Publication Information

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'https://openalex.org/W2120155947', 'https://openalex.org/W2103021125', 'https://openalex.org/W2062375825', 'https://openalex.org/W2051901836', 'https://openalex.org/W2040864908', 'https://openalex.org/W2026094729', 'https://openalex.org/W2018493658'], 'abstract_inverted_index': {'The': [0, 253, 537, 600, 627, 650, 658, 879, 887, 919, 960, 1598, 1622, 2901, 3126, 3639, 4026], 'inability': [1, 254], 'to': [2, 36, 52, 177, 204, 240, 255, 289, 305, 430, 457, 493, 532, 539, 552, 559, 605, 908, 950, 1651, 1719, 1768, 1786, 1978, 1985, 2029, 2081, 2448, 2468, 2481, 2697, 2876, 2909, 2923, 3044, 3048, 3057, 3097, 3112, 3170, 3404, 3439, 3448, 3598, 3637, 3658, 3790, 3803, 3872, 3905, 3926, 3933, 3948, 3996, 4012, 4019, 4039, 4067, 4097, 4140], 'quantify': [3, 53, 256, 306], 'large': [4, 257, 2283, 2773, 2846, 3050, 3761], 'numbers': [5, 258, 3051], 'of': [6, 70, 74, 92, 101, 104, 107, 114, 129, 144, 149, 151, 165, 184, 200, 259, 323, 327, 345, 354, 357, 360, 367, 382, 397, 402, 404, 418, 437, 453, 507, 517, 544, 555, 564, 571, 587, 630, 661, 726, 775, 795, 846, 863, 890, 911, 963, 977, 984, 986, 1010, 1017, 1019, 1036, 1052, 1062, 1237, 1242, 1247, 1275, 1280, 1286, 1295, 1298, 1400, 1405, 1410, 1433, 1448, 1477, 1488, 1491, 1517, 1528, 1531, 1551, 1628, 1637, 1646, 1732, 1737, 1758, 1777, 1789, 1814, 1845, 1851, 1864, 1868, 1874, 1892, 1920, 1960, 1975, 2021, 2023, 2036, 2045, 2072, 2101, 2127, 2148, 2156, 2194, 2282, 2321, 2358, 2415, 2429, 2445, 2451, 2462, 2470, 2485, 2510, 2518, 2556, 2612, 2619, 2686, 2729, 2772, 2798, 2807, 2845, 2871, 2890, 2933, 2950, 3007, 3021, 3042, 3052, 3060, 3069, 3075, 3087, 3104, 3117, 3122, 3137, 3163, 3323, 3328, 3333, 3376, 3381, 3499, 3524, 3548, 3621, 3644, 3646, 3661, 3670, 3690, 3701, 3760, 3814, 3825, 3850, 3988, 4004, 4029, 4036], 'proteins': [7, 54, 125, 246, 260, 307, 378, 499, 508, 1037, 1111, 1248, 1276, 1411, 1550, 1674, 1733, 1791, 1945, 2104, 2455, 2699, 2925, 3053, 3172, 3197, 3334, 3492, 3631, 3649, 4014], 'in': [8, 22, 55, 78, 88, 126, 208, 247, 261, 275, 308, 331, 341, 379, 461, 500, 534, 549, 562, 569, 728, 1038, 1112, 1249, 1277, 1292, 1412, 1462, 1556, 1580, 1586, 1591, 1631, 1640, 1675, 1741, 1792, 1817, 1967, 2018, 2033, 2042, 2057, 2238, 2362, 2492, 2615, 2661, 2804, 2884, 2915, 2926, 2954, 3054, 3090, 3119, 3198, 3335, 3358, 3485, 3508, 3521, 3618, 3650, 3696, 3719, 3920, 3984, 4024, 4033, 4061, 4092, 4143], 'tissues': [9, 262], 'and': [10, 16, 61, 95, 109, 141, 153, 169, 180, 236, 263, 269, 314, 348, 362, 394, 406, 422, 433, 489, 580, 584, 598, 602, 655, 773, 815, 826, 868, 884, 925, 992, 1025, 1043, 1049, 1118, 1240, 1270, 1403, 1428, 1430, 1465, 1499, 1539, 1574, 1589, 1604, 1624, 1681, 1752, 1774, 1784, 1824, 1879, 1890, 1901, 1944, 1946, 2063, 2103, 2109, 2178, 2187, 2236, 2244, 2331, 2385, 2417, 2472, 2479, 2487, 2540, 2549, 2610, 2632, 2659, 2667, 2695, 2713, 2722, 2888, 2903, 2919, 2977, 3009, 3040, 3056, 3072, 3085, 3092, 3101, 3111, 3143, 3145, 3160, 3177, 3204, 3326, 3371, 3379, 3398, 3421, 3435, 3478, 3544, 3563, 3571, 3589, 3801, 3816, 3936, 3954, 3974, 4112, 4119, 4124], 'biofluids': [11, 264, 2079, 3055], 'with': [12, 57, 138, 265, 310, 391, 509, 811, 994, 1027, 1423, 1501, 1541, 1745, 1754, 2464, 2700, 2917, 3387, 3518, 3575, 3793, 3821], 'high': [13, 58, 266, 311, 812, 869, 2182, 2544, 2687, 2701, 2717, 3851], 'precision,': [14, 267], 'sensitivity,': [15, 59, 268, 312, 814], 'throughput': [17, 270, 1850, 2183, 2545, 2688, 2718], 'is': [18, 271, 548, 857, 1266, 1848, 1855, 1982, 3151, 3652], 'a': [19, 191, 272, 444, 843, 909, 1701, 1755, 1935, 2016, 2031, 2040, 2055, 2323, 2427, 2483, 2616, 3019, 3066, 3079, 3388, 3486, 3642, 3725, 3822, 3856, 3906, 4002, 4099], 'major': [20, 273, 1077], 'bottleneck': [21, 274], 'biomarker': [23, 276, 596, 631, 653, 664, 856, 882, 893, 957, 2428, 3020], 'studies.': [24, 277], 'We': [25, 278, 574], 'previously': [26, 279, 3179, 3733], 'demonstrated': [27, 280, 1262, 2442, 2614, 3037], 'that': [28, 48, 226, 281, 301, 479, 769, 945, 1263, 1457, 1780, 1849, 1939, 1987, 2469, 3149, 3511, 3665, 3681, 3876], 'coupling': [29, 282], 'immunoaffinity': [30, 283, 1709, 2070, 2185, 2242, 2328, 2349, 2383, 2547, 2665, 2720, 2941, 2975], 'enrichment': [31, 284, 2071, 2147, 2186, 2243, 2330, 2384, 2509, 2548, 2666, 2721, 2976, 3476, 4077], 'using': [32, 285, 1055, 1707, 1895, 2105, 2289, 2456, 2779, 2852, 3139, 3175, 3360, 3394, 3710, 3767, 3899], 'anti-peptide': [33, 286, 995, 1028, 1502, 1542, 2066, 2112, 2813], 'antibodies': [34, 287, 1503, 1543, 2067, 2113, 2814, 2873, 3477, 3716, 3917], '(SISCAPA)': [35, 288, 2068], 'multiple': [37, 290, 972, 1005, 1072, 1243, 1406, 1471, 1479, 1511, 1519, 2188, 2550, 2723, 3109, 3329], 'reaction': [38, 291, 973, 979, 1006, 1012, 1073, 1244, 1407, 1472, 1480, 1512, 1520, 2189, 2551, 2724, 3330], 'monitoring': [39, 292, 974, 1007, 1074, 1473, 1481, 1513, 1521, 2190, 2552, 2725], 'mass': [40, 293, 625, 975, 1008, 1070, 1116, 1474, 1514, 1679, 1822, 1902, 2191, 2246, 2292, 2333, 2352, 2553, 2607, 2669, 2726, 2782, 2855, 2944, 3202, 3770], 'spectrometry': [41, 294, 1117, 1475, 1486, 1515, 1526, 1680, 1823, 2353, 2945, 3203], '(MRM-MS)': [42, 