Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2171729507', 'doi': 'https://doi.org/10.1242/jcs.110031', 'title': 'A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA', 'display_name': 'A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA', 'publication_year': 2013, 'publication_date': '2013-01-15', 'ids': {'openalex': 'https://openalex.org/W2171729507', 'doi': 'https://doi.org/10.1242/jcs.110031', 'mag': '2171729507', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23203802', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3613177'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.110031', 'pdf_url': 'https://jcs.biologists.org/content/joces/126/2/437.full.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://jcs.biologists.org/content/joces/126/2/437.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048527504', 'display_name': 'Maria A. Brehm', 'orcid': 'https://orcid.org/0000-0003-0416-8233'}, 'institutions': [{'id': 'https://openalex.org/I1309191912', 'display_name': 'Research Triangle Park Foundation', 'ror': 'https://ror.org/03eqttr49', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1309191912']}, {'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}, {'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}], 'countries': ['DE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Maria A. Brehm', 'raw_affiliation_strings': ['Inositol Signaling Section, Laboratory of Signal Transduction, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA', 'Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Inositol Signaling Section, Laboratory of Signal Transduction, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA', 'institution_ids': ['https://openalex.org/I1309191912']}, {'raw_affiliation_string': 'Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany', 'institution_ids': ['https://openalex.org/I4210108711', 'https://openalex.org/I159176309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034537472', 'display_name': 'Torsten Wundenberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}, {'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Torsten Wundenberg', 'raw_affiliation_strings': ['Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany', 'institution_ids': ['https://openalex.org/I4210108711', 'https://openalex.org/I159176309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073887611', 'display_name': 'Jason Williams', 'orcid': 'https://orcid.org/0000-0002-7500-7077'}, 'institutions': [{'id': 'https://openalex.org/I1309191912', 'display_name': 'Research Triangle Park Foundation', 'ror': 'https://ror.org/03eqttr49', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1309191912']}, {'id': 'https://openalex.org/I4210095140', 'display_name': 'National Institute of Environmental Health Sciences', 'ror': 'https://ror.org/00j4k1h63', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210095140']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jason Williams', 'raw_affiliation_strings': ['Protein Microcharacterization Core Facility, Mass Spectrometry Group at NIEHS/NIH, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA'], 'affiliations': [{'raw_affiliation_string': 'Protein Microcharacterization Core Facility, Mass Spectrometry Group at NIEHS/NIH, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA', 'institution_ids': ['https://openalex.org/I1309191912', 'https://openalex.org/I4210095140']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032409973', 'display_name': 'Georg W. Mayr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}, {'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Georg W. Mayr', 'raw_affiliation_strings': ['Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany', 'institution_ids': ['https://openalex.org/I4210108711', 'https://openalex.org/I159176309']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013107971', 'display_name': 'Stephen B. Shears', 'orcid': 'https://orcid.org/0000-0001-7309-8916'}, 'institutions': [{'id': 'https://openalex.org/I1309191912', 'display_name': 'Research Triangle Park Foundation', 'ror': 'https://ror.org/03eqttr49', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1309191912']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen B. Shears', 'raw_affiliation_strings': ['Inositol Signaling Section, Laboratory of Signal