'fits': [67, 235], 'tightly': [68, 236], 'into': [69, 147, 237, 315, 1727, 2426, 3256], 'binding': [71, 239, 1903, 2326, 2579, 3454], 'site': [72, 240, 2327, 3455], 'opsin.': [74, 242, 2138], 'In': [75, 243, 364, 1685, 1938, 2412, 3446, 3766], 'contrast,': [76, 244, 1686, 1939, 3447], 'bleaching': [77, 245, 1688, 1909, 2087], '11-cis-6-ring-Rho': [78, 246, 1690, 2089, 2447, 3715], 'modestly': [79, 247], 'activates': [80, 248], 'phototransductionin': [81, 249], 'at': [84, 252, 1706, 2431, 2539, 3368], 'low': [85, 253, 1707, 1844], 'pH': [86, 116, 254, 284, 1708, 2111, 2435, 2452, 2541], 'vitro.': [88, 256, 1684], 'These': [89, 137, 257, 305, 975, 1722, 2983, 3600], 'results': [90, 138, 258, 306, 1723, 1747, 1914, 3601], 'reveal': [91, 259], 'partial': [93, 261], 'caused': [96, 264, 1075, 3021], 'bonds': [102, 270, 1699, 1950], 'more': [104, 272], 'rigid': [105, 273, 2628], '6-locked': [106, 274, 2584], 'isomers': [108, 276, 861, 1657, 3657, 4264], 'protonation': [110, 278, 2151, 2297, 2371], 'key': [112, 280, 2153, 2373], 'residues': [113, 281, 2154], 'lowering': [115, 283], '11-cis-6-ring-Rhos.': [118, 286], 'Full': [119, 287, 399, 401, 560, 562, 629, 649, 758, 847, 849, 1228, 1257, 1276, 1278, 1605, 1607, 1885, 2003, 2023, 2051, 2053, 2169, 2171, 2256, 2258, 2401, 2403, 2494, 3154, 3156, 3273, 3275, 3470, 3472, 3546, 3548, 3638, 3640, 3801, 3803, 3962, 3964, 4032, 4052, 4161, 4250, 4252], 'achieved,': [123, 291], 'because': [124, 292, 3685], 'induce': [128, 296], 'a': [129, 152, 297, 320, 379, 439, 794, 1061, 1079, 1178, 1204, 1239, 1660, 1848, 1854, 1916, 2092, 2102, 2107, 2209, 2276, 2293, 2329, 2337, 2366, 2440, 2462, 2464, 2477, 2537, 2540, 2547, 3177, 3253, 3257, 3305, 3424, 3481, 3607, 3725, 3781, 3841, 4197], 'complete': [130, 298], 'set': [131, 299, 380, 3782], 'conformational': [133, 301, 2588], 'rearrangements': [134, 302], 'Rho.': [136, 304, 777, 1962, 2344, 4180], '6-': [140, 308, 1734, 2644], '7-ring-constrained': [142, 310, 1736], 'retinoids': [143, 311, 1737, 3559, 3674, 3709, 3744], 'provide': [144, 312, 1649, 1724], 'new': [145, 313, 795, 1725, 1788, 2210, 4198], 'insights': [146, 314, 1726], 'suggest': [151, 319, 1732, 3602], 'potential': [153, 321, 3096], 'use': [154, 322], 'locked': [156, 324, 989, 3557, 3654], 'retinals,': [157, 325], 'particularly': [158, 326], '11-cis-7-ring-retinal,': [159, 327], 'inactivate': [161, 329, 3400], 'opsin': [162, 330, 471, 491, 1859, 1902, 2387, 3610, 3873, 3893], 'some': [164, 332, 3418], 'degeneration': [166, 334, 2826, 3760], 'diseases.': [167, 335, 3765], 'photoactivated': [336], 'metarhodopsin': [339], 'II': [340, 449, 479, 802, 2066, 2100, 2474, 3851, 3881, 4205], 'pigment': [342, 373, 728, 998, 1069, 2840, 3775, 4131], 'epithelium': [343], 'retinol': [344], 'dehydrogenase': [345, 1243], 'electroretinogram': [346, 2800], 'all-trans-retinal-specific': [347], 'RDH': [348, 3662], 'lecithin:retinol': [349], 'acyltransferase': [350], 'transducin': [351], 'Leber': [352, 2649, 2663], 'congenital': [353, 2664, 2788], 'amaurosis': [354, 2665], '3-(N-morpholino)propanesulfonic': [355], 'acid': [356, 363], 'high': [357, 1306, 2104, 2420], 'pressure': [358], 'liquid': [359], 'chromatography': [360], '1,3-bis[tris(hydroxymethyl)-methylamino]propane': [361], '2-(N-morpholino)ethanesulfonic': [362], 'vertebrate': [365, 3249, 3767], 'photoreceptor': [367, 1064, 1562, 3769], 'cells,': [368, 1563, 3770], 'visual': [372, 727, 926, 1121, 3119, 3230, 3774, 4130, 4329], 'chromophore,': [374, 463, 3776, 3865], '11-cis-retinal': [375, 1109, 1554, 1640, 1656, 3431, 3777], 'all-trans-retinal,': [377, 3779], 'triggers': [378, 3780], 'reactions': [382, 1058, 3784], 'collectively': [383, 3785], 'termed': [384, 3786], 'phototransduction': [386, 428, 1711, 3788, 3830], 'cascade': [387, 3789], '(1Polans': [388, 3262, 3790], 'A.': [389, 705, 738, 1263, 1408, 1455, 1504, 1540, 2510, 2731, 2741, 2775, 2940, 2965, 3064, 3263, 3510, 3791, 4108, 4141], 'Baehr': [390, 1133, 3264, 3287, 3792], 'W.': [391, 1134, 3265, 3288, 3793], 'Palczewski': [392, 550, 839, 1131, 1400, 1447, 1496, 1597, 2043, 2159, 2248, 3056, 3146, 3266, 3285, 3502, 3538, 3630, 3794, 3952, 4242], 'K.': [393, 551, 605, 666, 670, 692, 713, 812, 840, 873, 945, 960, 1028, 1132, 1372, 1401, 1448, 1497, 1598, 2044, 2160, 2224, 2249, 2483, 3057, 3147, 3267, 3286, 3503, 3539, 3631, 3795, 3953, 4008, 4069, 4073, 4095, 4116, 4215, 4243, 4276, 4348], 'Trends': [394, 554, 2163, 3268, 3796, 3956], 'Neurosci.': [395, 3269, 3797], '1996;': [396, 3270, 3798], '19:': [397, 3271, 3799], '547-554Abstract': [398, 3272, 3800], 'Text': [400, 402, 561, 563, 630, 650, 759, 848, 850, 1229, 1258, 1277, 1279, 1606, 1608, 1886, 2004, 2024, 2052, 2054, 2170, 2172, 2257, 2259, 2402, 2404, 2495, 3155, 3157, 3274, 3276, 3471, 3473, 3547, 3549, 3639, 3641, 3802, 3804, 3963, 3965, 4033, 4053, 4162, 4251, 4253], 