295], 'produces': [43, 296], 'Immunoprecipitation': [44, 297], 'MRM-MS': [45, 298, 1484, 1524, 1860, 2084, 2471, 3482], '(immuno-MRM-MS)': [46, 299], 'assays': [47, 300, 1032, 1064, 1075, 1107, 1670, 1771, 2232, 2447, 2475, 2655, 2800, 2912, 3047, 3193], 'can': [49, 229, 302, 482, 2801], 'be': [50, 230, 241, 303, 483, 494, 2010, 2027, 2802, 3516, 3599, 3656], 'multiplexed': [51, 75, 227, 304, 328, 480, 964, 1106, 1669, 1730, 1770, 2179, 2231, 2541, 2654, 2714, 3046, 3076, 3192], 'plasma': [56, 309, 545, 776, 921, 1039, 1078, 1113, 1288, 1600, 1641, 1676, 1742, 1819, 2239, 2463, 2662, 2883, 3199, 3509, 3635, 3651, 4058, 4071, 4089, 4101, 4135], 'specificity,': [60, 313, 813], 'precision.': [62, 315], 'Here': [63, 316, 3063], 'we': [64, 317, 3064], 'report': [65, 318, 3065], 'the': [66, 71, 90, 123, 147, 157, 175, 182, 209, 238, 319, 324, 343, 376, 400, 410, 428, 435, 462, 491, 535, 542, 553, 662, 771, 847, 864, 891, 956, 1047, 1053, 1238, 1264, 1293, 1401, 1438, 1449, 1635, 1735, 1738, 1846, 1852, 1865, 1949, 1970, 1973, 1992, 2019, 2034, 2037, 2043, 2051, 2356, 2443, 2879, 2891, 2948, 3038, 3070, 3088, 3099, 3105, 3115, 3123, 3129, 3134, 3156, 3324, 3374, 3491, 3522, 3606, 3612, 3622, 3630, 3647, 3662, 3668, 3671, 3682, 3688, 3691, 3702, 3711, 3798, 3874, 3878, 3900, 3989, 4037, 4042, 4083, 4144], 'first': [67, 320], 'systematic': [68, 321, 3067], 'evaluation': [69, 322, 3068], 'interlaboratory': [72, 142, 325, 395, 1050, 1431, 3073, 3102], 'performance': [73, 326, 948, 961, 1443, 3074, 3136, 4043], '(8-plex)': [76, 329], 'immuno-MRM-MS': [77, 159, 228, 330, 412, 481, 3150], 'three': [79, 332, 3889], 'independent': [80, 234, 333, 487], 'labs.': [81, 334], 'A': [82, 335, 720, 767, 1644, 1843, 2125], 'staged': [83, 336], 'study': [84, 337, 4038], 'was': [85, 111, 133, 338, 364, 386, 1460, 1743, 3533, 3596, 3708, 3819, 3967], 'carried': [86, 339], 'out': [87, 340, 629], 'which': [89, 342, 905, 1976], 'effect': [91, 344], 'each': [93, 346, 1875, 3120, 3354, 3610, 3817, 3949, 4034], 'processing': [94, 347, 2689], 'analysis': [96, 349, 1285, 1861, 1873, 2082, 2898, 3466, 3588], 'step': [97, 350, 578], 'on': [98, 351, 541, 802, 2150, 2512, 3373, 3797, 3951], 'assay': [99, 160, 178, 214, 220, 352, 413, 431, 467, 473, 2287, 2354, 2777, 2850, 2946, 3124, 3131, 3496, 3765], 'coefficient': [100, 353, 1476, 1516], 'variance,': [102, 355], 'limit': [103, 106, 148, 356, 359, 401, 1487, 1490, 1527, 1530, 1634], 'detection,': [105, 358], 'quantification,': [108, 361], 'recovery': [110, 183, 363, 436], 'evaluated.': [112, 365], 'Limits': [113, 366, 1279], 'detection': [115, 368, 1489, 1529], 'were': [116, 369, 1291, 1445, 3095, 3173, 3356, 3385, 3426, 3437, 3453, 3461, 3493, 3551, 3565, 3572, 3580, 3625, 3632, 3717, 3788, 3810, 3831, 3893, 3918, 3931, 3946, 3991, 4022, 4031, 4054, 4085, 4129], 'at': [117, 370, 860, 1437, 1558, 1572, 1734, 1760, 1963, 2047, 2808, 3108, 3942, 3956, 3993, 4136], 'or': [118, 371, 514, 520, 1452, 1559, 2002, 2039, 2078, 2914, 3585, 3698, 3888], 'below': [119, 372], '1': [120, 373, 1561, 3506], 'ng/ml': [121, 374, 1573, 1739, 1965, 2453], 'for': [122, 135, 156, 206, 216, 244, 375, 388, 409, 459, 469, 497, 724, 782, 835, 841, 852, 955, 1033, 1059, 1076, 1108, 1272, 1671, 1772, 1858, 1872, 1980, 2005, 2012, 2153, 2181, 2233, 2355, 2390, 2419, 2454, 2515, 2543, 2606, 2656, 2690, 2716, 2897, 2930, 2947, 2982, 3011, 3081, 3128, 3154, 3194, 3353, 3481, 3495, 3641, 3807, 3886, 3938, 3981, 4104], 'assayed': [124, 377], '30': [127, 380], 'μl': [128, 381, 2461], 'plasma.': [130, 166, 252, 383, 419, 505, 1278, 1968], 'Assay': [131, 384, 2388, 2980], 'reproducibility': [132, 385, 1051, 1241, 1404, 1425, 1749, 2466, 3103, 3327], 'acceptable': [134, 387], 'verification': [136, 389, 725, 774, 958], 'studies,': [137, 390, 527], 'median': [139, 392, 1756], 'intra-': [140, 393, 1048, 3071, 3100], 'coefficients': [143, 396], 'variance': [145, 398, 1478, 1518], 'above': [146, 399, 1560], 'quantification': [150, 403, 1274, 1281, 1492, 1532, 1639, 1731, 1891, 1959, 1981, 2155, 2193, 2517, 2555, 2728], '11%': [152, 405], '<14%,': [154, 407], 'respectively,': [155, 408], 'entire': [158, 411], 'process,': [161, 414], 'including': [162, 415, 1046], 'enzymatic': [163, 416], 'digestion': [164, 168, 210, 417, 421, 463, 3645, 3676], 'Trypsin': [167, 420], 'its': [170, 423], 'requisite': [171, 424], 'sample': [172, 425, 1463, 1876, 3999], 'handling': [173, 426], 'contributed': [174, 427], 'most': [176, 429, 1566], 'variability': [179, 432], 'reduced': [181, 434], 'target': [185, 438, 809, 828, 2880], 'peptides': [186, 203, 439, 456, 1943, 1952, 1986, 2025, 2074, 2102, 2149, 2511, 2819, 2881, 2895, 3168, 3352, 3452, 3520, 3615, 3624, 3787, 3875, 3890, 4010, 4053, 4084], 'from': [187, 440, 524, 1923, 2075, 2129, 2310, 2882, 3428, 3535, 3553, 3567, 3963, 3969, 4016], 'digested': [188, 441, 1287, 2076, 3617, 4057, 4088], 'proteins.': [189, 442, 3713], 'Using': [190, 443, 1722], 'stable': [192, 201, 445, 454, 1119, 1468, 1496, 1508, 1536, 1682, 1825, 1898, 2106, 3205, 3390, 4120], 'isotope-labeled': [193, 202, 446, 455, 3391, 4121], 'protein': [194, 447, 546, 567, 663, 777, 797, 892, 913, 1299, 1568, 1629, 1638, 1705, 2038, 2058, 2195, 2421, 2490, 2557, 