Title: A Polymer–(Tandem Drugs) Conjugate for Enhanced Cancer Treatment
Abstract: Advanced Healthcare MaterialsVolume 2, Issue 6 p. 822-827 Communication A Polymer–(Tandem Drugs) Conjugate for Enhanced Cancer Treatment Dongfang Zhou, Dongfang Zhou State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China Graduate School of Chinese Academy of Sciences, Beijing 100039, P. R. ChinaSearch for more papers by this authorHaihua Xiao, Haihua Xiao State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorFanbo Meng, Corresponding Author Fanbo Meng [email protected] The Cardiology Department of China-Japan Union Hospital of Jilin University, No. 126 Xiantai Str., Changchun 130033, P. R. China, Tel & Fax: +86-13159757035 Fanbo Meng, The Cardiology Department of China-Japan Union Hospital of Jilin University, No. 126 Xiantai Str., Changchun 130033, P. R. China, Tel & Fax: +86-13159757035. Yubin Huang, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorXiaoyuan Li, Xiaoyuan Li State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorYuxin Li, Yuxin Li National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, P. R. ChinaSearch for more papers by this authorXiabin Jing, Xiabin Jing State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorYubin Huang, Corresponding Author Yubin Huang [email protected] State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China Fanbo Meng, The Cardiology Department of China-Japan Union Hospital of Jilin University, No. 126 Xiantai Str., Changchun 130033, P. R. China, Tel & Fax: +86-13159757035. Yubin Huang, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this author Dongfang Zhou, Dongfang Zhou State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China Graduate School of Chinese Academy of Sciences, Beijing 100039, P. R. ChinaSearch for more papers by this authorHaihua Xiao, Haihua Xiao State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorFanbo Meng, Corresponding Author Fanbo Meng [email protected] The Cardiology Department of China-Japan Union Hospital of Jilin University, No. 126 Xiantai Str., Changchun 130033, P. R. China, Tel & Fax: +86-13159757035 Fanbo Meng, The Cardiology Department of China-Japan Union Hospital of Jilin University, No. 126 Xiantai Str., Changchun 130033, P. R. China, Tel & Fax: +86-13159757035. Yubin Huang, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorXiaoyuan Li, Xiaoyuan Li State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorYuxin Li, Yuxin Li National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, P. R. ChinaSearch for more papers by this authorXiabin Jing, Xiabin Jing State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this authorYubin Huang, Corresponding Author Yubin Huang [email protected] State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China Fanbo Meng, The Cardiology Department of China-Japan Union Hospital of Jilin University, No. 126 Xiantai Str., Changchun 130033, P. R. China, Tel & Fax: +86-13159757035. Yubin Huang, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaSearch for more papers by this author First published: 07 January 2013 https://doi.org/10.1002/adhm.201200385Citations: 42Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A novel strategy for combination chemotherapy (platinum and demethylcantharidin) via a polymer–(tandem drugs) conjugate for enhanced cancer treatment is demonstrated. Cisplatin can be released inside cell by reduction to attack DNA, while DMC will be hydrolyzed subsequently to block DNA-damage-induced defense mechanisms by serine/threonine phosphatase PP2A inhibition. Synergistic effect of the polymer–(tandem drugs) conjugate causes complete suppression of H22 liver tumor xenografts without recurrence. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description adhm_201200385_sm_suppl.pdf2.1 MB suppl Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume2, Issue6June, 2013Pages 822-827 RelatedInformation
Publication Year: 2013
Publication Date: 2013-01-07
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 49
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