'PDF': [403, 564, 631, 651, 760, 851, 1230, 1259, 1280, 1609, 1887, 2005, 2025, 2055, 2173, 2260, 2405, 2496, 3158, 3277, 3474, 3550, 3642, 3805, 3966, 4034, 4054, 4163, 4254], 'PubMed': [404, 422, 506, 517, 565, 610, 632, 652, 675, 699, 761, 817, 852, 901, 970, 1144, 1196, 1231, 1260, 1281, 1330, 1378, 1412, 1459, 1508, 1546, 1610, 1888, 2006, 2026, 2056, 2174, 2229, 2261, 2406, 2497, 2514, 2527, 2708, 2747, 2779, 2870, 2901, 3068, 3159, 3220, 3278, 3298, 3354, 3475, 3514, 3551, 3643, 3806, 3824, 3908, 3919, 3967, 4013, 4035, 4055, 4078, 4102, 4164, 4220, 4255, 4304], 'Scopus': [405, 423, 507, 518, 530, 566, 611, 676, 700, 721, 762, 818, 853, 902, 971, 1145, 1197, 1282, 1331, 1379, 1413, 1460, 1509, 1547, 1611, 1889, 2057, 2175, 2230, 2262, 2407, 2515, 2528, 2675, 2709, 2748, 2780, 2820, 2857, 2871, 2902, 3069, 3160, 3221, 3279, 3299, 3355, 3476, 3515, 3552, 3644, 3807, 3825, 3909, 3920, 3932, 3968, 4014, 4079, 4103, 4124, 4165, 4221, 4256, 4305], '(265)': [406, 3280, 3808], 'Google': [407, 425, 509, 520, 532, 568, 613, 633, 653, 678, 702, 723, 764, 820, 855, 904, 953, 973, 1036, 1147, 1199, 1232, 1261, 1284, 1333, 1381, 1415, 1462, 1511, 1549, 1613, 1891, 2007, 2027, 2059, 2177, 2232, 2264, 2409, 2498, 2517, 2530, 2566, 2677, 2711, 2750, 2782, 2822, 2859, 2873, 2904, 2948, 2973, 3071, 3162, 3223, 3281, 3301, 3333, 3357, 3444, 3478, 3517, 3554, 3646, 3809, 3827, 3911, 3922, 3934, 3970, 4016, 4036, 4056, 4081, 4105, 4126, 4167, 4223, 4258, 4307, 4356], 'Scholar,': [408, 510, 521, 614, 634, 654, 679, 703, 954, 1382, 1512, 2008, 2028, 2233, 2499, 2518, 2678, 2860, 2949, 3282, 3518, 3810, 3912, 3923, 4017, 4037, 4057, 4082, 4106, 4357], '2Pugh': [409, 3811], 'Jr.,': [410, 1872, 3812], 'E.N.': [411, 3813], 'Nikonov': [412, 3814], 'S.': [413, 616, 638, 658, 681, 830, 958, 1187, 1356, 1407, 1454, 1503, 1990, 2012, 2034, 2239, 2481, 2501, 2509, 2774, 2959, 3063, 3509, 3815, 4019, 4041, 4061, 4084, 4233], 'Lamb': [414, 3816], 'T.D.': [415, 3817], 'Curr.': [416, 3818], 'Opin.': [417, 3819], 'Neurobiol.': [418, 3820], '1999;': [419, 2563, 3330, 3821], '9:': [420, 3822], '410-418Crossref': [421, 3823], '(268)': [424, 3826], 'Scholar).': [426, 533, 724, 821, 974, 1037, 1148, 1233, 1285, 1334, 1416, 1463, 1550, 1614, 1892, 2060, 2178, 2265, 2531, 2783, 2874, 3072, 3163, 3224, 3302, 3358, 3445, 3479, 3828, 3935, 3971, 4127, 4224], 'The': [427, 534, 1091, 1286, 1908, 2179, 2437, 2875, 3105, 3164, 3385, 3829, 3936, 3972], 'events': [429, 1049, 1712, 3261, 3831], 'are': [430, 1052, 1555, 1929, 1951, 3005, 3244, 3375, 3410, 3420, 3658, 3832], 'activated': [433, 3835], '(Rho*)1': [435, 3837], 'progress': [437, 3839], 'through': [438, 3840], 'classical': [440, 3842], 'cascade,': [442, 3844], 'ultimately': [443, 3845], 'leading': [444, 3846], 'neuronal': [446, 3848], 'signaling.': [447, 3849], 'Metarhodopsin': [448, 3850], '(or': [450, 3852], 'Meta': [451, 478, 801, 2065, 2099, 2414, 2473, 3853, 3880, 4204], 'II,': [452, 2415, 3854], 'Rho*),': [453, 3855], 'catalytically': [455, 3857], 'active': [456, 1702, 2062, 2290, 2382, 2428, 2444, 2551, 2625, 3858], 'intermediate': [457, 3859], 'generated': [458, 2339, 3860], 'contains': [464, 3866], 'all-trans-retinal': [465, 1094, 3604, 3867], 'covalently': [466, 3868], 'bound': [467, 3869], 'Lys296': [469, 3871], 'via': [472, 3874], 'deprotonated': [474, 3876], 'Schiff': [475, 3877], 'base.': [476, 3878], 'Subsequently,': [477, 3879], 'undergoes': [480, 3882], 'reprotonation,': [481, 3883], 'photolyzed': [484, 3886], 'hydrolyzed': [487, 3889], 'released': [489, 1095, 3891], 'from': [490, 1014, 1039, 1096, 1639, 1643, 1780, 2882, 3892], '(3Matthews': [492, 3894], 'R.G.': [493, 3895], 'Hubbard': [494, 3896], 'R.': [495, 935, 956, 1018, 2392, 3897, 4338, 4359], 'Brown': [496, 3898], 'P.K.': [497, 3899], 'Wald': [498, 3900], 'G.': [499, 512, 1522, 2737, 3901, 3914], 'J.': [500, 524, 623, 643, 685, 714, 754, 841, 1222, 1251, 1270, 1599, 1881, 1997, 2017, 2045, 2250, 2395, 2488, 2809, 2815, 3148, 3194, 3214, 3325, 3540, 3632, 3902, 3926, 4026, 4046, 4088, 4117, 4157, 4244], 'Gen.': [501, 3903], 'Physiol.': [502, 525, 3904, 3927], '1963;': [503, 3905], '47:': [504, 3906], '215-240Crossref': [505, 3907], '(428)': [508, 3910], '4Wald': [511, 3913], 'Science.': [513, 606, 813, 897, 2225, 3915, 4009, 4216, 4300], '1968;': [514, 3916], '162:': [515, 3917], '230-239Crossref': [516, 3918], '(784)': [519, 3921], '5Baumann': [522, 3924], 'C.': [523, 1248, 1267, 1516, 1520, 2682, 2690, 2963, 3925], '(Lond.).': [526, 3928], '1972;': [527, 3929], '222:': [528, 3930], '643-663Crossref': [529, 3931], '(61)': [531, 3933], 'precise': [535, 3937], 'photoisomerized': [542, 1092, 3944], 'unknown': [545, 3947], '(6Okada': [546, 2155, 3948], 'T.': [547, 662, 875, 877, 890, 1584, 2156, 2668, 2850, 2864, 3133, 3525, 3617, 3949, 4065, 4278, 4280, 4293], 'Ernst': [548, 2157, 