2730, 3013, 3165, 3355, 3530, 3608], 'as': [195, 249, 251, 448, 502, 504, 512, 1435, 2307, 2309, 2457, 2459, 3732, 3976, 4001], 'an': [196, 449, 1746, 3500, 3794], 'internal': [197, 450], 'standard': [198, 451, 803, 3512, 3519, 3531, 3726, 4132], 'instead': [199, 452], 'account': [205, 458], 'losses': [207, 460], 'process': [211, 464, 2465], 'nearly': [212, 465], 'doubled': [213, 466], 'accuracy': [215, 468], 'this': [217, 470, 576, 1653, 1723, 2048, 3985], 'while': [218, 471], 'improving': [219, 472], 'precision': [221, 474, 1239, 1402, 2702, 3325], '5%.': [222, 475], 'Our': [223, 476], 'results': [224, 477, 3127], 'demonstrate': [225, 478], 'made': [231, 484, 3455], 'reproducible': [232, 485, 1785], 'across': [233, 486, 4044], 'laboratories': [235, 488, 2131], 'has': [237, 490, 1765, 2692], 'potential': [239, 492, 511, 854], 'adopted': [242, 495], 'widely': [243, 496], 'assaying': [245, 498], 'matrices': [248, 501], 'complex': [250, 503], 'Hundreds': [506], 'claimed': [510], 'diagnostic': [513, 926, 1605], 'prognostic': [515], 'biomarkers': [516, 547, 568, 588, 727, 778, 798, 914, 1569, 1816, 2491, 2613], 'disease': [518, 2634], 'presence': [519], 'progression': [521], 'have': [522, 530, 906, 946, 1040, 1648, 1998, 2441, 2476, 3035], 'emerged': [523], 'discovery': [525, 583, 597, 654, 772, 883, 2609, 3159], 'proteomics': [526], 'but': [528, 3654], 'few': [529], 'progressed': [531], 'use': [533, 1979, 2414, 3006], 'clinic.': [536], 'failure': [538], 'deliver': [540], 'promise': [543], 'part': [550], 'due': [551, 2028, 3657], 'lack': [554, 3380, 3643], 'sufficiently': [556, 1782], 'precise': [557, 1271, 1958], 'methods': [558, 944, 1058, 3176, 3584], 'measure': [560, 808, 2482, 2698, 2924, 3049], 'changes': [561], 'abundance': [563, 1110, 1673, 3196], 'numerous': [565], 'candidate': [566, 780, 796, 855, 3164], 'hundreds': [570], 'patient': [572, 1793, 1818], 'samples.': [573], 'call': [575], 'critical': [577], '"verification,"': [579], 'it': [581, 2007], 'bridges': [582], 'clinical': [585, 606, 656, 885, 1063, 1552, 3161], 'validation': [586, 1061, 3162], '(1Rifai': [589], 'N.': [590], 'Gillette': [591, 749], 'M.A.': [592, 750, 760], 'Carr': [593, 765, 1103, 1233, 1396, 1666, 1811, 2228, 2277, 2651, 2767, 2840, 3189, 3319, 3755], 'S.A.': [594, 618, 766, 1104, 1234, 1397, 1667, 1812, 2229, 2278, 2652, 2768, 2841, 3190, 3320, 3756], 'Protein': [595, 621, 3578, 3594], 'validation:': [599, 657, 886], 'long': [601, 865, 3939], 'uncertain': [603], 'path': [604], 'utility.Nat.': [607], 'Biotechnol.': [608, 730, 785, 1251, 1414, 1904, 3337], '2006;': [609, 1082], '24:': [610], '971-983Crossref': [611], 'PubMed': [612, 637, 671, 734, 789, 900, 938, 1090, 1132, 1255, 1418, 1617, 1695, 1838, 1908, 1929, 2120, 2163, 2207, 2252, 2339, 2369, 2398, 2436, 2525, 2569, 2627, 2675, 2742, 2961, 2990, 3028, 3218, 3341, 3867], 'Scopus': [613, 638, 672, 735, 790, 901, 939, 1091, 1133, 1256, 1419, 1618, 1696, 1839, 1909, 1930, 2121, 2164, 2208, 2253, 2303, 2340, 2370, 2399, 2437, 2526, 2570, 2628, 2676, 2743, 2793, 2866, 2962, 2991, 3029, 3219, 3342, 3781, 3868], '(1367)': [614], 'Google': [615, 640, 674, 737, 792, 903, 941, 1093, 1135, 1258, 1421, 1620, 1698, 1841, 1911, 1932, 2123, 2166, 2210, 2255, 2305, 2342, 2372, 2401, 2439, 2528, 2572, 2630, 2678, 2745, 2795, 2868, 2964, 2993, 3031, 3221, 3344, 3783, 3870], 'Scholar,': [616, 641, 675, 738, 1094, 1136, 1912, 2167, 2211, 2256, 2343, 2373, 2402, 2529, 2573, 2746, 2965, 2994, 3222], '2Carr': [617], 'Anderson': [619, 917, 1221, 1384, 1596, 2088, 2142, 2172, 2273, 2504, 2534, 2707, 2763, 2836, 3307, 3751, 3842], 'L.': [620, 683, 693, 709, 1066, 1220, 1383, 2135, 2143, 2171, 2173, 2260, 2497, 2505, 2533, 2535, 2579, 2706, 2708, 2750, 2823, 3306, 3738], 'quantitation': [622, 2100, 2357, 2949], 'through': [623], 'targeted': [624, 721, 1115, 1678, 1821, 2073, 2245, 2668, 3201, 3623, 3703], 'spectrometry:': [626], 'way': [628], 'purgatory?.Clin.': [632], 'Chem.': [633, 1925, 2248, 2335, 2394, 2432, 2671, 2986, 3024], '2008;': [634, 668, 897, 2336], '54:': [635, 2337], '1749-1752Crossref': [636], '(124)': [639], '3Paulovich': [642], 'A.G.': [643, 719, 872, 1228, 1391, 2145, 2175, 2280, 2507, 2537, 2603, 2710, 2770, 2843, 3314, 3758], 'Whiteaker': [644, 873, 1217, 1380, 3303], 'J.R.': [645, 677, 874, 1218, 1381, 2133, 2169, 2258, 2495, 2531, 2575, 2704, 2748, 2821, 3304, 3736], 'Hoofnagle': [646, 875], 'A.N.': [647, 876, 2313], 'Wang': [648, 706, 877, 1215, 1378, 2580, 3301], 'P.': [649, 689, 707, 878, 1232, 1395, 2581, 3318], 'interface': [651, 880], 'between': [652, 881, 1426, 1750, 3158], 'tar': [659, 888], 'pit': [660, 889], 'pipeline.Proteomics': [665, 894], 'Clin.': [666, 895], 'Appl.': [667, 896], '2:': [669, 898], '1386-1402Crossref': [670, 899], '(171)': [673, 902], '4Whiteaker': [676], 'Lin': [678, 2267, 2757, 2830, 3745], 'C.': [679, 1166, 1329, 3252], 'Kennedy': [680], 'J.': [681, 1186, 1349, 2377, 2969, 3272], 'Hou': [682], 'Trute': [684], 'M.': [685, 748, 1100, 1188, 1216, 1351, 1379, 1663, 1800, 2219, 2264, 2272, 2642, 2754, 2762, 2827, 2835, 3186, 3274, 3302, 3742, 3750], 'Sokal': [686], 'I.': [687], 'Yan': [688], 'Schoenherr': [690], 'R.M.': [691], 'Zhao': [692, 1219, 1382, 2134, 2170, 2259, 