Antitumour activity of docetaxel following treatment with the CYP17A1 inhibitor abiraterone: clinical evidence for cross-resistance?

Name: Work Video:
Duration: 3 min 30 s
Janusz Mezynski; Carmel Pezaro; Diletta Bianchini; Andrea Zivi; Shahneen Sandhu; E. Thompson; John W. Hunt; Elizabeth Sheridan; Bindumalini Rao Baikady; Ajit Sarvadikar; Gal Maier; Alcuin Reid; Amy Mulick; David Olmos; Gerhardt Attard; Johann S. de Bono
{'id': 'https://openalex.org/W2170668585', 'doi': 'https://doi.org/10.1093/annonc/mds119', 'title': 'Antitumour activity of docetaxel following treatment with the CYP17A1 inhibitor abiraterone: clinical evidence for cross-resistance?', 'display_name': 'Antitumour activity of docetaxel following treatment with the CYP17A1 inhibitor abiraterone: clinical evidence for cross-resistance?', 'publication_year': 2012, 'publication_date': '2012-07-07', 'ids': {'openalex': 'https://openalex.org/W2170668585', 'doi': 'https://doi.org/10.1093/annonc/mds119', 'mag': '2170668585', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22771826'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/annonc/mds119', 'pdf_url': 'http://www.annalsofoncology.org/article/S0923753419375155/pdf', 'source': {'id': 'https://openalex.org/S41454044', 'display_name': 'Annals of Oncology', 'issn_l': '0923-7534', 'issn': ['0923-7534', '1569-8041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.annalsofoncology.org/article/S0923753419375155/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033993615', 'display_name': 'Janusz Mezynski', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J. Mezynski', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082144106', 'display_name': 'Carmel Pezaro', 'orcid': 'https://orcid.org/0000-0003-2471-5265'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'C. Pezaro', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088696108', 'display_name': 'Diletta Bianchini', 'orcid': 'https://orcid.org/0009-0002-5071-7301'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D. Bianchini', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107870578', 'display_name': 'Andrea Zivi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}, {'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A. Zivi', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I142947616', 'https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064026461', 'display_name': 'Shahneen Sandhu', 'orcid': 'https://orcid.org/0000-0002-8660-4475'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}, {'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S. Sandhu', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I142947616', 'https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112726174', 'display_name': 'E. Thompson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}, {'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'E. Thompson', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I142947616', 'https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025955409', 'display_name': 'John W. Hunt', 'orcid': 'https://orcid.org/0000-0002-1944-6921'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}, {'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J. Hunt', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I142947616', 'https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042528906', 'display_name': 'Elizabeth Sheridan', 'orcid': 'https://orcid.org/0000-0002-7804-3217'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'E. Sheridan', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041184791', 'display_name': 'Bindumalini Rao Baikady', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'B. Baikady', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008787080', 'display_name': 'Ajit Sarvadikar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A. Sarvadikar', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029427198', 'display_name': 'Gal Maier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}, {'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'G. Maier', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I142947616', 'https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104062258', 'display_name': 'Alcuin Reid', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A.H.M. Reid', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091335645', 'display_name': 'Amy Mulick', 'orcid': 'https://orcid.org/0000-0002-4009-2080'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A. Mulick Cassidy', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072116005', 'display_name': 'David Olmos', 'orcid': 'https://orcid.org/0000-0002-7003-4826'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}, {'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D. Olmos', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I142947616', 'https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000156180', 'display_name': 'Gerhardt Attard', 'orcid': 'https://orcid.org/0000-0002-4811-7983'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'G. Attard', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072378199', 'display_name': 'Johann S. de Bono', 'orcid': 'https://orcid.org/0000-0002-2034-595X'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}, {'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J. de Bono', 'raw_affiliation_strings': ['Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK'], 