3950], 'O.P.': [549, 2158, 3951], 'Hofmann': [552, 837, 1531, 2041, 2161, 2246, 2484, 2502, 3954, 4240], 'K.P.': [553, 838, 2042, 2162, 2247, 2485, 2503, 2559, 3955, 4241], 'Biochem.': [555, 1191, 2164, 3957], 'Sci.': [556, 949, 1032, 1405, 1452, 1501, 2165, 2507, 2772, 2944, 2969, 3061, 3329, 3440, 3507, 3958, 4352], '2001;': [557, 844, 1141, 1543, 2048, 2166, 2253, 2398, 3217, 3295, 3467, 3959, 4247], '26:': [558, 2167, 3960], '318-324Abstract': [559, 2168, 3961], '(367)': [567, 2176, 3969], 'Scholar).The': [569], 'photobleaching': [570, 3973], 'process': [571, 1116, 3345, 3974], 'has': [574, 1820, 2101, 2475, 3094, 3166, 3716, 3977], 'been': [575, 1156, 2657, 2981, 3168, 3978], 'investigated': [576, 3979], 'contained': [581, 3984], 'an': [582, 767, 1114, 1339, 2289, 2713, 2844, 3448, 3562, 3985, 4170], 'extra': [583, 3986], 'between': [585, 1663, 2606, 3338, 3988], 'C10and': [586, 3989], 'C13,': [587, 3990], 'making': [588, 3991], 'non-isomerizable': [590, 3993], '11-cis': [593, 3996], 'bond': [595, 771, 3998, 4174], '(7Borhan': [596, 803, 2215, 3999, 4206], 'B.': [597, 804, 1219, 2216, 2698, 2727, 2932, 2951, 4000, 4207], 'Souto': [598, 805, 2217, 4001, 4208], 'M.L.': [599, 806, 2218, 4002, 4209], 'Imai': [600, 807, 2219, 4003, 4210], 'H.': [601, 656, 808, 881, 943, 1026, 1526, 2220, 2758, 3347, 4004, 4059, 4211, 4284, 4346], 'Shichida': [602, 659, 809, 2221, 4005, 4062, 4212], 'Y.': [603, 660, 810, 1582, 2222, 3131, 3206, 3523, 3615, 4006, 4063, 4213], 'Nakanishi': [604, 669, 691, 712, 811, 944, 959, 1027, 2223, 4007, 4072, 4094, 4115, 4214, 4347], '2000;': [607, 814, 898, 1409, 1456, 1505, 2226, 2945, 2970, 3065, 3511, 4010, 4217, 4301], '288:': [608, 815, 2227, 4011, 4218], '2209-2212Crossref': [609, 816, 2228, 4012, 4219], '(216)': [612, 819, 2231, 4015, 4222], '8Bhattacharya': [615, 4018], 'Ridge': [617, 1991, 4020], 'K.D.': [618, 636, 1992, 2010, 4021, 4039], 'Knox': [619, 1993, 4022], 'B.E.': [620, 688, 1994, 4023, 4091], 'Khorana': [621, 641, 1995, 2015, 4024, 4044], 'H.G.': [622, 642, 1996, 2016, 4025, 4045], 'Biol.': [624, 644, 842, 1223, 1252, 1271, 1600, 1998, 2018, 2046, 2251, 2396, 2489, 3149, 3541, 3633, 4027, 4047, 4245], 'Chem.': [625, 645, 716, 843, 1224, 1253, 1272, 1601, 1999, 2019, 2047, 2252, 2397, 2490, 3150, 3542, 3634, 4028, 4048, 4119, 4246], '1992;': [626, 646, 1254, 2000, 2020, 4029, 4049], '267:': [627, 647, 1255, 2001, 2021, 4030, 4050], '6763-6769Abstract': [628, 2002, 4031], '9Ridge': [635, 2009, 4038], 'Bhattacharya': [637, 2011, 4040], 'Nakayama': [639, 2013, 4042], 'T.A.': [640, 2014, 4043], '6770-6775Abstract': [648, 2022, 4051], '10Kandori': [655, 4058], 'Matuoka': [657, 4060], 'Yoshizawa': [661, 4064], 'Ito': [663, 4066], 'M.': [664, 709, 742, 744, 894, 896, 1534, 2700, 2735, 2955, 2961, 4067, 4112, 4145, 4147, 4297, 4299], 'Tsukida': [665, 4068], 'Balogh-Nair': [667, 710, 963, 4070, 4113], 'V.': [668, 711, 828, 964, 1393, 1440, 1489, 1586, 2032, 2237, 3049, 3135, 3204, 3495, 3527, 3619, 4071, 4114, 4231], 'Biochemistry.': [671, 695, 2523, 4074, 4098], '1989;': [672, 755, 4075, 4158], '28:': [673, 3218, 4076], '6460-6467Crossref': [674, 4077], '(56)': [677, 4080], '11Hu': [680, 4083], 'Franklin': [682, 4085], 'P.J.': [683, 4086], 'Wang': [684, 4087], 'Ruiz': [686, 4089], 'Silva': [687, 4090], 'Derguini': [689, 4092], 'F.': [690, 832, 1518, 1532, 1592, 2036, 2241, 2394, 2680, 3141, 3533, 3625, 4093, 4235], 'Chen': [693, 1363, 4096], 'A.H.': [694, 4097], '1994;': [696, 2491, 4099], '33:': [697, 968, 4100], '408-416Crossref': [698, 4101], '(25)': [701, 4104], '12Akita': [704, 4107], 'Tanis': [706, 4109], 'S.P.': [707, 4110], 'Adams': [708, 4111], 'Am.': [715, 4118], 'Soc.': [717, 4120], '1980;': [718, 4121], '102:': [719, 4122], '6372-6376Crossref': [720, 4123], '(94)': [722, 4125], 'An': [725, 4128], 'artificial': [726, 4129], 'restricted': [730, 2351, 4133], 'C9–C11': [731, 4134], 'motion': [732, 4135], 'forms': [733, 1429, 4136], 'normal': [734, 982, 4137], 'photolysis': [735, 4138], 'intermediates': [736, 4139], '(13Albeck': [737, 4140], 'Friedman': [739, 4142], 'N.': [740, 1364, 4143], 'Ottolenghi': [741, 4144], 'Sheves': [743, 4146], 'Einterz': [745, 4148], 'C.M.': [746, 4149], 'Hug': [747, 4150], 'S.J.': [748, 1395, 1442, 1491, 3051, 3497, 4151], 'Lewis': [749, 4152], 'J.W.': [750, 4153], 'Kliger': [751, 4154], 'D.S.': [752, 4155], 'Biophys.': [753, 1192, 1880, 4156], '55:': [756, 4159], '233-241Abstract': [757, 4160], '(44)': [763, 4166], 'Scholar),': [765, 2712, 2751, 2823, 2905, 3334, 4168], 'importance': [768, 4171], 'More': [778, 4181], 'recently,': [779, 4182], 'reported': [782, 4185], 'after': [784, 3076, 4187], 'photoisomerization,': [785, 4188], 'β-ionone': [787, 2194, 4190], 'moves': [792, 4195], 'position': [796, 2211, 4199], 'during': [797, 2340, 3313, 4200], 'transition': [799, 4202], 'Jang': [822, 1587, 