Transduction, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA'], 'affiliations': [{'raw_affiliation_string': 'Inositol Signaling Section, Laboratory of Signal Transduction, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA', 'institution_ids': ['https://openalex.org/I1309191912']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.81, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.715581, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '126', 'issue': '2', 'first_page': '437', 'last_page': '444'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ribosome-biogenesis', 'display_name': 'Ribosome biogenesis', 'score': 0.7681577}, {'id': 'https://openalex.org/keywords/rna-structure', 'display_name': 'RNA Structure', 'score': 0.54404}, {'id': 'https://openalex.org/keywords/protein-synthesis', 'display_name': 'Protein Synthesis', 'score': 0.540693}, {'id': 'https://openalex.org/keywords/nucleosome-positioning', 'display_name': 'Nucleosome Positioning', 'score': 0.503584}, {'id': 'https://openalex.org/keywords/ribosomal-protein', 'display_name': 'Ribosomal protein', 'score': 0.47122896}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8495081}, {'id': 'https://openalex.org/C183873130', 'wikidata': 'https://www.wikidata.org/wiki/Q30869', 'display_name': 'Nucleolus', 'level': 3, 'score': 0.80063844}, {'id': 'https://openalex.org/C2779419633', 'wikidata': 'https://www.wikidata.org/wiki/Q7322423', 'display_name': 'Ribosome biogenesis', 'level': 5, 'score': 0.7681577}, {'id': 'https://openalex.org/C67905577', 'wikidata': 'https://www.wikidata.org/wiki/Q215980', 'display_name': 'Ribosomal RNA', 'level': 3, 'score': 0.70279783}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.5067311}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.496933}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.48885816}, {'id': 'https://openalex.org/C38062823', 'wikidata': 'https://www.wikidata.org/wiki/Q3408228', 'display_name': 'Ribosomal protein', 'level': 5, 'score': 0.47122896}, {'id': 'https://openalex.org/C3675279', 'wikidata': 'https://www.wikidata.org/wiki/Q211935', 'display_name': 'Protein biosynthesis', 'level': 2, 'score': 0.44362137}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.41562527}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3886672}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.3729119}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.30618662}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.08512148}], 'mesh': [{'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002466', 'descriptor_name': 'Cell Nucleolus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002466', 'descriptor_name': 'Cell Nucleolus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002466', 'descriptor_name': 'Cell Nucleolus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007294', 'descriptor_name': 'Inositol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007294', 'descriptor_name': 'Inositol', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007294', 'descriptor_name': 'Inositol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.110031', 'pdf_url': 'https://jcs.biologists.org/content/joces/126/2/437.full.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3613177', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613177', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23203802', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.110031', 'pdf_url': 'https://jcs.biologists.org/content/joces/126/2/437.full.pdf', 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1964996586', 'https://openalex.org/W1966677529', 'https://openalex.org/W1968686367', 'https://openalex.org/W1972897065', 'https://openalex.org/W1977314999', 'https://openalex.org/W1977846646', 'https://openalex.org/W1979891979', 'https://openalex.org/W1983467802', 'https://openalex.org/W1983629759', 'https://openalex.org/W1993749254', 'https://openalex.org/W2015214118', 'https://openalex.org/W2018714533', 'https://openalex.org/W2023040274', 'https://openalex.org/W2025648013', 'https://openalex.org/W2043427242', 'https://openalex.org/W2046015864', 'https://openalex.org/W2048442183', 'https://openalex.org/W2051503534', 'https://openalex.org/W2059494390', 'https://openalex.org/W2069340514', 'https://openalex.org/W2070887804', 'https://openalex.org/W2071737785', 'https://openalex.org/W2083644112', 