Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2170522132', 'doi': 'https://doi.org/10.1080/87565641.2011.606395', 'title': 'Advancing Neuroscience Through Epigenetics: Molecular Mechanisms of Learning and Memory', 'display_name': 'Advancing Neuroscience Through Epigenetics: Molecular Mechanisms of Learning and Memory', 'publication_year': 2011, 'publication_date': '2011-10-01', 'ids': {'openalex': 'https://openalex.org/W2170522132', 'doi': 'https://doi.org/10.1080/87565641.2011.606395', 'mag': '2170522132', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21978007', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3191880'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/87565641.2011.606395', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S133144118', 'display_name': 'Developmental Neuropsychology', 'issn_l': '1532-6942', 'issn': ['1532-6942', '8756-5641'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3191880?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091501240', 'display_name': 'David L. Molfese', 'orcid': 'https://orcid.org/0000-0002-1839-9262'}, 'institutions': [{'id': 'https://openalex.org/I44461941', 'display_name': 'University of Houston', 'ror': 'https://ror.org/048sx0r50', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44461941']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'David L. Molfese', 'raw_affiliation_strings': ['Department of Psychology, University of Houston, Houston, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychology, University of Houston, Houston, Texas, USA', 'institution_ids': ['https://openalex.org/I44461941']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5091501240'], 'corresponding_institution_ids': ['https://openalex.org/I44461941'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.653, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.529421, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '36', 'issue': '7', 'first_page': '810', 'last_page': '827'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorder Research', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/encode', 'display_name': 'ENCODE', 'score': 0.50962543}], 'concepts': [{'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.81823665}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.6334364}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.6328148}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.6180384}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.58089936}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.5436697}, {'id': 'https://openalex.org/C66746571', 'wikidata': 'https://www.wikidata.org/wiki/Q1134833', 'display_name': 'ENCODE', 'level': 3, 'score': 0.50962543}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.44391915}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.4273755}, {'id': 'https://openalex.org/C188147891', 'wikidata': 'https://www.wikidata.org/wiki/Q147638', 'display_name': 'Cognitive science', 'level': 1, 'score': 0.40119582}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.34719726}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32333377}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.19448075}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D007858', 'descriptor_name': 'Learning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009488', 'descriptor_name': 'Neurosciences', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057890', 'descriptor_name': 'Epigenomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057890', 'descriptor_name': 'Epigenomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/87565641.2011.606395', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S133144118', 'display_name': 'Developmental Neuropsychology', 'issn_l': '1532-6942', 'issn': ['1532-6942', '8756-5641'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3191880', 'pdf_url': 'https://europepmc.org/articles/pmc3191880?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191880', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21978007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3191880', 'pdf_url': 'https://europepmc.org/articles/pmc3191880?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.88, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W1502426712', 'https://openalex.org/W1711976313', 'https://openalex.org/W1964951942', 'https://openalex.org/W1965636455', 'https://openalex.org/W1967064280', 'https://openalex.org/W1971647523', 'https://openalex.org/W1971723950', 'https://openalex.org/W1974162725', 'https://openalex.org/W1977922402', 'https://openalex.org/W1979341611', 'https://openalex.org/W1981259598', 'https://openalex.org/W1982946759', 'https://openalex.org/W1984005657', 'https://openalex.org/W1989407684', 'https://openalex.org/W1990150167', 'https://openalex.org/W1993415518', 'https://openalex.org/W1994556689', 'https://openalex.org/W1998442739', 'https://openalex.org/W1999284470', 'https://openalex.org/W2001187532', 'https://openalex.org/W2002698073', 'https://openalex.org/W2005804818', 'https://openalex.org/W2013346353', 'https://openalex.org/W2017517270', 'https://openalex.org/W2018170064', 'https://openalex.org/W2027120715', 'https://openalex.org/W2027344089', 'https://openalex.org/W2029055705', 'https://openalex.org/W2030284957', 'https://openalex.org/W2036256995', 'https://openalex.org/W2039503157', 'https://openalex.org/W2041674913', 'https://openalex.org/W2042966900', 'https://openalex.org/W2044763721', 'https://openalex.org/W2045309105', 'https://openalex.org/W2046244011', 