3136, 3528, 3620, 4225], 'et': [823, 4226], 'al.': [824, 4227], '(14Jang': [825, 4228], 'G.F.': [826, 2030, 2235, 4229], 'Kuksa': [827, 1392, 1439, 1488, 1585, 2031, 2236, 3048, 3134, 3494, 3526, 3618, 4230], 'Filipek': [829, 2033, 2238, 4232], 'Bartl': [831, 2035, 2240, 4234], 'Ritter': [833, 2037, 2242, 4236], 'E.': [834, 1183, 1213, 1322, 1358, 1524, 2038, 2243, 2686, 2694, 2928, 2930, 4237], 'Gelb': [835, 2039, 2244, 4238], 'M.H.': [836, 2040, 2245, 4239], '276:': [845, 2049, 2254, 2399, 4248], '26148-26153Abstract': [846, 2050, 2255, 4249], '(51)': [854, 2058, 2263, 4257], 'Scholar)': [856, 905, 1200, 3555, 3647, 4259, 4308], 'showed': [857, 4260], '6-ring-constrained': [859, 4262], 'crystal': [864, 4267], 'structure': [865, 4268], 'ground': [870, 4273], 'state': [871, 2063, 2338, 4274], '(15Palczewski': [872, 4275], 'Kumasaka': [874, 4277], 'Hori': [876, 4279], 'Behnke': [878, 4281], 'C.A.': [879, 4282], 'Motoshima': [880, 4283], 'Fox': [882, 4285], 'B.A.,': [883, 4286], 'Le': [884, 4287], 'Trong': [885, 4288], 'I.': [886, 4289], 'Teller': [887, 4290], 'D.C.': [888, 4291], 'Okada': [889, 4292], 'Stenkamp': [891, 4294], 'R.E.': [892, 4295], 'Yamamoto': [893, 4296], 'Miyano': [895, 4298], '289:': [899, 4302], '739-745Crossref': [900, 4303], '(4983)': [903, 4306], 'if': [907, 3373, 4310], 'movement': [909, 4312], 'restricted,': [911, 4314], 'only': [912, 1821, 2183, 2450, 4315], 'residual': [913, 3717, 4316], 'activity': [914, 1318, 1825, 1845, 1964, 2105, 2318, 3595, 3719, 4317], 'could': [915, 1618, 1846, 3560, 4318], 'be': [916, 1297, 1619, 1739, 1847, 1966, 2320, 3027, 3561, 3689, 3724, 4319], 'observed.': [917, 4320], 'Locked': [918, 4321], 'were': [921, 1476, 3341, 4324], 'also': [922, 1830, 3167, 4325], 'used': [923, 4326], 'study': [925, 1750, 1786, 3108, 3227, 4328], 'transduction': [927, 3361, 4330], 'vitamin': [931, 4334], 'A-deprived': [932, 4335], 'rats': [933, 4336], '(16Crouch': [934, 1017, 4337], 'Nodes': [936, 1019, 4339], 'B.R.': [937, 1020, 4340], 'Perlman': [938, 1021, 4341], 'J.I.': [939, 1022, 4342], 'Pepperberg': [940, 1023, 1135, 3289, 4343], 'D.R.': [941, 1024, 1136, 3290, 4344], 'Akita': [942, 1025, 4345], 'Invest.': [946, 1029, 2941, 2966, 3326, 3437, 4349], 'Ophthalmol.': [947, 1030, 2670, 2852, 2866, 2967, 3327, 3438, 4350], 'Vis.': [948, 1031, 2943, 2968, 3328, 3439, 4351], '1984;': [950, 1033, 2524, 4353], '25:': [951, 1034, 4354], '419-428PubMed': [952, 1035, 4355], '17Crouch': [955, 4358], 'Katz': [957, 4360], 'Gawinowicz': [961], 'M.A.': [962], 'Photochem.': [965], 'Photobiol.': [966], '1981;': [967], '91-95Crossref': [969], '(10)': [972], 'animals': [976, 3004], 'had': [977, 1338], 'approximately': [978], 'half': [979], 'complement': [983], 'rhodopsin,': [985], 'injection': [987], 'led': [991], 'appearance': [994], 'analog': [997], 'photoreceptors': [1001, 1051, 1103, 3340], 'but': [1002, 1292, 3402, 3596], 'without': [1003, 1641], 'significant': [1004, 1677], 'effect': [1005], 'on': [1006, 1754, 1791, 2201, 3109, 3116], 'sensitivity': [1008, 2069], 'electroretinographic': [1010], 'b-wave': [1011], 'responses': [1012], 'recorded': [1013], 'rat': [1015], 'eye': [1016], 'Interference': [1038], 'wild-type': [1040, 1644, 1824, 2343, 3187], 'prevented': [1042], 'full': [1043, 2180], 'interpretation': [1044], 'results.The': [1047], 'light-triggered': [1048], 'intimately': [1053], 'intertwined': [1054], 'regeneration': [1057, 1084], 'involve': [1060, 2880], 'two-cell': [1062], 'system,': [1063], 'cells': [1065, 1071], 'epithelial': [1070], '(RPE).': [1072], 'Every': [1073], 'absorption': [1077], 'photon': [1080], 'counterbalanced': [1082], 'newly': [1088], 'synthesized': [1089], '11-cis-retinal.': [1090], 'product': [1093], 'Rho*': [1097], 'reduced': [1099, 2803, 3690], 'all-trans-retinol': [1101], 'then': [1105], 'converted': [1106], 'back': [1107], 'RPE': [1112, 1201, 1302, 1346, 2986, 3678, 3705], 'enzymatic': [1115, 1160], 'referred': [1117], 'as': [1119, 1717, 2133, 2212], 'cycle': [1122, 1126, 1154, 1175, 3020], 'or': [1123, 1427, 1682, 2583, 2790, 3758], 'retinoid': [1125, 1153, 1174, 1300, 1418, 1742, 1772, 3019], '(reviewed': [1127, 3319], 'Ref.18McBee': [1129], 'J.K.': [1130, 1877, 3284], 'Prog.': [1137, 3291], 'Retin.': [1138, 3292], 'Eye': [1139, 3293, 3349], 'Res.': [1140, 3294, 3350], '20:': [1142, 1376, 3296], '469-529Crossref': [1143, 3297], '(314)': [1146, 3300], 'Several': [1149], 'components': [1150], 'have': [1155, 1796, 2656, 2980, 3404], 'identified,': [1157], 'although': [1158, 1757, 3752], 'major': [1159], 'chemical': [1162], 'transformations': [1163], 'still': [1164, 1312, 2272, 3403], 'remain': [1165], 'poorly': [1166], 'understood.One': [1167], 'proteins': [1170], 'involved': [1171, 1298], 'RPE65,': [1177], 'highly': [1179], 'expressed': [1180], 'membrane-associated': [1181], '(19Tsilou': [1182], 'Hamel': [1184, 