'affiliations': [{'raw_affiliation_string': 'Section of Medicine, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK', 'institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5000156180'], 'corresponding_institution_ids': ['https://openalex.org/I1325846038', 'https://openalex.org/I142947616'], 'apc_list': {'value': 4060, 'currency': 'USD', 'value_usd': 4060, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 33.964, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 245, 'citation_normalized_percentile': {'value': 0.99997, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '23', 'issue': '11', 'first_page': '2943', 'last_page': '2947'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11395', 'display_name': 'Radiopharmaceutical Chemistry and Applications', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9692, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/abiraterone', 'display_name': 'Abiraterone', 'score': 0.6001527}, {'id': 'https://openalex.org/keywords/abiraterone-acetate', 'display_name': 'Abiraterone acetate', 'score': 0.504742}, {'id': 'https://openalex.org/keywords/refractory', 'display_name': 'Refractory (planetary science)', 'score': 0.5032057}, {'id': 'https://openalex.org/keywords/cabazitaxel', 'display_name': 'Cabazitaxel', 'score': 0.43289387}], 'concepts': [{'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.9757253}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8948411}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.78994465}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.6129587}, {'id': 'https://openalex.org/C2776421732', 'wikidata': 'https://www.wikidata.org/wiki/Q27888393', 'display_name': 'Abiraterone', 'level': 5, 'score': 0.6001527}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.55467165}, {'id': 'https://openalex.org/C2775832370', 'wikidata': 'https://www.wikidata.org/wiki/Q27888393', 'display_name': 'Abiraterone acetate', 'level': 5, 'score': 0.504742}, {'id': 'https://openalex.org/C142424586', 'wikidata': 'https://www.wikidata.org/wiki/Q7307572', 'display_name': 'Refractory (planetary science)', 'level': 2, 'score': 0.5032057}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.48854336}, {'id': 'https://openalex.org/C2778971682', 'wikidata': 'https://www.wikidata.org/wiki/Q412963', 'display_name': 'Cabazitaxel', 'level': 5, 'score': 0.43289387}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.3719334}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.36974704}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.343368}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.208967}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000737', 'descriptor_name': 'Androstenols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D043823', 'descriptor_name': 'Taxoids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059002', 'descriptor_name': 'Androgen Receptor Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000736', 'descriptor_name': 'Androstenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077143', 'descriptor_name': 'Docetaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/annonc/mds119', 'pdf_url': 'http://www.annalsofoncology.org/article/S0923753419375155/pdf', 'source': {'id': 'https://openalex.org/S41454044', 'display_name': 'Annals of Oncology', 'issn_l': '0923-7534', 'issn': ['0923-7534', '1569-8041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22771826', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/annonc/mds119', 'pdf_url': 'http://www.annalsofoncology.org/article/S0923753419375155/pdf', 'source': {'id': 'https://openalex.org/S41454044', 'display_name': 'Annals of Oncology', 'issn_l': '0923-7534', 'issn': ['0923-7534', '1569-8041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.63}], 'grants': [{'funder': 'https://openalex.org/F4320306163', 'funder_display_name': 'Prostate Cancer Foundation', 'award_id': None}, {'funder': 'https://openalex.org/F4320319990', 'funder_display_name': 'National Institute for Health and Care Research', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W2004973733', 'https://openalex.org/W2054281770', 'https://openalex.org/W2075004958', 'https://openalex.org/W2092172518', 'https://openalex.org/W2093868029', 'https://openalex.org/W2101606728', 'https://openalex.org/W2110534364', 'https://openalex.org/W2116458141', 'https://openalex.org/W2120292596', 'https://openalex.org/W2123629153', 'https://openalex.org/W2133489902', 'https://openalex.org/W2139248078', 'https://openalex.org/W2140855177', 'https://openalex.org/W2153790689', 'https://openalex.org/W2155273887', 'https://openalex.org/W2155679349', 'https://openalex.org/W2167331614', 'https://openalex.org/W2169737508', 'https://openalex.org/W2197001014'], 'related_works': ['https://openalex.org/W962578561', 'https://openalex.org/W4387263860', 'https://openalex.org/W3141232476', 'https://openalex.org/W3083945194', 'https://openalex.org/W3004928720', 'https://openalex.org/W2798351278', 'https://openalex.org/W2576228455', 'https://openalex.org/W2293130633', 'https://openalex.org/W2072623499', 'https://openalex.org/W2063032630'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2170668585', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 49}, {'year': 2014, 'cited_by_count': 54}, {'year': 2013, 'cited_by_count': 33}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-09T16:58:28.745396', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
