Publication Information

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1545, 1637, 1744, 1905, 1936, 1968, 2033, 2069, 2295, 2341, 2376, 2424, 2482, 2511, 2629, 3200], 'radical': [122], 'development,': [123], 'these': [125, 178, 202, 230, 386, 417, 425, 753, 991, 1061, 1166], 'few': [126], 'exceed': [128], 'everything': [129], 'that': [130, 235, 246, 399, 452, 481, 509, 564, 687, 764, 859, 941, 1004, 1017, 1245, 1284, 1287, 1300, 1330, 1365, 1384, 1426, 1500, 1769], 'published': [133, 1366], 'before.': [134], 'These': [135], 'comprise': [136], '2': [137, 146, 1305, 3337], 'anticholinesterase': [141, 165], 'donepezil': [142, 1898], 'dementia,1,2': [145], 'NMDA': [150], 'receptor': [151], 'antagonist': [152], 'memantine': [153, 1959, 1991], 'mild': [155, 1963, 1993], 'moderate': [157, 1965, 1995], 'dementia,3,4': [159], 'study': [162, 683, 738, 772, 943, 958, 1989], 'galantamine': [166, 484, 2021], '"probable': [168], "Alzheimer's": [172, 263, 306, 491, 757, 1591, 2027, 2052, 2177, 2198, 3091, 3151], 'disease': [173, 264, 492, 1037, 1114, 1592, 1607, 2028, 2374], 'combined': [174, 1273, 2029], 'with': [175, 503, 660, 675, 1035, 1199, 1428, 1526, 1728, 1962, 2030, 2223, 2267, 2279, 2302, 2896], 'cerebrovascular': [176, 2031, 2280], 'disease."5While': [177], 'findings': [179], 'are': [180, 187, 232, 376, 391, 402, 607, 754, 1171, 1178, 1593, 1705, 1758, 1809, 1847], 'exciting': [181], 'represent': [183], 'new': [184, 1085, 1638, 2048, 2226], 'developments,': [185], 'there': [186, 666, 1681], 'number': [189, 556], 'cautions.': [191], 'The': [192, 419, 604, 619, 680, 737, 876, 1159, 1303, 1466, 1730, 2219, 2328, 2561, 2883], 'first': [193], 'relatively': [196, 403], 'modest': [197, 338], 'benefits': [198, 979], 'seen': [199, 304, 769, 1308, 1436, 1503], 'all': [201, 251], 'trials.': [203, 426, 1754], 'For': [204], 'anticholinesterases,': [206], 'benefit': [208, 496, 648, 674, 902, 915], 'on': [209, 221, 265, 348, 357, 364, 516, 523, 823, 903, 916, 971, 1156, 1376, 2109, 2197, 2272, 2330, 2846, 2998], 'ADAS-Cog6': [211], 'amounts': [212], 'about': [214], 'points': [216], '<1': [219], 'point': [220, 1582], 'Mini-Mental': [223, 974], 'State': [224, 975], 'Examination': [225], '(MMSE).7': [226], 'While': [227, 444, 1350, 1821], 'statistically': [228], 'significant,': [229], 'effects': [231, 375, 384, 401, 768, 2108], 'so': [233, 326, 1056], 'slight': [234], 'they': [236, 1718], 'not': [238, 316, 734, 1050, 1150, 1172, 1264, 1486, 1601, 1790, 1822, 1848], 'useful': [240], 'routine': [241], 'treatments': [242, 245, 1072, 2698], 'but': [243, 252, 296, 360, 435, 911, 1149, 1219, 1477, 1614], 'perhaps': [244, 351], 'should': [247, 1677], 'tried': [249], 'maintained': [253, 852], 'only': [254, 1602], 'individual': [256], 'responders.These': [257], 'drugs': [258], 'were': [259, 422, 493, 692, 711, 773, 925], 'originally': [260], 'developed': [261], 'for': [262, 318, 729, 756, 787, 868, 886, 1087, 1165, 1217, 1357, 1473, 1562, 1640, 1646, 1663, 2051, 2072, 2079, 2137, 2257, 2478, 2947], 'basis': [267], 'cholinergic': [270, 280, 294, 313, 328], 'hypothesis;': [271], 'much': [272], 'made': [274], 'presence': [277, 310], 'deficit': [281, 314, 1551, 2568], 'dementia,': [284, 2666], 'which': [285, 788, 931, 1094], 'probably': [286, 700], 'occurs': [287], 'because': [288, 701, 1204, 1735], 'ischemic': [290, 2509], 'damage': [291, 1170, 1298, 1462, 1781, 3000], 'projections,': [295], 'this': [297, 647, 658, 732, 771, 1351, 1654, 1770, 1788, 1845], 'proportionately': [299], 'considerably': [300], 