2701], 'C.P.,': [1185], 'Yu,': [1186, 1355], 'Redmond': [1188, 1220, 1537, 2695], 'T.M.': [1189, 1221, 1538, 2696], 'Arch.': [1190, 2669, 2851, 2865], '1997;': [1193, 1882, 2705, 2744], '346:': [1194], '21-27Crossref': [1195], '(40)': [1198], 'protein': [1202, 1235, 2203, 2592], 'molecular': [1205], 'mass': [1206], '65': [1208], 'kDa': [1209], '(20Hamel': [1210], 'C.P.': [1211, 2702], 'Tsilou': [1212], 'Pfeffer': [1214], 'B.A.': [1215], 'Hooks': [1216], 'J.J.': [1217], 'Detrick': [1218], '1993;': [1225, 2511], '268:': [1226], '15751-15757Abstract': [1227], 'This': [1234, 1615, 1843, 1963, 2061, 2113, 2613, 3225, 3574, 3666, 3730], 'appears': [1236, 1895, 2570], 'form': [1238, 1349, 3681], 'complex': [1240], '11-cis-retinol': [1242], '(11-cis-RDH)': [1244], '(21Bavik': [1245], 'C.O.': [1246], 'Busch': [1247], 'Eriksson': [1249, 1268], 'U.': [1250, 1265, 1269, 1406, 1453, 1502, 2508, 2729, 2773, 3062, 3508], '23035-23042Abstract': [1256], 'Scholar,22Simon': [1262], 'Hellman': [1264], 'Wernstedt': [1266], '1995;': [1273], '270:': [1274], '1107-1112Abstract': [1275], '(215)': [1283], 'function': [1287, 3120, 3231], 'RPE65': [1289, 1311, 2654, 2907, 3023, 3101, 3188], 'unknown,': [1291], 'believed': [1295], 'processing.': [1301], 'microsomes': [1303], 'washed': [1304], 'salt': [1307, 2303], 'removed': [1309], '>95%': [1310], 'retained': [1313], 'most': [1314, 1920, 2188, 2312, 2996], '(23Choo': [1319], 'D.W.': [1320], 'Cheung': [1321], 'Rando': [1323], 'R.R.': [1324], 'FEBS': [1325], 'Lett.': [1326], '1998;': [1327, 1375, 2776], '440:': [1328], '195-198Crossref': [1329], '(18)': [1332], 'However,': [1335, 2085, 2139], 'unexpectedly,': [1336], 'Rpe65−/−mice': [1337], 'overaccumulation': [1340], 'all-trans-retinyl': [1342], 'esters': [1343], 'lipid-like': [1351], 'droplets': [1352], '(24Redmond': [1353], 'T.M.,': [1354], 'Lee': [1357], 'Bok': [1359, 3435], 'D.': [1360, 1362, 3323, 3436], 'Hamasaki': [1361], 'Goletz': [1365], 'P.,': [1366], 'Ma,': [1367], 'J.X.': [1368], 'Crouch': [1369, 3462], 'R.K.': [1370, 3463], 'Pfeifer': [1371], 'Nat.': [1373, 1541, 2703, 2742, 3215], 'Genet.': [1374, 1542, 2704, 2743, 2897, 3216], '344-351Crossref': [1377], '(774)': [1380], '25Van': [1383], 'Hooser': [1384, 1431, 1480, 1579, 3040, 3128, 3486, 3520, 3612], 'J.P.': [1385, 1432, 1481, 1580, 3041, 3129, 3487, 3521, 3613], 'Aleman': [1386, 1433, 1482, 3042, 3197, 3488], 'T.S.,': [1387, 1434, 1483, 3043, 3489], 'He,': [1388, 1435, 1484, 1589, 3044, 3138, 3490, 3530, 3622], 'Y.G.': [1389, 1436, 1485, 1590, 3045, 3139, 3491, 3531, 3623], 'Cideciyan': [1390, 1437, 1486, 3046, 3199, 3492], 'A.V.': [1391, 1438, 1487, 3047, 3200, 3493], 'Pittler': [1394, 1441, 1490, 3050, 3496], 'Stone': [1396, 1443, 1492, 3052, 3498], 'E.M.': [1397, 1444, 1493, 3053, 3499], 'Jacobson': [1398, 1445, 1494, 2935, 3054, 3209, 3500], 'S.G.': [1399, 1446, 1495, 2936, 3055, 3210, 3501], 'Proc.': [1402, 1449, 1498, 2504, 2769, 3058, 3504], 'Natl.': [1403, 1450, 1499, 2505, 2770, 3059, 3505], 'Acad.': [1404, 1451, 1500, 2506, 2771, 3060, 3506], '97:': [1410, 1457, 1506, 3066, 3512], '8623-8628Crossref': [1411, 1458, 1507, 3067, 3513], '(223)': [1414, 1461, 1510, 3070, 3516], 'Further': [1417], 'analysis': [1419], 'revealed': [1420, 1469, 1787], 'no': [1421], 'detectable': [1422], '11-cis-products': [1423], 'either': [1425], 'ester': [1426, 1576], 'alcohol': [1428], '(25Van': [1430, 1479, 3039, 3485], 'Electroretinogram': [1464], '(ERG)': [1465], 'measurements': [1466, 1982], 'ofRpe65−/−': [1467], 'mice': [1468, 3587], 'rod': [1472, 2833, 3079, 3084], 'cone': [1474, 3405, 3457], 'functions': [1475], 'severely': [1477], 'attenuated': [1478], '26Seeliger': [1513], 'M.W.': [1514], 'Grimm': [1515], 'Stahlberg': [1517], 'Friedburg': [1519], 'Jaissle': [1521], 'Zrenner': [1523, 2685, 2929], 'Guo': [1525], 'Reme': [1527], 'C.E.': [1528], 'Humphries': [1529], 'P.': [1530, 2688, 2920, 2953], 'Biel': [1533], 'Fariss': [1535], 'R.N.': [1536], 'Wenzel': [1539], '29:': [1544, 3468], '70-74Crossref': [1545], '(208)': [1548], 'Small': [1551], 'amounts': [1552], 'produced': [1556], 'photochemical': [1558], 'reactionin': [1559], 'situ': [1560], 'demonstrated': [1567, 1718], 'early': [1569], 'intervention': [1570, 3093, 3115], 'cis-retinoids': [1572], 'greatly': [1573], 'attenuates': [1574], 'retinyl': [1575, 3683], 'accumulation': [1577], '(27Van': [1578, 3127, 3611], 'Liang': [1581, 3130, 3522, 3614], 'Maeda': [1583, 3132, 3524, 3616], 'G.F.,': [1588, 3137, 3529, 3621], 'Rieke': [1591, 3140, 3532, 3624], 'Fong': [1593, 3142, 3534, 3626], 'H.K.': [1594, 3143, 3535, 3627], 'Detwiler': [1595, 3144, 3536, 3628], 'P.B.': [1596, 3145, 3537, 3629], '2002;': [1602, 2898, 3151, 3351, 3543, 3635], '277:': [1603, 3152, 3544, 3636], '19173-19182Abstract': [1604, 3153, 3545, 3637], '(133)': [1612, 3161, 3553, 3645], 'animal': [1616, 3237], 