Publication Information

{'id': 'https://openalex.org/W2171960002', 'doi': 'https://doi.org/10.1210/jcem-55-5-973', 'title': 'The Effect of Growth Hormone on Glucose Metabolism and Insulin Secretion in Man*', 'display_name': 'The Effect of Growth Hormone on Glucose Metabolism and Insulin Secretion in Man*', 'publication_year': 1982, 'publication_date': '1982-11-01', 'ids': {'openalex': 'https://openalex.org/W2171960002', 'doi': 'https://doi.org/10.1210/jcem-55-5-973', 'mag': '2171960002', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6749883'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/jcem-55-5-973', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205775358', 'display_name': 'The Journal of Clinical Endocrinology & Metabolism', 'issn_l': '0021-972X', 'issn': ['0021-972X', '1945-7197'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049558583', 'display_name': 'P. Bratusch-Marrain', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'PAUL R. BRATUSCH-MARRAIN', 'raw_affiliation_strings': ['Department of Internal Medicine, Yale University School of Medicine New Haven, Connecticut 06510'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Yale University School of Medicine New Haven, Connecticut 06510', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041591145', 'display_name': 'Douglas J. Smith', 'orcid': 'https://orcid.org/0000-0002-0018-671X'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'DOUGLAS SMITH', 'raw_affiliation_strings': ['Department of Internal Medicine, Yale University School of Medicine New Haven, Connecticut 06510'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Yale University School of Medicine New Haven, Connecticut 06510', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073917506', 'display_name': 'Ralph A. DeFronzo', 'orcid': 'https://orcid.org/0000-0002-8581-6273'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'RALPH A. DEFRONZO', 'raw_affiliation_strings': ['Department of Internal Medicine, Yale University School of Medicine New Haven, Connecticut 06510'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Yale University School of Medicine New Haven, Connecticut 06510', 'institution_ids': ['https://openalex.org/I32971472']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.809, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 331, 'citation_normalized_percentile': {'value': 0.996301, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '55', 'issue': '5', 'first_page': '973', 'last_page': '982'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/basal', 'display_name': 'Basal (medicine)', 'score': 0.6913515}, {'id': 'https://openalex.org/keywords/clamp', 'display_name': 'Clamp', 'score': 0.5740518}, {'id': 'https://openalex.org/keywords/glucose-clamp-technique', 'display_name': 'Glucose clamp technique', 'score': 0.55308926}, {'id': 'https://openalex.org/keywords/carbohydrate-metabolism', 'display_name': 'Carbohydrate Metabolism', 'score': 0.48793575}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.91228783}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.9048964}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.85071146}, {'id': 'https://openalex.org/C2778024521', 'wikidata': 'https://www.wikidata.org/wiki/Q55639806', 'display_name': 'Basal (medicine)', 'level': 3, 'score': 0.6913515}, {'id': 'https://openalex.org/C2776161997', 'wikidata': 'https://www.wikidata.org/wiki/Q846600', 'display_name': 'Clamp', 'level': 3, 'score': 0.5740518}, {'id': 'https://openalex.org/C2778808658', 'wikidata': 'https://www.wikidata.org/wiki/Q2975183', 'display_name': 'Glucose clamp technique', 'level': 5, 'score': 0.55308926}, {'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.496985}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.49409178}, {'id': 'https://openalex.org/C17093226', 'wikidata': 'https://www.wikidata.org/wiki/Q2734081', 'display_name': 'Carbohydrate metabolism', 'level': 2, 'score': 0.48793575}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.48436746}, {'id': 'https://openalex.org/C2777866211', 'wikidata': 'https://www.wikidata.org/wiki/Q5572349', 'display_name': 'Glucose uptake', 'level': 3, 'score': 0.4837756}, {'id': 'https://openalex.org/C2780352109', 'wikidata': 'https://www.wikidata.org/wiki/Q728309', 'display_name': 'Pancreatic hormone', 'level': 4, 'score': 0.44770694}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37261957}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36315358}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29747492}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.21716401}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C84111939', 