'less': [301, 343, 610], 'disease.': [307, 777, 1059, 2053, 2281], 'Indeed,': [308], 'required': [317], 'anticholinesterases': [320, 347], 'produce': [322, 447], 'improvement8': [324], 'hypothesis': [329], 'neither': [331], 'necessary': [332], 'nor': [333], 'sufficient': [334], 'explain': [336], 'benefits.': [339], 'Memantine': [340], 'slightly': [342], 'effect': [344, 354, 363, 514, 791, 822, 870], 'ADAS-Cog,': [350], 'better': [353], '(2': [355], 'points)': [356], 'MMSE': [359, 741], 'no': [361, 789, 821, 2766], 'detectable': [362], 'Clinical': [366, 2174, 3191], 'Global': [367, 3319], 'Impression': [368], 'Change': [370], '(CGI-C)': [371], 'while': [372, 1234], 'side': [374], 'very': [377, 393, 1022, 1795], 'close': [378], 'placebo': [380], 'level.': [381], 'That': [382], 'different': [387, 450, 1071], 'classes': [388], 'drug': [390, 677], 'similar': [394], 'magnitude': [395], 'raises': [396], 'possibility': [398, 2884], 'nonspecific.There': [404], 'further': [407, 664, 1224], 'question': [408], 'as': [409, 459, 461, 1097, 1456, 1504, 1595, 1624, 1717, 1743, 2481], 'what': [411], 'actually': [413], 'being': [414, 649, 1760, 1811], 'treated': [415], 'patients.': [418], 'NINDS-AIREN9': [420], 'criteria': [421, 446, 2136], 'used': [423, 739, 926, 1402], 'They': [427], 'extensively': [430], 'criticized': [431], 'several': [433, 1554], 'respects,': [434], 'relevant': [437, 1052], 'fault': [438], 'here': [439, 927], 'their': [441, 550, 1641, 1753], 'Alzheimer-based': [442], 'origin.10': [443], 'population': [449, 2632, 2855], 'from': [451, 578, 634, 643, 1141, 1229, 2228], 'obtained': [453], 'by': [454, 463, 775, 1020, 1118, 1181, 1346, 1481, 1544, 1616, 2527, 2804, 3240], 'pure': [455], 'Alzheimer': [456, 518, 2422, 2659, 2677], 'criteria,': [457], 'such': [458, 1383, 1763], 'NINCDS-ADRDA,11': [460], 'witnessed': [462], 'almost': [465, 1474, 1710], 'universal': [466], 'lack': [467, 670], 'progression': [469], 'control': [472], 'groups': [473, 835, 861], 'studies,': [477], 'noteworthy': [480], 'study,5': [485], 'where': [486, 1192, 1586], 'mixed': [487, 504, 776, 1587, 1629], 'recognized,': [494], 'was': [499, 667, 733, 816, 825, 897, 944], 'confined': [500], 'those': [502, 1672, 1850], 'disease,': [505, 758, 936, 2660], 'supporting': [506], 'notion': [508], 'bulk': [511], 'component.PreventionThe': [519], 'appearance': [520], 'data': [522, 1732], 'preventative': [524, 1563, 1731], 'also': [527, 1446, 1615], 'recent': [529], 'phenomenon,': [530, 1467], 'end': [532], 'product': [533], 'decade': [536], 'exhortation': [538], 'clinical': [540, 1911, 2567], 'trialists': [541], 'include': [543], 'measures': [544], 'cognition,': [546], 'however': [547], 'simple,': [548], 'trials': [551, 1757], 'treatments.': [554], 'A': [555, 1985, 2047, 2414, 3032, 3273], 'long-term': [559], 'now': [562, 1083, 1635], 'reported': [563], 'modifying': [565], 'risk': [567, 631, 1029, 2371, 3124], 'factors': [568, 3125], 'reduces': [569], 'incident': [570, 602], 'dementia.': [574, 603, 750, 1108, 2156], 'In': [575, 794, 954, 1396], 'updated': [576], 'results': [577, 1903, 2339], 'Syst-Eur': [580], 'study,12': [581], 'an': [582, 869, 1309, 1488, 1657], 'reduction': [583, 705], '7': [585], 'mm': [586, 592, 818], 'Hg': [587, 593], 'systolic': [589], '3.2': [591, 887], 'diastolic': [595], 'blood': [596, 707, 784, 809, 840, 1529, 2264], 'pressure': [597, 785, 810, 841, 2265], '3.9': [599, 626], 'years': [600, 627, 1306], 'halved': [601], 'absolute': [605], 'figures': [606], 'little': [609, 1033], 'impressive': [611], 