'https://openalex.org/W2046934643', 'https://openalex.org/W2050643804', 'https://openalex.org/W2054017008', 'https://openalex.org/W2057382500', 'https://openalex.org/W2061076014', 'https://openalex.org/W2066606056', 'https://openalex.org/W2067180576', 'https://openalex.org/W2068194528', 'https://openalex.org/W2069717852', 'https://openalex.org/W2072677280', 'https://openalex.org/W2074489888', 'https://openalex.org/W2075907707', 'https://openalex.org/W2076312647', 'https://openalex.org/W2086187432', 'https://openalex.org/W2088077925', 'https://openalex.org/W2088620464', 'https://openalex.org/W2091868956', 'https://openalex.org/W2095241812', 'https://openalex.org/W2103425386', 'https://openalex.org/W2104261628', 'https://openalex.org/W2105463149', 'https://openalex.org/W2106797333', 'https://openalex.org/W2107733280', 'https://openalex.org/W2121392264', 'https://openalex.org/W2124607109', 'https://openalex.org/W2130685024', 'https://openalex.org/W2136936410', 'https://openalex.org/W2138163279', 'https://openalex.org/W2143658931', 'https://openalex.org/W2146070554', 'https://openalex.org/W2150609732', 'https://openalex.org/W2152293970', 'https://openalex.org/W2152668149', 'https://openalex.org/W2166647372', 'https://openalex.org/W2168909179', 'https://openalex.org/W2169780620', 'https://openalex.org/W2187181884', 'https://openalex.org/W2764846053', 'https://openalex.org/W3021288834', 'https://openalex.org/W4242691082', 'https://openalex.org/W4244494658'], 'related_works': ['https://openalex.org/W3212149434', 'https://openalex.org/W2988126442', 'https://openalex.org/W2468279273', 'https://openalex.org/W2354198838', 'https://openalex.org/W2291484187', 'https://openalex.org/W2214376880', 'https://openalex.org/W2136950754', 'https://openalex.org/W2103419012', 'https://openalex.org/W2073893804', 'https://openalex.org/W1989130879'], 'abstract_inverted_index': {'Abstract': [0], 'Humans': [1], 'share': [2], '96%': [3], 'of': [4, 53, 109, 114, 125, 158, 170, 176, 202, 209], 'our': [5, 49, 54], '30,000': [6], 'genes': [7, 12, 40], 'with': [8, 112, 195], 'Chimpanzees.': [9], 'The': [10, 226], '1,200': [11], 'that': [13, 34, 37, 135, 162], 'differ': [14], 'appear': [15], 'at': [16, 191], 'first': [17], 'glance': [18], 'insufficient': [19], 'to': [20, 75], 'describe': [21], 'what': [22], 'makes': [23], 'us': [24], 'human': [25], 'and': [26, 69, 154, 222, 232, 248, 250], 'them': [27], 'apes.': [28], 'However,': [29], 'we': [30], 'are': [31, 41, 56, 98, 165], 'now': [32], 'discovering': [33], 'the': [35, 80, 87, 104, 123, 139, 144, 159, 168, 174, 192, 251], 'mechanisms': [36, 150, 204], 'regulate': [38], 'how': [39], 'expressed': [42], 'tell': [43], 'a': [44, 95, 119, 179], 'much': [45], 'richer': [46], 'story': [47], 'than': [48], 'DNA': [50, 55, 141, 152, 164], 'alone.': [51], 'Sections': [52], 'constantly': [57], 'being': [58], 'turned': [59], 'on': [60], 'or': [61, 67, 156, 216], 'off,': [62], 'marked': [63], 'for': [64, 207, 236], 'easy': [65], 'access,': [66], 'secluded': [68], 'hidden': [70], 'away,': [71], 'all': [72], 'in': [73, 103, 132, 167], 'response': [74], 'ongoing': [76], 'cellular': [77, 88], 'activity.': [78], 'In': [79, 146], 'brain,': [81], 'neurons': [82, 97], 'encode': [83], 'information—in': [84], 'effect': [85], 'memories—at': [86], 'level.': [89], 'Yet': [90], 'while': [91], 'memories': [92, 186], 'may': [93], 'last': [94], 'lifetime,': [96], 'dynamic': [99], 'structures.': [100], 'Every': [101], 'protein': [102], 'synapse': [105], 'undergoes': [106], 'some': [107, 111], 'form': [108], 'turnover,': [110], 'half-lives': [113], 'only': [115], 'hours.': [116], 'How': [117], 'can': [118], 'memory': [120, 189, 210], 'persist': [121], 'beyond': [122], 'lifetimes': [124], 'its': [126], 'constitutive': [127], 'molecular': [128, 193], 'building': [129], 'blocks?': [130], 'Epigenetics—changes': [131], 'gene': [133], 'expression': [134], 'do': [136], 'not': [137], 'alter': [138], 'underlying': [140], 'sequence—may': [142], 'be': [143], 'answer.': [145], 'this': [147], 'article,': [148], 'epigenetic': [149], 'including': [151, 218], 'methylation': [153, 157], 'acetylation': [155], 'histone': [160], 'proteins': [161], 'package': [163], 'described': [166], 'context': [169], 'animal': [171], 'learning.': [172], 'Through': [173], 'interaction': [175], 'these': [177, 203], 'modifications': [178], '"histone': [180], 'code"': [181], 'is': [182], 'emerging': [183], 'wherein': [184], 'individual': [185], 'leave': [187], 'unique': [188], 'traces': [190], 'level': [194], 'distinct': [196], 'time': [197], 'courses.': [198], 'A': [199], 'better': [200], 'understanding': [201], 'has': [205], 'implications': [206], 'treatment': [208], 'disorders': [211], 'caused': [212], 'by': [213], 'normal': [214], 'aging': [215], 'diseases': [217], 'schizophrenia,': [219], "Alzheimer's,": [220], 'depression,': [221], 'drug': [223], 'addiction.': [224], 'ACKNOWLEDGMENTS': [225], 'author': [227], 'thanks': [228], 'J.': [229], 'David': [230], 'Sweatt': [231], 'Caterina': [233], 'M.': [234], 'Hernandez': [235], 'helpful': [237], 'discussions.': [238], 'Notes': [239], 'Funding': [240], 'was': [241], 'provided': [242], 'through': [243], 'NIH': [244], '(MH82106,': [245], 'MH57014,': [246], 'AG013722,': [247], 'NS057098)': [249], 'Evelyn': [252], 'F.': [253], 'McKnight': [254], 'Brain': [255], 'Research': [256], 'Foundation.': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2170522132', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T12:53:39.555586', 'created_date': '2016-06-24'}