2496, 2532, 2578, 2705, 2749, 2822, 3305, 3737], 'Voytovich': [694], 'U.J.': [695], 'Kelly-Spratt': [696, 2582], 'K.S.': [697, 2583], 'Krasnoselsky': [698], 'A.': [699, 1180, 1212, 1343, 1375, 3266, 3298], 'Gafken': [700], 'P.R.': [701], 'Hogan': [702], 'J.M.': [703, 1176, 1339, 3262], 'Jones': [704], 'L.A.': [705, 711, 758, 2597], 'Amon': [708], 'Chodosh': [710, 2596], 'Nelson': [712], 'P.S.': [713], 'McIntosh': [714, 2600], 'M.W.': [715, 2601], 'Kemp': [716, 2598], 'C.J.': [717, 2599], 'Paulovich': [718, 1227, 1390, 2144, 2174, 2279, 2506, 2536, 2602, 2709, 2769, 2842, 3313, 3757], 'proteomics-based': [722], 'pipeline': [723, 768, 2605], 'plasma.Nat.': [729, 1250, 1413, 3336], '2011;': [731, 786, 2296, 2786, 2859, 3774], '29:': [732, 787], '625-634Crossref': [733], '(291)': [736], '5Addona': [739], 'T.A.': [740, 1138, 1190, 1301, 1353, 3224, 3276], 'Shi': [741, 1803], 'X.': [742, 1804], 'Keshishian': [743, 1155, 1318, 1655, 2216, 2639, 3241], 'H.': [744, 1096, 1156, 1198, 1319, 1361, 1659, 1796, 1882, 1918, 2217, 2347, 2375, 2577, 2640, 2939, 2967, 3182, 3242, 3284], 'Mani': [745, 1145, 1308, 1801, 2220, 2643, 3231], 'D.R.': [746, 1146, 1309, 1802, 2221, 2644, 3232], 'Burgess': [747, 1099, 1662, 1799, 2218, 2263, 2641, 2753, 2826, 3185, 3741], 'Clauser': [751], 'K.R.': [752], 'Shen': [753], 'D.': [754, 1196, 1202, 1359, 1365, 2379, 2971, 3282, 3288], 'Lewis': [755], 'G.D.': [756], 'Farrell': [757], 'Fifer': [759], 'Sabatine': [761, 1807, 2224, 2647], 'M.S.': [762, 1808, 2225, 2648], 'Gerszten': [763, 1809, 2226, 2649], 'R.E.': [764, 1810, 2227, 2650], 'integrates': [770], 'reveals': [779], 'markers': [781, 1776], 'cardiovascular': [783, 1778, 1815, 2633], 'disease.Nat.': [784], '635-643Crossref': [788], '(202)': [791], 'Scholar).': [793, 942, 1259, 1621, 1842, 2124, 2679, 2796, 2869, 3032, 3784], 'Verification': [794], 'currently': [799], 'relies': [800], 'primarily': [801, 1862], 'immunoassays.': [804, 3062], 'Analytically': [805], 'validated': [806], 'immunoassays': [807, 839, 851, 951], 'analytes': [810], 'throughput,': [816], 'although': [817], 'these': [818, 1441, 1790, 2024, 2872], 'are': [819, 952, 1554, 1570, 1781, 2874, 2906], 'not': [820, 858, 1997, 2009, 3977], 'without': [821, 2054, 3591], 'problems': [822], 'caused': [823], 'by': [824, 1114, 1283, 1289, 1642, 1677, 1712, 1820, 1953, 2065, 2083, 2111, 2240, 2327, 2663, 2811, 2899, 3200, 3400, 3463, 3582, 3603, 3627, 3677, 3833, 3855, 3896, 4131], 'autoantibodies': [825], 'off': [827], 'interferences.': [829], 'In': [830, 2014, 3489, 3785, 4050, 4080, 4109], 'addition,': [831, 2015], 'antibody': [832, 3847, 4075, 4106], 'reagents': [833, 3854], 'suitable': [834, 1999], 'constructing': [836], 'useful': [837], 'sandwich': [838], 'exist': [840], 'only': [842], 'small': [844], 'fraction': [845], 'proteome.': [848], 'Developing': [849, 2230, 2653], 'reliable': [850], 'every': [853], 'practical': [859], 'present': [861, 1555, 1571], 'because': [862, 1863, 3498], 'development': [866, 2288, 2389, 2778, 2851, 2981, 3497, 3766], 'times': [867], 'cost': [870], '(3Paulovich': [871], 'Scholar),': [904, 1422, 2306, 2440], 'led': [907], 'dearth': [910], 'new': [912, 3487], '(6Anderson': [915, 1594], 'N.L.': [916, 1222, 1385, 1595, 2087, 2274, 2764, 2837, 3308, 3752, 3843], 'N.G.': [918, 1172, 1335, 1597, 2089, 3258], 'human': [920, 1599, 3965, 3978], 'proteome:': [922, 1601], 'History,': [923, 1602], 'character,': [924, 1603], 'prospects.Mol.': [927, 1606], 'Cell.': [928, 1080, 1122, 1607, 1685, 1828, 2197, 2294, 2559, 2732, 2784, 2857, 3208, 3772], 'Proteomics.': [929, 1081, 1123, 1608, 1686, 1829, 2198, 2295, 2560, 2733, 2785, 2858, 3209, 3773], '2002;': [930, 1609], '1:': [931, 1610], '845-867Abstract': [932, 1611], 'Full': [933, 935, 1085, 1087, 1127, 1129, 1612, 1614, 1690, 1692, 1833, 1835, 2202, 2204, 2298, 2300, 2564, 2566, 2737, 2739, 2788, 2790, 2861, 2863, 3213, 3215, 3776, 3778], 'Text': [934, 936, 1086, 1088, 1128, 1130, 1613, 1615, 1691, 1693, 1834, 1836, 2203, 2205, 2299, 2301, 2565, 2567, 2738, 2740, 2789, 2791, 2862, 2864, 3214, 3216, 3777, 3779], 'PDF': [937, 1089, 1131, 1616, 1694, 1837, 2206, 2302, 2568, 2741, 2792, 2865, 3217, 3780], '(3550)': [940, 1619], 'Alternative': [943], 'similar': [947, 2467], 'attributes': [949], 'clearly': [953, 3036], 'needed': [954], 'step.': [959], 'characteristics': [962], 'SID-MRM-MS': [965, 1290], '1The': [966, 999], 'abbreviations': [967, 1000], 'used': [968, 1001, 1767, 2875, 3590, 4032, 4142], 'are:SID-MRM-MSstable': [969, 1002], 'isotope': [970, 990, 1003, 1023, 1120, 1469, 1497, 1509, 1537, 1683, 1826, 1899, 2061, 2107, 3206], 'dilution': [971, 1004, 1470, 1510], 'spectrometryCVcoefficient': [976, 1009], 'varianceMRMmultiple': [978, 1011], 'monitoringfMRM(chromatographic)': [980, 1013], 'fractionation': [981, 1014, 1483, 1523, 1715, 1726], 'MRM-MSimmuno-MRM-MSimmunoprecipitation-MRM-mass': [982, 1015], 'spectrometryLODlimit': [983, 1016], 'detectionLOQlimit': [985, 1018], 'quantificationPARpeak': [987, 1020], 'area': [988, 1021, 1494, 1534], 'ratioSISCAPAstable': [989, 1022], 'standards': [991, 1024, 1498, 1538, 2062, 2108, 3609], 'capture': [993, 1026, 1500, 1540, 2064, 2110, 3142], 'antibodiesRErelative': [996, 1029], 