'https://openalex.org/W2084929037', 'https://openalex.org/W2097259918', 'https://openalex.org/W2098724662', 'https://openalex.org/W2098940989', 'https://openalex.org/W2102424174', 'https://openalex.org/W2108044369', 'https://openalex.org/W2119799603', 'https://openalex.org/W2123282517', 'https://openalex.org/W2124008535', 'https://openalex.org/W2135064107', 'https://openalex.org/W2138865242', 'https://openalex.org/W2146609854', 'https://openalex.org/W2162874229', 'https://openalex.org/W2162895146', 'https://openalex.org/W2164410997', 'https://openalex.org/W2418361432', 'https://openalex.org/W4242012798'], 'related_works': ['https://openalex.org/W973862478', 'https://openalex.org/W4223600679', 'https://openalex.org/W4205183794', 'https://openalex.org/W2522970136', 'https://openalex.org/W2121038367', 'https://openalex.org/W2045332931', 'https://openalex.org/W2010296800', 'https://openalex.org/W1988587250', 'https://openalex.org/W1964611614', 'https://openalex.org/W194301324'], 'abstract_inverted_index': {'Fundamental': [0], 'to': [1, 135, 157, 177], 'the': [2, 10, 21, 24, 40, 59, 82, 119, 158, 161, 168, 178, 186, 212], 'life': [3], 'and': [4, 36, 47, 103, 109], 'destiny': [5], 'of': [6, 12, 26, 121, 142, 160, 170, 181, 189, 210, 215], 'every': [7], 'cell': [8], 'is': [9, 32, 76], 'regulation': [11], 'protein': [13, 99, 191], 'synthesis': [14, 56], 'through': [15], 'ribosome': [16], 'biogenesis,': [17], 'which': [18], 'begins': [19], 'in': [20, 53, 81, 163, 231], 'nucleolus': [22], 'with': [23, 92, 127], 'production': [25], 'ribosomal': [27], 'RNA': [28], '(rRNA).': [29], 'Nucleolar': [30, 129], 'organization': [31], 'a': [33, 69, 78, 202], 'highly': [34], 'dynamic': [35], 'tightly': [37], 'regulated': [38], 'process;': [39], 'structural': [41, 79], 'factors': [42], 'that': [43, 62, 68, 86, 95, 123, 145, 151, 192, 198], 'direct': [44], 'nucleolar': [45], 'assembly': [46], 'disassembly': [48], 'are': [49, 58], 'just': [50], 'as': [51, 57, 201], 'important': [52], 'controlling': [54], 'rRNA': [55, 97, 147, 171], 'catalytic': [60], 'activities': [61], 'synthesize': [63], 'rRNA.': [64], 'Here,': [65], 'we': [66, 112], 'report': [67], 'signaling': [70], 'enzyme,': [71], 'inositol': [72], '1,3,4,5,6-pentakisphosphate': [73], '2-kinase': [74], '(IP5K)': [75], 'also': [77], 'component': [80], 'nucleolus.': [83], 'We': [84, 149], 'demonstrate': [85], 'IP5K': [87, 122, 130, 152, 199], 'has': [88], 'functionally': [89], 'significant': [90], 'interactions': [91], 'three': [93], 'proteins': [94], 'regulate': [96], 'synthesis:': [98], 'kinase': [100, 187], 'CK2,': [101], 'TCOF1': [102], 'upstream-binding-factor': [104], '(UBF).': [105], 'Through': [106], 'molecular': [107, 203], 'modeling': [108], 'mutagenic': [110], 'studies,': [111], 'identified': [113], 'an': [114, 206, 229], 'Arg-Lys-Lys': [115], 'tripeptide': [116], 'located': [117], 'on': [118], 'surface': [120], 'mediates': [124], 'its': [125], 'association': [126], 'UBF.': [128], 'spatial': [131], 'dynamics': [132], 'were': [133], 'sensitive': [134, 155], 'experimental': [136], 'procedures': [137], '(serum': [138], 'starvation': [139], 'or': [140], 'addition': [141], 'actinomycin': [143], 'D)': [144], 'inhibited': [146], 'production.': [148], 'show': [150], 'makes': [153], 'stoichiometrically': [154], 'contributions': [156], 'architecture': [159], 'nucleoli': [162], 'intact': [164], 'cells,': [165], 'thereby': [166], 'influencing': [167], 'degree': [169], 'synthesis.': [172], 'Our': [173, 196], 'study': [174], 'adds': [175], 'significantly': [176], 'biological': [179, 213], 'significance': [180], 'IP5K;': [182], 'previously,': [183], 'it': [184], 'was': [185], 'activity': [188], 'this': [190], 'had': [193], 'attracted': [194], 'attention.': [195], 'demonstration': [197], "'moonlights'": [200], 'scaffold': [204], 'offers': [205], 'unexpected': [207], 'new': [208], 'example': [209], 'how': [211], 'sophistication': [214], 'higher': [216], 'organisms': [217], 'can': [218], 'arise': [219], 'from': [220], 'gene': [221, 232], 'products': [222], 'acquiring': [223], 'multiple': [224], 'functions,': [225], 'rather': [226], 'than': [227], 'by': [228], 'increase': [230], 'number.': [233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2171729507', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-08-15T13:46:58.673202', 'created_date': '2016-06-24'}