'model': [1617, 3179, 3238, 3387], 'very': [1620], 'useful': [1621, 1740, 3391, 3569], 'for': [1622, 1744, 1806, 2136, 2315, 2911, 3000, 3308, 3565, 3661, 3664], 'studying': [1623, 3393], 'properties': [1626], 'synthetic': [1631], 'undergo': [1635, 1676], 'photoactivation': [1636, 2341], 'processes': [1637, 3315], 'differently': [1638], 'interference': [1642], 'Rho.In': [1645], 'study,': [1647], 'we': [1648, 2274], 'evidence': [1650], 'Rho,': [1652], 'ring-constrained': [1655], 'containing': [1659], '3-carbon': [1661], 'bridge': [1662, 2304], 'C10': [1664], 'C13': [1666], 'prevents': [1668], 'C11–C12double': [1672], 'activationin': [1680], '(2-carbon': [1691], 'bridge)': [1692], 'leads': [1693, 2090, 2586], 'produces': [1701], 'species': [1703, 2445, 2471, 2552], 'trigger': [1710, 1956], 'vivoand': [1714], 'vitro': [1716, 3749], 'FTIR': [1720, 1839, 1926, 2076, 2286], 'spectroscopy.': [1721], 'concurrently': [1731], 'may': [1738, 3026, 3668, 3695], 'therapy': [1743], 'pathologies.DISCUSSIONThe': [1746], 'lead': [1751], 'conclusions': [1753], 'two': [1755], 'related': [1758], 'topics,': [1759], 'namely': [1760, 2283], 'utilization': [1769], 'vivo.Rho': [1775], 'Activation:': [1776], 'New': [1777], 'Lessons': [1778], 'Learned': [1779], 'Studies': [1782], 'Retinoid': [1784], 'AnalogsThis': [1785], 'important': [1789, 3226], 'information': [1790], 'process.': [1794], 'found': [1797], 'three': [1798], 'sharply': [1799], 'distinct': [1800], 'classes': [1801], 'chromophore-protein': [1804], 'interaction': [1805, 2081], '11-cis-7-ring-': [1807], '11-cis-6-ring-containing': [1809], 'retinals': [1810, 2585, 2622, 3592], '11-cis-': [1812], 'retinal.': [1813, 3655], '1)': [1814], '11-cis-7-ring': [1818], 'isomer': [1819, 1923], '0.1%': [1822], '(Fig.': [1826, 1836, 1841, 1971, 1978], '5);': [1827], 'inactive': [1831, 3376], 'both': [1833, 2621, 3339], 'sensitive': [1834], 'ERG': [1835], '7)': [1837, 1972], 'experiments': [1840, 3409], '4).': [1842], 'result': [1849, 2114], 'presence': [1852], 'small': [1855], 'amount': [1856, 3671], 'free': [1858, 1868, 2465], 'consistent': [1861, 1930, 3577], 'estimated': [1864], 'ratio': [1866], 'opsin:Rho*,': [1869], 'i.e.106:1': [1870], '(44Melia': [1871], 'T.J.': [1873], 'Cowan': [1874], 'C.W.': [1875], 'Angleson': [1876], 'Wensel': [1878], 'T.G.': [1879], '73:': [1883], '3182-3191Abstract': [1884], '(128)': [1890, 3356], 'Therefore,': [1893, 3480], '11-cis-7-ring-retinal': [1897], 'stabilized': [1899], 'pocket,': [1904], 'forming': [1905], 'stable': [1906, 1921], '11-cis-7-ring-Rho.': [1907], '9,11-dicis': [1911], '9,11,13-tricis': [1913], 'conversion': [1917], 'isomer,': [1922], '3,': [1924], 'spectra': [1927], 'lack': [1933], 'Gt': [1935, 2083, 2093], 'activation.': [1936], '2)': [1937], 'possible': [1941, 3398], 'movements': [1942], '11-cis-6-ring-retinal': [1944], 'C9=C10': [1946], 'C13=C14': [1948], 'sufficient': [1952, 2123, 2357], 'overcome': [1954, 3028], 'barrier': [1957], 'can': [1965, 2199, 3723], 'clearly': [1967], 'detected': [1968], 'light-scattering': [1976], 'assays': [1977, 1988], '5),': [1979], 'advancing': [1980], 'previous': [1981], 'nucleotide': [1984], 'uptake': [1985], 'phosphorylation': [1987, 3582], '(8Bhattacharya': [1989], '14Jang': [2029, 2234], 'resembles': [2064, 2336], 'its': [2068, 2080, 2202, 2309, 2544], 'hydroxylamine,': [2071], 'features': [2073], 'spectrum,': [2077], 'peptide.': [2084], 'pH-dependent,': [2097], 'whereas': [2098, 2292, 2468], 'broad': [2103], 'over': [2106], 'wide': [2108], 'range': [2109], 'values.': [2112, 2436], 'suggests': [2115], 'C9–C10': [2119], 'C13–C14': [2121], 'causes': [2122], 'relaxation': [2124], 'allow': [2131, 2594], 'observed': [2135, 2550], 'chromophore-free': [2137], 'achieved': [2147], 'proper': [2149], '“forced”': [2150], 'occurs': [2182, 3459], 'when': [2184, 3100, 3588], 'all-trans-retinylidene': [2185], 'assumes': [2186], 'extended': [2189], 'conformation': [2190, 2383, 2619], 'act': [2200], 'environment,': [2204], 'possibly': [2205], 'moving': [2207], 'proposed': [2213], 'previously': [2214], 'Although': [2266, 3407], 'unclear,': [2273], 'suspect': [2275], 'profound': [2277], 'relationship': [2278], 'another': [2280], 'surprising': [2281], 'observation,': [2282], 'spectrum': [2287], 'indicated': [2288, 3228], 'species,': [2291], 'spectral': [2294, 2310], 'motif': [2295], 'indicating': [2296], 'counterion': [2300], 'Glu113': [2301], 'breaking': [2305], 'altered': [2307], 'properties.The': [2311], 'obvious': [2313], 'explanation': [2314, 2347], 'pH-dependent': [2317], 'would': [2319, 3379], 'H+': [2322], 'adjusts': [2323], 'way': [2330, 2367], 'partially': [2333, 2359], 'photoactivatable': [2334], 'Another': [2345], 'non-exclusive': [2346], 'photochemistry': [2352], '6-ring-retinals': [2355], 'remove': [2360], 'their': [2361, 2627, 3366], 'reverse': [2362], 'agonist-like': [2363], 