'errorAAamino': [997, 1030], 'acid(s).': [998, 1031, 1507, 1547], 'direct': [1034, 1273, 1284, 1859], 'measurement': [1035], 'been': [1041, 1649, 1766, 1989, 2477, 2693], 'systematically': [1042, 3113], 'rigorously': [1044], 'evaluated,': [1045], 'technology,': [1054], 'well': [1056, 2308], 'established': [1057], 'analytical': [1060], '(7Anderson': [1065], 'Hunter': [1067], 'C.L.': [1068], 'Quantitative': [1069], 'spectrometric': [1071, 2099], 'proteins.Mol.': [1079], '5:': [1083], '573-588Abstract': [1084], '(1078)': [1092], '8Keshishian': [1095], 'Addona': [1097, 1660, 1797, 2214, 2637, 3183], 'T.': [1098, 1178, 1341, 1661, 1798, 2215, 2638, 3184, 3264], 'Kuhn': [1101, 1664, 1805, 2265, 2755, 2828, 3187, 3743], 'E.': [1102, 1665, 1806, 2213, 2266, 2591, 2636, 2756, 2829, 3188, 3744], 'Quantitative,': [1105, 1668, 3191], 'low': [1109, 1672, 1964, 3195, 3502, 3697], 'dilution.Mol.': [1121, 1684, 1827, 3207], '2007;': [1124, 1687, 1926, 2160, 2433, 2522, 2624, 3025, 3210], '6:': [1125, 1688, 2625, 3211], '2212-2229Abstract': [1126, 1689, 3212], '(576)': [1134, 1697, 3220], '9Addona': [1137, 3223], 'Abbatiello': [1139, 1302, 2261, 2751, 2824, 3225, 3739], 'S.E.': [1140, 1303, 2262, 2752, 2825, 3226, 3740], 'Schilling': [1141, 1304, 3227], 'B.': [1142, 1305, 3228], 'Skates': [1143, 1306, 3229], 'S.J.': [1144, 1224, 1307, 1387, 3230, 3310], 'Bunk': [1147, 1310, 3233], 'D.M.': [1148, 1311, 3234], 'Spiegelman': [1149, 1312, 3235], 'C.H.': [1150, 1164, 1313, 1327, 3236, 3250], 'Zimmerman': [1151, 1314, 3237], 'L.J.': [1152, 1210, 1315, 1373, 3238, 3296], 'Ham': [1153, 1316, 3239], 'A.J.': [1154, 1317, 3240], 'Hall': [1157, 1320, 3243], 'S.C.': [1158, 1321, 3244], 'Allen': [1159, 1322, 3245], 'S.': [1160, 1214, 1323, 1377, 3246, 3300], 'Blackman': [1161, 1324, 3247], 'R.K.': [1162, 1192, 1325, 1355, 3248, 3278], 'Borchers': [1163, 1326, 3249], 'Buck': [1165, 1328, 3251], 'Cardasis': [1167, 1330, 3253], 'H.L.': [1168, 1331, 3254], 'Cusack': [1169, 1332, 3255], 'M.P.': [1170, 1333, 3256], 'Dodder': [1171, 1334, 3257], 'Gibson': [1173, 1336, 3259], 'B.W.': [1174, 1337, 3260], 'Held': [1175, 1338, 3261], 'Hiltke': [1177, 1340, 3263], 'Jackson': [1179, 1342, 3265], 'Johansen': [1181, 1344, 3267], 'E.B.': [1182, 1345, 3268], 'Kinsinger': [1183, 1346, 3269], 'C.R.': [1184, 1347, 3270], 'Li': [1185, 1348, 1883, 3271], 'Mesri': [1187, 1350, 3273], 'Neubert': [1189, 1352, 2346, 2938, 3275], 'Niles': [1191, 1354, 3277], 'Pulsipher': [1193, 1356, 3279], 'T.C.': [1194, 1357, 3280], 'Ransohoff': [1195, 1358, 3281], 'Rodriguez': [1197, 1360, 3283], 'Rudnick': [1199, 1362, 3285], 'P.A.': [1200, 1363, 3286], 'Smith': [1201, 1364, 3287], 'Tabb': [1203, 1366, 3289], 'D.L.': [1204, 1367, 3290], 'Tegeler': [1205, 1368, 3291], 'T.J.': [1206, 1369, 3292], 'Variyath': [1207, 1370, 3293], 'A.M.': [1208, 1371, 3294], 'Vega-Montoto': [1209, 1372, 3295], 'Wahlander': [1211, 1374, 3297], 'Waldemarson': [1213, 1376, 3299], 'Fisher': [1223, 1386, 3309, 3910], 'Liebler': [1225, 1388, 3311], 'D.C.': [1226, 1389, 3312], 'Regnier': [1229, 1392, 3315], 'F.E.': [1230, 1393, 3316], 'Tempst': [1231, 1394, 3317], 'Multi-site': [1235, 1398, 3321], 'assessment': [1236, 1399, 2932, 3322], 'monitoring-based': [1245, 1408, 3331], 'measurements': [1246, 1409, 3332], '2009;': [1252, 1415, 1830, 2249, 2672, 3338, 3864], '27:': [1253, 1416, 3339], '633-641Crossref': [1254, 1417, 3340], '(862)': [1257, 1420, 3343], 'These': [1260, 3033], 'studies': [1261, 3034], 'technology': [1265, 1764, 3089, 3153], 'highly': [1267, 1936], 'specific,': [1268], 'sensitive,': [1269], '(LOQ)': [1282], 'range': [1294, 1627, 1740, 1966, 2484], '1–5': [1296], 'μg/ml': [1297, 1562], '(9Addona': [1300], 'intralaboratory': [1424], '6.6': [1427], '54.9%': [1429], 'imprecision': [1432, 3118], '18.5%': [1434], 'measured': [1436, 3832], 'LOQ.': [1439], 'Importantly,': [1440], 'excellent': [1442], 'levels': [1444, 1576, 1788, 2806], 'achieved': [1446, 1744, 2803], 'regardless': [1447], 'specific': [1450, 1584, 3169, 3885], 'LC': [1451], 'MS': [1453], 'instrument': [1454, 1869], 'employed,': [1455], 'provided': [1456], 'proper': [1458], 'care': [1459], 'exercised': [1461], 'preparation': [1464, 4000], 'data': [1466], 'analysis.': [1467], '(chromatographic)': [1482, 1522], 'immunoprecipitation-MRM-mass': [1485, 1525], 'peak': [1493, 1533], 'ratio': [1495, 1535], 'relative': [1504, 1544], 'error': [1505, 1545], 'amino': [1506, 1546, 3392, 3464, 3586], 'Although': [1548, 3605], 'many': [1549], 'utility': [1553], 'blood': [1557, 1632], '(e.g.': [1563, 1577], 'C-reactive': [1564], 'protein),': [1565], 'disease-specific': [1567], 'lower': [1575, 1856], 'cardiac': [1578, 2430, 3022], 'troponins': [1579], 'heart': [1581], 'failure,': [1582], 'prostate': [1583, 1587], 'antigen': [1585], 'cancer': [1588, 2493], 'thyroglobulin': [1590], 'thyroid': [1592], 'cancer)': [1593], 'complexity': [1623], '1011': [1625], 'dynamic': [1626], 'abundances': [1630], 'severely': [1633], 'sensitivity': [1636], 'SID-MRM-MS.': [1643], 'number': [1645, 2126, 3541], 'approaches': [1647], 'taken': [1650], 'address': [1652], 'problem.': [1654], 'et': [1656], 'al.': [1657], '(8Keshishian': [1658, 3181], 'Scholar)': [1699, 1933, 2631, 3345, 3871], 'developed': [1700, 