'cases': [614, 813], 'per': [615], '100': [616], 'patient': [617], 'years.': [618, 832], 'PROGRESS': [620, 682, 2259, 2289], 'study13': [621], 'demonstrated': [622, 1487], 'reduction,': [624], 'follow-up,': [629], '7.1%': [635], '6.3%': [637], '(nonsignificant)': [638], 'decline': [642, 717, 2276], '11%': [644], '9.1%,': [646], 'attributable': [650], 'prevention': [653, 662, 1704, 1725, 2220], 'recurrent': [655], 'stroke.': [656], 'Despite': [657], 'association': [659, 672, 1034], 'stroke,': [665, 699, 904, 1191], 'surprising': [669], 'regimen': [678, 2298], 'used.': [679], 'main': [681], 'results14': [684], 'had': [685, 965], 'shown': [686], 'combination': [688], 'perindopril': [689, 2268], 'indapamide': [691, 2270], 'more': [693], 'effective': [694], 'monotherapy': [696], 'preventing': [698, 984], 'greater': [704], 'pressure.': [708], 'If': [709], 'stroke': [710, 2304, 2852], 'sole': [713], 'determinant': [714], 'PROGRESS,': [719], 'same': [721, 1155, 1262], 'pattern': [722, 1257, 1278], 'change': [724, 786, 1201], 'would': [725], 'expected': [728], 'cognition': [730, 744, 824, 905, 3127], 'case.': [736], 'rate': [743], 'DSM-IV': [747], 'diagnose': [749], 'Both': [751, 1519], 'optimized': [755], 'well': [762, 1243, 1516], 'some': [765, 996], 'confounded': [774, 1180], 'There': [778], 'may,': [779], 'however,': [780], 'levels': [782], 'demonstrable.': [793], 'SCOPE': [796], 'study15': [797], 'Candesartan': [799], 'therapy': [800, 849, 994, 2271, 2893], '5000': [802], 'individuals': [803, 881, 2301, 2369], 'aged': [804, 882], '70': [805, 883], '89,': [807], 'difference': [811], 'between': [812, 990, 2451, 3122], 'controls': [815], '3.2/1.6': [817], 'Hg,': [819], 'demonstrable': [826], 'mean': [829], '3.7': [831], 'Importantly,': [833], 'both': [834, 851, 860, 1283, 1724], 'enjoyed': [836], 'fall': [838], 'approximately': [843], '20/10': [844], 'due': [845], 'permitted': [847], 'add-on': [848], 'stable': [854], 'MMSE.': [855], 'It': [856, 1327, 1660], 'likely': [858], 'were,': [862], 'effect,': [864], 'groups.Interestingly,': [866], 'evidence': [867, 2227], 'statins': [873, 982, 1048], 'weaker.': [875], 'PROSPER': [877], 'study16': [878], 'followed': [879], '6000': [880], '82': [885], 'years,': [888], 'half': [889], 'them': [891], 'receive': [894], 'pravastatin,': [895], 'unable': [898], 'demonstrate': [900], 'any': [901, 1605], 'or': [906, 1838, 1854, 2305], 'activities': [907], 'daily': [909], 'living': [910], 'did': [912], 'show': [913], 'myocardial': [917], 'infarction': [918], 'TIA.': [920], 'Several': [921], 'rating': [923, 1807, 2049], 'scales': [924, 1808], 'including': [928, 1556], 'Stroop,': [930], 'sensitive': [933, 1231, 1411], 'subcortical': [935, 1005, 1098], 'unlikely': [940], 'artifactually': [945], 'negative': [946], 'through': [947, 1145, 1461], 'use': [948], 'inappropriate': [950], 'tests': [951], 'cognition.': [953], '4-year': [956], 'observational': [957], '1000': [960], 'postmenopausal': [961], 'women,': [962], 'statin': [963, 2396], 'users': [964], 'trivially': [967], '(1%)': [968], 'higher': [969], 'score': [970], 'modified': [973], 'Examination.17Given': [976], 'established': [978], 'adverse': [985], 'events,': [987], 'discrepancy': [989], 'antihypertensive': [993, 2224], 'requires': [995, 1282], 'explanation.': [997], 'lie': [1000], 'fact': [1003], 'single': [1010, 1103], 'commonest': [1011, 1104], 'form': [1012, 1105], 'hypertension': [1018], 'is,': [1019], 'considerable': [1023], 'margin,': [1024], 'powerful': [1027], 'treatable': [1028], 'factor.': [1030], 