'wikidata': 'https://www.wikidata.org/wiki/Q5125465', 'display_name': 'Clamping', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013006', 'descriptor_name': 'Growth Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005230', 'descriptor_name': 'Fatty Acids, Nonesterified', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005230', 'descriptor_name': 'Fatty Acids, Nonesterified', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013006', 'descriptor_name': 'Growth Hormone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009000', 'descriptor_name': 'Monocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/jcem-55-5-973', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205775358', 'display_name': 'The Journal of Clinical Endocrinology & Metabolism', 'issn_l': '0021-972X', 'issn': ['0021-972X', '1945-7197'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6749883', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W141312638', 'https://openalex.org/W1480810179', 'https://openalex.org/W1506549174', 'https://openalex.org/W1509595586', 'https://openalex.org/W1600232156', 'https://openalex.org/W174670461', 'https://openalex.org/W1893795204', 'https://openalex.org/W1944989204', 'https://openalex.org/W1966969214', 'https://openalex.org/W1969572070', 'https://openalex.org/W1974106130', 'https://openalex.org/W1974898644', 'https://openalex.org/W1981936195', 'https://openalex.org/W1984084795', 'https://openalex.org/W1995945960', 'https://openalex.org/W1996156072', 'https://openalex.org/W2003781513', 'https://openalex.org/W2012898950', 'https://openalex.org/W2017756513', 'https://openalex.org/W2020976394', 'https://openalex.org/W2033777213', 'https://openalex.org/W2044957767', 'https://openalex.org/W2053415578', 'https://openalex.org/W2055904353', 'https://openalex.org/W2056935382', 'https://openalex.org/W2069537526', 'https://openalex.org/W2071046118', 'https://openalex.org/W2072484901', 'https://openalex.org/W2075387131', 'https://openalex.org/W2079802859', 'https://openalex.org/W2081255606', 'https://openalex.org/W2085677391', 'https://openalex.org/W2086486141', 'https://openalex.org/W2092607349', 'https://openalex.org/W2096217291', 'https://openalex.org/W2103498629', 'https://openalex.org/W2104785536', 'https://openalex.org/W2121322249', 'https://openalex.org/W2135157112', 'https://openalex.org/W2142481399', 'https://openalex.org/W2156435407', 'https://openalex.org/W2157667727', 'https://openalex.org/W2158888587', 'https://openalex.org/W2160436622', 'https://openalex.org/W2163098588', 'https://openalex.org/W2166915794', 'https://openalex.org/W2169069107', 'https://openalex.org/W2169401893', 'https://openalex.org/W2282755628', 'https://openalex.org/W2319820122', 'https://openalex.org/W2416801106', 'https://openalex.org/W28452575', 'https://openalex.org/W313442901', 'https://openalex.org/W80789305'], 'related_works': ['https://openalex.org/W2762714136', 'https://openalex.org/W2377421468', 'https://openalex.org/W2377249418', 'https://openalex.org/W2352832354', 'https://openalex.org/W2168853799', 'https://openalex.org/W2144150558', 'https://openalex.org/W2080751768', 'https://openalex.org/W2070126267', 'https://openalex.org/W2057279912', 'https://openalex.org/W2051066158'], 'abstract_inverted_index': {'Pharmacological': [0], 'doses': [1], 'of': [2, 28, 52, 76, 117, 144, 188, 202, 207, 341, 366, 371, 385, 402, 435, 457], 'GH': [3, 33, 77, 118, 145, 184, 203, 231, 277, 289, 342, 367, 380, 386, 430], 'are': [4], 'known': [5], 'to': [6, 24, 43, 195, 247, 352, 373, 404, 418, 472, 492, 512, 517], 'impair': [7, 444], 'glucose': [8, 108, 121, 149, 165, 209, 261, 303, 450, 497], 'tolerance.': [9], 'In': [10, 85, 224, 297], 'the': [11, 17, 26, 40, 74, 86, 92, 138, 178, 186, 196, 225, 269, 298, 312, 454, 468, 494, 513, 518], 'present': [12], 'study': [13], 'we': [14], 'have': [15], 'employed': [16], 'euglycemic': [18], 'insulin': [19, 44, 48, 56, 60, 89, 94, 228, 243, 257, 349, 393, 436, 458, 470, 480, 502, 520], 'and': [20, 45, 62, 72, 82, 99, 283, 306, 333, 363, 474], 'hyperglycemic': [21, 63, 299], 'clamp': [22, 90, 229, 258, 300], 'techniques': [23], 'examine': [25], 'effect': [27, 447], 'physiological': [29, 427], 'elevations': [30, 428], 'in': [31, 67, 137, 177, 219, 268, 317, 347, 350, 390, 421, 429, 461, 479, 487, 496], 'plasma': [32, 93, 107, 242, 302, 348, 469, 501], 'concentrations': [34, 503], '(27': [35], '±': [36, 130, 134, 154, 157, 168, 