1934, 2478, 2694, 3096, 3132], 'method': [1702, 2180, 2542, 2715], 'involving': [1703], 'abundant': [1704], 'depletion': [1706], 'commercial': [1708], 'columns': [1710], 'followed': [1711], 'limited': [1713, 1984], 'peptide': [1714, 1977, 1995, 2184, 2241, 2290, 2329, 2382, 2546, 2664, 2719, 2780, 2853, 2974, 3768, 3834, 3902], '(6–8': [1716], 'fractions)': [1717], 'prior': [1718, 2080, 3447, 3636], 'on-line': [1720], 'LC-SID-MRM-MS.': [1721], 'approach,': [1724, 1972], 'termed': [1725], 'MRM': [1727, 3628], '(fMRM),': [1728], 'robust,': [1729], 'bottom': [1736], 'overall': [1747], 'technical': [1748], '2.6': [1751], '37%': [1753], 'CV': [1757], '9.8%': [1759], '2.5': [1761], 'ng/ml.': [1762], 'This': [1763, 1955], 'develop': [1769, 2910], 'known': [1773, 2486], 'novel': [1775, 2489], 'injury': [1779], 'sensitive': [1783], 'assess': [1787, 3098], 'samples': [1794, 3982, 3990], '(10Keshishian': [1795], 'Quantification': [1813, 2320], '8:': [1831], '2339-2349Abstract': [1832], '(253)': [1840], 'limitation': [1844], 'approach': [1847, 1853, 1938, 1956], 'fMRM': [1854, 1971], 'than': [1857, 3406, 3505, 3601], 'increased': [1866], 'amount': [1867], 'time': [1870], 'required': [1871], 'fraction.': [1877], 'Zhang': [1878, 1917, 2136, 2498, 2576], 'co-workers': [1880], '(11Zhang': [1881], 'X.J.': [1884], 'Martin': [1885], 'D.B.': [1886, 2093], 'Aebersold': [1887, 1915], 'R.': [1888, 1916], 'Identification': [1889], 'N-linked': [1893, 1921, 1961], 'glycoproteins': [1894, 1962], 'hydrazide': [1896], 'chemistry,': [1897], 'labeling': [1900], 'spectrometry.Nat.': [1903], '2003;': [1905], '21:': [1906], '660-666Crossref': [1907], '(1275)': [1910], '12Zhou': [1913], 'Y.': [1914, 2406, 2998], 'Isolation': [1919], 'glycopeptides': [1922], 'plasma.Anal.': [1924], '79:': [1927, 2434, 3026], '5826-5837Crossref': [1928], '(119)': [1931, 2304, 2794, 2867, 3782], 'selective': [1937], 'specifically': [1940], 'enriches': [1941], 'N-glycosylated': [1942, 1994], 'then': [1947], 'quantifies': [1948], 'formerly': [1950, 1993], 'glycosylated': [1951], 'MRM-MS.': [1954], 'permitted': [1957], 'Unlike': [1969], 'choice': [1974], 'strictly': [1983], 'had': [1988], 'N-glycosylated.': [1990], 'If': [1991], 'does': [1996], 'HPLC': [2000], 'retention': [2001], 'ionization': [2003], 'properties': [2004], 'LC-MS/MS,': [2006], 'will': [2008], 'usable': [2011], 'quantification.': [2013], 'change': [2017, 2032, 2041, 2056], 'level': [2020, 2035], 'one': [2022, 3927, 3994], 'could': [2026, 3515, 3655, 3666, 3686], 'either': [2030], 'extent': [2044], 'glycosylation': [2046], 'particular': [2049], 'site,': [2050], 'latter': [2052], 'occurring': [2053], 'level.': [2059], 'Stable': [2060], 'employs': [2069], 'tissue': [2077], '(immuno-MRM)': [2085], '(13Anderson': [2086], 'Haines': [2090], 'L.R.': [2091], 'Hardie': [2092], 'Olafson': [2094], 'R.W.': [2095], 'Pearson': [2096, 2275, 2765, 2838, 3753, 3844], 'T.W.': [2097, 2276, 2766, 2839, 3754, 3845], 'Mass': [2098], '(SISCAPA).J.': [2114], 'Proteome': [2115, 2622], 'Res.': [2116, 2623], '2004;': [2117], '3:': [2118], '235-244Crossref': [2119], '(694)': [2122], 'reports': [2128], 'our': [2130], '(14Whiteaker': [2132, 2494], 'H.Y.': [2137, 2499], 'Feng': [2138, 2500, 2588], 'L.C.': [2139, 2501, 2589], 'Piening': [2140, 2502, 2586], 'B.D.': [2141, 2503, 2587], 'Antibody-based': [2146, 2508], 'magnetic': [2151, 2513, 2682, 4074, 4105], 'beads': [2152, 2514, 2892], 'mass-spectrometry-based': [2154, 2516], 'serum': [2157, 2325, 2519], 'biomarkers.Anal.': [2158, 2520], 'Biochem.': [2159, 2365, 2521, 2957], '362:': [2161, 2523], '44-54Crossref': [2162, 2524], '(233)': [2165, 2527], '15Whiteaker': [2168, 2530], 'An': [2176, 2348, 2538, 2680, 2711, 2940], 'automated': [2177, 2539, 2681, 2712, 3140], 'spectrometry-based': [2192, 2554, 2608, 2727], 'biomarkers.Mol.': [2196, 2558, 2731], '2010;': [2199, 2366, 2395, 2561, 2734, 2958, 2987], '9:': [2200, 2562, 2735], '184-196Abstract': [2201, 2563, 2736], '(274)': [2209, 2571, 2744], '16Kuhn': [2212], 'Lee': [2222, 2645], 'R.T.': [2223, 2646], 'troponin': [2234, 2657], 'I': [2235, 2658], 'interleukin-33': [2237, 2660], 'spectrometry.Clin.': [2247, 2334, 2670], '55:': [2250, 2673], '1108-1117Crossref': [2251, 2674], '(210)': [2254, 2677], '17Whiteaker': [2257, 2747], 'C.W.': [2268, 2758, 2831, 3746], 'Pope': [2269, 2759, 2832, 3747], 'M.E.': [2270, 2760, 2833, 3748, 3837], 'Razavi': [2271, 2761, 2834, 3749], 'Evaluation': [2281, 2771, 2844, 3759], 'scale': [2284, 2774, 2847, 3762], 'quantitative': [2285, 2775, 2848, 3763], 'proteomic': [2286, 2776, 2849, 3764], 'affinity-based': [2291, 2781, 2854, 3769], 'spectrometry.Mol.': [2293, 2783, 2856, 3771], '10.1074/mcp.M110.005645Abstract': [2297, 2787, 2860, 3775], 'others': [2311], '(18Hoofnagle': [2312], 'Becker': [2314], 'J.O.': [2315], 'Wener': [2316], 'M.H.': [2317], 'Heinecke': [2318], 'J.W.': [2319], 'thyroglobulin,': [2322], 'low-abundance': [2324], 'protein,': [2326, 3693, 3892], 'tandem': [2332], '1796-1804Crossref': [2338], '(242)': [2341], '19Ocaña': [2344], 'M.F.': [2345, 2937], 'liquid': [2350, 2942], 'chromatography-tandem': [2351, 2943], 'matrix': [2359, 2951], 'metalloproteinase': [2360, 2952], '9': [2361, 2953], 'mouse': [2363, 