'Cholesterol': [1031], 'small-vessel': [1036, 1058], 'plaque-stabilizing,': [1040], 'antioxidant,': [1041], 'other': [1043], 'properties': [1044], 'attributed': [1045], 'lipohyalinosis': [1054], 'Taking': [1060], 'observations': [1062], 'together,': [1063], 'readily': [1066, 1394, 1791], 'see': [1069], 'why': [1070], 'differing': [1075, 1167], 'effects.White': [1076], 'Matter': [1077, 3309], 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'degrees': [1168], 'same.': [1174], 'Simple': [1175], 'volume': [1176], 'measurements': [1177], 'additionally': [1179], 'importance': [1183, 1208], 'location.': [1185, 1211], 'exemplified': [1188], 'completed': [1190], 'attempts': [1193], 'correlate': [1195], 'closely': [1196], 'infarct': [1197], 'volumes': [1198], 'routinely': [1202], 'fail': [1203], 'overriding': [1207], 'lesion': [1210, 1289, 1546], 'generally': [1214], 'overlooked': [1216], 'will': [1223, 1336, 1352, 1380, 1552, 1583, 1620, 1661], 'confound': [1225], 'problems': [1227, 1274], 'arising': [1228], 'highly': [1230], 'imaging.': [1232, 2458], 'cortical': [1236, 1454, 1528, 1568, 2479, 2602], 'location': [1237], 'function': [1240, 1455, 2400], 'sufficiently': [1242], 'characterized': [1244], 'neurologist': [1247], 'can': [1248, 1400, 1434], 'look': [1249], 'brain': [1252, 2675], 'scan': [1253], 'predict': [1255, 1539], 'deficits,': [1260], 'does': [1263], 'apply': [1265, 1584], 'lesions.A': [1269], 'solution': [1270], 'severity': [1276], 'loss': [1281, 1452, 1783, 3061], 'tract': [1286, 1301, 1407], 'lies': [1290], 'identifiable': [1293], 'degree': [1296], 'quantifiable.': [1302], 'explosion': [1310], 'work': [1312], 'using': [1313, 2456], 'diffusion': [1314, 2457, 2512], 'tensor': [1315, 2513], 'map': [1318], 'out': [1319], 'tracts,': [1322], 'process': [1324], 'termed': [1325, 1468], 'tractography.19': [1326], 'near': [1333], 'future': [1334], 'we': [1335], 'ability': [1340, 1489, 1537], 'identify': [1342], 'tracts': [1344], 'affected': [1345, 1543], 'lesions.': [1349], 'remain': [1353], 'research': [1355, 2138], 'tool': [1356], 'foreseeable': [1359], 'future,': [1360], 'quite': [1363], 'maps': [1367], 'major': [1370], 'pathways': [1371], 'set': [1372], 'against': [1373], 'landmarks': [1374], 'visible': [1375, 1421, 1439], 'scans': [1379], 'become': [1381, 1621], 'available': [1382, 1806], 'cognitively': [1385], 'unimportant': [1388], 'lesions': [1391], 'might': [1392, 1501], 'distinguished.': 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'locations': [1533], 'following': [1534, 2812], 'deep': [1535], 'infarcts.24The': [1536], 'domain': [1542], 'development': [1558], 'surrogate': [1560], 'markers': [1561], 'treatments,': [1564, 1572], 'demonstration': [1566], 'responses': [1569], 'improvements': [1574], 'diagnostic': [1576, 2135], 'prognostic': [1578], 'accuracy.': [1579], 'last': [1581], 'particularly': [1585], 'suspected,': [1594], 'determination': [1600], 'whether': [1604], 'present': [1608, 1787], 'contributing': [1610], 'decline,': [1613], 'how': [1617], 'much.': [1618], 'increasingly': [1622, 1632, 1739], 'common': [1623, 3069, 3243], 'prevalence': [1627], 'recognized.25,26These': [1633], 'forum': [1639], 'exposition,': [1642], 'International': [1644, 2864], 'Society': [1645], 'Vascular': [1647, 2133, 2155, 2948, 3034], 'Behavioral': [1648, 3156], 'Disorders': [1651], '(http://www.congrex.se/VAS-COG2003/),': [1652], 'itself': [1656], 'development.': [1659], 'meet': [1662], 'second': [1665], 'time': [1666], 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