'property': [2364, 2600, 3667, 3700], 'eventually': [2369], 'allows': [2370], 'residue(s)': [2374], '(including': [2375], 'Glu134)': [2376], 'formation': [2379], '(similar': [2384], '↔': [2388], 'opsin*': [2389], 'equilibrium': [2390], '(45Vogel': [2391], 'Siebert': [2393], '38487-38493Abstract': [2400], '(100)': [2408], 'Scholar)).': [2410], '3)': [2411], 'native': [2413, 2545, 2554, 2582], 'energy': [2417], 'content': [2418], 'enough': [2421], 'force': [2423], 'conformation,': [2429], 'even': [2430, 2604, 3372], 'neutral': [2432], 'basic': [2434], 'apparent': [2438], 'pK': [2439, 2461, 2476, 2546], 'light-induced': [2443, 3598], '5.4,': [2449], 'one': [2451], 'unit': [2453], 'lower': [2454], 'thus': [2456, 3089], '∼1.5': [2457], 'kcal': [2458], 'off': [2459], 'Glu': [2466], 'residue,': [2467], 'protonated': [2470], '6.7': [2479], '(46Arnis': [2480], 'Fahmy': [2482], 'Sakmar': [2486], 'T.P.': [2487, 2768], '269:': [2492], '23879-23881Abstract': [2493], '47Arnis': [2500], '90:': [2512], '7849-7853Crossref': [2513], '(176)': [2516], '48Parkes': [2519], 'J.H.': [2520], 'Liebman': [2521], 'P.A.': [2522, 2938], '23:': [2525], '5054-5061Crossref': [2526], '(127)': [2529], 'Energy': [2532], 'required': [2534], 'protonate': [2536], 'residue': [2538], 'higher': [2542], 'than': [2543], '11-cis-6-ring-retinal-regenerated': [2556], '(49Hofmann': [2558], 'Novartis': [2560], 'Found.': [2561], 'Symp.': [2562], '224:': [2564], '158-180PubMed': [2565], 'Scholar).In': [2567], 'conclusion,': [2568], 'pocket': [2580], 'changes': [2589], 'coupling': [2595], 'Gt.': [2597], 'Interestingly,': [2598, 3714], 'specific': [2602], 'distinguishes': [2605], 'closely': [2607], 'similar': [2608], '6-ring-': [2609], '7-ring-containing': [2611, 3708], 'retinals.': [2612], 'difference': [2614], 'probably': [2615], 'resides': [2616], 'site,': [2626], 'nature': [2629], 'imposed': [2630], 'ring,': [2633], 'susceptibility': [2637], '6-ring-containing': [2639], 'isomerization.Use': [2642], '7-Ring-containing': [2646, 3656], 'Analogs': [2647], 'Congenital': [2650], 'AmaurosisMutations': [2651], 'gene': [2655, 2908, 2988, 3024, 3171], 'identified': [2658], 'patients': [2660], 'diagnosed': [2661], '(LCA)': [2666], '(50Leber': [2667, 2849], '(Paris).': [2671, 2853], '1869;': [2672, 2854], '15:': [2673, 2855], '1-25Crossref': [2674, 2856], '(179)': [2676, 2858], '51Marlhens': [2679], 'Bareil': [2681], 'Griffoin': [2683], 'J.M.': [2684], 'Amalric': [2687], 'Eliaou': [2689], 'Liu': [2691], 'S.Y.': [2692], 'Harris': [2693], 'Arnaud': [2697], 'Claustres': [2699], '17:': [2706, 2745], '139-141Crossref': [2707], '(504)': [2710], 'autosomal': [2714, 2753], 'recessive': [2715, 2754], 'childhood-onset': [2716], 'severe': [2717], 'dystrophy': [2719], '(52Gu': [2720], 'S.M.': [2721], 'Thompson': [2722], 'D.A.': [2723, 2918], 'Srikumari': [2724], 'C.R.': [2725], 'Lorenz': [2726, 2931], 'Finckh': [2728], 'Nicoletti': [2730], 'Murthy': [2732], 'K.R.': [2733], 'Rathmann': [2734], 'Kumaramanickavel': [2736], 'Denton': [2738], 'M.J.': [2739], 'Gal': [2740, 2939, 2964], '194-197Crossref': [2746], '(522)': [2749], 'retinitis': [2755], 'pigmentosa': [2756], '(53Morimura': [2757], 'Fishman': [2759], 'G.A.': [2760], 'Grover': [2761], 'S.A.': [2762], 'Fulton': [2763], 'A.B.': [2764], 'Berson': [2765], 'E.L.': [2766, 2924], 'Dryja': [2767], '95:': [2777], '3088-3093Crossref': [2778], '(387)': [2781], 'LCA': [2784, 2879, 2915, 2979, 3181, 3389, 3572], 'characterized': [2786], 'blindness': [2789], 'poor': [2792, 3659], 'central': [2793], 'vision,': [2794], 'slight': [2795], 'fundus': [2796], 'changes,': [2797], 'nearly': [2798], 'absent': [2799], 'signal,': [2801], 'nystagmus,': [2802], 'papillary': [2804], 'reactions,': [2805], 'occasional': [2806], 'photophobia': [2807], '(54Schappert-Kimmijser': [2808], 'Henkes': [2810], 'H.E.': [2811], 'Van': [2812, 2888], 'Den': [2813, 2889, 2892], 'Bosch': [2814], 'Ophthalmologica.': [2816], '1949;': [2817], '137:': [2818], '420-422Crossref': [2819], '(3)': [2821], 'eventual': [2824], 'pigmentary': [2825], 'retina,': [2829], 'absence': [2831, 2845], 'photoreceptors,': [2834], 'remnants': [2835], 'cones,': [2837], 'clumping': [2838], 'RPE,': [2842], 'chorioretinal': [2847], 'adhesions': [2848], '55Kroll': [2861], 'A.J.': [2862], 'Kuwabara': [2863], '1964;': [2867], '71:': [2868], '683-690Crossref': [2869], '(27)': [2872], 'genetic': [2876], 'abnormalities': [2877], 'genes': [2881], 'physiological': [2884], 'pathways': [2885], '(56Cremers': [2886], 'F.P.': [2887], 'Hurk': [2890], 'J.A.': [2891], 'Hollander': [2893], 'A.I.': [2894], 'Hum.': [2895], 'Mol.': [2896], '11:': [2899], '1169-1176Crossref': [2900], '(171)': [2903], 'mutations': [2909, 3025], 'account': [2910], '∼12%': [2912], 'all': [2914], 'cases': [2916], '(57Thompson': [2917], 'Gyurus': [2919, 2952], 'Fleischer': [2921], 