2617, 2955], 'serum.Anal.': [2364, 2956], '399:': [2367, 2959], '202-210Crossref': [2368, 2960], '(59)': [2371, 2963], '20Neubert': [2374, 2966], 'Gale': [2376, 2968], 'Muirhead': [2378, 2970], 'Online': [2380, 2972], 'high-flow': [2381, 2973], 'nanoflow': [2386, 2978], 'LC-MS/MS:': [2387, 2979], 'total': [2391, 2983], 'salivary': [2392, 2984], 'pepsin/pepsinogen.Clin.': [2393, 2985], '56:': [2396, 2988], '1413-1423Crossref': [2397, 2989], '(85)': [2400, 2992], '21Berna': [2403, 2995], 'M.J.': [2404, 2996], 'Zhen': [2405, 2997], 'Watson': [2407, 2999], 'D.E.': [2408, 3000], 'Hale': [2409, 3001], 'J.E.': [2410, 3002], 'Ackermann': [2411, 3003], 'B.L.': [2412, 3004], 'Strategic': [2413, 3005], 'immunoprecipitation': [2416, 3008], 'LC/MS/MS': [2418, 3010], 'trace-level': [2420, 3012], 'quantification:': [2422, 3014], 'Myosin': [2423, 3015], 'light': [2424, 3016, 4009], 'chain': [2425, 3017], '1,': [2426, 3018, 4052], 'necrosis.Anal.': [2431, 3023], '4199-4205Crossref': [2435, 3027], '(88)': [2438, 3030], 'ability': [2444], 'immuno-MRM': [2446, 2691, 2799, 2911, 3043, 3077, 3138], 'achieve': [2449], 'LODs': [2450], '∼1': [2452], 'little': [2458], '10': [2460, 2810], 'fMRM-MS.': [2473], 'Immuno-MRM': [2474], 'applied': [2480], 'potentially': [2488], '22Whiteaker': [2574], 'Ivey': [2584], 'R.G.': [2585], 'Kasarda': [2590], 'Gurley': [2592], 'K.E.': [2593], 'Eng': [2594], 'J.K.': [2595], 'Integrated': [2604], 'confirmation': [2611], 'model': [2618], 'breast': [2620], 'cancer.J.': [2621], '3962-3975Crossref': [2626], '(161)': [2629], '(16Kuhn': [2635], 'bead-based': [2683], 'platform': [2684], 'capable': [2685], 'tested': [2696], '(15Whiteaker': [2703], 'Multiplexing': [2797], 'plex': [2805], 'least': [2809], 'combining': [2812], 'produced': [2815], 'against': [2816], 'different': [2817, 3823], 'distinct': [2818, 3827], '(17Whiteaker': [2820, 3735], 'Mixtures': [2870], 'immuno-affinity': [2877], 'enrich': [2878], 'multiplex.': [2885], 'Subsequent': [2886], 'washing': [2887, 3144], 'elution': [2889], 'releases': [2893], 'all': [2894, 3349, 3573, 4045], 'captured': [2896], 'LC-MRM-MS.': [2900], 'pharmaceutical': [2902], 'biotechnology': [2904], 'industries': [2905], 'now': [2907], 'beginning': [2908], 'internally': [2913], 'partnership': [2916], 'academia': [2918, 3091], 'contract': [2920], 'research': [2921, 3980], 'organizations': [2922], 'preclinical': [2927], 'animal': [2928], 'models': [2929], 'pharmacodynamic': [2931], 'drug': [2934], 'candidates': [2935], '(19Ocaña': [2936], 'advantages': [3039], 'potentials': [3041], 'construct': [3045], 'overcome': [3058], 'limitations': [3059], 'traditional': [3061], 'assays,': [3078], 'prerequisite': [3080], 'more': [3082], 'widespread': [3083], 'acceptance': [3084], 'adoption': [3086], 'industry.': [3093], 'Protocols': [3094], 'technique': [3106], 'performed': [3107], 'sites': [3110], 'examine': [3114], 'sources': [3116], 'phase': [3121, 3402, 4035, 4051, 4081], 'process.': [3125], '8-plex': [3130], 'define': [3133], 'achievable': [3135], 'bead': [3141, 4076, 4107], 'provide': [3146], 'additional': [3147, 3795], 'support': [3148], 'valuable': [3152], 'bridging': [3155], 'gap': [3157], 'biomarkers.': [3166], 'Eight': [3167], 'six': [3171, 4013], 'selected': [3174, 3357, 3479, 3494], 'criteria': [3178], 'described': [3180, 3734], '(Table': [3346], 'I).': [3347], 'Briefly,': [3348], 'possible': [3350], 'tryptic': [3351, 3614], 'silico': [3359], 'Agilent': [3361], 'Spectrum': [3362], 'Mill': [3363], 'Peptide': [3364, 3459], 'Selector': [3365], '(http://proteomics.broadinstitute.org/millhtml/mssluice.htm;': [3366], 'Agilent,': [3367], 'Santa': [3368], 'Clara,': [3369], 'CA)': [3370, 3731], 'chosen': [3372], 'basis': [3375], 'uniqueness,': [3377], 'size,': [3378], 'modifiable': [3382], 'residues.': [3383], 'They': [3384], 'synthesized': [3386, 3789], 'single': [3389], 'acid': [3393, 3465, 3587], 'Fmoc': [3395], '(N-(9-fluorenyl)methoxycarbonyl)': [3396], 'chemistry': [3397], 'purified': [3399, 3894], 'reversed': [3401], 'chromatography': [3403, 3898], 'greater': [3405, 3600], '90%': [3407, 3602], '(MIT': [3408], 'Biopolymer': [3409], 'Lab,': [3410], 'Cambridge,': [3411], 'MA).': [3412, 3433], '[13C6]Leucine': [3413], '(98.4%': [3414], 'isotopic': [3415, 3419, 3424], 'enrichment),': [3416, 3420], '[13C6]lysine': [3417, 3436], '(99.6%': [3418], '[13C6]arginine': [3422], '(99.2%': [3423], 'enrichment)': [3425], 'purchased': [3427, 3534, 3566, 3968], 'Cambridge': [3429], 'Isotope': [3430], 'Laboratories': [3431], '(Andover,': [3432], '[13C6]Arginine': [3434], 'attached': [3438, 3904], 'Tentagel': [3440], 'S': [3441], 'resin': [3442], '(Rapp': [3443], 'Polymere,': [3444], 'Tübingen,': [3445], 'Germany)': [3446], 'synthesis.': [3449], 'Corresponding': [3450], 'unlabeled': [3451], 'also': [3454], '(Genscript,': [3456], 'Piscataway,': [3457], 'NJ).': [3458], 'concentrations': [3460, 3579, 4028, 4138], 'determined': [3462, 3581, 3597], '(Dana': [3467], 'Farber': [3468], 'Cancer': [3469], 'Institute,': [3470], 'Boston,': [3471], 'MA).Table': [3472], 'IProteins,': [3473], 'unique': [3474, 4011], 'peptides,': [3475], 'masses': [3480], 'Open': [3483], 'table': [3484], 'tab': [3488], 'general,': [3490], 'expected': [3501, 