175, 191, 212, 249, 265, 280, 292, 320, 328, 336, 356, 377, 396, 412], '2': [37, 81, 115, 236, 331, 362, 383], 'ng/ml)': [38], 'on': [39, 46, 448], 'tissue': [41], 'responses': [42], 'glucose-stimulated': [47], 'secretion.': [49], 'Three': [50], 'types': [51], 'studies': [53], '(low': [54], 'dose': [55, 59, 88, 227, 256], 'clamp,': [57, 61], 'high': [58, 226, 500], 'clamp)': [64], 'were': [65, 245], 'performed': [66], 'young': [68], 'healthy': [69], 'volunteers': [70], 'before': [71, 379], 'after': [73, 240, 286, 330, 338, 361], 'infusion': [75, 278, 290], '(2': [78], 'μg/kg-h)': [79], 'for': [80, 234], '12': [83, 142, 200, 238, 339, 364, 400], 'h.': [84], 'low': [87], 'studies,': [91, 230, 301], 'concentration': [95], 'was': [96, 100, 109, 123, 171, 193, 214, 232, 263, 304, 324, 359, 375, 409], 'acutely': [97], 'raised': [98, 305], 'maintained': [101, 110, 307], 'at': [102, 111, 308, 499], '59': [103], '±4': [104], 'μU/ml,': [105], 'while': [106, 252], 'basal': [112, 313], 'levels.': [113], 'After': [114, 141, 181, 199, 382, 399], 'h': [116, 143, 201, 332, 340, 365, 384, 401], 'infusion,': [119, 146, 185, 204], 'insulin-mediated': [120, 148], 'metabolism': [122, 316, 498], 'slightly,': [124], 'although': [125], 'not': [126, 466], 'significantly,': [127], 'decreased': [128, 151, 325, 410], '(4.48': [129], '0.56': [131], 'vs.': [132], '5.04': [133], '0.39': [135], 'mg/kg-min)': [136, 170, 282], 'control': [139, 179, 197, 270], 'study.': [140, 180], 'however,': [147, 205, 406], 'uptake': [150, 262], 'by': [152, 173, 326, 334], '32': [153], '9%': [155], '(3.36': [156], '0.40': [158], 'mg/kg-min;': [159, 294], 'P': [160, 295, 414], '<': [161, 222, 415], '0.01).': [162], 'Basal': [163], 'endogenous': [164, 208, 449], 'production': [166, 210], '(2.02': [167], '0.07': [169], 'suppressed': [172], '89': [174], '4%': [176], 'short': [182, 275], 'term': [183, 276, 288], 'degree': [187], 'suppression': [189, 206], '(90': [190], '5%)': [192, 213], 'similar': [194], 'value.': [198], '(78': [211], 'slightly': [215, 272, 443], 'less': [216], 'than': [217], 'that': [218, 426, 453, 482, 505], 'controls': [220, 318], '(P': [221], '0.05).': [223], 'infused': [233], 'either': [235], 'or': [237], 'h,': [239, 440], 'which': [241], 'levels': [244], 'increased': [246], '2292': [248], '96': [250], 'μU/ml': [251], 'maintaining': [253], 'euglycemia': [254], '(high': [255], 'study).': [259], 'Insulin-mediated': [260], '11.22': [264], '0.53': [266, 321], 'mg/kg-min': [267], 'study,': [271], 'lower': [273], 'during': [274], '(9.56': [279], '1.00': [281], 'significantly': [284], 'diminished': [285], 'long': [287], '(7.16': [291], '1.12': [293], '<0.02).': [296], '125': [309], 'mg/dl': [310], 'above': [311], 'level.': [314], 'Glucose': [315], '(8.68': [319], 'mg/': [322], 'kg-min)': [323], '31': [327], '7%': [329], '44': [335], '6%': [337], 'infusion.': [343, 381], 'The': [344, 490], 'mean': [345], 'increment': [346], 'response': [351, 471], 'hyperglycemia': [353], '(control,': [354], '56': [355], '10': [357], 'μU/ml)': [358], 'unaltered': [360], 'administration.': [368], 'Total': [369], 'binding': [370, 394, 408, 481], '[125I]insulin': [372], 'monocytes': [374], '7.0': [376], '0.5%': [378], 'administration,': [387], 'no': [388], 'change': [389], 'total': [391, 407], 'specific': [392], '(7.4': [395], '0.4%)': [397], 'occurred.': [398], 'exposure': [403], 'GH,': [405], '(5.9': [411], '0.4%': [413], '0.02)': [416], 'due': [417], 'a': [419, 434, 477, 485, 506], 'decrease': [420, 478, 486], 'receptor': [422, 488, 514], 'affinity.': [423, 489], 'We': [424], 'conclude': [425], '1)': [431], 'induce': [432], 'state': [433], 'resistance': [437, 459], 'within': [438], '2–12': [439], '2)': [441], 'only': [442], "insulin's": [445], 'suppressive': [446], 'production,': [451], 'indicating': [452], 'primary': [455], 'site': [456], 'resides': [460], 'peripheral': [462], 'tissues,': [463], '3)': [464], 'do': [465], 'alter': [467], 'hyperglycemia,': [473], '4)': [475], 'cause': [476], 'results': [483], 'from': [484], 'inability': [491], 'overcome': [493], 'defect': [495, 509], 'suggests': [504], 'significant': [507], 'postreceptor': [508], '(in': [510], 'addition': [511], 'defect)': [515], 'contributes': [516], 'observed': [519], 'resistance.': [521], '(J': [522], 'Clin': [523], 'Endocrinol': [524], 'Metab55:': [525], '973,': [526], '1982)': [527]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2171960002', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-28T02:39:19.959226', 'created_date': '2016-06-24'}