'L.L.': [2922], 'Bingham': [2923], 'McHenry': [2925], 'C.L.': [2926], 'Apfelstedt-Sylla': [2927], 'Richards': [2933], 'J.E.': [2934], 'Sieving': [2937], 'Ophthal.': [2942], '41:': [2946, 2971], '4293-4299PubMed': [2947], '58Lorenz': [2950], 'Preising': [2954], 'Bremser': [2956], 'D.,': [2957], 'Gu,': [2958], 'Andrassi': [2960], 'Gerth': [2962], '2735-2742PubMed': [2972], 'Scholar).Several': [2974], 'therapeutical': [2975, 2998], 'approaches': [2976], 'treating': [2978], 'proposed.': [2982], 'methods': [2984], 'include': [2985], 'transplantation,': [2987], 'replacement': [2989], 'therapy,': [2990, 3172], 'pharmacological': [2992, 3092], 'intervention.': [2993], 'To': [2994], 'date,': [2995], 'experimental': [2997], 'interventions': [2999], 'inherited': [3001], 'degenerations': [3002], 'aimed': [3006], 'slow': [3008], 'down': [3009], 'progression': [3011], 'degeneration.': [3013], 'Encouragingly,': [3014], 'block': [3016], 'pharmacologically': [3029], 'oral': [3032], 'addition': [3033], '9-cis-retinal,': [3035], 'thereby': [3036], 'creating': [3037], 'iso-Rho': [3038], 'Within': [3073], '48': [3074], 'h': [3075], 'cis-retinoid': [3077], 'administration,': [3078], 'photopigment': [3080], 'formed': [3082], 'physiology': [3085], 'improved': [3087], 'dramatically,': [3088], 'demonstrating': [3090], 'restore': [3098], 'vision': [3099, 3175, 3570, 3757], 'present.': [3104], 'long': [3106], 'term': [3107], 'effectiveness': [3111], '9-cis-retinal': [3114, 3484, 3711], 'restoration': [3117], 'further': [3121], 'lends': [3122], 'support': [3123], 'idea': [3126], 'defect': [3165], 'corrected': [3169], 'restored': [3174, 3233], 'canine': [3178], 'recombinant': [3183], 'adeno-associated': [3184], 'virus': [3185], 'carrying': [3186], '(59Acland': [3189], 'G.M.': [3190], 'Aguirre': [3191], 'G.D.': [3192], 'Ray': [3193], 'Zhang': [3195], 'Q.': [3196], 'T.S.': [3198], 'Pearce-Kelling': [3201], 'S.E.': [3202], 'Anand': [3203], 'Zeng': [3205], 'Maguire': [3207], 'A.M.': [3208], 'Hauswirth': [3211], 'W.W.': [3212], 'Bennett': [3213], '92-95Crossref': [3219], '(1018)': [3222], 'large': [3236], 'childhood': [3240], 'blindness.Rods': [3241], 'cones': [3243, 3312], 'critical': [3245], 'neurons': [3246], 'retina': [3250], 'translate': [3252], 'light': [3254], 'signal': [3255, 3360], 'chain': [3258], 'biochemical': [3260], '18McBee': [3283], 'There': [3303], 'strong': [3306], 'interdependency': [3307], 'survival': [3310, 3382], 'degenerative': [3314], 'affect': [3317], 'rods': [3318, 3363, 3401], 'Ref.': [3321], '60Hicks': [3322], 'Sahel': [3324], '40:': [3331], '3071-3074PubMed': [3332], 'gap': [3336], 'junctions': [3337], 'implicated': [3342], '(61Ripps': [3346], 'Exp.': [3348], '74:': [3352], '327-336Crossref': [3353], 'Blocking': [3359], 'sparing': [3365], 'demise': [3367], 'cellular': [3370], 'level,': [3371], 'they': [3374, 3686], 'phototransduction,': [3378], 'prolong': [3380], 'cones.': [3384], 'mouse': [3386], 'relationship.': [3395], 'Is': [3396], 'function?': [3406], 'these': [3408, 3673, 3743], 'outside': [3411], 'scope': [3413], 'current': [3416], 'studies,': [3417], 'predictions': [3419], 'worth': [3421], 'considering.': [3422], 'From': [3423], 'practical': [3425], 'point': [3426], 'view,': [3428], 'binds': [3430], 'irreversibly': [3432], '(62Defoe': [3433], 'D.M.': [3434], '1983;': [3441], '24:': [3442], '1211-1226PubMed': [3443], 'exchange': [3449], 'within': [3452], 'readily': [3458], '(63Kefalov': [3460], 'V.J.': [3461], 'Cornwall': [3464], 'M.C.': [3465], 'Neuron.': [3466], '749-755Abstract': [3469], '(54)': [3477], 'combination': [3482], '27Van': [3519], 'photostable': [3558], 'alternative': [3563], 'approach': [3564], 'restoring': [3566, 3756], 'maintaining': [3568], 'patients.': [3573], 'notion': [3575], 'observation': [3580], 'Rpe65−/−': [3586], 'treatment': [3589], '7-locked': [3591], 'eliminated': [3593], 'constitutive': [3594], 'phosphorylation.': [3599], 'coupled': [3605], 'fraction': [3608], 'competed': [3650], 'out': [3651], 'exogenous': [3653], 'substrates': [3660], 'LRAT.': [3665], 'reduce': [3669], 'stored': [3675], 'esters,': [3684], 'need': [3687], 'prior': [3691], 'esterification.': [3693], 'One': [3694], 'take': [3696], 'advantage': [3697], 'overloading': [3703], 'system': [3706], 'before': [3710], 'provided.': [3713], 'light-sensitive': [3718], 'part': [3726], 'light-driven': [3728], 'responses.': [3729], 'work': [3731], 'provides': [3732], 'first': [3734], 'step': [3735], 'understanding': [3737], 'chemistry': [3739], 'enzymology': [3741], 'toward': [3750], 'achievable': [3751], 'difficult': [3753], 'steps': [3754], 'preventing': [3759], 'otherwise': [3762], 'incurable': [3763], 'blinding': [3764]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2172086172', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-29T18:06:38.788452', 'created_date': '2016-06-24'}