3613], 'concentration': [3503], '(less': [3504], 'ng/ml)': [3507], 'so': [3510], 'addition': [3513, 4133], 'experiments': [3514], 'generated': [3517, 3718], 'absence': [3523], 'endogenous': [3525], 'analyte.': [3526], 'Granulocyte': [3527], 'colony-stimulating': [3528], 'factor': [3529], '(CSF3)': [3532], 'US': [3536], 'Biological': [3537], '(Swampscott,': [3538], 'MA;': [3539], 'catalogue': [3540], 'G8951-26P).': [3542], 'Unlabeled': [3543], 'fully': [3545], '15N-labeled': [3546], 'forms': [3547], 'recombinant': [3549], 'S100B': [3550, 4116], 'obtained': [3552], 'Argonne': [3554], 'National': [3555], 'Laboratory': [3556], '(Argonne,': [3557], 'IL).': [3558], 'Proteins': [3559], 'S100A7,': [3560], 'S100A8,': [3561], 'S100A12,': [3562], 'IL1RN': [3564], 'Abnova': [3568], '(Taipei,': [3569], 'Taiwan)': [3570], 'expressed': [3574], 'GST': [3576, 3663, 3684], 'tags.': [3577], 'colorimetric': [3583], 'further': [3592, 3706], 'formulation.': [3593], 'purity': [3595, 3792], 'SDS-PAGE.': [3604], 'GST-tagged': [3607, 3648, 3712], 'yielded': [3611], 'when': [3616, 3629], 'buffer,': [3619], 'none': [3620], 'observed': [3626], 'spiked': [3633, 4055, 4086], 'into': [3634, 3812, 4056, 4087, 4134], 'digestion.': [3638], 'reason': [3640], 'unclear,': [3653], 'facile': [3659], 'homodimerization': [3660], 'tag': [3664, 3685], 'decrease': [3667, 3687], 'accessibility': [3669], 'tagged': [3672, 3692], 'proteins,': [3673, 4115], 'thereby': [3674], 'limiting': [3675], 'trypsin': [3678], 'or,': [3679], 'alternatively,': [3680], 'dimerized': [3683], 'solubility': [3689], 'again': [3694], 'resulting': [3695], 'no': [3699], 'yield': [3700], 'peptides.': [3704, 3828], 'No': [3705], 'work': [3707], 'done': [3709], 'Rabbit': [3714], 'polyclonal': [3715, 3916], 'New': [3720], 'Zealand': [3721], 'White': [3722], 'rabbits': [3723], 'following': [3724], '98-day': [3727], 'protocol': [3728], '(Epitomics,': [3729], 'Burlingame,': [3730], 'brief,': [3786], '80%': [3791], 'cysteine': [3796], 'C': [3799], 'terminus': [3800], 'conjugated': [3802], 'keyhole': [3804], 'limpet': [3805], 'hemocyanin': [3806], 'immunization.': [3808], 'Peptides': [3809], 'combined': [3811], 'groups': [3813], 'five,': [3815], 'rabbit': [3818], 'immunized': [3820], 'mixture': [3824], 'five': [3826], 'Antisera': [3829], 'titers': [3830], 'ELISA': [3835], '(23Pope': [3836], 'Soste': [3838], 'M.V.': [3839], 'Eyford': [3840], 'B.A.': [3841], 'Anti-peptide': [3846, 3882], 'screening:': [3848], 'Selection': [3849], 'affinity': [3852, 3897], 'monoclonal': [3853], 'refined': [3857], 'surface': [3858], 'plasmon': [3859], 'resonance': [3860], 'technique.J.': [3861], 'Immunol.': [3862], 'Methods.': [3863], '341:': [3865], '86-96Crossref': [3866], '(41)': [3869], 'determine': [3873], 'elicited': [3877], 'highest': [3879], 'immune': [3880], 'response.': [3881], 'antibodies,': [3883], 'typically': [3884], 'two': [3887, 4114], 'per': [3891], 'separately': [3895], 'immunizing': [3901], 'covalently': [3903], 'Sulfolink': [3907], 'column': [3908], '(Thermo': [3909], 'Scientific,': [3911], 'San': [3912], 'Jose,': [3913], 'CA).': [3914], 'Affinity-purified': [3915], 'shipped': [3919], '1×': [3921, 4093], 'PBS,': [3922, 4094], '0.02%': [3923], 'sodium': [3924], 'azide': [3925], 'site': [3928, 3950, 3995], 'where': [3929], 'they': [3930], 'formulated': [3932], '25%': [3934], 'glycerol': [3935], 'aliquotted': [3937], 'term': [3940], 'storage': [3941], '−20': [3943], '°C.': [3944], 'Antibodies': [3945], 'sent': [3947], 'wet': [3952], 'ice': [3953], 'stored': [3955], '4': [3957], '°C': [3958], 'until': [3959], 'use.': [3960], 'Plasma': [3961], 'pooled': [3962], 'deidentified': [3964], 'specimens': [3966], 'Bioreclamation': [3970], 'Inc.': [3971], '(Westbury,': [3972], 'NY)': [3973], 'treated': [3975], 'subjects': [3979], 'prepared': [3983, 3992, 4023, 4103], 'study.': [3986], 'All': [3987], 'remove': [3997], 'initial': [3998], 'source': [4003], 'variability.': [4005], 'Curves': [4006], 'containing': [4007], 'eight': [4008], 'ranging': [4015], '3': [4017, 4111], 'amol/μl': [4018], '500': [4020], 'fmol/μl': [4021], 'triplicate.': [4025], 'same': [4027], 'analyte': [4030], 'directly': [4040], 'compare': [4041], 'phases': [4046, 4110], '(supplemental': [4047], 'Table': [4048], '1).': [4049], 'diluted': [4059, 4090], '1:500': [4060], '5%': [4062], 'acetic': [4063], 'acid,': [4064], '0.03%': [4065, 4095], 'CHAPS': [4066, 4096], 'simulate': [4068, 4098], 'nonspecifically': [4069], 'bound': [4070], 'remaining': [4072], 'after': [4073], '(120': [4078], 'μg/ml).': [4079], '2,': [4082], '1:5': [4091], 'resuspended': [4100], 'digest': [4102], 'enrichment.': [4108], '4,': [4113], '(unlabeled': [4117], '(light)': [4118], '(heavy)': [4122], 'forms)': [4123], 'CSF3': [4125], '(light': [4126], 'form': [4127], 'only)': [4128], 'added': [4130], 'molar': [4137], 'equivalent': [4139], 'those': [4141]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2172080431', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 22}, {'year': 2015, 'cited_by_count': 21}, {'year': 2014, 'cited_by_count': 33}, {'year': 2013, 'cited_by_count': 28}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-15T08:54:52.865041', 'created_date': '2016-06-24'}